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成果及论文

Publications

2024

  1. Wang, K. B.; Wang, Y.;  Dickerhoff, J.; Yang, D.*,DNA G-Quadruplexes as Targets for Natural Product Drug Discovery, Engineering 2024,38, 39-51.

  2. Xiao, C#; Li, Y#; Liu, Y#; Dong, R; He, X; Lin, Q; Zang, X; Wang, K. B.*; Xia, Y.*; Kong, L. Y*., Overcoming Cancer Persister Cells by Stabilizing the ATF4 Promoter G-quadruplex. Advanced Science., 2024, Jul 12:e2401748.

2023

  1. Liu, Y.#; Li, J#.; Zhang, Y.; Wang, Y.; Chen, J.; Bian, Y.; Xia, Y.; Yang, M. H.; Zheng, K.; Wang, K. B.* Kong, L. Y*., Structure of the Major G-Quadruplex in the Human EGFR Oncogene Promoter Adopts a Unique Folding Topology with a Distinctive Snap-Back Loop. Journal of the American Chemical Society 2023, 145 (29), 16228−16237.  

2022

  1.  Wang, K. B.#*; Liu, Y.#; Li, J.; Xiao, C.; Wang, Y.; Gu, W.; Li, Y.; Xia, Y. Z.; Yan, T.; Yang, M. H.; Kong, L. Y.*, Structural insight into the bulge-containing KRAS oncogene promoter G-quadruplex bound to berberine and coptisine. Nature Communications 2022, 13, 6016.

  2.  Wang, K. B.#; Liu, Y.#; Li, Y.; Dickerhoff, J.; Li, J.; Yang, M. H.; Yang, D.*; Kong, L. Y.*, Oxidative damage induces a vacancy G-quadruplex that binds guanine metabolites: solution structure of a cGMP fill-in vacancy G-quadruplex in the oxidized BLM gene promoter. Journal of the American Chemical Society 2022, 144 (14), 6361−6372.    

2021

  1.  Wang, K. B.; Dickerhoff, J.; Yang, D.*, Solution structure of ternary complex of berberine bound to a dGMP-fill-in vacancy G-quadruplex formed in the PDGFR-β promoter. Journal of the American Chemical Society 2021, 143 (40), 16549-16555.  

  2. Dickerhoff, J.; Warnecke, KR.; Wang, K. B.; Deng, N, Yang, D.* Evaluating Molecular Docking Software for Small Molecule Binding to G-Quadruplex DNA. International Journal of Molecular Sciences 2021, 22(19):10801.

2020

  1.  Wang, K. B.; Dickerhoff, J.; Wu, G.; Yang, D., PDGFR-β promoter forms a vacancy G-quadruplex that can be filled-in by dGMP: solution structure and molecular recognition of guanine metabolites and drugs. Journal of the American Chemical Society 2020, 142 (11), 5204-5211.

  2. Li, S. G.; Wang, Y. T.; Zhang, Q.; Wang, K. B.; Xue, J. J.; Li, D. H.; Jing, Y. K.; Lin, B.; Hua, H. M., Pegaharmols A-B, Axially Chiral β-Carboline-quinazoline Dimers from the Roots of Peganum harmala. Organic letters 2020, 22(19), 7522–7525. 

  3. Liu, Y.; Zhang, L.; Xue, J.; Wang, K. B.; Hua, H.; Yuan, T., Norcolocynthenins A and B, two cucurbitane 3-nor-Triterpenoids from Citrullus colocynthis and their cytotoxicity. Bioorganic chemistry 2020, 101, 104045.

2019

  1.  Wang, K. B.; Elsayed, M. S.; Wu, G.; Deng, N.; Cushman, M.; Yang, D., Indenoisoquinoline topoisomerase inhibitors strongly bind and stabilize the MYC promoter G-quadruplex and downregulate MYC. Journal of the American Chemical Society 2019, 141 (28), 11059-11070.  

  2.  Deng, N.; Xia, J.; Wickstrom, L.; Lin, C.; Wang, K. B.; He, P.; Yin, Y.; Yang, D., Ligand Selectivity in the Recognition of Protoberberine Alkaloids by Hybrid-2 Human Telomeric G-Quadruplex: Binding Free Energy Calculation, Fluorescence Binding, and NMR Experiments. Molecules (Basel, Switzerland), 2019, 24(8), 1574. 

  3. Wang, K. B.; Flaherty, D. P.; Chen, L.; Yang, D., High-throughput screening of G-quadruplex ligands by  FRET assay. Methods in Molecular Biology 2019, 2035, 323-331. (Book Chapter)

2018

  1.  Lin, C.; Wu, G.; Wang, K. B.; Onel, B.; Sakai, S.; Shao, Y.; Yang, D., Molecular recognition of the hybrid-2 human telomeric G-quadruplex by Epiberberine: insights into conversion of telomeric G-quadruplex structures. Angewandte Chemie International Edition 2018, 57 (34), 10888-10893. 

