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成果及论文


2024年

Photoinduced, Palladium-Catalyzed Enantioselective 1,2-Alkylsulfonylation of 1,3-Dienes

  • Zhi-Lin Liu
  • Zhi-Peng Ye
  • Zi-hao Liao
  • Wei-Dong Lu
  • Jian-Ping Guan
  • Zi-Yi Gao
  • Kai Chen
  • Xiao-Qing Chen
  • Hao-Yue Xiang*
  • , and 
  • Hua Yang

https://doi.org/10.1021/acscatal.4c00470


Photoredox/Nickel Dual Catalysis-Enabled Aryl Formylation with 2,2-Dimethoxy-N,N-dimethylethan-1-amine as CO Source


2023年

Photoredox-Catalyzed Selective α-Scission of PR3–OH Radicals to Access Hydroalkylation of Alkenes

  • Zhen-Zhen Xie
  • Zi-Hao Liao
  • Yu Zheng
  • Chu-Ping Yuan
  • Jian-Ping Guan
  • Ming-Zhi Li
  • Ke-Yi Deng
  • Hao-Yue Xiang
  • Kai Chen*
  • , and 
  • Hua Yang*

Photoredox/Nickel Dual Catalysis-Enabled Cross-Dehydrogenative C–H Amination of Indoles with Unactivated Amine


Visible-Light-Induced Nickel-Catalyzed Cross-Coupling of Aryl Bromides with Nitriles

  • Jie Gao
  • Xian-Chen He
  • Yan-Ling Liu
  • Ke-Rong Li
  • Jian-Ping Guan
  • Hong-Bin Chen
  • Hao-Yue Xiang
  • Kai Chen*
  • , and 
  • Hua Yang*

Org. Lett. 2023, 25, 49, 8824–8828

Photoinduced catalyst-free borylation of alkenyl triflates with Lewis base complexes of boranes

Zhi-Peng Ye,a   Si-Jia Yang,a   Zhi-Lin Liu,a   Jie Gao,a   Yong-Qing Ye,a   Hong-Bin Chen,b   Peng-Ju XiaORCID logo c   Kai ChenORCID logo a   Hao-Yue Xiang ORCID logo *ad  and  Hua Yang

Org. Chem. Front., 2023,10, 5667-5671

Visible-Light-Induced, Catalyst-Free Monofluoromethyl Sulfonylation of Alkenes with Iodine(III) Reagent and DABSO

  • Zhi-Peng Ye
  • Jing-Song Yang
  • Si-Jia Yang
  • Meng Guo
  • Chu-Ping Yuan
  • Yong-Qing Ye
  • Hong-Bin Chen
  • Hao-Yue Xiang
  • Kai Chen*
  • , and 
  • Hua Yang*

Org. Lett. 2023, 25, 38, 7062–7066

Photocatalysed C–H amidation of indoles enabled by tert-butyl alkyl((perfluoropyridin-4-yl)oxy)carbamate

Ke-yi Deng,a   Zhi-wei Wang,a   Zhen-zhen Xie,a   Jun-tao He,a   Jian-ping Guan,a   Kai ChenORCID logo a   Hao-yue Xiang ORCID logo *ab  and  Hua Yang

Chem. Commun., 2023,59, 11401-11404


Visible-Light-Induced, Palladium-Mediated Desaturation/Sulfonation Cascade To Access 4-Sulfonyltetrahydropyridine Scaffolds

  • Wei-Dong Lu
  • Yu Zheng
  • Zhi-Peng Zhang
  • Hong-Bin Chen
  • Kai Chen
  • Hao-Yue Xiang*
  • , and 
  • Hua Yang*

Org. Lett. 2023, 25, 32, 6077–6081

N-Chlorosulfonyl carbamate-enabled, photoinduced amidation of quinoxalin-2(1H)-ones

Chu-Ping Yuan,a   Zhen-Zhen Xie,a   Yu Zheng,a   Jun-Tao He,a   Jian-Ping Guan,a   Hong-Bin Chen,ab   Hao-Yue XiangORCID logo a   Kai Chen ORCID logo *a  and  Hua Yang

Chem. Commun., 2023,59, 10125-10128

Photoexcited NiII–Aryl Complex-Mediated Giese Reaction of Aryl Bromides

  • Xian-Chen He
  • Ke-Rong Li
  • Jie Gao
  • Jian-Ping Guan
  • Hong-Bin Chen
  • Hao-Yue Xiang
  • Kai Chen*
  • , and 
  • Hua Yang*

Org. Lett. 2023, 25, 22, 4056–4060


Visible-light-driven oxidation of organosilanes by a charge-transfer complex

Yi-Xuan Chen,a   Jun-Tao He,a   Mei-Chun Wu,ab   Zhi-Lin Liu,a   Peng-Ju XiaORCID logo c   Kai ChenORCID logo a   Hao-Yue Xiang ORCID logo *ad  and  Hua Yang 

