代表性论文
In HUST
2025
45. Tianci Xie#, Changjiang Li#, Minghao Hu#, Xingyu Zhong, Junbin Xiao, Zhen Zhang, Ze Wang, Tongbo Wu*, DNA sequential logic circuits for counters and bioinformatics repositories, preprint
https://doi.org/10.21203/rs.3.rs-5097045/v1
44. Xiaolong Li, Changjiang Li, Chaopeng Shi, Jiarun Wang, Bei Yan*, Xianjin Xiao, Tongbo Wu*, CRISPR-Cas systems in DNA functional circuits: Strategies, challenges, prospects, Chinese Chemical Letters, 2024, doi: 10.1016/j.cclet.2024.110507. (IF=9.4)
https://www.sciencedirect.com/science/article/abs/pii/S100184172401026X
2024
43. Ruyi Liang#, Yiyang Shen#, Tanqing Long, Peilin Yang, Chuanrui Xu, Tongbo Wu*, and Mingxia Zhang*, Improving Dynamic Control of Toehold-Mediated Strand Displacement Reactions through Phosphorothioate Modifications, Nanoscale, 2024, 16(48), 22393-22402. (IF=5.8)
https://pubs.rsc.org/en/content/articlelanding/2024/nr/d4nr04201h
42. Minghao Hu#, Xianzhi Cheng#, Tongbo Wu*, Modular CRISPR/Cas12a synergistic activation platform for detection and logic operations, Nucleic Acids Research, 2024, 52(12), 7384-7396. (IF=14.9)
https://doi.org/10.1093/nar/gkae470
学校报道：https://news.hust.edu.cn/info/1003/52561.htm
http://pharm.tjmu.edu.cn/info/1056/4231.htm
新媒体报道：https://mp.weixin.qq.com/s/h4bv1fs7NEv9MuqVRYj67Q
https://mp.weixin.qq.com/s/fJSHc0dLQA5itz8o-d2zIA
41. Minghao Hu#, Mengyao Yang#, Xianzhi Cheng, Tongbo Wu*, Time-Controlled Authentication Strategies for Molecular Information Transfer, Small, 2024, 20(36), 202400261. (IF=13.3)
https://onlinelibrary.wiley.com/doi/10.1002/smll.202400261
新媒体报道：https://mp.weixin.qq.com/s/sXw6Dg5EUVU2uyiCFUQhxQ
40. Xiaolong Li#, Minghao Hu#, Tianci Xie, Zixuan Zhu, Chen Ling, Tongbo Wu*, Enzyme-driven converter and amplifier for inert double-stranded DNA without sequence restrictions, Chemical Engineering Journal, 2024, 490, 151508. (IF=15.1)
https://www.sciencedirect.com/science/article/abs/pii/S1385894724029954
39. Changjiang Li, Yuqiang Hu, Tianzi Shi, Kejun Dong, Tongbo Wu*, Label-free colorimetric detection platform based on catalytic hairpin self-assembly and G-quadruplex/hemin DNAzyme for comprehensive biomarker profiling, Talanta, 2024, 272, 125835. (IF=6.1)
https://www.sciencedirect.com/science/article/pii/S0039914024002145
38. Yiyang Shen#, Zhen Zhang#*, Yuyi Liang, Tongbo Wu*, Unraveling the interplay of DNAzyme and interfacial factors for enhanced biosensing, Chinese Chemical Letters, 2024, 35(12), 109638. (IF=9.1)
https://www.sciencedirect.com/science/article/abs/pii/S1001841724001578
37. Xiaolong Li, Tongbo Wu*, Unlocking all activation modes of Thermus thermophilus Argonaute for comprehensive gold nanoparticle sensor, Chemical Engineering Journal, 2024, 482, 149112. (IF=15.1)
https://www.sciencedirect.com/science/article/pii/S1385894724005977
36. Minghao Hu#, Xiaolong Li#, Jiani Wu, Mengyao Yang, Tongbo Wu*, DNAzyme-based circular dissipative DNA strand displacement for constructing temporal logic gates, ACS Nano, 2024, 18(3), 2184–2194. (IF=17.1)
https://pubs.acs.org/doi/10.1021/acsnano.3c09506
新媒体报道：https://mp.weixin.qq.com/s/cmmVCQ9ny5gcTeQN0IDK0g
https://mp.weixin.qq.com/s/_wHu8fACoiIzVUxcjYf_4g
