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成果及论文

58. Photolabile ortho-Nitro-Benzyl Carbonate as a Permanent Hydroxyl Protecting Group for the Synthesis of Digalactosyl Diacylglycerol

Jibin Zheng, Hongyu Chen, Jintao Shang, Lvfeng Zhang, Youling Liang, Dongsheng Chang, You Yang*. Chin. J. Chem. 202543, 169–174.


57. A Semisynthetic Oligomannuronic Acid-Based Glycoconjugate Vaccine against Pseudomonas aeruginosa

Yiyue Zhang, Xiaotong Wang, Youling Liang, Liangliang Zhang, Jiahao Fan, You Yang*. ACS Cent. Sci. 202410, 1515–1523. (: co-first author)

·  Cover article

·  Highlighted by ACS美国化学会 (July 21, 2024)

·  Highlighted by 枫林糖话 (July 13, 2024)

·  Highlighted by 科学网 (July 12, 2024)

·  Highlighted by《上海科技报》(July 12, 2024)

·  Highlighted by 华理要闻 (July 10, 2024)


56. Insight into Gold-Catalyzed Glycosylation of Glycosyl Ynenoates

Lvfeng ZhangYouling LiangXiaona LiRongkun LiuJibin ZhengPeng XuBiao Yu, You Yang*. J. Carbohydr. Chem. 202443, 21–36


55. Microwave-Assisted Synthesis of Highly Sulfated Mannuronate Glycans as Potential Inhibitors against SARS-CoV-2

Yirong Zhu, Xiaotong Wang, Siqian Lu, Jibin Zheng, Youling Liang, Liangliang Zhang, Pengfei Fang, Peng Xu, Biao Yu, You Yang*.  Org. Biomol. Chem. 202422, 3986–3994(: co-first author)


54. Additive-Assisted Synthesis of α-Kdo Glycosides with Peracetylated Glycosyl Ynenoate as Donor

He Miao, Siqian Lu, Hongyu Chen, Jintao Shang, Jibin Zheng, You Yang*.  Org. Biomol. Chem. 2024, 222365–2369.


53. Chemical Synthesis and Antitumor Evaluation of Chikusetsusaponin IVa Butyl Ester and Its Analogues

Jibin Zheng, Yanxiao Wang, Yiyue Zhang, Jingjing Rong, Dongjuan He, Xiaotong Wang, Liangliang Zhang, Jianguang Xu, Peng Cao,* You Yang*. Synlett 2024, DOI: 10.1055/a-2239-6717.


52. Promoter-Controlled Synthesis and Conformational Analysis of Cyclic Mannosides up to a 32-mer

Xiaona Li, Cristina Di Carluccio, He Miao, Lvfeng Zhang, Jintao Shang, Antonio Molinaro, Peng Xu,* Alba Silipo,* Biao Yu, You Yang*. Angew. Chem. Int. Ed. 2023, 62, e202307851. 

·  Back cover

·  Hot paper

·  Highlighted by 枫林糖话 (July 14, 2023)

·  Highlighted by 化学深耕堂 (July 14, 2023)


51. Stereoselective Synthesis of α-Glucosides with Glucosyl (Z)-Ynenoates as Donors 

Zhi Ma, Yi Hu, Xiaona Li, Rongkun Liu, E Xia, Peng Xu, You Yang*. Carbohydr. Res. 2023523, 108710. (: co-first author)


50. Synthesis of Nucleosides and Deoxynucleosides via Gold(I)-Catalyzed N‑Glycosylation of Glycosyl (Z)‑Ynenoates 

    Rongkun Liu, Yan Chen, Jibin Zheng, Lvfeng Zhang, Tong Xu, Peng Xu, You Yang*. Org. Lett. 2022, 24, 9479−9484. (: co-first author)


    49. Promoter-Controlled Synthesis and Antigenic Evaluation of Mannuronic Acid Alginate Glycans of Pseudomonas aeruginosa

    Liangliang Zhang, Yiyue Zhang, Qingting Hua, Tong Xu, Junru Liu, Yirong Zhu, You Yang*. Org. Lett. 2022, 24, 8381–8386. (: co-first author)


    48. Automated Chemical Solid-Phase Synthesis of Glycans

    Xiaona Li, You Yang*. Chin. J. Chem. 202240, 1714−1728.