Chem. Commun., 2023,59, 6588-6591

Photochemical Alkene Trifluoromethylimination Enabled by Trifluoromethylsulfonylamide as a Bifunctional Reagent

  • Yu Zheng
  • Zihao Liao
  • Zhenzhen Xie
  • Hongbin Chen
  • Kai Chen
  • Haoyue Xiang*
  • , and 
  • Hua Yang*

Org. Lett. 2023, 25, 12, 2129–2133


Photosensitized Vicinal Sulfonylamination of Alkenes with Oxime Ester and DABCO·(SO2)2

  • Chu-Ping Yuan
  • Yu Zheng
  • Zhen-Zhen Xie
  • Ke-Yi Deng
  • Hong-Bin Chen
  • Hao-Yue Xiang
  • Kai Chen*
  • , and 
  • Hua Yang*

Org. Lett. 2023, 25, 10, 1782–1786


2022年

Photoredox-catalysed chlorination of quinoxalin-2(1H)-ones enabled by using CHCl3 as a chlorine source

Mei-Chun Wu,ab   Ming-Zhi Li,a   Jia-Yi Chen,c   Jun-An XiaoORCID logo d   Hao-Yue XiangORCID logo a   Kai Chen ORCID logo *a  and  Hua Yang

Chem. Commun., 2022,58, 11591-11594

Photoredox-Catalyzed Deoxygenation of Hexafluoroacetone Hydrate Enables Hydroxypolyfluoroalkylation of Alkenes

Zhen-Zhen XieYu ZhengChu-Ping YuanJian-Ping GuanZhi-Peng YeProf. Dr. Jun-An XiaoProf. Dr. Hao-Yue XiangDr. Kai ChenProf. Dr. Xiao-Qing ChenProf. Dr. Hua Yang

https://doi.org/10.1002/anie.202211035


Regioselective Access to Vicinal Diamines by Metal-Free Photosensitized Amidylimination of Alkenes with Oxime Esters

Yu ZhengZhu-Jun WangZhi-Peng YeKai TangZhen-Zhen Xie,Prof. Dr. Jun-An Xiao Prof. Dr. Hao-Yue XiangDr. Kai ChenProf. Dr. Xiao-Qing ChenProf. Dr. Hua Yang

https://doi.org/10.1002/anie.202212292


Photoredox-Catalyzed C–H Trideuteromethylation of Quinoxalin-2(1H)-ones with CDCl3 as the “CD3” source

Visible-Light-Induced, Palladium-Catalyzed Annulation of 1,3-Dienes to Construct Vinyl N-Heterocycles

  • Yu Zheng
  • Weidong Lu
  • Zhenzhen Xie
  • Kai Chen
  • Haoyue Xiang*
  • , and 
  • Hua Yang*

Org. Lett. 2022, 24, 29, 5407–5411

Visible-Light-Promoted Cross-Coupling of O-Aryl Oximes and Nitrostyrenes to Access Cyanoalkylated Alkenes

  • Jie Gao
  • Zhi-Peng Ye
  • Yu-Fei Liu
  • Xian-Chen He
  • Jian-Ping Guan
  • Fang Liu
  • Kai Chen
  • Hao-Yue Xiang*
  • Xiao-Qing Chen
  • , and 
  • Hua Yang*

Org. Lett. 2022, 24, 25, 4640–4644

Photocatalyzed Defluorinative Dichloromethylation of α-CF3 Alkenes Using CHCl3 as the Radical Source

  • Mei-Chun Wu
  • Yi-Xuan Chen
  • Ming-Zhi Li
  • Jun-An Xiao
  • Zhi-Peng Ye
  • Jian-Ping Guan
  • Hao-Yue Xiang*
  • Kai Chen*
  • , and 
  • Hua Yang*

J. Org. Chem. 2023, 88, 10, 6354–6363

Photochemical Organocatalytic Aerobic Cleavage of C═C Bonds Enabled by Charge-Transfer Complex Formation

  • Yi-Xuan Chen
  • Jun-Tao He
  • Mei-Chun Wu
  • Zhi-Lin Liu
  • Kai Tang
  • Peng-Ju Xia
  • Kai Chen
  • Hao-Yue Xiang*
  • Xiao-Qing Chen*
  • , and 
  • Hua Yang*

Org. Lett. 2022, 24, 22, 3920–3925

[3 + 2] vs. [4 + 1] Annulation: revisiting mechanism studies on the phosphine-catalysed domino sequence of alkynoates and activated methylenes

Yan-Shan Chen,a   Yu Zheng,a   Kai Tang,a   Zhen-Zhen Xie,a   Zhi-Peng Ye,a   Ming-Zhi Li,a   Kai ChenORCID logo *a   Hao-Yue Xiang ORCID logo a  and  Hua Yang

