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成果及论文

[1]. Tang, Y.; Zhao, Y.; and Lin, W. Preparation of robust fluorescent probes for tracking endogenous formaldehyde in living cells and mouse tissue slices. Nat. Protoc., 2020, 15, 3499-3526. 

[2]. Tang, Y.; Ma, Y.; Yin, J.; and Lin, W. Strategies for designing organic fluorescent probes for biological imaging of reactive carbonyl species. Chem. Soc. Rev., 2019, 48, 4036-4048. 

[3]. Ai, L.; Tan, T.; Tang, Y.(共同第一作者); Yang, J.; Cui, D.; et al. Endogenous formaldehyde is a memory-related molecule in mice and humans. Commun. Biol., 2019, 2, 446. 

[4]. Tang, Y.; Lee, D.; Wang, J.; Li, G.; Yu, J.; Lin, W.; and Yoon. J. Development of fluorescent probes based on protection-deprotection of the key functional groups for biological imaging. Chem. Soc. Rev., 2015, 44, 5003- 5015.

[5]. Tang, Y.; Kong, X.; Xu, A.; Dong, B.; Lin. W. Development of a Two-photon Fluorescent Probe for Imaging of Endogenous Formaldehyde in Living Tissues. Angew. Chem., Int. Ed., 2016, 55, 3356-3359.

[6]. Tang, Y.; Kong, X.; Liu, Z.; Xu, A.; Lin. W. Lysosome-targeted turn-on fluorescent probe for endogenous formaldehyde in living cells. Anal. Chem., 2016, 88, 9359 - 9363.

[7]. Lee, Y. H.; Tang, Y.(共同第一作者); Verwilst, P.; Lin, W.; Kim. J. S. A biotin-guided formaldehyde sensor selectively detecting endogenous concentrations in cancerous cells and tissues. Chem. Commun., 2016, 52, 11247 -11250.

[8]. Tang, Y.; Xu, A.; Ma, Y.; Xu, G.; Gao, S.; Lin, W. A turn-on endoplasmic reticulum-targeted two-photon fluorescent probe for hydrogen sulfide and bio-imaging applications in living cells, tissues, and zebrafish. Sci. Rep., 2017, 12944. 

[9]. Tang, Y.; Ma, Y.; Xu, A.; Xu, G.; Lin, W. A turn-on fluorescent probe for endogenous formaldehyde in endoplasmic reticulum of living cells. Methods Appl. Fluoresc., 2017, 2017, 5, 024005. 

[10].Zhang, Y.; Tang, Y.; Kong, X.; Lin, W. An endoplasmic reticulum targetable turn-on fluorescence probe for imaging application of carbon monoxide in living cells. Spectrochim. Acta, Part A, 2021, 247, 119150. 

[11].Gu, L.; Tang, Y.; Lin, W. A new highly selective fluorescence probe for the imaging of endogenous formaldehyde in living cells. Tetrahedron, 2021, 78, 13180 

[12].Ma, Y.; Tang, Y.; Zhao, Y.; Lin, W. Rational Design of a Reversible Fluorescent Probe for Sensing Sulfur Dioxide/Formaldehyde in Living Cells, Zebrafish, and Living Mice. Anal. Chem., 2019, 91, 10723-10730.

[13].Guo, R.; Ma, Y.; Tang, Y.; Xie, P.; Wang, Q.; Lin, W. A novel mitochondria-targeted near-infrared (NIR) probe for detection of viscosity changes in living cell, zebra fishes and living mice. Talanta, 2019, 204, 868-874.

[14].Gao, S.; Tang, Y.; Lin, W. Development of a highly selective two-photon probe for methylglyoxal and its applications in living cells, tissues, and zebrafish. J. Fluoresc., 2019, 29, 155-163. 

[15].Ai, L,; Wang, J.; Li, T.; Zhao, C.; Tang, Y.; et al. A rapid and sensitive fluorescence method for detecting urine formaldehyde in patients with Alzheimer’s disease. Ann. Clin. Biochem., 2019, 56, 210-218. 

[16].Tian, M.; Sun, J.; Tang, Y.; Dong, B.; Lin, W. Discriminating live and dead cells in dual-color mode with a two-photon fluorescent probe based on ESIPT mechanism. Anal. Chem., 2018, 90, 998−1005. 

[17].Gao, S.; Tang, Y.; Lin, W. Development of a two-photon turn-on fluorescent probe for cysteine and its bio-imaging applications in living cells, tissues, and zebrafish. New J. Chem., 2018, 42, 14075-14078. 

[18].Xu, G.; Tang, Y.; Lin, W. A multi-signal fluorescent probe for discrimination of cysteine/homocysteine, and glutathione and the application in living cells and zebrafish. New J. Chem., 2018, 42, 12615-12620. 

[19].Xu, A.; Tang, Y.; Lin, W. Development of a mitochondrial-targeted two-photon fluorescence turn-on probe for formaldehyde and its bio-imaging applications in living cells and tissue. New J. Chem., 2018, 42, 8325 - 8329. 

[20].Xu, A.; Tang, Y.; Lin, W. Endoplasmic reticulum-targeted two-photon turn-on fluorescent probe for nitroreductase in tumor cells and tissues. Spectrochim. Acta, Part A, 2018, 204, 770 -776. 

[21].Xu, G.; Tang, Y.; Ma, Y.; Xu, A.; Lin, W. A new aggregation-enhanced emission fluorescent probe for rapid detection of nitroreductase and its application in living cells. Spectrochim. Acta, Part A, 2018, 188, 197- 201. 

