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成果及论文

主持主要课题(总经费约1200万):

1、国家高层次人才计划(青年项目,Y82H55),300万元

2、国家自然科学基金(21572162)17万元

3、德国洪堡基金高级洪堡学者项目(DE8136HaV25)53万元

4、温州生物材料与工程研究所重大科研项目(WIBEZD2014002-02)300万元

5、国科温州研究院重大专项(WIUCASQD2019009)300万元

6、国家重点研发计划项目(2017YFC1104602)子课题180万元

7、温州市高水平创新团队(科技类)子课题100万元

8、温州市科技局应急攻关项目(ZY202005)子课题30万元


发明专利:

1)昝兴杰,黄文健基于组氨酸多肽的金属有机配位聚合物包裹生物大分子的方法201910129351.5 

2)昝兴杰,黄文娟一种pH响应的组氨酸多肽-金属配位聚合物纳米颗粒的制备方法201910129178.9 

3)昝兴杰,史鹏忠一步吸附法制备多肽微胶囊的方法201711328419.X

4)昝兴杰,史鹏忠一步法制备多聚蛋白质微胶囊的方法201711327499.7

5)昝兴杰,史鹏忠一步法吸附制备阳离子型聚电解质微胶囊的方法201711328281.3

6)昝兴杰,史鹏忠一步法制备多聚胺类化合物微胶囊的方法201711328110.0

7)昝兴杰,杨硕硕一种自组装蛋白质多层膜制备方法201611139364.3

8)昝兴杰,杨硕硕具有抗菌性和生物祥绒线的自组装溶菌酶多层膜制备方法 201710099816.8

9)昝兴杰,史鹏忠碱性蛋白包载载体、包载载体植被方法和包载方法201610210632.X

10)昝兴杰,翁文雅尺寸形状独立可控的聚电解质微胶囊的制备方法201510228624.3

11)昝兴杰,翁文雅一种尺寸形状可控的聚电解质中空微胶囊及其应用201510228416.3

12)昝兴杰,张廷虹,史鹏忠一种亚单位疫苗及其应用202010356882.0

13)昝兴杰,史鹏忠一种止血粉及其制备方法202010356866.1

14)昝兴杰,汪丽雯一种将多种药物递送至眼部的药物缓释制剂2021110248163.1

15)昝兴杰,汪丽雯一种眼部药物递送系统202110241911.3 


代表性文章(红色标注为IF>10的论文,共15篇):

2023

23. zhou, S.; Yang, R.; Xie, X.; Tang, B.; Zheng, S; Tang, S. Zan, X.*; pH-Responsive Hexa-histidine Metal Assembly (HmA) with Enhanced Biocatalytic Cascades as the Vehicle for Glucose-Mediated Long-acting Insulin Delivery. Advanced Science  (中科院一区, IF 17.521)  DOI: 10.1002/advs.202301771

22. Lu, R.; Zhao, B.; Yang, L.; Zheng, S.; Zan, X.*; Li, N.,Role of Driving Force on Engineering Layer-by-Layer Protein/Polyphenol Coating with Flexible Structures and Properties. ACS APPLIED MATERIALS & INTERFACES (中科院一区, IF 10.383) 2023, 10.1021/acsami.3c02047

2022

20. Wen, R.; Wang, S.; Wang, K.; Yang, D.; Zan, X.*; Meng, Q.*, Complete gene sequence and mechanical property of the fourth type of major ampullate silk protein Acta Biomaterialia (中科院一区, IF 10.633) 2022, 155, 282-291.

21. Chen, W.; Yu, B.; Zhang, X.; Zhang, F.; Zan, X.*; Li, T., Precisely controlling the surface roughness of silica nanoparticles for enhanced functionalities and applications; JOURNAL OF COLLOID AND INTERFACE SCIENCE (中科院一区, IF 8.554) 2022, 629, 173-181.

19. Chen, X.; Zhu, Y.; Tang, S.; Lu, R.; Zhang, X.; Li, N.*; Zan, X.*, Material priority engineered metal-polyphenol networks: mechanism and platform for multifunctionalities JOURNAL OF NANOBIOTECHNOLOGY  (中科院一区, IF 11.509) 2022, 20, NO. 255.

18.   Wen, R.; Yang, D.; Wang, K.; Zan, X.*, Characterization of two full-length Araneus ventricosus major ampullate silk protein genes. International Journal of Biological Macromolecules (中科院一区, IF 8.025) 2022, 213, 297-304.

17.   Wen, R.; Wang, K.; Zan, X.*, Characterization of two full-length tubuliform silk gene sequences from Neoscona theisi reveals intragenic concerted evolution and multiple copies in genome. International Journal of Biological Macromolecules (中科院一区, IF 8.025) 2022, 223 (Pt A), 1015-1023.

16.   Wen, R.; Wang, K.; Yang, D.; Yu, T.; Zan, X.*; Meng, Q., The novel aciniform silk protein (AcSp2-v2) reveals the unique repetitive domain with high acid and thermal stability and self-assembly capability. International Journal of Biological Macromolecules (中科院一区, IF 8.025) 2022, 202, 91-101.

