Selected Publications
13. Yue Jiang#, Min Zhao#, Jia Miao, Wan Chen, Yuan Zhang, Minqian Miao, Li Yang, Qing Li, Qingqing Miao*. Acidity-activatable upconversion afterglow luminescence cocktail nanoparticles for ultrasensitive in vivo imaging. Nat. Commun., 2024, 15, 2124.
12. Jieli Zhu, Wan Chen, Li Yang, Yuyang Zhang, Baoliang Cheng, Wei Gu, Qing Li, and Qingqing Miao*. A Self-Sustaining Near-Infrared Afterglow Chemiluminophore for High-Contrast Activatable Imaging. Angew. Chem. Int. Ed., 2024, 63, e202318545.
11. Li Yang, Min Zhao, Wan Chen, Jieli Zhu, Weina Xu, Qing Li, Kanyi Pu*, Qingqing Miao*. A Highly Bright Near-Infrared Afterglow Luminophore for Activatable Ultrasensitive In Vivo Imaging. Angew. Chem. Int. Ed., 2024, 63, e202313117. (Hot Paper)
10. Min Zhao, Yuyang Zhang, Jia Miao, Hui Zhou, Yue Jiang, Yuan Zhang, Minqian Miao, Wan Chen, Wei Xing*, Qing Li*, Qingqing Miao*. An Activatable Phototheranostic Probe for Anti-hypoxic Type I Photodynamic- and Immuno-Therapy of Cancer. Adv. Mater., 2024, 36, 2305243.
9. Hui Zhou, Yuan Zhang, Ruru Zhang, Min Zhao, Wan Chen, Yinghua Liu, Yue Jiang, Qing Li, Qingqing Miao*, Minyuan Gao*. Tumor Microenvironment‐Activatable Molecular Pro‐theranostic Agent for Photodynamic and Immunotherapy of Cancer. Adv. Mater., 2023, 35, 2211485.
8. Jia Miao#, Minqian Miao#, Yue Jiang, Min Zhao, Qing Li*, Yuan Zhang, Yi An, Kanyi Pu*, Qingqing Miao*. An Activatable NIR‐II Fluorescent Reporter for In Vivo Imaging of Amyloid‐β Plaques. Angew. Chem. Int. Ed., 2023, 62, e202216351. (Hot Paper)
7. Wan Chen, Yuan Zhang, Qing Li*, Yue Jiang, Hui Zhou, Yinghua Liu, Qingqing Miao*, Minyuan Gao*. Near-Infrared Afterglow Luminescence of Chlorin Nanoparticles for Ultrasensitive In Vivo Imaging. J. Am. Chem. Soc., 2022, 144, 6719-6726.
6. Yan Zhang#,*, Shasha He#, Wan Chen, Yinghua Liu, Xuefei Zhang, Qingqing Miao*, Kanyi Pu*. Activatable Polymeric Nanoprobe for Near‐Infrared Fluorescence and Photoacoustic Imaging of T Lymphocytes. Angew. Chem. Int. Ed., 2021, 60, 5921-5927.
5. Qing Li#, Shenhua Li#, Shasha He, Wan Chen, Penghui Cheng, Yan Zhang, Qingqing Miao*, and Kanyi Pu*. An Activatable Polymeric Reporter for Near-Infrared Fluorescent and Photoacoustic Imaging of Invasive Cancer. Angew. Chem. Int. Ed., 2020, 59, 7018 – 7023. (Hot Paper, Cover)
4. Qingqing Miao, and Kanyi Pu*. Organic semiconducting agents for deep‐tissue molecular imaging: second near‐infrared fluorescence, self‐luminescence, and photoacoustics. Adv. Mater., 2018, 30, 1801778.
3. Qingqing Miao#, David C. Yeo#, Christian Wiraja, Jianjian Zhang, Xiaoyu Ning, Chenjie Xu, and Kanyi Pu*. Near‐Infrared Fluorescent Molecular Probe for Sensitive Imaging of Keloid. Angew. Chem. Int. Ed., 2018, 57, 1256 –1260.
2. Qingqing Miao, Chen Xie, Xu Zhen, Yan Lyu, Hongwei Duan, Xiaogang Liu, Jesse V Jokerst, and Kanyi Pu*. Molecular afterglow imaging with bright, biodegradable polymer nanoparticles. Nat. Biotechnol., 2017, 35, 1102. (Highlighted by Nature Methods, citation: 661 times)
1. Qingqing Miao, Yan Lyu, Dan Ding and Kanyi Pu*. Semiconducting oligomer nanoparticles as an activatable photoacoustic probe with amplified brightness for in vivo imaging of pH. Adv. Mater., 2016, 28, 3662-3668.