Org. Biomol. Chem., 2022,20, 4415-4420

Photoinduced Construction of a Benzothienopyridine-S,S-dioxide Framework Enabled by Polychloropyridyl Multifunctional Motifs

  • Zhu-Jun Wang
  • Yu Zheng
  • Kai Tang
  • Jian-Ping Guan
  • Zhi-Peng Ye
  • Jun-Tao He
  • Jun-An Xiao
  • Kai Chen
  • Hao-Yue Xiang*
  • , and 
  • Hua Yang*

J. Org. Chem. 2022, 87, 7, 4732–4741

Programmable iodization/deuterolysis sequences of phosphonium ylides to access deuterated benzyl iodides and aromatic aldehydes

Yu Zheng,a   Xian-Chen He,a   Jie Gao,a   Zhen-Zhen Xie,a   Zhi-Wei Wang,a   Zhi-Lin Liu,a   Kai ChenORCID logo a   Hao-Yue XiangORCID logo *ab   Xiao-Qing Chen ORCID logo a  and  Hua Yang

Chem. Commun., 2022,58, 4215-4218

Visible-Light-Induced, Palladium-Catalyzed 1,4-Difunctionalization of 1,3-Dienes with Bromodifluoroacetamides

  • Zhi-Lin Liu
  • Zhi-Peng Ye
  • Yi-Xuan Chen
  • Yu Zheng
  • Zhen-Zhen Xie
  • Jian-Ping Guan
  • Jun-An Xiao
  • Kai Chen
  • Hao-Yue Xiang*
  • , and 
  • Hua Yang*

Org. Lett. 2022, 24, 3, 924–928

Phosphine-Mediated Morita–Baylis–Hillman-Type/Wittig Cascade: Access to E-Configured 3-Styryl- and 3-(Benzopyrrole/furan-2-yl) Quinolinones

  • Yu Zheng
  • Zhi-Wei Wang
  • Wen-Shuo Cheng
  • Zhen-Zhen Xie
  • Xian-Chen He
  • Yan-Shan Chen
  • Kai Chen
  • Hao-Yue Xiang*
  • Xiao-Qing Chen
  • , and 
  • Hua Yang*

J. Org. Chem. 2022, 87, 2, 974–984

Photoredox-Catalyzed Cascade of o-Hydroxyarylenaminones to Access 3-Aminated Chromones

  • Zhi-Wei Wang
  • Yu Zheng
  • Yu-En Qian
  • Jian-Ping Guan
  • Wei-Dong Lu
  • Chu-Ping Yuan
  • Jun-An Xiao
  • Kai Chen
  • Hao-Yue Xiang*
  • , and 
  • Hua Yang*

J. Org. Chem. 2022, 87, 2, 1477–1484


2021年

Visible-Light-Promoted Hydroxydifluoroalkylation of Alkenes Enabled by Electron Donor–Acceptor Complex

  • Zhen-Zhen Xie
  • Yu Zheng
  • Kai Tang
  • Jian-Ping Guan
  • Chu-Ping Yuan
  • Jun-An Xiao
  • Hao-Yue Xiang*
  • Kai Chen*
  • Xiao-Qing Chen
  • , and 
  • Hua Yang*

Org. Lett. 2021, 23, 24, 9474–9479

Visible Light-Promoted Radical Relay Cyclization/C–C Bond Formation of N-Allylbromodifluoroacetamides with Quinoxalin-2(1H)-ones

  • Zhi-Peng Ye
  • Fang Liu
  • Xin-Yu Duan
  • Jie Gao
  • Jian-Ping Guan
  • Jun-An Xiao
  • Hao-Yue Xiang
  • Kai Chen*
  • , and 
  • Hua Yang*

J. Org. Chem. 2021, 86, 23, 17173–17183

TBN-triggered, manipulable annulations of o-hydroxyarylenaminones for divergent syntheses of oximinochromanones and oximinocoumaranones

Yu-En Qian,a   Lan Zheng,a   Qing-Lan Zhao,a   Jun-An Xiao,b   Kai ChenORCID logo a   Hao-Yue Xiang ORCID logo *ac  and  Hua Yang ORCID logo *a  

Chem. Commun., 2021,57, 12285-12288

N,N,N’,N’-Tetramethylethylenediamine-Enabled Photoredox-Catalyzed C–H Methylation of N-Heteroarenes

  • Fang Liu
  • Zhi-Peng Ye
  • Yuan-Zhuo Hu
  • Jie Gao
  • Lan Zheng
  • Kai Chen*
  • Hao-Yue Xiang*
  • Xiao-Qing Chen
  • , and 
  • Hua Yang*