[22].Xu, G.; Tang, Y.; Lin, W. Development of a two-photon ratiometric fluorescent probe for glutathione and its applications in living cells. Chem. Res. Chin. Univ., 2018, 34, 523-527. 

[23].Chen, H.; Dong, B.; Tang, Y.; Lin, W. A Unique “Integration” Strategy for the Rational Design of Optically Tunable Near-Infrared Fluorophores. Acc. Chem. Res., 2017, 50, 1410 -1422.

[24].Shang, H.; Chen, H.; Tang, Y.; Ma, Y.; Lin, W. Development of a two-photon fluorescent turn-on probe with far-red emission for thiophenols and its bioimaging application in living tissues. Biosens. Bioelectron., 2017, 95, 81-86. 

[25].Liu, Z.; Tang, Y.; Xu, A.; Lin, W. A new fluorescent probe with a large turn-on signal for imaging nitroreductase in tumor cells and tissues by two-photon microscopy. Biosens. Bioelectron., 2017, 89, 853 -858. 

[26].Ma, Y.; Tang, Y.; Zhao, Y.; Gao, S.; Lin, W. Two-Photon and Deep-Red Emission Ratiometric Fluorescent Probe with a Large Emission Shift and Signal Ratios for Sulfur Dioxide: Ultrafast Response and Applications in Living Cells, Brain Tissues, and Zebrafishes. Anal. Chem., 2017, 89, 9388 -9393. 

[27].Xu, A.; Tang, Y.; Ma, Y.; Xu, G.; Gao, S.; Zhao, Y.; Lin, W. A fast-responsive two-photon fluorescent turn-on probe for nitroreductase and its bioimaging application in living tissues. Sens. Actuators, B, 2017, 252, 927-933. 

[28].Chen, H.; Tang, Y.; Shang, H.; Kong, X.; Guo, R.; Lin, W. Development of a Unique Family of Two-photon Full-color-tunable Fluorescent Materials for Imaging in Live Subcellular Organelles, Cells, and Tissues. J. Mater. Chem. B, 2017, 5, 2436 -2444. 

[29].Invited Book chapter: Ren, M.; Deng, B.; Kong, X.; Tang, Y.; Lin, W. Preparation of a Two-photon Fluorescent Probe for Imaging H2O2 in Lysosomes in Living Cells and Tissues, "Lysosomes: Methods and Protocols", "Methods in Molecular Biology" (Editors: Karin Öllinger and Hanna Appelqvist), Springer, 2017, Chapter 7, 129-139. 

[30].Dong, B.; Song, X.; Kong, X.; Wang, C.; Tang, Y.; et al. Simultaneous Near-Infrared and Two-photon in vivo Imaging of H2O2 Using a Ratiometric Fluorescent Probe Based on the Unique Oxidative Rearrangement of Oxonium. Adv. Mater., 2016, 28, 8755-8759. 

[31].Chen, H.; Tang, Y.; Ren, M.; Lin, W. Single near-infrared fluorescent probe with high and low sensitivity sites for sensing different concentration ranges of biological thiols with distinct modes of fluorescence signals. Chem. Sci., 2016, 7, 1896-1903.

[32].Zhang, H.; Kong, X.; Tang, Y.; Lin, W. Hydrogen sulfide triggered charge-reversal micelles for cancer-targeted drug delivery and imaging. ACS Appl. Mater. Interfaces, 2016, 8, 16227-16239.

[33].He, L.; Xu, Q.; Liu, Y.; Wei, H.; Tang, Y.; Lin, W. Coumarin Based Turn-on Fluorescence Probe for Specific Detection of Glutathione over Cysteine and Homocysteine. ACS Appl. Mater. Interfaces, 2015, 7, 12809-12813. 

[34].Chen, H.; Tang, Y.; Lin, W. Recent progress in the fluorescent probes for specific imaging small molecular weight thiols in living cells. TrAC, Trends Anal. Chem., 2016, 76, 166-181. 

[35].Dong, B.; Song, X.; Wang, C.; Kong, X.; Tang, Y.; Lin, W. Dual-site Controlled and Lysosome-targeted ICT-PET-FRET Fluorescent Probe for Monitoring pH Changes in Living Cells. Anal. Chem., 2016, 88, 4085 -4091. 

[36].Shang, H.; Chen, H.; Tang, Y.; Guo, R.; Lin, W. Construction of a two-photon fluorescent turn-on probe for hydrogen persulfide and polysulfide and its bioimaging application in living mice. Sens. Actuators, B, 2016, 230, 773-778. 

[37].Dong, B.; Song, X.; Tang, Y.;  Lin, W. *. A rapid and facile fluorimetric method for detecting formaldehyde. Sens. Actuators, B, 2016, 222, 325-330. 

[38].Dong, B.; Song, X.; Tang, Y.; Lin, W. Development of green to near-infrared turn-on fluorescent probes for multicolour imaging of nitroxyl in living system. J. Mater. Chem. B, 2016, 4, 1263-1269. 

[39].Liu, Y.; Meng, F.; Tang, Y.; Yu, X.; Lin, W. A photostable fluorescent probe for rapid monitoring and tracking trans membrane process and mitochondrial fission and fusion dynamics. New J. Chem., 2016, 40, 3726-3731. 

[40].Chen, H.; Dong, B.; Tang, Y.; Lin, W. Construction of a near-infrared fluorescent turn-on probe for selenol and its bioimaging application in living animals. Chem. - Eur. J., 2015, 21, 11696-11700.