35. Zhujun Liu, Jie Xu, Shan Huang, Wei Dai, Wei Zhang, Longjie Li, Xianjin Xiao, Tongbo Wu*, Gene point mutation information translation and detection: Leveraging single base extension and CRISPR/Cas12a, Biosensors and Bioelectronics, 2024, 247, 115936. (IF=12.6)
https://www.sciencedirect.com/science/article/pii/S0956566323008783
新媒体报道：https://mp.weixin.qq.com/s/gjsDtDWP1dz7u8jTP-iC8g
34. Minghao Hu#, Tianci Xie#, Yuqiang Hu, Longjie Li, Ting Wang, Tongbo Wu*, Allosteric DNAzyme-based encoder for molecular information transfer, Chinese Chemical Letters, 2024, 35(7), 109232. (IF=9.1)
https://www.sciencedirect.com/science/article/pii/S100184172300983X
新媒体报道：https://mp.weixin.qq.com/s/jbPGDDeM-6RP1MJDUhPxQQ
2023
33. Wei Chen#, Haiqi Xu#, Shenbin Dai#, Jiayu Wang, Ziyu Yang, Yuewen Jin, Mengbing Zou, Xianjin Xiao*, Tongbo Wu*, Wei Yan, Bin Zhang, Zhimiao Lin & Meiping Zhao*, Detection of low-frequency mutations in clinical samples by increasing mutation abundance via the excision of wild-type sequences, Nature Biomedical Engineering, 2023, 7(12), 1602-1613. (IF=28.1)
https://www.nature.com/articles/s41551-023-01072-8
可分享的免费全文链接：https://rdcu.be/dhUlL
新媒体报道：https://mp.weixin.qq.com/s/Hqh_Ci-UObhO5oZG3CUV6A
32. Jie Xu#, Zhujun Liu#, Zhen Zhang, and Tongbo Wu*, Unlocking the Full Potential of Cas12a: Exploring the Effects of Substrate and Reaction Conditions on Trans-Cleavage Activity, Analytical Chemistry, 2023, 95(28), 10664−10669. (IF=7.4)
https://pubs.acs.org/doi/full/10.1021/acs.analchem.3c01307
新媒体报道：https://mp.weixin.qq.com/s/IOi4vZSd8CtzhG9M0yHENA
31. Zirui Xi, Mengyao Yang, Yuqiang Hu, Tongbo Wu*, Addressable DNA information processing system with a fluorescent readout for rewritable memory, Chinese Journal of Chemistry, 2023, 41, 2628-2634. (IF=5.560)
https://doi.org/10.1002/cjoc.202300272
本文被选为41卷20期正封面：https://onlinelibrary.wiley.com/doi/10.1002/cjoc.202390201
30. Yuhan Deng#, Zhen Zhang#, Yujie Zhou, Xiaojing Pei*, Yifan He*, Tongbo Wu*, Introducing uracil-containing oligo to improve exponential amplification reaction performance in biosensor application, Microchemical Journal, 2023,191, 108866. (IF=5.304)
https://www.sciencedirect.com/science/article/pii/S0026265X23004848
29. Minghao Hu†, Yuqiang Hu†, Tongbo Wu*, A multifunctional monolithic interfacial sensor based on gold nanoparticle, Talanta, 2023, 259, 124546. (IF=6.556)
https://www.sciencedirect.com/science/article/pii/S0039914023002977?via%3Dihub
28. Minghao Hu#, Ziyi Chu#, Haitao Wang, Wenbo Zhao*, Tongbo Wu*, Transformation of remote toehold-mediated strand displacement for expanding the regulatory toolbox, Microchemical Journal, 2023, 190, 108706. (IF=5.304)
https://www.sciencedirect.com/science/article/abs/pii/S0026265X23003247
27. Weicong Ye#, Zhen Zhang#, Caie Wang, Zishan Feng, Zhe Hu, Qingxu Liu*, Tongbo Wu*, Detection of small molecules by extending the terminal protection to the polymerase, Microchemical Journal, 2023, 190, 108701. (IF=5.304)
https://www.sciencedirect.com/science/article/pii/S0026265X23003193
26. Yuqiang Hu#, Changjiang Li#, Minghao Hu, Zhen Zhang, Ruolan Fu, Xinjing Tang, Tongbo Wu*, Allosteric Nucleic Acid Enzyme: A Versatile Stimuli-Responsive Tool for Molecular Computing and Biosensing Nanodevices, Small, 2023, 19(27), 202300207. (IF=15.153)