2024
55. Wei Gu#, Yuan Zhang#, Wan Chen, Jieli Zhu, Yuyang Zhang, Baoliang Cheng, Qing Li*, and Qingqing Miao*. Sequentially Dual-Targeted Molecular Theranostic Probe for Radionuclide and Anti-Hypoxic Activatable Photodynamic Therapy of Cancer. ACS Materials Lett. 2024, 6, 5179–5189.
54. Yuyang Zhang#, Min Zhao#, Diedie Cheng, Jieli Zhu, Baoliang Cheng, Minqian Miao, Qing Li*, Qingqing Miao*. Self-Assembled Type I Nanophotosensitizer with NIR-II Fluorescence Emission for Imaging-Guided Targeted Phototherapy of Glioblastoma. ACS Appl. Nano Mater., 2024, 7, 18, 22117–22129.
53. Yue Jiang#, Min Zhao#, Jia Miao, Wan Chen, Yuan Zhang, Minqian Miao, Li Yang, Qing Li, Qingqing Miao*. Acidity-activatable upconversion afterglow luminescence cocktail nanoparticles for ultrasensitive in vivo imaging. Nat. Commun., 2024, 15, 2124.
52. Jieli Zhu, Wan Chen, Li Yang, Yuyang Zhang, Baoliang Cheng, Wei Gu, Qing Li, and Qingqing Miao*. A Self-Sustaining Near-Infrared Afterglow Chemiluminophore for High-Contrast Activatable Imaging. Angew. Chem. Int. Ed., 2024, 63, e202318545.
51. Li Yang, Min Zhao, Wan Chen, Jieli Zhu, Weina Xu, Qing Li, Kanyi Pu*, Qingqing Miao*. A Highly Bright Near-Infrared Afterglow Luminophore for Activatable Ultrasensitive In Vivo Imaging. Angew. Chem. Int. Ed., 2024, 63, e202313117.
50. Min Zhao, Yuyang Zhang, Jia Miao, Hui Zhou, Yue Jiang, Yuan Zhang, Minqian Miao, Wan Chen, Wei Xing*, Qing Li*, Qingqing Miao*. An Activatable Phototheranostic Probe for Anti-hypoxic Type I Photodynamic- and Immuno-Therapy of Cancer. Adv. Mater., 2024, 36, 2305243.
2023
49. Yuyang Zhang, Min Zhao, Jia Miao, Wei Gu, Jieli Zhu, Baoliang Cheng, Qing Li, Qingqing Miao*. Hemicyanine-Based Type I Photosensitizers for Antihypoxic Activatable Photodynamic Therapy. ACS Mater. Lett., 2023, 5, 3058–3067.
48. Yi An, Wei Gu, Minqian Miao, Jia Miao, Hui Zhou, Min Zhao, Yue Jiang, Qing Li, Qingqing Miao*. A Self-Assembled Organic Probe with Activatable Near-Infrared Fluoro-Photoacoustic Signals for In Vivo Evaluation of the Radiotherapy Effect. Anal. Chem., 2023, 95, 13984–13991.
47. Minqian Miao, Jia Miao, Yuan Zhang, Jinglin Zhang, Meng She, Min Zhao, Qingqing Miao, Li Yang*, Kailong Zhou*, Qing Li*. An activatable near-infrared molecular reporter for fluoro-photoacoustic imaging of liver fibrosis. Biosens. Bioelectron., 2023, 235, 115399.
46. Zhuorun Song, Jia Miao, Minqian Miao, Baoliang Cheng, Shenhua Li, Yinghua Liu, Qingqing Miao, Qing Li*, Mingyuan Gao*. Cathepsin K‐Activated Probe for Fluoro‐Photoacoustic Imaging of Early Osteolytic Metastasis. Adv. Sci., 2023, 10, 2300217.
45. Hui Zhou, Yuan Zhang, Ruru Zhang, Min Zhao, Wan Chen, Yinghua Liu, Yue Jiang, Qing Li, Qingqing Miao*, Minyuan Gao*. Tumor Microenvironment‐Activatable Molecular Pro‐theranostic Agent for Photodynamic and Immunotherapy of Cancer. Adv. Mater., 2023, 35, 2211485.
44. Wan Chen, Yue Jiang, Min Zhao, Yi An, Yuan Zhang, Li Yang, Qingqing Miao*. 1O2-Relevant Afterglow Luminescence of Chlorin Nanoparticles for Discriminative Detection and Isotopic Analysis of H2O and D2O. Anal. Chem., 2023, 95, 5340-5345.