15.   Tang, B.; Xie, X.; Yang, R.; Zhou, S.; Hu, R.; Feng, J.; Zheng, Q.; Zan, X.*, Decorating hexahistidine-metal assemblies with tyrosine enhances the ability of proteins to pass through corneal biobarriers. Acta Biomaterialia (中科院一区, IF 10.633) 2022, 153, 231-242.

14.   Li, K.; Zan, X.#; Tang, C.; Liu, Z.; Fan, J.; Qin, G.; Yang, J.; Cui, W.; Zhu, L.; Chen, Q., Tough, Instant, and Repeatable Adhesion of Self-Healable Elastomers to Diverse Soft and Hard Surfaces. Advanced Science  (中科院一区, IF 17.521)  2022, 9 (12).

13.   Huang, W.; Wang, L.; Yang, R.; Hu, R.; Zheng, Q.; Zan, X.*, Combined delivery of small molecule and protein drugs as synergistic therapeutics for treating corneal neovascularization by a one-pot coassembly strategy. Materials Today Bio (中科院一区, IF 10.761) 2022, 17, 100456-100456.

12.   He, X.; Dai, L.; Ye, L.; Sun, X.; Enoch, O.; Hu, R.; Zan, X.*; Lin, F.; Shen, J., A Vehicle-Free Antimicrobial Polymer Hybrid Gold Nanoparticle as Synergistically Therapeutic Platforms for Staphylococcus aureus Infected Wound Healing. Advanced Science  (中科院一区, IF 17.521)  2022, 9 (14).

2021

11.   Xu, H.; Tang, B.; Huang, W.; Luo, S.; Zhang, T.; Yuan, J.; Zheng, Q.; Zan, X.*, Deliver protein across bio-barriers via hexa-histidine metal assemblies for therapy: a case in corneal neovascularization model. Materials Today Bio (中科院一区, IF 10.761)  2021, 12.

10.   Huang, W.; Zhou, S.; Tang, B.; Xu, H.; Wu, X.; Li, N.; Zan, X.*; Geng, W., Efficient delivery of cytosolic proteins by protein-hexahistidine-metal co-assemblies. Acta Biomaterialia (中科院一区, IF 10.633) 2021, 129, 199-208.

2019

9.     Zhang, L.; Wang, Y.; Yang, D.; Huang, W.; Hao, P.; Feng, S.; Appelhans, D.; Zhang, T.; Zan, X.*, Shape Effect of Nanoparticles on Tumor Penetration in Monolayers Versus Spheroids. Molecular Pharmaceutics (中科院一区, IF 5.364) 2019, 16 (7), 2902-2911.

8.     Yang, S.; Xu, Y.; Lin, Q.; Bai, Y.; Zan, X.*; Ye, Q., A bio-inspired, one-step but versatile coating onto various substrates with strong antibacterial and enhanced osteogenesis. Chemical Communications (中科院一区, IF 6.065) 2019, 55 (14), 2058-2061.

7.     Shi, P.; Qin, J.; Wu, X.; Wang, L.; Zhang, T.; Yang, D.; Zan, X.*; Appelhans, D., A Facile and Universal Method to Efficiently Fabricate Diverse Protein Capsules for Multiple Potential Applications. Acs Applied Materials & Interfaces (中科院一区, IF 10.383) 2019, 11 (42), 39209-39218.

6.     Huang, W.; Hao, P.; Qin, J.; Luo, S.; Zhang, T.; Peng, B.; Chen, H.; Zan, X.*, Hexahistidine-metal assemblies: A promising drug delivery system. Acta Biomaterialia (中科院一区, IF 10.633) 2019, 90, 441-452.

2013

5.     Zan, X.#; Feng, S.; Balizan, E.; Lin, Y.; Wang, Q., Facile Method for Large Scale Alignment of One Dimensional Nanoparticles and Control over Myoblast Orientation and Differentiation. Acs Nano (中科院一区, IF 18.027) 2013, 7 (10), 8385-8396.

4.     Li, T.; Zan, X.#; Winans, R. E.; Wang, Q.; Lee, B., Biomolecular Assembly of Thermoresponsive Superlattices of the Tobacco Mosaic Virus with Large Tunable Interparticle Distances. Angewandte Chemie-International Edition (中科院一区, IF 16.823) 2013, 52 (26), 6638-6642.

2012

3.     Zan, X.#; Sitasuwan, P.; Powell, J.; Dreher, T. W.; Wang, Q., Polyvalent display of RGD motifs on turnip yellow mosaic virus for enhanced stem cell adhesion and spreading. Acta Biomaterialia (中科院一区, IF 10.633) 2012, 8 (8), 2978-2985.

2.     Zan, X.#; Hoagland, D. A.; Wang, T.; Su, Z., Ion Dispositions in Polyelectrolyte Multilayer Films. Macromolecules (中科院一区, IF 6.057) 2012, 45 (21), 8805-8812.

2011

1.     Zan, X.#; Kozlov, M.; McCarthy, T. J.; Su, Z., Covalently Attached, Silver-Doped Poly(vinyl alcohol) Hydrogel Films on Poly(L-lactic acid). Biomacromolecules (中科院一区, IF 6.978) 2010, 11 (4), 1082-1088.