    Cornerstones in Chemistry:聚糖的自动化固相化学合成


    47. Chemical Synthesis of Polysaccharides

    Shengyang Wang, You Yang*, Qian Zhu, Guo-Qiang Lin, Biao Yu*Curr. Opin. Chem. Biol. 202269, 102154. 


    46. Photolabile Protecting Group-Mediated Synthesis of 2-Deoxy-Glycosides

    Xiaoqian Li, Zhi Ma, Rongkun Liu, Mattan Hurevich, You Yang*. Chin. J. Chem. 2021, 39, 3309−3314. (: co-first author)

    ·  Inside cover


    45. Promoter-Assisted Stereoselective Synthesis of the 6-Deoxy-β-d-manno-heptopyranose Oligosaccharides

    Yan Chen, Zunxian Wu, Xiaona Li, Yi Hu, You Yang*. Org. Lett. 2021, 23, 3216−3220.


    44. NIS/TMSOTf-Promoted Glycosidation of Glycosyl ortho-Hexynylbenzoates for Versatile Synthesis of O-Glycosides and Nucleosides

    Rongkun Liu, Qingting Hua, Qixin Lou, Jiazhe Wang, Xiaona Li, Zhi Ma, You Yang*. J. Org. Chem. 2021, 86, 4763−4778.


    43. Total Synthesis and Immunological Evaluation of the Tri-d-glycero-d-manno-heptose Antigen of the Lipopolysaccharide as a Vaccine Candidate against Helicobacter pylori

    Junchang Wang, Yiyue Zhang, Yirong Zhu, Junru Liu, Yan Chen, Xin Cao, You Yang*. Org. Lett. 2020, 22, 8780–8785. (: co-first author)

    · Highlighted by ChemBeanGo (November 17, 2020)


    42. Synthesis of l-glycero- and d-glycero-d-manno-Heptose Building Blocks for Stereoselective Assembly of the Lipopolysaccharide Core Trisaccharide of Vibrio parahemolyticus O2

    Junchang Wang, Jingjing Rong, Qixin Lou, Yirong Zhu, You Yang*. Org. Lett. 2020, 22, 8018−8022.

    · Highlighted by ChemBeanGo (October 19, 2020)


    41. Synthesis and Immunomodulatory Activity of the Sulfated Tetrasaccharide Motif of Type B Ulvanobiuronic Acid 3-Sulfate

    Liangliang Zhang, Xiaotong Wang, Qingting Hua, Junchang Wang, Jianwen Liu*, You Yang*. Org. Biomol. Chem. 2020, 18, 7932–7935. 

          

    40. Advances in Research on the Synthesis of 3-Deoxy-d-manno-2-octulosonic Acid Oligosaccharides

    Liqin Zhuang, Yu Deng, Zheng Zeng, Qixin Lou, You Yang*. Prog. Pharm. Sci. 2020, 44, 521−534.


    39. Dimethylformamide-Modulated Kdo Glycosylation for Stereoselective Synthesis of α‑Kdo Glycosides

    Qixin Lou, Qingting Hua, Liangliang Zhang, You Yang*. Org. Lett. 2020, 22, 981−985.

    ·  Highlighted by ChemBeanGo (January 22, 2020)

     

    38. Gold(I)-Catalyzed Glycosylation with Glycosyl Ynenoates as Donors

    Xiaona Li, Chenyu Li, Rongkun Liu, Jiazhe Wang, Zixuan Wang, Yan Chen, You Yang*. Org. Lett. 2019, 21, 9693−9698.

    ·  Highlighted by ChemBeanGo (December 5, 2019)

     

    37. Gold(I)-catalyzed Intermolecular Rearrangement Reaction of Glycosyl Alkynoic β-Ketoesters for the Synthesis of 4-O-Glycosylated 2-Pyrones

    Rongkun Liu, Xiaoqian Li, Xiaona Li, Jiazhe Wang, You Yang*. J. Org. Chem. 2019, 84, 14141−14150. 

