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成果及论文

学术任职

  • 美国生殖医学会会员及年度会议特约审稿人

  • 中国医疗促进保健交流会生殖医学分会委员

  • 广东省医学会循证医学分会常委

  • 广东省生保健协会生殖健康分会委员

  • 广东省医师协会生殖医学医师分会女科医师专业组组员


主持及参与课题

  1. 主持国家自然基金面上项目《线粒体分裂因子MFF调节线粒体稳态影响卵巢衰老的机制研究》，2024.1-2027.12

  2. 主持深圳市医学研究专项基金 《女性生殖衰老对早期着床后阶段人类胚胎发育的影响及分子机制研究》，2024.1-2027.12

  3. 主持国家自然基金面上项目《线粒体应激反应基因Clpp通过线粒体质量控制对卵巢衰老的作用及机制研究》，2020.1-2023.12

  4. 主持国家自然基金青年基金《Clpp介导线粒体功能对卵母细胞发育和成熟的作用及其调控机制》，2016.1-2018.12

  5. 主持深圳市基础研究重点项目《卵巢早衰的发病机理、诊断和治疗的基础研究》，基2020N389 ，2020.7-2023.7

  6. 参与973课题《雌性生育力维持调节机制研究及生殖资源库建立》的研究

  7. 参与国家十一五科技支撑项目《多囊卵巢综合征诊断、防治新技术新方法的研究》课题的研究


Publication

  1. Guo, C.; Xiao, Y.; Gu, J.; Zhao, P.; Hu, Z.; Zheng, J.; Hua, R.; Hai, Z.; Su, J.; Zhang, J. V.; Yeung, W. S. B.; Wang, T. ClpP/ClpX deficiency impairs mitochondrial functions and mTORC1 signaling during spermatogenesis. Communications Biology 2023, 6,1012.

  2. Peikun Zhao, Chenxi Guo, Huijia Du, Jiaping Su, Xiaohui Wang, and Kui Liu, Willian S.B. Yeung, Tianren Wang*. Chemotherapy-induced damage to the ovary and protective strategies. Human Fertility. 2023 

  3. J Zhang, R Hua, L Ma, C Liu, Y Zhang, X Lü, T Wang (co-corresponding author), N Wan. Ovarian juvenile granulosa cell tumors with Ollier’s disease in children with IDH1 gene somatic mutation. Frontiers in Endocrinology. 14, 1093273, 2023 Apr. (IF6.05; JCR 2)

  4. Li G, Gu J, Zhou X, Wu T, Li X, Hua R, Hai Z, Xiao Y, Su J, Yeung WSB, Liu K, Guo C and Wang T (2023) Mitochondrial stress response gene Clpp deficiency impairs oocyte competence and deteriorate cyclophosphamide-induced ovarian damage in young mice. Front. Endocrinol. 14:1122012. doi: 10.3389/fendo.2023.1122012 (IF6.05; JCR 2)

  5. Miao, S.; Guo, C.; Jiang, Z.;Wei, H.-X.; Jiang, X.; Gu, J.; Hai, Z.;Wang, T.; Liu, Y.-H. Development of an Open Microfluidic Platform for Oocyte One-Stop Vitrification with Cryotop Method. Biosensors 2022, 12,766. https://doi.org/10.3390/bios12090766

  6. Wang T, Xiao Y, Hu Z, et al. Guo C*. MFN2 Deficiency Impairs Mitochondrial Functions and PPAR Pathway During Spermatogenesis and Meiosis in Mice. Front Cell Dev Biol. 2022;10:862506. Published 2022 Apr 14. doi: 10.3389/fcell.2022.862506

  7. Cao D, Shi F, Guo C, Liu Y, Lin Z, Zhang J, Li RHW, Yao Y, Liu K, Ng EHY, Yeung WSB, Wang T. A pathogenic DMC1 frameshift mutation causes nonobstructive azoospermia but not primary ovarian insufficiency in humans. Molecular human reproduction. 2021,Sep.

  8. Wang T, Xia X, Yeung WSB. Embryo-endometrium crosstalk: a new understanding from in vitro model. Fertil Steril. 2021 Apr;115(4):907-908.