https://onlinelibrary.wiley.com/doi/10.1002/smll.202300207
新媒体报道：https://mp.weixin.qq.com/s/MfkWxDnOuP9jreh1dUSlFQ
25. Minghao Hu, Yuqiang Hu, Wenqian Yuan, Zhen Zhang, Tongbo Wu*, DNA reaction network mimicking the basic steps of synaptic communication, Chinese Journal of Chemistry, 2023, 41(11), 1313-1318. (IF=5.560)
https://onlinelibrary.wiley.com/doi/10.1002/cjoc.202200845
本文被选为41卷11期内封底：https://doi.org/10.1002/cjoc.202390114
2022
24. Zhe Hu#, Weicong Ye#, Zhen Zhang, Tianci Xie, Wenqian Yuan, Tongbo Wu*, Sensitive detection of abasic sites in double-stranded DNA based on the selective reaction of enzymes, Analytica Chimica Acta, 2022, 1223, 340220. (IF=6.911)
https://www.sciencedirect.com/science/article/pii/S0003267022007917
23. Tianci Xie, Yuhan Deng, Jiarui Zhang, Zhen Zhang, Zhe Hu, Tongbo Wu*, DNA circuits compatible encoder and demultiplexer based on a single biomolecular platform with DNA strands as outputs, Nucleic Acids Research, 2022, 50(15), 8431-8440. (IF=19.160)
https://academic.oup.com/nar/advance-article/doi/10.1093/nar/gkac650/6651866
新媒体报道：https://mp.weixin.qq.com/s/JcC41KmnsB-CeDRFY_ks5g
22. Yujie Zhou#, Zhiyuan Zhou#, Tianci Xie#, Yuqiang Hu, Wei Zhang, Changjiang Li, Zhen Zhang, Xianjin Xiao and Tongbo Wu*, Sensitive detection of uracil-DNA glycosylase based on AND-gate triggers, Sensors and Actuators: B. Chemical, 2022, 368, 132174. (IF=9.221)
https://www.sciencedirect.com/science/article/pii/S0925400522008164
21. Jianbo Sun#, Changjiang Li#, Yuqiang Hu*, Yawen Ding, Tongbo Wu*, A structure change-induced fluorescent biosensor for uracil-DNA glycosylase activity detection based on the substrate preference of Lambda exonuclease, Talanta, 2022, 243, 123350. (IF=6.556)
https://www.sciencedirect.com/science/article/pii/S0039914022001461
20. Wenqian Yuan#, Zhen Zhang#, Yuqiang Hu, Minghao Hu, Zhe Hu, Tongbo Wu*, A sensitive and selective mutation detection strategy based on non-canonical dsDNA structure preference of endonuclease IV, Sensors and Actuators B: Chemical, 2022, 359, 131575. (IF=9.221)
https://www.sciencedirect.com/science/article/pii/S0925400522002179
19. Bei Yan#, Weicong Ye#, Juan Wang, Shaotong Jia, Xiuli Gu, Hao Hu, Wenpei Xiang*, Tongbo Wu*, Xianjin Xiao*, Evaluation of sperm DNA integrity by mean number of sperm DNA breaks rather than sperm DNA fragmentation index, Clinical Chemistry, 2022, 68(4), 540-549. (IF=12.114)
https://academic.oup.com/clinchem/advance-article/doi/10.1093/clinchem/hvab280/6511429
新媒体报道：https://mp.weixin.qq.com/s/kGWCCkxsBv-v8QrXA1P-fQ
18. Zhen Zhang, Yuqiang Hu, Wenqian Yuan, Yuhan Deng, Tongbo Wu*, Endonuclease IV-mediated substrate structure allosteric for universal and sensitive mutant allele enrichment and discrimination, Sensors and Actuators B: Chemical, 2022, 357, 131378. (IF=9.221)
https://www.sciencedirect.com/science/article/pii/S092540052200020X
17. Weicong Ye#, Longjie Li#, Zishan Feng, Bocheng Tu, Zhe Hu, Xianjin Xiao, Tongbo Wu*, Sensitive detection of alkaline phosphatase based on terminal deoxynucleotidyl transferase and endonuclease IV-assisted exponential signal amplification. Journal of Pharmaceutical Analysis, 2022, 12(4), 692-697. (IF=14.026)