    ·  Highlighted by Org. Chem. Portal (May 11, 2020)

     

    36. Gold(I)-promoted α-Selective Sialylation of Glycosyl ortho-Hexynylbenzoates for the Latent-active Synthesis of Oligosialic Acids

    Jiazhe Wang, Qixin Lou, Jingjing Rong, You Yang*. Org. Biomol. Chem. 2019, 17, 6580–6584.

     

    35. Gold(I)-promoted Synthesis of a β-(1,3)-Glucan Hexadecasaccharide via the Highly Convergent Strategy

    Zixuan Wang, Qingting Hua, You Yang*. Carbohydr. Res. 2019, 482, 107735.

     

    34. Highly Convergent Synthesis of a β-Mannuronic Acid Alginate Hexadecasaccharide

    Dingyi Pan, Liangliang Zhang, Qingting Hua, You Yang*. Org. Biomol. Chem. 2019, 17, 6174–6177.

     

    33. Total Synthesis of the Trisaccharide Antigen of the Campylobacter jejuni RM1221 Capsular Polysaccharide via de Novo Synthesis of the 6-Deoxy-d-manno-heptose Building Blocks

    Xiaoman Wang, Yan Chen, Junchang Wang, You Yang*. J. Org. Chem. 2019, 84, 2393−2403. (: co-first author)

    ·  Cover

     

    32. Synthesis of the β-Linked GalNAc-Kdo Disaccharide Antigen of the Capsular Polysaccharide of Kingella kingae KK01

    Liqin Zhuang, Yan Chen, Qixin Lou, You Yang*. Org. Biomol. Chem. 2019, 17, 1694–1697.

    ·  Outside front cover

    ·  New Talent

    ·  OBC HOT article

     

    31. Microbe-focused Glycan Array Screening Platform

    Andreas Geissner, Anika Reinhardt, Christoph Rademacher, Timo Johannssen, João Monteiro, Bernd Lepenies, Michel Thépaut, Franck Fieschi, Jana Mrázková, Michaela Wimmerova, Frank Schuhmacher, Sebastian Götze, Dan Grünstein, Xiaoqiang Guo, Heung Sik Hahm, Jeyakumar Kandasamy, Daniele Leonori, Christopher E. Martin, Sharavathi G. Parameswarappa, Sandip Pasari, Mark K. Schlegel, Hidenori Tanaka, Guozhi Xiao, You Yang, Claney L. Pereira, Chakkumkal Anish, Peter H. Seeberger*. Proc. Natl. Acad. Sci. USA. 2019, 116, 1958–1967.

     

    30. Synthesis of 3-C-Branched Kdo Analogues via Sonogashira Coupling of 3-Iodo Kdo Glycal with Terminal Alkynes

    Wenjing Fan, Yan Chen, Qixin Lou, Liqin Zhuang, You Yang*. J. Org. Chem. 2018, 83, 6171–6177.

    ·  Highlighted by ChemBeanGo (May 28, 2018)

     

    29. Design, Synthesis and Evaluation of Ribose-modified Anilinopyrimidine Derivatives as EGFR Tyrosine Kinase Inhibitors

    Xiuqin Hu, Disha Wang, Yi Tong, Linjiang Tong, Xia Wang, Lili Zhu, Hua Xie, Shiliang Li, You Yang*, Yufang Xu*. Front. Chem. 2017, 5, 101.

     

    28. Recent Advances in the Chemical Synthesis of C-Glycosides

    You Yang*, Biao Yu*. Chem. Rev. 2017, 117, 12281–12356.

    ·  ESI "Highly Cited Paper"

    ·  Most Read Articles in October, 2017

     

    27. Gold(I)-catalyzed Synthesis of β-Kdo Glycosides Using Kdo ortho-Hexynylbenzoate as Donor

    Xuemeng Mi, Qixin Lou, Wenjing Fan, Liqin Zhuang, You Yang*. Carbohydr. Res. 2017, 448, 161–165.

    ·  Young Carbohydrate Researchers in Asia

     

    26. Rapid and Efficient Conversion of Sialyl Thioglycosides to Sialyl Esters via NIS/BF3OEt2-Promoted Glycosylation

    Jiazhe Wang, Rongkun Liu, You Yang*. Tetrahedron Lett. 2017, 58, 2370–2373.