J. Org. Chem. 2021, 86, 17, 11905–11914

Visible-light-promoted olefinic trifluoromethylation of enamides with CF3SO2Na

Kai Tang,a   Yixuan Chen,a   Jianping Guan,a   Zhujun Wang,a   Kai ChenORCID logo *ab   Haoyue Xiang ORCID logo a  and  Hua Yang ORCID logo *a  

Org. Biomol. Chem., 2021,19, 7475-7479

Visible-Light-Driven Sulfonation of α-Trifluoromethylstyrenes: Access to Densely Functionalized CF3-Substituted Tertiary Alcohol

  • Yi-Xuan Chen
  • Zhu-Jun Wang
  • Jun-An Xiao
  • Kai Chen
  • Hao-Yue Xiang*
  • , and 
  • Hua Yang*

Electrochemical heterodifunctionalization of α-CF3 alkenes to access α-trifluoromethyl-β-sulfonyl tertiary alcohols

Zhi-Peng Ye,a   Jie Gao,a   Xin-Yu Duan,a   Jian-Ping Guan,a   Fang Liu,a   Kai ChenORCID logo a   Jun-An Xiao,b   Hao-Yue Xiang ORCID logo *ac  and  Hua Yang ORCID logo *a  

Chem. Commun., 2021,57, 8969-8972

A phosphine-catalysed one-pot domino sequence to access cyclopentene-fused coumarins

Yan-Shan Chen,a   Yu Zheng,a   Zhi-Jun Chen,b   Zhen-Zhen Xie,a   Xian-Chen He,a   Jun-An Xiao,c   Kai ChenORCID logo *ad   Hao-Yue Xiang ORCID logo a  and  Hua Yang ORCID logo *a  

Org. Biomol. Chem., 2021,19, 7074-7080

Unveiling the abnormal effect of temperature on enantioselectivity in the palladium-mediated decabonylative alkylation of MBH acetate

Xian-Zhou Zheng,a   Kai ChenORCID logo *ab   Jun-An XiaoORCID logo *c   Jun Li,a   Sha-Sha Wang,a   Qing-Lan Zhao,a   Hao-Yue XiangORCID logo a   Xiao-Qing Chen ORCID logo a  and  Hua Yang 

Org. Chem. Front., 2021,8, 5058-5063

Photocatalytic Cyclization/Defluorination Domino Sequence to Access 3-Fluoro-1,5-dihydro-2H-pyrrol-2-one Scaffold

  • Zhi-Peng Ye
  • Yuan-Zhuo Hu
  • Jian-Ping Guan
  • Kai Chen
  • Fang Liu
  • Jie Gao

Org. Lett. 2021, 23, 12, 4754–4758

Organocatalytic domino sequence to asymmetrically access spirocyclic oxindole-α-methylene-γ-lactams

Zhen-Zhen Xie aYu-Lun Qian aYu Zheng aQing-Lan Zhao aJun-An Xiao bHao-Yue Xiang aKai Chen a cHua Yang a

https://doi.org/10.1016/j.tet.2021.132163

Recent progress in the nitration of arenes and alkenes
Yu-En Qian,a   Lan Zheng,a   Hao-Yue Xiang ORCID logo *a  and  Hua Yang ORCID logo *a  
Org. Biomol. Chem., 2021,19, 4835-4851

CuI-mediated benzannulation of (ortho-arylethynyl)phenylenaminones to assemble α-aminonaphthalene derivatives

Wen-Nian Jiang,a   Qing-Lan Zhao,a   Wen-Shuo Cheng,a   Jun-An XiaoORCID logo b   Hao-Yue XiangORCID logo *a   Kai Chen ORCID logo a  and  Hua Yang ORCID logo *a  

Org. Chem. Front., 2021,8, 3250-3254

Phosphonium Ylide-Mediated Programmable Fluorination to Access Mono- and Difluoromethylarenes

  • Yu Zheng
  • Zhen-Zhen Xie
  • Xian-Chen He
  • Yan-Shan Chen
  • Wen-Shuo Cheng
  • Kai Chen
  • Hao-Yue Xiang*
  • Xiao-Qing Chen*
  • , and 
  • Hua Yang*

Org. Lett. 2021, 23, 7, 2538–2542

Intramolecular [3+2]-cycloaddition of salicylaldehydes-based cyclic azomethine imines to access novel tetrahydrochromeno[4,3-c]pyrazolo[1,2-a]pyrazol-9-ones

Mei-Chun Wu a bPeng-Ju Xia aYuan-Zhuo Hu aZhi-Peng Ye aKai Chen aHao-Yue Xiang aHua Yang a

https://doi.org/10.1016/j.tet.2021.131992

Visible-Light-Driven, Photocatalyst-Free Cascade to Access 3-Cyanoalkyl Coumarins from ortho-Hydroxycinnamic Esters