  9. Shahbazi M, Wang T(co-first author), Tao X, Sun L, Zhan Y, Pellicer A, Scott T, Seli E and Zernicka-Goetz M. Developmental potential of aneuploid human embryos cultured beyond implantation. Nature Communications, 2020, July

  10. Wang T, Zhang M, Jiang Z, Seli E. Mitochondrial unfolded protein response gene Clpp is required to maintain ovarian follicular reserve during aging. Aging Cell. 2018, May 30:e12784.

  11. Wang T, Zhang M, Jiang Z, Seli E. Mitochondrial dysfunction and ovarian aging. Am J Reprod Immunol. 2017, May 1:77(5).

  12. Babayev E, Wang T(co-first author), Szigeti-Buck K, Lowther K, Taylor HS, Horvath T, Seli E Reproductive aging is associated with changes in oocyte mitochondrial dynamics, function, and mtDNA quantity. Maturitas. 2016, Nov 93:121-130.

  13. Tianren Wang, Jie Yan, Cuiling Lu et al. Human single follicle growth in vitro from cryopreserved ovarian tissue after slow freezing or vitrification. Human Reproduction. 2016, 31(4):763-773.

  14. Tianren Wang, Liying Yan, Jie Yan et al. Basic fibroblast growth factor promotes human ovarian early follicles development during in vitro growth. Human Reproduction. 2014, 29(3):568-576

  15. Zhao, Y., Feng, H., Zhang, Y., Zhang, J.V., Wang, X., Liu, D., Wang, T., Li, R.H.W., Ng, E.H.Y., Yeung, W.S.B., et al. (2021). Current Understandings of Core Pathways for the Activation of Mammalian Primordial Follicles. Cells. 2021, Jun.

  16. Seli E, Wang T, Horvath TL. Mitochondrial unfolded protein response: a stress response with implications for fertility and reproductive aging. Fertility and Sterility. 2019, Feb: 111(2):197-204.

  17. Sanchez T, Wang T, Pedro MV, Zhang M, Esencan E, Sakkas D, Needleman D, Seli E. Metabolic imaging with the use of fluorescence lifetime imaging microscopy (FLIM) accurately detects mitochondrial dysfunction in mouse oocytes. Fertility and Sterility. 2018, 110(7): 1387-1397.

  18. Zhang Y, Yan Z, Qin Q, Nisenblat V, Chang HM, Yu Y, Wang T, Lu C et al. Transcriptome Landscape of Human Folliculogenesis Reveals Oocyte and Granulosa Cell Interactions. Molecular Cell. 2018, Dec 20; 72(6):1021-1034.e4.

  19. Jiao J, Shi B, Wang T, Fang Y, Cao T, Zhou Y, Wang X, Li D. Characterization of long non-coding RNA and messenger RNA profiles in follicular fluid from mature and immature ovarian follicles of healthy women and women with polycystic ovary syndrome. Human Reproduction. 2018, Sep 1; 33(9):1735-1748.

  20. Shen ZQ, Shi B, Wang TR, Jiao J, Shang X, Wu QJ, Zhou YM, Cao TF, Du Q, Wang XX, Li D. Characterization of the Sperm Proteome and Reproductive Outcomes with in Vitro Fertilization after a Reduction in Male Ejaculatory Abstinence Period. Mol Cell Proteomics. 2018, Aug 20. pii: mcp.RA117.000541.

  21. Li D, Liu HX, Fang YY, Huo JN, Wu QJ, Wang TR, Zhou YM, Wang XX, Ma XX. Hyperhomocysteinemia in polycystic ovary syndrome: decreased betaine-homocysteine methyltransferase and cystathionine β-synthase-mediated homocysteine metabolism. Reprod Biomed Online. 2018, Aug;37(2):234-241.

  22. Li D, You Y, Bi FF, Zhang TN, Jiao J, Wang TR, Zhou YM, Shen ZQ, Wang XX, Yang Q. Autophagy is activated in the ovarian tissue of polycystic ovary syndrome. Reproduction. 2018, Jan; 155(1):85-92.