https://www.sciencedirect.com/science/article/pii/S2095177921001131
16. Yuqiang Hu, Zhen Zhang, Wei Zhang, Minghao Hu, Xianjin Xiao, Tongbo Wu*, Probing and modulating the interactions of the DNAzyme with DNA-functionalized nanoparticles. Chinese Chemical Letters, 2022, 33(6), 3026-3030. (IF=8.455)
https://www.sciencedirect.com/science/article/pii/S1001841721007518
新媒体报道：https://mp.weixin.qq.com/s/soA28_pMbk929IRJ4BBCeA
2021
15. Zhen Zhang, Xia Xiang*, Yuqiang Hu, Yuhan Deng, Longjie Li, Wenbo Zhao*, Tongbo Wu*, A sensitive biomolecules detection device with catalytic hairpin assembly and cationic conjugated polymer-assisted dual signal amplification strategy. Talanta, 2021, 223, 121716. (IF=6.556)
https://www.sciencedirect.com/science/article/pii/S0039914020310079?dgcid=author
14. Yuqiang Hu, Zhen Zhang, Weicong Ye, Wei Zhang, Minghao Hu, Wenqian Yuan, Hongbo Wang, Xianjin Xiao, Tongbo Wu*, A DNA structure-mediated fluorescent biosensor for apurinic/apyrimidinic endonuclease 1 activity detection with ultra-high sensitivity and selectivity, Sensors and Actuators B: Chemical, 2021, 330, 129332. (IF=9.221)
https://www.sciencedirect.com/science/article/pii/S0925400520316725
13. Zishan Feng, Wei Zhang, Longjie Li, Bocheng Tu, Weicong Ye, Xiaofeng Tang, Hongbo Wang, Xianjin Xiao* and Tongbo Wu*. A cost-effective detection of low-abundance mutation with DNA three-way junction structure and lambda exonuclease. Chinese Chemical Letters, 2021, 32, 779-782. (IF=8.455)
https://www.sciencedirect.com/science/article/abs/pii/S1001841720303478?via%3Dihub
12. Ziyu Yang, Wei Chen, Jiayu Wang, Minghe Shi, Ruilan Zhang, Shenbin Dai, Tongbo Wu*, and Meiping Zhao*. Programmable One-Pot Enzymatic Reaction for Direct Fluorescence Detection of Ultralow-Abundance Mutations in the DNA Duplex. Analytical Chemistry, 2021, 93, 18, 7086–7093. (IF=8.008)
https://pubs.acs.org/doi/10.1021/acs.analchem.1c005643
11. Zhen Zhang, Longjie Li, Qingxu Liu, Yuqiang Hu, Wenqian Yuan, Xianjin Xiao* and Tongbo Wu*. Sensitive DNA mutation detection at physiological temperature with Endonuclease IV by inhibiting its side activity. Chinese Journal of Chemistry, 2021, 39, 2477-2482. (IF=5.560)
https://onlinelibrary.wiley.com/doi/abs/10.1002/cjoc.202100349
10. Bocheng Tu, Zishan Feng, Haitao Wang, Wei Zhang, Weicong Ye, Hongbo Wang, Xianjin Xiao, Wenbo Zhao* and Tongbo Wu*. Development of a background signal suppression probe for 8-oxoguanine DNA glycosylase detection, Analytica Chimica Acta, 2021, 1175, 338741. (IF=6.911)
https://www.sciencedirect.com/science/article/pii/S0003267021005675
9. Zhen Zhang, Yuqiang Hu, Wenqian Yuan, Minghao Hu, Yuhan Deng, Xianjin Xiao, and Tongbo Wu*. Endonuclease IV-Regulated DNAzyme Motor for Universal Single-nucleotide Variation Discrimination, Analytical Chemistry, 2021, 93, 28, 9939–9948. (IF=8.008)
https://pubs.acs.org/doi/full/10.1021/acs.analchem.1c02230
新媒体报道：https://mp.weixin.qq.com/s/Ox9GhwlZU4k07SJzIweOcg
2019-2020