  • Yuan-Zhuo Hu
  • Zhi-Peng Ye
  • Peng-Ju Xia
  • Dan Song
  • Xu-Jie Li
  • Zhi-Lin Liu
  • Fang Liu
  • Kai Chen
  • Hao-Yue Xiang*
  • , and 
  • Hua Yang*

J. Org. Chem. 2021, 86, 5, 4245–4253

O-Perhalopyridin-4-yl Hydroxylamines: Amidyl-Radical Generation Scaffolds in Photoinduced Direct Amination of Heterocycles

  • Lan Zheng
  • Yu-En Qian
  • Yuan-Zhuo Hu
  • Jun-An Xiao
  • Zhi-Peng Ye
  • Kai Chen
  • Hao-Yue Xiang*
  • Xiao-Qing Chen*
  • , and 
  • Hua Yang*

Org. Lett. 2021, 23, 5, 1643–1647

Enantioselectivity-Switchable Organocatalytic [4 + 2]-Annulation to Access the Spirooxindole–Norcamphor Scaffold

  • Jing Wang
  • Xian-Zhou Zheng
  • Jun-An Xiao
  • Kai Chen*
  • Hao-Yue Xiang
  • Xiao-Qing Chen*
  • , and 
  • Hua Yang*

Org. Lett. 2021, 23, 3, 963–968


2020年

An organocatalytic enantioselective ring-reorganization domino sequence of methyleneindolinones with 2-aminomalonates

Ji-Wei Ren,ab   Zhen-Zhen Xie,a   Lan Zheng,a   Zhi-Peng Ye,a   Zhi-Xiong Deng,a   Qing-Lan Zhao,a   Jun-An XiaoORCID logo c   Kai ChenORCID logo *a   Hao-Yue XiangORCID logo *a   Xiao-Qing Chen ORCID logo a  and  Hua Yang ORCID logo *a  

Org. Chem. Front., 2021,8, 778-783

Photocatalytic intermolecular anti-Markovnikov hydroamination of unactivated alkenes with N-hydroxyphthalimide

Zhi-Peng Ye,a   Yuan-Zhuo Hu,a   Peng-Ju Xia,*ab   Hao-Yue XiangORCID logo *a   Kai Chen ORCID logo *ac  and  Hua Yang ORCID logo *a  

Org. Chem. Front., 2021,8, 273-277

A phosphine-mediated domino sequence of salicylaldehyde with but-3-yn-2-one: rapid access to chromanone

Zhen-Zhen Xie,a   Zhi-Xiong Deng,a   Yu Zheng,a   Yan-Shan Chen,a   Jun-An XiaoORCID logo b   Kai ChenORCID logo a   Hao-Yue Xiang ORCID logo *a  and  Hua Yang ORCID logo *ac  

Org. Biomol. Chem., 2020,18, 8916-8920


Photocatalytic Hydroacylation of Alkenes by Directly Using Acyl Oximes

  • Lan Zheng
  • Peng-Ju Xia
  • Qing-Lan Zhao
  • Yu-En Qian
  • Wen-Nian Jiang
  • Hao-Yue Xiang*
  • , and 
  • Hua Yang*

J. Org. Chem. 2020, 85, 18, 11989–11996

Visible-Light-Induced, Catalyst-Free Radical Cross-Coupling Cyclization of N-Allylbromodifluoroacetamides with Disulfides or Diselenides

  • Zhi-Peng Ye
  • Peng-Ju Xia
  • Fang Liu
  • Yuan-Zhuo Hu
  • Dan Song
  • Jun-An Xiao
  • Ping Huang
  • Hao-Yue Xiang*
  • Xiao-Qing Chen*
  • , and 
  • Hua Yang*

J. Org. Chem. 2020, 85, 8, 5670–5682

Photocatalytic C–F Bond Borylation of Polyfluoroarenes with NHC-boranes

  • Peng-Ju Xia
  • Zhi-Peng Ye
  • Yuan-Zhuo Hu
  • Jun-An Xiao
  • Kai Chen*
  • Hao-Yue Xiang*
  • Xiao-Qing Chen*
  • , and 
  • Hua Yang*

Org. Lett. 2020, 22, 5, 1742–1747

O-Perfluoropyridin-4-yl Oximes: Iminyl Radical Precursors for Photo- or Thermal-Induced N–O Cleavage in C(sp2)–C(sp3) Bond Formation

  • Peng-Ju Xia
  • Yuan-Zhuo Hu
  • Zhi-Peng Ye
  • Xu-Jie Li
  • Hao-Yue Xiang*
  • , and 
  • Hua Yang*

J. Org. Chem. 2020, 85, 5, 3538–3547


2019年

A BHT-regulated chemoselective access to monofluorinated chromones

Qing-Lan Zhao aPeng-Jiu Xia aLan Zheng aZhen-Zhen Xie aYuan-Zhuo Hu aGuang-Jian Chen cXiao-Qing Chen a bHao-Yue Xiang aHua Yang

https://doi.org/10.1016/j.tet.2019.130833

Photoinduced Single-Electron Transfer as an Enabling Principle in the Radical Borylation of Alkenes with NHC–Borane

