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成果及论文

https://orcid.org/0000-0003-3788-3575https://scholar.google.com/citations?user=Odt96p4AAAAJ&hl=en


23 An antagonist-based two-photon fluorogenic probe for imaging metabotropic glutamate receptor 5 in neuronal cells

Mingran Si,Xinyi Cai,Yani Liu,Zheng Li,Xiangjie Luo,Hai-Liang Zhu,Yong Qian

Talanta2024

DOI: 10.1016/j.talanta.2024.126167



22 Cascading Detection of Hydrogen Sulfide and N-Acetyltransferase 2 in Hepatocellular Carcinoma Cells Using a Two-Photon Fluorescent Probe

Yani Liu, Xueao Wang, Zheng Li, Liping Chen, Xinyi Cai, Zhigang Sun, Wei Cheng, Xiangjie Luo, Hai-Liang Zhu, and Yong Qian

Analytical Chemistry,2024

https://doi.org/10.1021/acs.analchem.4c00061


21 Activatable Dual-Optical Molecular Probe for Bioimaging Superoxide Anion in Epilepsy

Mingran Si, Li Lv, Yifan Shi, Zheng Li, Wenjing Zhai, Xiangjie Luo, Ling Zhang, Yong Qian

Analytical Chemistry,2024

https://doi.org/10.1021/acs.analchem.3c05641


Figure 1


20 Engineered human serum albumin for mapping drug fluctuations: Generatation of pseudo-fluorescent proteins by covalently coupling dyes for probing tamoxifen in vitro, in cellulo, and in vivo

Xueting Wang, Xianwen Wang, Rui Wang, Xueao Wang, Zheng Li, Yanli Yang, Hai-Liang Zhu,Yong Qian

Chemical Engineering Journal, 2024, 484, 149484.

DOI:10.1016/j.cej.2024.149484



19 A Near-Infrared Fluorogenic Probe for Rapid, Specific, and Ultrasensitive Detection of Sphingosine in Living Cells and In Vivo

Yanyan ChenTingting HaoJing WangYiming ChenXiuxiu WangWei WeiJing Zhao,Yong Qian

Advanced Science, 2024, 11, 2307598.

DOI: 10.1002/advs.202307598



18 A fluorescent prodrug to fight drug-resistant lung cancer cells via autophagy-driven ferroptosis.

 F.J. Chen, X.T. Wang, W. Chen, C.W. Shao, Yong Qian

Sensors and Actuators B: Chemical, 2024, 400, 134871.

https://doi.org/10.1016/j.snb.2023.134871



17 Novel 1,8-Naphthalimide Derivatives As Antitumor Agents and Potent Demethylase Inhibitors

Chao Ge, Lu LiuYanqing WangXiaojiao Di, Xiangjie Luo, Hongke Liu, Yong Qian

ACS Medicinal Chemistry Letters, 2023, 14, 11, 1551–1557.

DOI:10.1021/acsmedchemlett.3c00353



16 3D dynamic tracking Aβ plaques in live brains using vinyl-bridged dyes with two-photon excitation/NIR emission and large Stokes shifts

Xueao Wang, Yani Liu, Xueting Wang, Xiaolian Ye, Wei Cheng, Guiquan Chen, Hai-Liang Zhu, Jing Zhao, Yong Qian

Biosensors and Bioelectronics, 2023, 238, 115563.

https://doi.org/10.1016/j.bios.2023.115563



15 Activity-Based Imaging of Macrophage Migration Inhibitory Factor with a Two-Photon Fluorescent Probe

Xueao Wang, Xueting Wang, Yani Liu, Zhigang Sun, Huan Liu, Jiawen Shen, Hai-Liang Zhu, and Yong Qian

ACS Sensors, 2023, 8, 1, 335–343.        
DOI:10.1021/acssensors.2c02326


                                                    


14 3D tracking of ferrous iron in the epileptic mouse brain and screening of iron homeostasis regulators with a two-photon fluorescent probe. 

Chenwen Shao, Zhang-Peng ChenChao Yan, Yong Qian 

STAR Protocols, 2022, 3,101522. 

https://doi.org/10.1016/j.xpro.2022.101522.



13  A high selective colorimetric fluorescent probe for detection of silver ions in vitro and in vivo and its application on test strips.

Yumeng Song, Xueting Wang, Huan Liu, Xueao Wang, Dongdong LiHai-Liang Zhu, Yong Qian 

Talanta, 2022, 246, 123366. 

 https://doi.org/10.1016/j.talanta.2022.123366



12 3D two-photon brain imaging reveals dihydroartemisinin exerts antiepileptic effects by modulating iron homeostasis.

Chenwen Shao, Yani Liu, Zhangpeng Chen, Yajuan Qin, Xueao Wang, Xueting Wang, Chao Yan, Hai-Liang Zhu, Jing Zhao, Yong Qian 

Cell Chem. Biol. 2022, 29, 43-56.

https://doi.org/10.1016/j.chembiol.2021.12.006.