43. Jia Miao#, Minqian Miao#, Yue Jiang, Min Zhao, Qing Li*, Yuan Zhang, Yi An, Kanyi Pu*, Qingqing Miao*. An Activatable NIR‐II Fluorescent Reporter for In Vivo Imaging of Amyloid‐β Plaques. Angew. Chem. Int. Ed., 2023, 62, e202216351.
2022
42. Jieli Zhu#, Ran Zhu#, Qingqing Miao*. Polymeric agents for activatable fluorescence, self-luminescence and photoacoustic imaging. Biosens. Bioelectron., 2022, 210, 114330.
41. Yan Zhang, Shasha He, Cheng Xu, Yue Jiang, Qingqing Miao, Kanyi Pu*. An Activatable Polymeric Nanoprobe for Fluorescence and Photoacoustic Imaging of Tumor‐Associated Neutrophils in Cancer Immunotherapy. Angew. Chem. Int. Ed., 2022, 61, e202203184.
40. Shenhua Li#, Qing Li#,*, Wan Chen, Yi An, Peixin Chen, Yan Wu, Guanglin Wang, Yayi He, Qingqing Miao*. A Renal‐Clearable Activatable Molecular Probe for Fluoro‐Photacoustic and Radioactive Imaging of Cancer Biomarkers. Small, 2022, 18, 2201334.
39. Yinghua Liu#, Jianfeng Zeng#, Qing Li*, Zhuorun Song, Minqian Miao, Min Zhao, Qingqing Miao*, Minyuan Gao*. An APN‐Activated Chemiluminescent Probe for Image‐Guided Surgery of Malignant Tumors. Adv. Opt. Mater., 2022, 10, 2102709.
38. Wan Chen, Yuan Zhang, Qing Li*, Yue Jiang, Hui Zhou, Yinghua Liu, Qingqing Miao*, Minyuan Gao*. Near-Infrared Afterglow Luminescence of Chlorin Nanoparticles for Ultrasensitive In Vivo Imaging. J. Am. Chem. Soc., 2022, 144, 6719-6726.
37. Yuan Zhang#, Guanglin Wang#, Qing Li*, Yue Jiang, Wan Chen, Min Zhao, Gaoling Liang, Qingqing Miao*, Acidity-Activated Charge Conversion of 177Lu-Labeled Nanoagent for the Enhanced Photodynamic Radionuclide Therapy of Cancer. ACS Appl. Mater. Interfaces, 2022, 14, 3875-3884.
2021
36. Xiangyan Wang, Lei Chen, Jianxian Ge, Mohammad Javad Afshari, Lei Yang, Qingqing Miao, Ruixue Duan, Jiabin Cui, Chunyi Liu, Jianfeng Zeng*, Jian Zhong, Mingyuan Gao*. Rational Constructed Ultra-Small Iron Oxide Nanoprobes Manifesting High Performance for T1-Weighted Magnetic Resonance Imaging of Glioblastoma. Nanomaterials, 2021, 11, 2601.
35. Yan Zhang#,*, Shasha He#, Wan Chen, Yinghua Liu, Xuefei Zhang, Qingqing Miao*, Kanyi Pu*. Activatable Polymeric Nanoprobe for Near‐Infrared Fluorescence and Photoacoustic Imaging of T Lymphocytes. Angew. Chem. Int. Ed., 2021, 60, 5921-5927.
2020
34. Wu Cai#, Guohua Fan#, Hui Zhou#, Lei Chen, Jianxian Ge, Baoxing Huang, Dandan Zhou, Jianfeng Zeng*, Qingqing Miao*, Chunhong Hu*. Self-assembled hybrid nanocomposites for multimodal imaging-guided photothermal therapy of lymph node metastasis. ACS Appl. Mater. Interfaces, 2020, 12, 49407-49415.
33. Qing Li#, Shenhua Li#, Shasha He, Wan Chen, Penghui Cheng, Yan Zhang, Qingqing Miao*, and Kanyi Pu*. An Activatable Polymeric Reporter for Near-Infrared Fluorescent and Photoacoustic Imaging of Invasive Cancer. Angew. Chem. Int. Ed., 2020, 59, 7018 – 7023.
32. Penghui Cheng, Qingqing Miao, Jiaguo Huang, Jingchao Li, Kanyi Pu*. Multiplex optical urinalysis for early detection of drug-induced kidney injury. Anal. Chem. 2020, 92, 6166-6172.