Peng-Ju XiaDan SongZhi-Peng YeYuan-Zhuo HuProf. Jun-An XiaoProf. Hao-Yue XiangProf. Xiao-Qing ChenProf. Hua Yanghttps://doi.org/10.1002/anie.201913398

Phosphine-Mediated MBH-Type/Umpolung Addition Domino Sequence: Divergent Construction of Coumarins

  • Zhi-Xiong Deng
  • Yu Zheng
  • Zhen-Zhen Xie
  • Yue-Heng Gao
  • Jun-An Xiao
  • Si-Qi Xie
  • Hao-Yue Xiang*
  • Xiao-Qing Chen*
  • , and 
  • Hua Yang*

Org. Lett. 2020, 22, 2, 488–492

Visible-Light-Driven, Photoredox-Catalyzed Cascade of ortho-Hydroxycinnamic Esters To Access 3-Fluoroalkylated Coumarins

  • Dan Song
  • Chao-Ming Wang
  • Zhi-Peng Ye
  • Peng-Ju Xia
  • Zhi-Xiong Deng
  • Jun-An Xiao
  • Hao-Yue Xiang*
  • , and 
  • Hua Yang*

J. Org. Chem. 2019, 84, 11, 7480–7487

Photocatalytic, Phosphoranyl Radical-Mediated N–O Cleavage of Strained Cycloketone Oximes

  • Peng-Ju Xia
  • Zhi-Peng Ye
  • Yuan-Zhuo Hu
  • Dan Song
  • Hao-Yue Xiang*
  • Xiao-Qing Chen*
  • , and 
  • Hua Yang*

Org. Lett. 2019, 21, 8, 2658–2662

Organocatalytic, Enantioselective, Polarity-Matched Ring-Reorganization Domino Sequence Based on the 3-Oxindole Scaffold

  • Ji-Wei Ren
  • Lan Zheng
  • Zhi-Peng Ye
  • Zhi-Xiong Deng
  • Zhen-Zhen Xie
  • Jun-An Xiao
  • Fa-Wei Zhu
  • Hao-Yue Xiang*
  • Xiao-Qing Chen*
  • , and 
  • Hua Yang*

Org. Lett. 2019, 21, 7, 2166–2170

A One-Pot Ring-Opening/Ring-Closure Sequence for the Synthesis of Polycyclic Spirooxindoles

Ji-Wei RenQing-Lan ZhaoDr. Jun-An XiaoPeng-Ju XiaProf. Dr. Hao-Yue XiangProf. Dr. Xiao-Qing ChenProf. Dr. Hua Yang

https://doi.org/10.1002/chem.201900409

Intramolecular hydrogen-bonding-assisted phosphine-catalysed [3 + 2] cyclisation of ynones with o-hydroxy/amino benzaldehydes

Zhi-Xiong Deng,a   Zhen-Zhen Xie,a   Yu Zheng,a   Jun-An XiaoORCID logo b   Rui-Jia Wang,a   Hao-Yue Xiang ORCID logo *a  and  Hua Yang ORCID logo *ac  

Org. Biomol. Chem., 2019,17, 2187-2191

Photocatalytic reductive radical–radical coupling of N,N′-cyclicazomethine imines with difluorobromo derivatives

Peng-Ju Xia,a   Zhi-Peng Ye,a   Dan Song,a   Ji-Wei Ren,a   Han-Wen Wu,a   Jun-An XiaoORCID logo c   Hao-Yue XiangORCID logo *a   Xiao-Qing Chen*ab  and  Hua Yang ORCID logo *ab  

Chem. Commun., 2019,55, 2712-2715

Construction of Bispirooxindole Heterocycles via Palladium-Catalyzed Ring-Opening Formal [3 + 2]-Cycloaddition of Spirovinylcyclopropyl Oxindole and 3-Oxindole Derivatives

  • Jun-An Xiao
  • Yu-Chun Li
  • Zhi-Jin Luo
  • Xiu-Liang Cheng
  • Zhi-Xiong Deng
  • Wen-Qiang Chen
  • Wei Su*
  • , and 
  • Hua Yang

J. Org. Chem. 2019, 84, 4, 2297–2306

Palladium-catalysed ring-opening [3 + 2]-annulation of spirovinylcyclopropyl oxindole to diastereoselectively access spirooxindoles

Jun-An XiaoORCID logo ab   Xiu-Liang Cheng,a   Yu-Chun Li,a   Yi-Miao HeORCID logo ab   Jin-Lian Li,a   Zhi-Ping Liu,ab   Peng-Ju Xia,c   Wei Su*ab  and  Hua Yang ORCID logo *c  

