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成果及论文

https://www.researchgate.net/profile/Pengpeng-Zhang-21/publications

代表作:

1.  Carbonylative difunctionalization of unactivated alkenes initiated by unstabilized enolates. 

Zhang, P.; Newhouse, T. R.*  Angew. Chem. Int. Ed. 202362, e202307455. 

https://doi.org/10.1002/anie.202307455

Featured in 岳麓化学https://mp.weixin.qq.com/s/hmPtmd2owwU7ykDHXjA_FQ 

 


2. A neural network model informs the total synthesis of clovane sesquiterpenoids. 

Zhang, P.; Eun, J.; Elkin, M.; Zhao, Y. Z.; Cantrell, R. L.; Newhouse, T. R. Nat. Synth. 2023, 2, 527 – 534. 

https://doi.org/10.1038/s44160-023-00271-0

• Highlighted in News & Views of Nature Synthesis, https://doi.org/10.1038/s44160-023-00297-4

• Featured in 化学加https://mp.weixin.qq.com/s/9Dh2BmPrTwKIjHIzvtMw9g
• Featured in X-MOL: https://www.x-mol.com/news/848268 
• Featured in Chem-Stationhttps://mp.weixin.qq.com/s/i6yS85MaXZL107As19PcJA
• Featured in Spotlight Research of Chem-Station: https://mp.weixin.qq.com/s/MhycOAyCI5ziG-xyU5HZig 

                      

3. Coordination-controlled nickel-catalyzed benzylic allylation of unactivated electron-deficient heterocycles. 

Zhang, P.; Wang, J.; Robertson, Z. R.; Newhouse, T. R.* Angew. Chem. Int. Ed. 202261, e202200602. .

https://doi.org/10.1002/anie.202200602

• Highlighted in Synfacts, 2022, 18, 0606.


4. Aryl-nickel-catalyzed benzylic dehydrogenation of electron-deficient heteroarenes. 

Zhang, P.; Huang, D.; Newhouse, T. R.*  J. Am. Chem. Soc. 2020142, 1757 – 1762. 

https://doi.org/10.1021/jacs.9b12706


5. Oxidation stepping-stones: α-oxytriflation enables asymmetric arylation of amides. 

Zhang, P.; Newhouse, T. R.*  Chem, 20195, 1690 – 1692. 

DOI: 10.1016/j.chempr.2019.06.008


6. Enantioselective total synthesis of (–)-pavidolide B. 

Zhang, P.-P.; Yan, Z.-M.; Li, Y.-H.; Gong, J.*; Yang Z.* J. Am. Chem. Soc. 2017, 139, 13989 – 13992. 

• JACS封面the most read articles of JACS in 12 months (2017).

• Highlighted in Synfacts, 2017, 13, 1233.

• Highlighted in Org. Chem. Highlights 2017, April 2.

• Highlighted in ChemistryWorld, 2017, Nov,  1.

• Highlighted in Chin. J. Org. Chem. 2018, 38, 282.

 

其他论文及著作:

7. Shee, Y.; Li H.; Zhang, P.; Nikolic, A. M.; Lu, W.; Kelly, H. R.; Manee, V.; Sreekumar, S.; Buono, F. G.; Song, J.; Newhouse, T. R.*; Batista, V. S.* Site-specific template generative approach for retrosynthetic planning. Nat. Comm. 2024, 15, 7818.

 

8. Zhang, P.; Cantrell, R. L.; Newhouse, T. R.* Role of benzylic deprotonation in Ni-catalyzed benzylic dehydrogenation. Synlett, 202132, 1652 – 1656.   

 

9. Zhang, P.; Newhouse, T. R.* "Thiophene, 2-bromo-5-methyl-" e-EROS Encyclopedia of Reagents for Organic Synthesis, Wiley, Hoboken, NJ, 2021, DOI:10.1002/047084289X.rn02366.

10. Zhang, P.; Li, Y.; Yan, Z.; Gong, J.*; Yang Z.* Asymmetric total synthesis of (–)-pavidolide B via a thiyl-radical-mediated [3+2] annulation reaction.J. Org. Chem. 201984, 15958 – 15971.

 

11. Li, S.Zhang, P.-P.; Li, Y.-H.; Lu, S.-M.; Gong, J.*; Yang Z.* Diastereoselective synthesis of diquinanes and triquinanes bearing vicinal quaternary carbon stereocenters from acyclic allene-based precursors via a cascade reaction. Org. Lett. 201719, 4416 – 4419. 

12. Huang, D.; Olivieri, D.; Yang, S.; Zhang, P.; Newhouse, T. R.* Nickel-catalyzed difunctionalization of unactivated alkenes initiated by unstabilized enolates. J. Am. Chem. Soc. 2019141, 16249 – 16254.

 

13. Huang, D.; Szewczyk, S. M.; Zhang, P.; Newhouse, T. R.* Allyl-nickel catalysis enables carbonyl dehydrogenation and oxidative cycloalkenylation of ketones. J. Am. Chem. Soc. 2019141, 5669 – 5674. 

 

14. Cuomo, A. E.; Ibarraran, S.; Sreekumar, S.; Li, H.; Eun, J.; Menzel, J. P.; Zhang, P.; Helbrault, D.; Buono, F.; Crabtree, R. H.; Batista, V. S.*; Newhouse, T. R.Feed Forward Neural Network for Predicting Enantioselectivity of the Asymmetric Negishi Reaction. ACS Cent. Sci. 2023, 9, 1768–1774.

 

15. Li, F.-Z.; Li, S.; Zhang, P.-P.; Huang, Z.-H.; Zhang, W.-B.*; Gong, J.*; Yang Z.* A chiral pool approach for asymmetric syntheses of (-)-antrocin, (+)-asperolide C and (-)-trans-ozic acid. Chem. Commun. 201652, 12426 – 12429.

 

16. Gu, Y.-Q.; Zhang, P.-P.; Fu, J.-K.; Liu, S.; Lan, Y.*; Gong, J.*; Yang Z.* Regio- and stereoselective syntheses of 7-oxabicyclo[2.2.1]heptanes via a gold (I)-catalyzed cycloisomerization of alkynediols: asymmetric total synthesis of farnesiferol C. Adv. Synth. Catal. 2016358, 1392 – 1397.

 

17. Song, L.; Liu, J.; Gui, H.; Hui, C.; Zhou, J.; Guo, Y.; Zhang, P.; Xu, Z.*; Ye, T.* Synthesis of the macrocyclic core of rhizopodin. Chem.-Asian J. 20138, 2955 – 2959. 


获批专利:

1. Li, F.-Z.; Zhang, W.-B.; Zhang, P.-P.; Huang, Z.-H.; Gong, J.; Zeng, Y.; Yang Z. 牛樟芝素的制备方法,Method for the synthesis of (-)-antrocin. 中国 国家专利 CN 107216299, 2017.09.29.