(39) Chen, Z., Yang, Y., Qiu, X., Zhou, H., Wang, R., Xiong, H.* Crown-Like Biodegradable Lipids Enable Lung-Selective mRNA Delivery and Dual-Modal Tumor Imaging In Vivo. Journal of the American Chemical Society, 2024, 146, 34209–34220.

(38) Yang, K., Tian, Y., Zheng, B., Wu, F., Hu, T., Yang, Y., Pan, J., Xiong, H.*, Wang, S.* Fast-Responsive HClO-Activated Near-Infrared Fluorescent Probe for In Vivo Diagnosis of Inflammatory Bowel Disease and Ex Vivo Optical Fecal Analysis. Analytical Chemistry, 2024, 96, 12065–12073.

(37) Zhu, Y., Wu, F., Zheng, B., Yang, Y., Yang, J., Xiong, H.* Electron-Withdrawing Substituents Enhance Type-I PDT and NIR-II Fluorescence of BODIPY J-aggregates for Bioimaging and Cancer Therapy. Nano Letters, 2024, 24, 8287–8295.

(36) Chen, Z., Yang, Y., Tian, Y., Yang, J., Xiong, H.* Diagnosis of Non-alcoholic Fatty Liver Disease via a H2S-responsive Bioluminescent Probe Combined with Firefly Luciferase mRNA Delivery. Analytical Chemistry, 2024, 96, 9236–9243.

(35) Yang, J., Chen, Z., Yang, Y., Zheng, B., Zhu, Y., Wu, F., Xiong, H.* Visualization of Endogenous Hypochlorite in Drug-induced Liver Injury Mice via a Bioluminescent Probe Combined with Firefly Luciferase mRNA-loaded Lipid Nanoparticles. Analytical Chemistry, 2024, 96, 6978–6985.

(34) Wu, F., Liu, S., Zheng, B., Cao, W., Zhu, Y., Yang, J., Xiong, H.* High Spatiotemporal Tracking of Intestinal Peristalsis and Bowel Disease via In Situ Generated NIR-II Cyanine-Albumin Complex. Nano Today, 2024, 55, 102218.

(33) Xu, W.#, Liu, S.#, Cao, W., Xiong, H.* Acid-promoted fluorescent probe for monitoring endogenous methylglyoxal in tumors and gastritis. Sensors & Diagnostics, 2024, 3, 147-152.

(32) Zhu, Y., Wu, P., Liu, S., Yang, J., Wu, F., Cao, W., Yang, Y., Zheng, B., Xiong, H.* Electron-Withdrawing Substituents Allow Boosted NIR-II Fluorescence in J-Type Aggregates for Bioimaging and Information Encryption. Angewandte Chemie International Edition, 2023, 62, e202313166.

(31) Chen, Z., Tian, Y., Yang, J., Wu, F., Liu, S., Cao, W., Xu, W., Hu, T., Siegwart, D. J., Xiong, H.* Modular Design of Biodegradable Ionizable Lipids for Improved mRNA Delivery and Precise Cancer Metastasis Delineation In Vivo. Journal of the American Chemical Society, 2023, 145, 24302–24314.

(30) Tian, Y., Chen, Z., Liu, S., Wu, F., Cao, W., Pang, D.-W.*, Xiong, H.* “Dual-Key-and-Lock” NIR-II NSCyanines Enable High-Contrast Activatable Phototheranostics in Extrahepatic Diseases. Angewandte Chemie International Edition, 2023, 62, e202309768.

(29) Zheng, B., Tian, Y., Liu, S., Yang, J., Wu, F., Xiong, H.* Non-Solvatochromic Cell Membrane-Targeted NIR Fluorescent Probe for Visualization of Polarity Abnormality in Drug-Induced Liver Injury Mice. Analytical Chemistry, 2023, 95, 12054–12061.

(28) Liu, S., Xu, W., Li, X., Pang, D.-W., Xiong, H.* BOIMPY-based NIR-II Fluorophore with High Brightness and Long Absorption beyond 1000 nm for In Vivo Bioimaging: Synergistic Steric Regulation Strategy. ACS Nano, 2022, 16, 17424–17434.

(27) Cao, W., Zhu, Y., Wu, F., Tian, Y., Chen, Z., Xu, W., Liu, S., Liu, T.*, Xiong, H.* Three Birds with One Stone: Acceptor Engineering of Hemicyanine Dye with NIR-II Emission for Synergistic Photodynamic and Photothermal Anticancer Therapy. Small, 2022, 18, 2204851.