31. Penghui Cheng, Wan Chen, Shenhua Li, Shasha He, Qingqing Miao, Kanyi Pu*. Fluoro‐photoacoustic polymeric renal reporter for real‐time dual imaging of acute kidney injury. Adv. Mater., 2020, 32, 1908530.
2019
30. Hui Zhou, Jianxian Ge, Qingqing Miao, Ran Zhu, Ling Wen, Jianfeng Zeng*, Mingyuan Gao. Biodegradable inorganic nanoparticles for cancer theranostics: insights into the degradation behavior. Bioconjugate Chem., 2019, 31, 315-331.
29. Qing Li, Jianfeng Zeng, Qingqing Miao*, Mingyuan Gao. Self-illuminating agents for deep-tissue optical imaging. Front. Bioeng. Biotechnol., 2019, 7, 326.
28. Jiaguo Huang, Jingchao Li, Yan Lyu, Qingqing Miao, Kanyi Pu*. Molecular optical imaging probes for early diagnosis of drug-induced acute kidney injury. Nat. Mater., 2019, 18, 1133-1143.
27. Penghui Cheng, Qingqing Miao, Jingchao Li, Jiaguo Huang, Chen Xie, Kanyi Pu*. Unimolecular chemo-fluoro-luminescent reporter for crosstalk-free duplex imaging of hepatotoxicity. J. Am. Chem. Soc., 2019, 141, 10581-10584.
26. Yuyan Jiang, Jiaguo Huang, Xu Zhen, Ziling Zeng, Jingchao Li, Chen Xie, Qingqing Miao, Jie Chen, Peng Chen, Kanyi Pu*. A generic approach towards afterglow luminescent nanoparticles for ultrasensitive in vivo imaging. Nat. Commun., 2019, 10, 2064.
Before independent work
2018
25. Qingqing Miao, and Kanyi Pu*. Organic semiconducting agents for deep‐tissue molecular imaging: second near‐infrared fluorescence, self‐luminescence, and photoacoustics. Adv. Mater., 2018, 30, 1801778.
24. David C Yeo, Christian Wiraja, Qingqing Miao, Xiaoyu Ning, Kanyi Pu, Chenjie Xu*. Anti-scarring drug screening with near-infrared molecular probes targeting fibroblast activation protein-α. ACS Appl. Bio Mater., 2018, 1, 2054-2061.
23. Chen Xie, Yan Lyu, Xu Zhen, Qingqing Miao, Kanyi Pu*. Activatable semiconducting oligomer amphiphile for near-infrared luminescence imaging of biothiols. ACS Appl. Bio Mater., 2018, 1, 1147-1153.
22. Xu Zhen, Jianjian Zhang, Jiaguo Huang, Chen Xie, Qingqing Miao, Kanyi Pu*. Macrotheranostic probe with disease‐activated near‐infrared fluorescence, photoacoustic, and photothermal signals for imaging‐guided therapy. Angew. Chem. Int. Ed., 2018, 57, 7804-7807.
21. Chen Xie, Xu Zhen, Qingqing Miao, Yan Lyu, Kanyi Pu*. Self‐assembled semiconducting polymer nanoparticles for ultrasensitive near‐infrared afterglow imaging of metastatic tumors. Adv. Mater., 2018, 30, 1801331.
20. Jingchao Li, Chen Xie, Jiaguo Huang, Yuyan Jiang, Qingqing Miao, Kanyi Pu*. Semiconducting polymer nanoenzymes with photothermic activity for enhanced cancer therapy. Angew. Chem. Int. Ed., 2018, 57, 3995-3998.
19. Qingqing Miao#, David C. Yeo#, Christian Wiraja, Jianjian Zhang, Xiaoyu Ning, Chenjie Xu, and Kanyi Pu*. Near‐Infrared Fluorescent Molecular Probe for Sensitive Imaging of Keloid. Angew. Chem. Int. Ed., 2018, 57, 1256 –1260.
18. Penghui Cheng, Jianjian Zhang, Jiaguo Huang, Qingqing Miao, Chenjie Xu, Kanyi Pu*. Near-infrared fluorescence probes to detect reactive oxygen species for keloid diagnosis. Chem. Sci., 2018, 9, 6340-6347.
2017
17. Qingqing Miao, Chen Xie, Xu Zhen, Yan Lyu, Hongwei Duan, Xiaogang Liu, Jesse V Jokerst, and Kanyi Pu*. Molecular afterglow imaging with bright, biodegradable polymer nanoparticles. Nat. Biotechnol., 2017, 35, 1102.