  2. Wang, K. B.;  Hu, X.; Li, S. G.; Li, X. Y.; Li, D. H.; Bai, J.; Pei, Y. H.; Li, Z. L.; Hua, H. M., Racemic indole alkaloids from the seeds of Peganum harmala. Fitoterapia 2018, 125, 155–160. 

  3. Li, S. G.; Wang, K. B.; Gong, C.; Bao, Y.; Qin, N. B.; Li, D. H.; Li, Z. L.; Bai, J.; Hua, H. M., Cytotoxic quinazoline alkaloids from the seeds of Peganum harmala. Bioorganic & medicinal chemistry letters 2018, 28(2), 103–106.

2017

  1.  Wang, K. B.; Li, D. H.; Bao, Y.; Cao, F.; Wang, W.-J.; Lin, C.; Bin, W.; Bai, J.; Pei, Y. H.; Jing, Y. K.; Yang, D.; Li, Z. L.; Hua, H. M., Structurally diverse alkaloids from the seeds of Peganum harmala. Journal of Natural Products 2017, 80 (2), 551-559.

  2. .Wang, K. B.; Li, S. G.; Huang, X. Y.; Li, D. H.; Li, Z. L.; Hua, H. M., (±)-Peharmaline A: a pair of rare β-carboline-vasicinone hybrid alkaloid enantiomers from Peganum harmala. European Journal of Organic  Chemistry 2017, 2017, 1876-1879.

  3. Li, D. H.; Li, J. Y.; Xue, C. M.; Han, T.; Sai, C. M.; Wang, K. B.; Lu, J. C.; Jing, Y. K.; Hua, H. M.; Li, Z. L. , Antiproliferative Dimeric Aporphinoid Alkaloids from the Roots of Thalictrum cultratum. Journal of natural products 2017, 80(11), 2893–2904. 

  4. Niu, S. L.;  Li, D. H.; Wang, Y. T.; Wang, K. B.; Lin, B.; Jing, Y. K.; Hua, H. M.; Bai, J.; Li, Z. L., Neobraclactones A-C, three unprecedented chaise longue-shaped xanthones from Garcinia bracteata. Organic & biomolecular chemistry 2017, 15(22), 4901–4906.

2016

  1.  Wang, K. B.; Li, D. H.; Hu, P.; Wang, W. J.; Lin, C.; Wang, J.; Lin, B.; Bai, J.; Pei, Y. H.; Jing, Y. K.; Li, Z. L.; Yang, D.; Hua, H. M., A series of β-carboline alkaloids from the seeds of Peganum harmala show G-quadruplex interactions. Organic Letters 2016, 18 (14), 3398-3401.

  2. Guo, F.; Li, Z.; Xu, X.;  Wang, K. B.; Shao, M.; Zhao, F.; Wang, H.; Hua, H.; Pei, Y.; Bai, J., Butenolide derivatives from the plant endophytic fungus Aspergillus terreus. Fitoterapia 2016, 113, 44–50. 

  3. Li, D. H.; Guo, J.; Bin, W.; Zhao, N.; Wang, K. B.;  Li, J. Y.; Li, Z. L.; Hua, H. M., Two new benzylisoquinoline alkaloids from Thalictrum foliolosum and their antioxidant and in vitro antiproliferative properties. Archives of pharmacal research 2016, 39(7), 871–877.

2015

  1.   Sai, C. M.; Li, D. H.; Xue, C. M.;                 Wang, K. B.; Hu, P.; Pei, Y. H.; Bai, J.; Jing, Y. K.; Li, Z. L.; Hua, H. M., Two Pairs of Enantiomeric Alkaloid Dimers from Macleaya cordata.                 Organic letters                2015, 17(16), 4102–4105. 

2014

  1.  Wang, K. B.; Di, Y. T.; Bao, Y.; Yuan, C. M.; Chen, G.; Li, D. H.; Bai, J.; He, H. P.; Hao, X. J.; Pei, Y. H.; Jing, Y. K.; Li, Z. L.; Hua, H. M., Peganumine A, a β-carboline dimer with a new octacyclic scaffold from Peganum harmala. Organic Letters 2014, 16 (15), 4028-4031.

  2. Wang, K. B.; Yuan, C. M.; Xue, C. M.; Li, D. H.; Jing, Y. K.; He, H. P.; Hao, X. J.; Di, Y. T.; Li, Z. L.; Hua, H. M., Pegaharmalines A and B, two novel β-carboline alkaloids with unprecedented carbon skeletons from Peganum harmala. RSC Advances 2014, 4 (96), 53725-53729.