(26) Xu, W., Liu, S., Chen, Z., Wu, F., Cao, W., Tian, Y., Xiong, H.* Bichromatic Imaging with Hemicyanine Fluorophores Enable Simultaneous Visualization of Non-alcoholic Fatty Liver Disease and Metastatic Intestinal Cancer. Analytical Chemistry, 2022, 94, 13556–13565.

(25) Tian, Y., Liu, S., Cao, W., Wu, P., Chen, Z., Xiong, H.* H2O2-activated NIR-II Fluorescent Probe with Large Stokes Shift for High-contrast Imaging in Drug-induced Liver Injury Mice. Analytical Chemistry, 2022, 94, 11321–11328.

(24) Wu, P., Xiong, H.* An Acid-Enhanced OFF-ON Fluorescent Probe for the Detection of Hypochlorous Acid in Rheumatoid Arthritis. Talanta, 2022, 247, 123584.

(23) Wu, P., Zhu, Y., Liu, S., Xiong, H.* Modular Design of High-Brightness pH-Activatable Near-Infrared BODIPY Probes for Noninvasive Fluorescence Detection of Deep-Seated Early Breast Cancer Bone Metastasis: Remarkable Axial Substituent Effect on Performance. ACS Central Science, 2021, 7, 2039–2048.

(22) Wu, P., Zhu, Y., Chen, L., Tian, Y., Xiong, H.* A Fast-Responsive OFF-ON Near-Infrared-II Fluorescent Probe for in Vivo Detection of Hypochlorous Acid in Rheumatoid Arthritis. Analytical Chemistry, 2021, 93, 13014–13021.

(21) Li, X., Wu, P., Cao, W., Xiong, H.* Development of pH-activatable fluorescent probes for rapid visualization of metastatic tumours and fluorescence-guided surgery via topical spraying. Chemical Communications, 2021, 57, 10636-10639.

(20) Xu, W., Wu, P., Li, X., Liu, S., Feng, L., Xiong, H.* Two birds with one stone: A highly sensitive near-infrared BODIPY-based fluorescent probe for the simultaneous detection of Fe2+ and H+ in vivo. Talanta, 2021, 233, 122601.

(19) Wu, P., Siegwart, D. J., Xiong, H.* Recent advances in the targeted fluorescent probes for the detection of metastatic bone cancer. SCIENCE CHINA Chemistry, 2021, 64, 1283–1296.

(18) Liu, S., Zhu, Y., Wu, P., Xiong, H.* Highly Sensitive D−A−D-Type Near-Infrared Fluorescent Probe for Nitric Oxide Real-Time Imaging in Inflammatory Bowel Disease. Analytical Chemistry, 2021, 93, 4975−4983.

(17) Xiong, H.*, Liu, S., Wei, T., Cheng, Q., Siegwart, D. J.* Theranostic dendrimer-based lipid nanoparticles containing PEGylated BODIPY dyes for tumor imaging and systemic mRNA delivery in vivo. Journal of Controlled Release, 2020, 325, 198–205.

(16) Zhou, K., Johnson, L. T., Xiong, H., Barrios, S., Minnig, J. T., Yan, Y., Abram, B., Yu, X., Siegwart, D. J.* Hydrophobic Domain Structure of Linear-Dendritic Poly(ethyleneglycol) Lipids Affects RNA Delivery of Lipid Nanoparticles. Molecular Pharmaceutics, 2020, 17, 1575-1585.

(15) Xiong, H., Zhou, K., Yan, Y., Miller, J. B., Siegwart, D. J.* Tumor activated water-soluble photosensitizers for near-infrared photodynamic cancer therapy. ACS Applied Materials & Interfaces, 2018, 10, 16335−16343.

(14) Xiong, H., Zuo, H., Yan, Y., Occhialini, G., Zhou, K., Wan, Y., Siegwart, D. J.* High-contrast fluorescence detection of metastatic breast cancer including bone and liver micrometastases via size-controlled pH-activatable water-soluble probes. Advanced Materials, 2017, 29, 1700131.

(13) Yan, Y., Xiong, H., Zhang, X., Cheng, Q., Siegwart, D. J.* Systemic mRNA delivery to the lungs by functional polyester-based carriers. Biomacromolecules, 2017, 18, 4307−4315.