     

    25. Synthesis of d-manno-Heptulose via a Cascade Aldol/hemiketalization Reaction

    Yan Chen, Xiaoman Wang, Junchang Wang, You Yang*. Beilstein J. Org. Chem. 2017, 13, 795–799.

     

    24. An Efficient Approach to Chloro(organophosphine) Gold(I) Complexes for the Synthesis of Auranofin

    Junchang Wang, Xuemeng Mi, Jiazhe Wang, You Yang*. Green Chem. 2017, 19, 634–637.

     

    23. Structure Binding Relationship of Human Surfactant Protein D and Various Lipopolysaccharide Inner Core Structures

    Anika Reinhardt, Marko Wehle, Andreas Geissner, Erika C. Crouch, Yu Kang, You Yang, Chakkumkal Anish, Mark Santer*, Peter H. Seeberger*. J. Struct. Biol. 2016, 195, 387–395.

     

    22. ortho-(Methyltosylaminoethynyl)benzyl Glycosides as New Glycosyl Donors for Latent-active Glycosylation

    Xiaoping Chen, Dacheng Shen, Qiaoling Wang, You Yang, Biao Yu*. Chem. Commun. 2015, 51, 13957–13960.

     

    21. O-Glycosylation Methods in the Total Synthesis of Complex Natural Glycosides

    You Yang*, Xiaheng Zhang, Biao Yu*. Nat. Prod. Rep. 2015, 32, 1331–1355. 

    ·  ESI "Highly Cited Paper"

    ·  RSC "Top 1% Highly Cited Chinese Authors"

    ·  Abstracted by ChemInform 2015, 43-237

     

    20. Naturally Occurring Polyphenolic Glucosidase Inhibitors

    You Yang*, Gaoyan Lian, Biao Yu*. Isr. J. Chem. 2015, 55, 268–284. (Chi-Huey Wong – Wolf Prize Special Issue)

    ·  Chi-Huey Wong – Wolf Prize Special Issue

    ·  Abstracted by ChemInform 2015, 24-287

     

    19. Antigenic Potential of a Highly Conserved Neisseria meningitidis Lipopolysaccharide Inner Core Structure Defined by Synthetic Approach

    Anika ReinhardtYou Yang, Heike Claus, Claney L. Pereira, Andrew D. Cox, Ulrich Vogel, Chakkumkal Anish*, Peter H. Seeberger*. Chem. Biol. 2015, 22, 38–49. (: co-first author)


    18. Chemical Synthesis of Saponins

    You Yang*, Stephane Laval, Biao Yu*. Adv. Carbohydr. Chem. Biochem. 2014, 71, 137–226.

     

    17. Efficient Synthesis of a Library of Heparin Tri- and Tetrasaccharides Relevant to the Substrate of Heparanase

    Peng Xu, Weichang Xu, Yuanwei Dai, You Yang, Biao Yu*. Org. Chem. Front. 2014, 1, 405–414.

     

    16. Epitope Recognition of Antibodies against a Yersinia pestis Lipopolysaccharide Trisaccharide Component

    Felix Broecker, Jonas Aretz, You Yang, Jonas Hanske, Xiaoqiang Guo, Anika Reinhardt, Annette Wahlbrink, Christoph Rademacher, Chakkumkal Anish*, Peter H. Seeberger*. ACS Chem. Biol. 2014, 9, 867–873.

     

    15. Recent Advances in the Synthesis of Chitooligosaccharides and Congeners

    You Yang*, Biao Yu*. Tetrahedron 2014, 70, 1023–1046.

    ·  Abstracted by ChemInform 2014, 17-257

     

    14. Diversity-oriented Synthesis of Inner Core Oligosaccharides of the Lipopolysaccharide of Pathogenic Gram-negative Bacteria

    You Yang, Shunsuke Oishi, Christopher E. Martin, Peter H. Seeberger*. J. Am. Chem. Soc. 2013, 135, 6262–6271.

     

    13. Total Synthesis of the Core Tetrasaccharide of Neisseria meningitidis Lipopolysaccharide, a Potential Vaccine Candidate for Meningococcal Diseases

    You Yang, Christopher E. Martin, Peter H. Seeberger*. Chem. Sci. 2012, 3, 896–899.