Org. Biomol. Chem., 2019,17, 103-107


2018年

Unraveling and Manipulating the Stereospecific Retro-Aldol Reaction in the Organocatalytic Asymmetric Aldol Reaction of Isatin and Cyclohexanone

  • Jing Wang
  • Zhi-Xiong Deng
  • Chao-Ming Wang
  • Peng-Ju Xia
  • Jun-An Xiao
  • Hao-Yue Xiang*
  • Xiao-Qing Chen*
  • , and 
  • Hua Yang*

Org. Lett. 2018, 20, 23, 7535–7538

Diastereospecific entry to pyrrolidinyldispirooxindole skeletons via three-component 1,3-dipolar cycloadditions

Yu-Lun QianBo LiPeng-Ju XiaJing WangHao-Yue XiangHua Yang

https://doi.org/10.1016/j.tet.2018.09.055


Organocatalytic Domino Entry to an Octahydroacridine Scaffold Bearing Three Contiguous Stereocenters

  • Shuang Li
  • Jing Wang
  • Peng-Ju Xia
  • Qing-Lan Zhao
  • Chao-Ming Wang
  • Jun-An Xiao
  • Xiao-Qing Chen
  • Hao-Yue Xiang*
  • , and 
  • Hua Yang*

J. Org. Chem. 2018, 83, 19, 12284–12290

Photoredox-catalyzed direct aminoalkylation of isatins: diastereoselective access to 3-hydroxy-3-aminoalkylindolin-2-ones analogues

Chao-Ming Wang,a   Dan Song,a   Peng-Ju Xia,a   Zhi-Peng Ye,a   Jun-An Xiao,b   Hao-Yue XiangORCID logo *a   Xiao-Qing Chena  and  Hua Yang 

Org. Chem. Front., 2018,5, 1608-1612

Visible-Light-Induced External Radical-Triggered Annulation To Access CF2-Containing Benzoxepine Derivatives

Org. Lett. 2018, 20, 5, 1363–1366

Solvent-Minimized, Chromatography-Free, Diastereoselective Synthesis of Oxazolidine-Dispirooxindoles viaoxa-1,3-Dipolar Cycloaddition of 3-Oxindole

J. Org. Chem. 2018, 83, 5, 2948–2953


2017年

Visible-Light-Promoted Synthesis of 1,4-Dicarbonyl Compounds via Conjugate Addition of Aroyl Chlorides

Dr. Chao-Ming WangDan SongDr. Peng-Ju XiaDr. Jing WangDr. Hao-Yue XiangProf. Hua Yang

https://doi.org/10.1002/asia.201701738

Unusual Ligand-to-Metal-Ratio-Controlled Bidirectional Enantioselectivity in Pd-Catalysed [3+3]-Annulation of Morita–Baylis–Hillman Acetate

Jun LiSha-Sha WangPeng-Ju XiaQing-Lan ZhaoJun-An XiaoHao-Yue XiangXiao-Qing ChenHua Yang

https://doi.org/10.1002/ejoc.201701315

Organocatalytic Asymmetric Allylic Alkylation of Morita–Baylis–Hillman Carbonates with Diethyl 2-Aminomalonate Assisted by In Situ Protection

J. Org. Chem. 2017, 82, 23, 12202–12208

Diversity-driven and facile 1,3-dipolar cycloaddition to access dispirooxindole-imidazolidine scaffolds

Yu-Lun Qian,a   Peng-Ju Xia,a   Jun Li,a   Qing-Lan Zhao,a   Jun-An Xiao,b   Hao-yue Xiang ORCID logo *a  and  Hua Yang ORCID logo *a  

Org. Biomol. Chem., 2017,15, 8705-8708

Selectfluor-Triggered Tandem Cyclization of o-Hydroxyarylenaminones To Access Difluorinated 2-Amino-Substituted Chromanones

J. Org. Chem. 2017, 82, 18, 9837–9843

L-Pyroglutamic Sulphonamide as Hydrogen-Bonding Organocatalyst: Enantioselective Diels–Alder Cyclization to Construct Carbazolespirooxindoles

J. Org. Chem. 2017, 82, 12, 6441–6449

Photoredox-Catalyzed Reductive Dimerization of Isatins and Isatin-Derived Ketimines: Diastereoselective Construction of 3,3′-Disubstituted Bisoxindoles

J. Org. Chem. 2017, 82, 7, 3895–3900

Discovery of temperature-dependent, autoinductive reversal of enantioselectivity: palladium-mediated [3+3]-annulation of 4-hydroxycoumarins

Shasha Wang,a   Junan Xiao,a   Jun Li,a   Haoyue XiangORCID logo a   Chaoming Wang,a   Xiaoqing Chen,*a   Rich G. Carterb  and  Hua Yang