  23.  Zhang Y, Xia X, Yan J, Yan L, Lu C, Zhu X, Wang T, Yin T, Li R, Chang HM, Qiao J. Mesenchymal stem cell-derived angiogenin promotes primodial follicle survival and angiogenesis in transplanted human ovarian tissue. Reprod Biol Endocrinol. 2017, Mar 9;15(1):18.

  24. Zhu K, Yan L, Zhang X, Lu X, Wang T, Yan J, Liu X, Qiao J, Li L. Identification of a human subcortical maternal complex. Molecular Human Reproduction. 2015 Apr; 21(4):320-9.

  25.  Xia X, Wang T, Yin T, Yan L, Yan J, Lu C, Zhao L, Li M, Zhang Y, Jin H, Zhu X, Liu P, Li R, Qiao J. Mesenchymal Stem Cells Facilitate In Vitro Development of Human Preantral Follicle. Reprod Sci. 2015 Nov; 22(11):1367-76.

  26.  Xia X, Yin T, Yan J, Yan L, Jin C, Lu C, Wang T, Zhu X, Zhi X, Wang J, Tian L, Liu J, Li R, Qiao J. Mesenchymal Stem Cells Enhance Angiogenesis and Follicle Survival in Human Cryopreserved Ovarian Cortex Transplantation. Cell Transplant. 2015; 24(10):1999-2010.

  27. Lu CL, Yan J, Zhi X, Xia X, Wang TR, Yan LY, Yu Y et al. Basic fibroblast growth factor promotes macaque follicle development in vitro. Reproduction. 2015, 149(5):425-433.

  28. Tang W, Yan J, Wang T, Xia X, Zhuang X, Hong K, Li R, Liu P, Jiang H, Qiao J. Up-regulation of heme oxygenase-1 expression modulates reactive oxygen species level during the cryopreservation of human seminiferous tubules. Fertil Steril. 2014,102(4): 974-980

  29.  Jiangman Gao, Jie Yan, Rong Li, Min Li, Liying Yan, Tianren Wang, Hongcui Zhao, Yue Zhao, Yang Yu, Jie Qiao. Improvement in the quality of heterotopic allotransplanted mouse ovarian tissues with basic fibroblast growth factor and fibrin hydrogel. Human Reproduction. 2013, 28(10):2784-2793.

 

Conferences Presentation

 

§  2021  3rd Summit Meeting of Gynecological oncology of University of Hong Kong, Shenzhen Hospital, Invited speaker

§  2021  Association of Guangdong Province Evidence based medicine annual meeting, Invited speaker

§  2021  Asia-Pacific Association for Fertility Preservation Annual meeting, Invited session Chairman

§  2021  The 18th Cornell-China Circle Seminar,  Invited guest for discussion

§  2021  2nd Summit Meeting of Ovarian Disease and Reproductive Health, Invited speaker

§  2021  ASRM (American Society of Reproductive Medicine) Scientific Congress  Poster

§  2020  Controversies in Reproductive Medicine, Invited speaker

§  2020  OVARIAN CLUB XVI Online Meeting, Invited speaker

§  2019  1st Summit Meeting of Ovarian Disease and Reproductive Health, Invited speaker

§  2018  ASRM (American Society of Reproductive Medicine) Scientific Congress    Oral

§  2017  ASRM (American Society of Reproductive Medicine) Scientific Congress    Oral

§  2017  SRI (Society for Reproductive Investigation) Scientific Congress            Oral

§  2016  ASRM (American Society of Reproductive Medicine) Scientific Congress    Oral

§  2014  ASRM (American Society of Reproductive Medicine) Scientific Congress  Poster

§  2014  Congress of the Asia Pacific Initiative on Reproduction                    Oral

 

Manuscripts Reviewed

§  Journal: Fertility and Sterility

§  Journal: Reproductive BioMedicine Online

§  Journal: Reproductive Biology and Endocrinology

§  Journal: Journal of Assisted Reproduction and Genetics

§  2018-2021 ASRM Scientific Congress &Expo (abstract)



参编论著

《生育力保护与生殖储备》第七章：女性生育力的保存 | 乔杰 | 北京大学医学出版社 | 2013