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成果及论文

代表性论文

  1. Yuran Duan*, Zhigiang Hu*, Peng Han*, Bo Lei*, Shuo Wang*, Yueru Hou, Yanni Lin, Min Li, Liwei Xiao, Qingang Wu, Ying Meng, Guijun Liu, Shenghan Lou, Laishou Yang, Xueli Bai, Shengzhong Duan, Peng Zhan, Tong Liu, Zhimin Lu, and Daqian Xu#.  ADSL-generated fumarate binds and inhibits STING to promote tumor immune evasion. Nature Cell Biology,in press. (*co-first author, #corresponding author)

  2. Lei Wang*, Runze Shi*, Shuo Wang*, Yuran Duan*, Zheng Wang*, Peixiang Zheng, Xue Sun, Xiaohan Chen, Guimei Ji, Yuli Shen, Bofei Dong, Yanni Lin, Ting Wen, Qi Tian, Zhanpeng Guo, Yueru Hou, Shiqi Wu, Ling Xiao, Min Li, Liwei Xiao, Qingang Wu, Ying Meng, Guijun Liu, Sofie Bi Duan, Xueli Bai, Tong Liu, Zhiren Zhang, Peng Zhan, Zhimin Lu, and Daqian Xu#. ADSL promotes autophagy and liver tumor growth through fumarate-mediated Beclin1 dimethylation. Nature Chemical Biology,in press. (*co-first author, #corresponding author)

  3. Meng Y*, Guo D*, Lin L*, Zhao H, Xu W, Luo S, Jiang X, Li S, He X, Zhu R, Shi R, Xiao L, Wu Q, He H, Tao J, Jiang H, Wang Z, Yao P, Xu D#, Lu Z#. Glycolytic enzyme PFKL governs lipolysis by promoting lipid droplet-mitochondria tethering to enhance β-oxidation and tumor cell proliferation. Nature Metabolism. 2024 Jun;6(6):1092-1107. (*co-first author, #co-corresponding author)

  4.  Li M*, Wang Z*, Tao J*, Jiang H, Yang H, Guo D, Zhao H, He X, Luo S, Jiang X, Yuan L, Xiao L, He H, Yu R, Fang J, Liang T, Mao Z, Xu D#, Lu Z#. Fructose-1,6-bisphosphatase 1 dephosphorylates and inhibits TERT for tumor suppression. Nature Chemical Biology 2024 Mar 27.  Epub ahead of print. (*co-first author, #co-corresponding author)
  5. Wang Z*, Yan M*, Ye L*, Zhou Q*, Duan Y, Jiang H, Wang L, Ouyang Y, Zhang H, Shen Y, Ji G, Chen X, Tian Q, Xiao L, Wu Q, Meng Y, Liu G, Ma L, Lei B#, Lu Z# and Xu D#. VHL suppresses autophagy and tumor growth through PHD1-dependent Beclin1 hydroxylation. The EMBO Journal. (2024) . (*co-first author, #co-corresponding author)
  6.  Wang Z, Ma L, Meng Y, Fang J#Xu D#, Lu Z#. The interplay of the circadian clock and metabolic tumorigenesis. Trends in Cell Biology. (2023) Dec; online ahead of print. (#co-corresponding author)
  7.  Wu K*, Yan M*, Liu T*, Wang Z*, Duan Y, Xia Y, Ji G, Shen Y, Wang L, Li L, Zheng P, Dong B, Wu Q, Xiao L, Yang X, Shen H, Wen T, Zhang J, Yi J, Deng Y, Qian X, Ma L, Fang J, Zhou Q#, Lu Zand Xu D#. Creatine kinase B suppresses ferroptosis by phosphorylating GPX4 through a moonlighting function. Nature Cell Biology. (2023) May;25(5):714-725. (*co-first author,#co-corresponding author)
  8.  Liu T*, Wang Z*, Ye L*, Duan Y*, Jiang H, He H, Xiao L, Wu Q, Xia Y, Yang M, Wu K, Yan M, Ji G, Shen Y, Wang L, Li L, Zheng P, Dong B, Shao F, Qian X, Yu R, Zhang Z, Lu Zand Xu D#. Nucleus-exported CLOCK acetylates PRPS to promote de novo nucleotide synthesis and liver tumour growth. Nature Cell Biology. (2023) Feb;25(2):273-284. (*co-first author,#co-corresponding author)
  9.  Wang Z*, Li M*, Jiang H, Luo S, Shao F, Xia Y, Yang M, Ren X, Liu T, Yan M, Qian X, He H, Guo D, Duan Y, Wu K, Wang L, Ji G, Shen Y, Li L, Zheng P, Dong B, Fang J, Zheng M, Liang T, Li H, Yu R, Xu Dand Lu Z#. Fructose-1,6-bisphosphatase 1 functions as a protein phosphatase to dephosphorylate histone H3 and suppresses PPARα-regulated gene transcription and tumour growth. Nature Cell Biology. (2022) Nov;24(11):1655-1665. (*co-first author,#co-corresponding author)
  10.  Xu D*, Shao F*, Bian X*, Meng Y, Liang T and Lu Z. The Evolving Landscape of  Noncanonical Functions of  Metabolic Enzymes in Cancer and Other Pathologies. Cell Metabolism. (2021) Jan 5;33(1):33-50.(*co-first author)
  11.  Xu D*#, Wang Z*, Xia Y, Shao F, Xia W, Wei Y, Li X, Qian X, Lee JH, Du L, Zheng Y, Lv G, Leu J, Wang H, Xing D, Liang T, Hung MC# and Lu Z#. The gluconeogenic enzyme PCK1 phosphorylates INSIG1/2 for lipogenesis. Nature. (2020) Apr;580(7804):530-535. (*co-first author,#co-corresponding author)