8. Jiarui Zhang#, Wenbo Zhao#, Wei Zhang, Yizhou Liu, Yang Qin, Wenkai Zhang, Zhiyuan Zhou, Yujie Zhou, Hongbo Wang, Xianjin Xiao*, Tongbo Wu*. A path-choice-based biosensor to detect the activity of the alkaline phosphatase as the switch. Analytica Chimica Acta, 2020, 1135, 64-72. (IF=6.911)
https://www.sciencedirect.com/science/article/pii/S0003267020308734
7. Na Chen#, Xiaofei Ouyang#, Meng Lin, Na Liu, Tongbo Wu*, Xianjin Xiao*, Branch migration based selective PCR for DNA mutation enrichment and detection, Chemical Communications, 2019, 55, 8466-8469. (IF=6.065)
https://pubs.rsc.org/en/content/articlelanding/2019/CC/C9CC04161C#!divAbstract
Prior to HUST
6. Tongbo Wu, Yufei Yang, Wei Chen, Jiayu Wang, Ziyu Yang, Shenlin Wang, Xianjin Xiao, Mengyuan Li and Meiping Zhao*, Noncanonical substrate preference of lambda exonuclease for 5’-nonphosphate-ended dsDNA and a mismatch-induced acceleration effect on the enzymatic reaction, Nucleic Acids Research, 2018, 46, 3119-3129. (IF=19.160)
https://academic.oup.com/nar/article/46/6/3119/4911552
5. Tongbo Wu#, Wei Chen#, Ziyu Yang, Haocheng Tan, Jiayu Wang, Xianjin Xiao, Mengyuan Li and Meiping Zhao*, DNA terminal structure-mediated enzymatic reaction for ultra-sensitive discrimination of single nucleotide variations in circulating cell-free DNA, Nucleic Acids Research, 2018, 46, e24. (IF=19.160)
https://academic.oup.com/nar/article/46/4/e24/4668656?searchresult=1
4. Tongbo Wu, Xianjin Xiao, Zhe Zhang and Meiping Zhao*, Enzyme-mediated single-nucleotide variation detection at room temperature with high discrimination factor, Chemical Science, 2015, 6, 1206–1211. (IF=9.969)
https://pubs.rsc.org/en/content/articlelanding/2015/sc/c4sc03375b
3. Tongbo Wu, Xianjin Xiao, Feidan Gu and Meiping Zhao*, Sensitive discrimination of stable mismatched base pairs by abasic site modified fluorescent probe and lambda exonuclease, Chemical Communications, 2015, 51, 17402–17405. (IF=6.065)
https://pubs.rsc.org/doi/c5cc05749c
2. Xuzhe Zhang#, Tongbo Wu#, Hongbo Wang, Yufan Zou, Wei Chen, Meiping Zhao, Shanshan Wang* and Xianjin Xiao*, A time-dependent fluorescent biosensor for uracil-DNA glycosylase detection based on the uracil inhibition effect towards archaebacterial DNA polymerases, Sensors and Actuators B: Chemical, 2018, 270, 277-282. (IF=9.221)
https://www.sciencedirect.com/science/article/pii/S0925400518309432?via%3Dihub
1. Tongbo Wu, Yuan Liang, Xiaocui Zhu, Meiping Zhao* and Huwei Liu, Separation and quantification of four isomers of indole-3-acetyl-myo-inositol in plant tissues using high-performance liquid chromatography coupled with quadrupole time-of-flight tandem mass spectrometry, Analytical and Bioanalytical Chemistry, 2014, 406, 3239–3247. (IF=4.478)
https://link.springer.com/article/10.1007/s00216-014-7739-2
专利
1. 一种调控核酸酶序列选择性的酶复合物及方法，专利号：ZL201410797398.6，发明人：赵美萍 肖先金 吴曈勃 苏昕
2. 基于RNA聚合酶的体外转录及其快速多重检测NTPs的方法及试剂盒与应用，专利号：ZL201710100553.8，发明人：赵美萍 董建桐 吴曈勃 徐磊 邹梦冰
3. EGFR基因19号外显子缺失突变的快速应该检测方法及应用，专利号：ZL201910851694.2，发明人：赵美萍 杨子煜 陈维 吴曈勃
4. 一种基于以碱性磷酸酶为开关的路径选择器的碱性磷酸酶测定方法、试剂盒及其应用，专利号：ZL202010057011.9，发明人：吴曈勃 肖先金 张家瑞
5. 一种基于背景信号抑制探针的8-氧代鸟嘌呤DNA糖基化酶测定方法、试剂盒及其应用，专利号：ZL202110476983.6，发明人：吴曈勃 涂博成 肖先金 冯子珊
6. 检测DNA点突变的探针、试剂盒及应用，专利号：ZL202110721028.4，发明人：吴曈勃 张珍 胡鱼强
7. 用于裂解DNARNA嵌合体的DNAzyme组合、长链DNAzyme及应用，专利号：ZL2021109264382，发明人：吴曈勃 胡鱼强 张珍