    ·  Broadcasted by Deutschlandfunk (30 Dec. 2011)

    ·  Highlighted in Chemistry World (February 2012)

     

    12. Synthesis, Evaluation, and Mechanism of N,N,N-Trimethyl-d-glucosamine-(1→4)-chitooligosaccharides as Selective Inhibitors of Glycosyl Hydrolase Family 20 β-N-Acetyl-d-hexosaminidases

    You Yang, Tian Liu, Yongliang Yang, Qingyue Wu, Qing Yang*, Biao Yu*. ChemBioChem 2011, 12, 457–467. (: co-first author)


    11. Chemoselective Glycosylation of Carboxylic Acid with Glycosyl ortho-Hexynylbenzoates as Donors

    You Yang, Yao Li, Biao Yu*. Tetrahedron Lett. 2010, 51, 1504–1507.

     

    10. Gold(I)-Catalyzed Glycosylation with Glycosyl ortho-Alkynylbenzoates as Donors, General Scope and Application to the Synthesis of a Cyclic Triterpene Saponin

    Yao Li, Xiaoyu Yang, Yunpeng Liu, Cunsheng Zhu, You Yang, Biao Yu*. Chem. Eur. J. 2010, 16, 1871–1882.

    ·  Abstracted by ChemInform 2010, 24-183

     

    9. Total Synthesis and Structure Revision of TMG-chitotriomycin, a Specific Inhibitor of Insect and Fungal β-N-Acetylglucosaminidases

    You Yang, Yao Li, Biao Yu*. J. Am. Chem. Soc. 2009, 131, 12076–12077.

    ·  Highlighted in Chin. J. Org. Chem. 2009, 29, 1867

    ·  Abstracted by ChemInform 2009, 51-199

     

    8. An Efficient Glycosylation Protocol with Glycosyl ortho-Alkynylbenzoates as Donors under the Catalysis of PPh3AuOTf

    Yao Li, You Yang, Biao Yu*. Tetrahedron Lett. 2008, 49, 3604–3608.

    ·  Abstracted by ChemInform 2008, 36-196

     

    7. N-Dimethylphosphoryl-Protection in the Efficient Synthesis of Glucosamine-containing Oligosaccharides with Alternate N-acyl Substitutions

    You Yang, Biao Yu*. Tetrahedron Lett. 2007, 48, 7049–7052.

     

    6. N-Dimethylphosphoryl-Protected Glucosamine Trichloroacetimidate as an Effective Glycosylation Donor

    You Yang, Biao Yu*. Tetrahedron Lett. 2007, 48, 4557–4560.

    ·  Abstracted by ChemInform 2007, 41-173

     

    5. Size-Controlled Synthesis and Growth Mechanism of Monodisperse Tellurium Nanorods by a Surfactant-Assisted Method

    Zhaoping Liu, Zhaokang Hu, Jianbo Liang, Shu Li, You Yang, Sheng Peng, Yitai Qian*. Langmuir 2004, 20, 214–218.

     

    4. Complex-Surfactant-Assisted Hydrothermal Route to Ferromagnetic Nickel Nanobelts

    Zhaoping Liu, Shu Li, You Yang, Sheng Peng, Zhaokang Hu, Yitai Qian*. Adv. Mater. 2003, 15, 1946–1948.

     

    3. Large-scale Synthesis of Ultralong Bi2S3 Nanoribbons via a Solvothermal Process

    Zhaoping Liu, Sheng Peng, Qin Xie, Zhaokang Hu, You Yang, Shuyuan Zhang, Qitai Qian*. Adv. Mater. 2003, 15, 936–940.

     

    2. Shape-controlled Synthesis and Growth Mechanism of One-dimensional Nanostructures of Trigonal Tellurium

    Zhaoping Liu, Shu Li, You Yang, Zhaokang Hu, Sheng Peng, Jianbo Liang, Yitai Qian*. New J. Chem. 2003, 27, 1748–1752.

     

    1. Synthesis of Copper Nanowires via a Complex-Surfactant-Assisted Hydrothermal Reduction Process

    Zhaoping Liu, You Yang, Jianbo Liang, Zhaokang Hu, Shu Li, Sheng Peng, Yitai Qian*. J. Phys. Chem. B 2003, 107, 12658–12661.