11 Biotinylated curcumin as a novel chemosensitizer enhances naphthalimide-induced autophagic cell death in breast cancer cells

Chenwen Shao, Jian Wu, Siqi Han, Yani Liu, Zhi Su, Hai-Liang Zhu, Hong-Ke Liu, Yong Qian 

Eur. J. Med. Chem. 2022, 222, 114029. 

https://doi.org/10.1016/j.ejmech.2021.114029 



10  In vivo brain imaging amyloid-β aggregates in Alzheimer’s disease by near-infrared fluorescence probe

Jian Wu, Chenwen Shao, Xiaolian Ye, Xiaojiao Di, Dongdong Li, Hu Zhao, Bing Zhang, Guiquan Chen, Hong-Ke Liu, Yong Qian 

ACS Sensors, 2021, 6, 3, 863–870.

DOI: 10.1021/acssensors.0c01914.


Figure 1


9 In vivo imaging macrophage migration inhibitory factor in liver cancer with an activity-based probe

Chenwen Shao, Christian Hedberg, Yong Qian 

Anal. Chem., 2021, 93, 2152–2159.

DOI: 10.1021/acs.analchem.0c03964.


Figure 1


8 Hydrogen sulfide triggered molecular agent for imaging and cancer therapy

Chao Ge, Xiaojiao Di, Siqi Han, Mengmeng Wang, Xiaoting Qian, Zhi Su, Hong-Ke Liu, Yong Qian 

Chem. Commun., 2021, 57, 1931-1934.

DOI: 10.1039/D0CC07982K.


Graphical abstract: Hydrogen sulfide triggered molecular agent for imaging and cancer therapy


 7 Monitoring hydrogen polysulfide during ferroptosis with a two-photon fluorescent probe

Xiaojiao Di, Chao Ge, Yani Liu, Chenwen Shao, Hai-Liang Zhu, Hong-Ke Liu, Yong Qian

Talanta, 2021, 232, 122467.

https://doi.org/10.1016/j.talanta.2021.122467


Scheme 1


 6 A self-immolated fluorogenic agent triggered by H2S exhibiting potential anti-glioblastoma activity, Analyst

Chao Ge, Ji Li, Lu Liu, Hong-Ke Liu, Yong Qian

Analyst, 2021, 146, 3510-3515.

DOI: 10.1039/D1AN00457C.


Graphical abstract: A self-immolated fluorogenic agent triggered by H2S exhibiting potential anti-glioblastoma activity


5 In vivo Tracking Cystine/Glutamate Antiporter-Mediated Cysteine/Cystine Pool under Ferroptosis, Analytica Chimica Acta

Zhen Li, Yan Li, Yushun Yang, Zhiyuan Gong, Hailiang Zhu, Yong Qian 

Analytica Chimica Acta, 2020, 1125, 66-75.

DOI: 10.1016/j.aca.2020.05.049. 


Image 1


4 Epileptic brain fluorescent imaging reveals apigenin can relieve the myeloperoxidase-mediated oxidative stress and inhibit ferroptosis

Chenwen Shao, Jiwen Yuan, Yani Liu, Yajuan Qin, Xueao Wang, Jin Gu, Guiquan Chen, Bing Zhang, Hong-Ke Liu, Jing Zhao, Hai-Liang Zhu, Yong Qian 

Proc. Natl. Acad. Sci. USA., 2020, 117 (19), 10155-10164.

DOI: 10.1073/pnas.1917946117.



 Imaging of formaldehyde fluxes in epileptic brains with a two-photon fluorescence probe

Jian Chen, Chenwen Shao, Xueao Wang, Jin Gu, Hai-Liang Zhu, Yong Qian 

Chem. Commun., 2020, 56: 3871-3874.

DOI: 10.1039/D0CC00676A. 


Graphical abstract: Imaging of formaldehyde fluxes in epileptic brains with a two-photon fluorescence probe


2  Imaging Dynamic Peroxynitrite Fluxes in Epileptic Brains with a Near‐Infrared Fluorescent Probe

Jiong-Sheng Hu, Chenwen Shao, Xueao Wang, Xiaojiao Di, Xuling Xue, Zhi Su, Jing Zhao, Hai-Liang Zhu, Hong-Ke Liu, Yong Qian 

Adv. Sci., 2019, 6, 1900341.

DOI: 10.1002/advs.201900341.


Details are in the caption following the image


1 Imaging dynamic changes of an intracellular cysteine pool that responds to the stimulation of external oxidative stress

Kun Chen, Meng Zhang, Yalin Qi, Jing Fan, Xiang Ma, Hailiang ZhuYong Qian 

Analyst, 2019, 144, 2320-2326.

DOI: 10.1039/C8AN02232A. 


Graphical abstract: Imaging dynamic changes of an intracellular cysteine pool that responds to the stimulation of external oxidative stress