Chem. Commun., 2017,53, 4441-4444

Visible-Light-Driven, Radical-Triggered Tandem Cyclization of o-Hydroxyaryl Enaminones: Facile Access to 3-CF2 /CF3-Containing Chromones

Org. Lett. 2017, 19, 1, 146–149


2016年

Diastereoselective Intramolecular [3 + 2]-Annulation of Donor–Acceptor Cyclopropane with Imine-Assembling Hexahydropyrrolo[3,2-c]quinolinone Scaffolds

J. Org. Chem. 2016, 81, 22, 11185–11194


Acid-Relayed Organocatalytic exo-Diels–Alder Cycloaddition of Cyclic Enones with 2-Vinyl-1H-indoles

Ji-Wei RenZhao-Fang ZhouJun-An XiaoXiao-Qing ChenHua Yang

https://doi.org/10.1002/ejoc.201501619

Divergent Aerobic Oxidative Ring-Opening Cascades of Isatins with 1,2,3,4-Tetrahydroisoquinoline

Peng-Ju XiaJun-An XiaoYan-Hua SunJun LiHao-Yue XiangXiao-Qing ChenHua Yang

https://doi.org/10.1002/ejoc.201601037

Organocatalytic Enantioselective Conjugate Addition of Azlactones to Enolizable Linear and Cyclic Enones

J. Org. Chem. 2016, 81, 17, 8001–8008

Amide-assisted intramolecular [3+2] annulation of cyclopropane ring-opening: a facile and diastereoselective access to the tricyclic core of (±)-scandine

Chem. Commun., 2016,52, 2177-2180


2015年

Regioselectivity-Tunable Self-1,3-Dipolar [3+3] Cyclizations of Azomethine Ylides To Assemble Dispirooxindole-piperazines

J. Org. Chem. 2015, 80, 22, 11573–11579

Dually activated Michael-Michael-acetalization cascade: facile and highly diastereoselective construction of tetrahydro-6-hydroxyl-6H-benzo[c]chromen-9-one polycyclic scaffold

Jian LiuSai-Shuai WenJing WangJun-An XiaoShao-Jie HuangHua Yang

https://doi.org/10.1016/j.tet.2015.05.014


2014年

Highly stereoselective synthesis of novel spiroimidazolidinones directed by pyridine prolinamide

Jun-An Xiao aChao-Ming Wang aJing Wang aGuang-Chuan Ou bXing-Yu Zhang bHua Yang 

https://doi.org/10.1016/j.tet.2014.12.055

Synthesis of functionalized chromones via organocatalysis

Sai-Shuai WenJing WangYi-Ming LuoHua Yang

https://doi.org/10.1016/j.tet.2014.10.045

Highly Enantioselective Construction of Polycyclic Spirooxindoles by Organocatalytic 1,3-Dipolar Cycloaddition of 2-Cyclohexenone Catalyzed by Proline-Sulfonamide

Jun-An XiaoQi LiuJi-Wei RenJian LiuRich G. CarterXiao-Qing ChenHua Yang

https://doi.org/10.1002/ejoc.201402953


2013年及以前

Synthesis of Pyrrolo(spiro-[2.3′]-oxindole)-spiro-[4.3″]-oxindole via 1,3-Dipolar Cycloaddition of Azomethine Ylides with 3-Acetonylideneoxindole

J. Org. Chem. 2013, 78, 22, 11577–11583

Proline sulphonamide-catalysed Yamada–Otani condensation: reaction development, substrate scope and scaffold reactivity

Hua Yang,a   Somdev Banerjeeb  and  Rich G. Carter*b  

Org. Biomol. Chem., 2012,10, 4851-4863

Highly Stereoselective and Scalable anti-Aldol Reactions Using N-(p-Dodecylphenylsulfonyl)-2-pyrrolidinecarboxamide: Scope and Origins of Stereoselectivities

J. Org. Chem. 2010, 75, 21, 7279–7290

Development of an Enantioselective Route toward the Lycopodium Alkaloids: Total Synthesis of Lycopodine

J. Org. Chem. 2010, 75, 15, 4929–4938

Synthesis of All-Carbon, Quaternary Center-Containing Cyclohexenones through an Organocatalyzed, Multicomponent Coupling

Org. Lett. 2010, 12, 13, 3108–3111

Organocatalyzed, enantioselective synthesis of bicyclo-[2.2.2]-octanes containing benzylic, all-carbon quaternary centers

Hua YangRich G. Carter

https://doi.org/10.1016/j.tet.2010.01.094

N-(p-Dodecylphenylsulfonyl)-2-pyrrolidinecarboxamide: A Practical Proline Mimetic for Facilitating Enantioselective Aldol Reactions

Org. Lett. 2008, 10, 20, 4649–4652

Enantioselective Total Synthesis of Lycopodine

J. Am. Chem. Soc. 2008, 130, 29, 9238–9239