16. Houjuan Zhu, Yuan Fang, Qingqing Miao, Xiaoying Qi, Dan Ding, Peng Chen, Kanyi Pu*. Regulating near-infrared photodynamic properties of semiconducting polymer nanotheranostics for optimized cancer therapy. ACS Nano, 2017, 8998-9009.
2016
15. Xu Zhen, Chengwu Zhang, Chen Xie, Qingqing Miao, Kah Leong Lim, Kanyi Pu*. ACS Nano, 2016, 10, 6400-6409.
14. Qingqing Miao, Yan Lyu, Dan Ding and Kanyi Pu*. Semiconducting oligomer nanoparticles as an activatable photoacoustic probe with amplified brightness for in vivo imaging of pH. Adv. Mater., 2016, 28, 3662-3668.
13. Qingqing Miao, and Kanyi Pu*. Emerging designs of activatable photoacoustic probes for molecular imaging. Bioconjugate Chem., 2016, 27, 2808-2823.
12. Yan Lyu, Yuan Fang, Qingqing Miao, Xu Zhen, Dan Ding, Kanyi Pu*. Intraparticle Molecular Orbital Engineering of Semiconducting Polymer Nanoparticles as Amplified Theranostics for in Vivo Photoacoustic Imaging and Photothermal Therapy. ACS Nano, 2016, 10, 4472-4481.
2015
11. Ling Dong, Qingqing Miao, Zijuan Hai, Yue Yuan, Gaolin Liang*. Enzymatic hydrogelation-induced fluorescence turn-off for sensing alkaline phosphatase in vitro and in living cells. Anal. Chem., 2015, 87, 6475-6478.
10. Qingqing Miao, Qing Li, Qingpan Yuan, Lingli Li, Zijuan Hai, Shuang Liu, and Gaolin Liang*. Discriminative fluorescence sensing of biothiols in vitro and in living cells. Anal. Chem., 2015, 87, 3460-3466.
9. Zijuan Hai, Yajie Bao, Qingqing Miao, Xiaoyi Yi, Gaolin Liang*. Pyridine–biquinoline–metal complexes for sensing pyrophosphate and hydrogen sulfide in aqueous buffer and in cells. Anal. Chem., 2015, 87, 2678-2684.
8. Qingqing Miao, Chunying Yin, Maolin Xie, Yufeng Luo, Zijuan Hai, Qingpan Yuan, Jun Jiang and Gaolin Liang*. Gathering nanorings via Fe2+–bipyridine coordination. Chem. Commun., 2015, 51, 11045-11047.
7. Yaling Liu, Qingqing Miao, Pei Zou, Longfei Liu, Xiaojing Wang, Linna An, Xiaoliu Zhang, Xiangping Qian, Shineng Luo, Gaolin Liang*. Enzyme-controlled intracellular self-assembly of 18F nanoparticles for enhanced microPET imaging of tumor. Theranostics, 2015, 5, 1058.
6. Bin Mei, Qingqing Miao, Anming Tang, Gaolin Liang*. Enzyme-instructed self-assembly of taxol promotes axonal branching. Nanoscale, 2015, 7, 15605-15608.
5. Qingqing Miao, Ziye Wu, Zijuan Hai, Changlu Tao, Qingpan Yuan, Yadi Gong, Yafeng Guan, Jun Jiang, Gaolin Liang*. Bipyridine hydrogel for selective and visible detection and absorption of Cd2+. Nanoscale, 2015, 7, 2797-2804.
2014
4. Yue Yuan, Shenlong Jiang, Qingqing Miao, Jia Zhang, Mengjing Wang, Linna An, Qinjingwen Cao, Yafeng Guan, Qun Zhang, Gaolin Liang*. Fluorescent switch for fast and selective detection of mercury (II) ions in vitro and in living cells and a simple device for its removal. Talanta, 2014, 125, 204-209.
3. Xiaojing Wang, Qingqing Miao, Tingjie Song, Qingpan Yuan, Jinhao Gao, Gaolin Liang*. A fluorescent switch for sequentially and selectively sensing copper (II) and L-histidine in vitro and in living cells. Analyst, 2014, 139, 3360-3364.
2013
2. Longfei Liu, Qingqing Miao, Gaolin Liang*. Quantum dots as multifunctional materials for tumor imaging and therapy. Materials, 2013, 6, 483-499.
2012
1. Qingqing Miao, Xiaoyu Bai, Yingying Shen, Bin Mei, Jinhao Gao, Li Li, Gaolin Liang*. Intracellular self-assembly of nanoparticles for enhancing cell uptake. Chem. Commun., 2012, 48, 9738-9740.