(12) Miller, J. B., Zhang, S., Kos, P., Xiong, H., Zhou, K., Perelman, S. S., Zhu, H., Siegwart, D. J.* Non-viral CRISPR/Cas gene editing in vitro and in vivo enabled by synthetic nanoparticle co-delivery of Cas9 mRNA and sgRNA. Angew. Chem. Int. Ed. 2017, 56, 1059−1063.

(11) Feng, L.-W., Ren, H., Xiong, H., Wang, P., Wang, L.*, Tang, Y.* Reaction of Donor-Acceptor Cyclobutanes with Indoles: A General Protocol for the Formal Total Synthesis of (±)-Strychnine and the Total Synthesis of (±)-Akuammicine. Angew. Chem. Int. Ed. 2017, 129, 3101−3104.

(10) Chen, P., Zuo, H., Xiong, H., Kolar, M. J., Chu, Q., Saghatelian, A., Siegwart, D. J., Wan, Y.* Gpr132 Sensing of Lactate Mediates Tumor-Macrophage Interplay to Promote Breast Cancer Metastasis. Proc. Natl. Acad. Sci. U. S. A. 2017, 114, 580−585.

(9) Yan, Y., Zhou, K., Xiong, H., Miller, J. B., Motea, E. A., Boothman, D. A., Liu, L.*, Siegwart, D. J.* Aerosol delivery of stabilized polyester-siRNA nanoparticles to silence gene expression in orthotopic lung tumors. Biomaterials, 2017, 118, 84−93.

(8) Yan, Y., Liu, L., Xiong, H., Miller, J. B., Zhou, K., Kos, P., Huffman, K. E., Elkassih, S., Norman, J. W., Carstens, R., Kim, J., Minna, J. D., Siegwart, D. J.* Functional polyesters enable selective siRNA delivery to lung cancer over matched normal cells. Proc. Natl. Acad. Sci. U. S. A. 2016, 113, 5702−5710.

(7) Xiong, H., Kos, P., Yan, Y., Zhou, K., Miller, J. B., Elkassih, S., Siegwart, D. J.* Activatable water-soluble probes enhance tumor imaging by responding to dysregulated pH and exhibiting high tumor-to-liver fluorescence emission contrast. Bioconjugate Chemistry, 2016, 27, 1737−1744.

(6) Zhou, K., Kos, P., Yan, Y., Xiong, H., Min, Y.-L., Minnig, J. T., Miller, J. B., Siegwart D. J.* Intercalation-mediated nucleic acid nanoparticles for siRNA delivery. Chemical Communications, 2016, 52, 12155-12158.

(5) Zhou, K., Nguyen, L. H., Miller, J. B., Yan, Y., Kos, P., Xiong, H., Li, L., Hao, J., Minnig, J. T., Zhu, H., Siegwart, D. J.* Modular degradable dendrimers enable small RNAs to extend survival in an aggressive liver cancer model. Proc. Natl. Acad. Sci. U. S. A. 2016, 113, 520−525.

(4) Hao, J., Kos, P., Zhou, K., Miller, J. B., Xue, L., Yan, Y., Xiong, H., Elkassih, S., Siegwart, D. J.* Rapid synthesis of a lipocationic polyester library via ring-opening polymerization of functional valerolactones for efficacious siRNA delivery. J. Am. Chem. Soc. 2015, 137, 9206−9209.

(3) Xiong, H.^#, Xu, H.^#, Liao, S., Xie, Z.*, Tang, Y.* Copper-Catalyzed Highly Enantioselective Cyclopentannulation of Indoles with Donor-Acceptor Cyclopropanes. J. Am. Chem. Soc. 2013, 135, 7851−7854. (Highlighted in SYNFORM 2013, 10, 122.)

(2) Xu, H., Qu, J.-P., Liao, S., Xiong, H., Tang, Y.* Highly Enantioselective [3+2] Annulation of Cyclic Enol Silyl Ethers with Donor–Acceptor Cyclopropanes: Accessing 3a-Hydroxy [n.3.0] Carbobicycles. Angew. Chem. Int. Ed. 2013, 52, 4004-4007.

(1) Li, J., Liao, S.-H., Xiong, H., Zhou, Y.-Y., Sun, X.-L., Zhang, Y., Zhou, X.-G., Tang, Y.* Highly Diastereo- and Enantioselective Cyclopropanation of 1,2-Disubstituted Alkenes. Angew. Chem. Int. Ed. 2012, 51, 8838-8841.