课题组代表性论文：

2025年：

• [1] R Wang, J Li, Q Bi, B Yang, T He, K Lin, X Zhu, K Zhang, R Jin*, C Huang, Y Nie*, X Zhang. Crystallographic plane-induced selective mineralization of nanohydroxyapatite on fibrous-grained titanium promotes osteointegration and biocorrosion resistance. Biomaterials, 313 (2025) 122800.

DOI: 10.1016/j.biomaterials.2024.122800

2024年：

• [1] H Liang, R Wang, T Luo, M Yuan, X He, R Jin, Y Zhao*, R Tong, Y Nie*. Operation-friendly and accurate naked-eye observation assay for fast zoonotic echinococcosis and pulmonary tuberculosis monitoring in clinics. Analytica Chimica Acta, 1314 (2024) 342769.

 DOI: 10.1016/j.aca.2024.342769

• [2] Xiu Zheng, Hong Yang, Zongquan Zhang, Xiaoya Liang, Yan Liu, Chenglong Wang, Xi Yang, Jun Tang, Jingying Mao, Yu Nie*, Xiangyu Zhou*, Chunhong Li*. pH-responsive size-adjustable liposomes induce apoptosis of fibroblasts and macrophages for rheumatoid arthritis treatment. Acta Biomaterialia, 2024, 179: 256-271.

DOI: 10.1016/j.actbio.2024.03.006

• [3] Qingchen Feng, Mei Zhang, Guanning Zhang, Hongxiang Mei, Chongying Su, Lisa Liu, Xiaoxia Wang, Ziqianhong Wan, Zhengyi Xu, Liangkui Hu, Yu Nie*, Juan Li*. A whole-course-repair system based on ROS/glucose stimuli-responsive EGCG release and tunable mechanical property for efficient treatment of chronic periodontitis in diabetic rats. Journal of Materials Chemistry B, 2024, 12(15): 3719-3740.

DOI: 10.1039/d3tb02898d

• [4] Linghong Guo, Yong Yang, Yiyao Pu, Shuangfa Mao, Yu Nie*, Yin Liu*, Xian Jiang*. Dendrobium officinale Kimura & Migo polysaccharide and its multilayer emulsion protect skin photoaging. Journal of Ethnopharmacology, 2024, 318: 116974.

DOI: 10.1016/j.jep.2023.116974

• [5] Ting He, Yichun Wang, Ruohan Wang, Huan Yang, Xueyi Hu, Yiyao Pu, Binbin Yang, Jingyuan Zhang, Juan Li*, Chongxiang Huang*, Rongrong Jin*, Yu Nie*, Xingdong Zhang*. Fibrous topology promoted pBMP2-activated matrix on titanium implants boost osseointegration. Regenerative Biomaterials, 2024, 11: rbad111.

DOI: 10.1093/rb/rbad111

• [6] Ao Hu, Yiyao Pu, Na Xu, Huan Yang, Xueyi Hu, Ran Sun, Rongrong Jin*, Yu Nie*. Hierarchically decorated magnetic nanoparticles amplify the oxidative stress and promote the chemodynamic/magnetic hyperthermia/immune therapy. Acta Biomaterialia, 2024, 173: 457-469.

DOI: 10.1016/j.actbio.2023.11.023

2023年：

• [1] T Luo, H Yang, R Wang, Y Pu, Z Cai, Y Zhao, Q Bi, J Lu, R Jin*, Y Nie*, X Shuai. Bifunctional Cascading Nanozymes Based on Carbon Dots Promotes Photodynamic Therapy by Regulating Hypoxia and Glycolysis. ACS Nano, 2023, 17, 17, 16715–16730.

DOI: 10.1021/acsnano.3c03169

• [2] R Wang, M Wang, R Jin, Y Wang, M Yi, Q Li, J Li, K Zhang, C Sun*, Y Nie*, C Huang*, A. Mikos, X Zhang. High Strength Titanium with Fibrous Grain for Advanced Bone Regeneration. Adv. Sci., 2023, 2207698.

DOI: 10.1002/advs.202207698

• [3] Y Zhao, Q Bi, Y Wei, R Wang, G Wang, G Fu, Z Ran, J Lu, H Zhang, L Zhang, R Jin*, Y Nie*. A DNA vaccine (EG95-PT1/2/3-IL2) encoding multi-epitope antigen and IL-2 provokes efficient and long-term immunity to echinococcosis. Journal of Controlled Release, 2023, 361, 402-416.

DOI: 10.1016/j.jconrel.2023.07.047

• [4] Qunjie Bi, Xu Song, Yangyang Zhao, Xueyi Hu, Huan Yang, Rongrong Jin*, Yu Nie*. Mucus-penetrating nonviral gene vaccine processed in the epithelium for inducing advanced vaginal mucosal immune responses. Acta Pharmaceutica Sinica B, 2023;13(3):1287-1302.

DOI: 10.1016/j.apsb.2022.11.004

• [5] A Hu, Y Pu, N Xu, Z Cai, R Sun, S Fu, R Jin*, Y Guo, H Ai, Y Nie*, X Shuai. Controlled intracellular aggregation of magnetic particles improves permeation and retention for magnetic hyperthermia promotion and immune activation. Theranostics, 2023, 13(4): 1454-1469.

DOI: 10.7150/thno.80821cite

2022年：

• [1] Rongrong Jin, Xiaomin Fu, Yiyao Pu, Shengxiang Fu, Hong Liang, Li Yang, Yu Nie*, Hua Ai*. Clinical translational barriers against nanoparticle-based imaging agents. Advanced Drug Delivery Reviews, 2022, 191, 114587.

DOI: 10.1016/j.addr.2022.114587

2021年：

• [1] X Chen, R Jin, Q Jiang, Q Bi, T He, X Song, M Barz, H Ai, X Shuai*, Y Nie*. Delivery of siHIF-1α to reconstruct tumor normoxic microenvironment for effective chemotherapeutic and photodynamic anticancer treatments. Small, 2021, 17(25):2100609.

DOI: 10.1002/smll.202100609

• [2] T Luo#, Y Nie#, J Lu, Q Bi, Z Cai, X Song, H Ai, R Jin. Iron Doped Carbon Dots based Nanohybrids as a Tetramodal Imaging Agent for Gene Delivery promotion and Photothermal-Chemodynamic Cancer Synergistic Theranostics. Materials and Design, 2021, 208, 109878.

DOI: 10.1016/j.matdes.2021.109878

2020年及之前：

• [1] H Liang, X Chen, R Jin, B Ke*, M Barz, H Ai, Y Nie*. Integration of Indocyanine Green Analogs as Near-Infrared Fluorescent Carrier for Precise Imaging-Guided Gene Delivery. Small, 2020, 16(10):1906538.

DOI: 10.1002/smll.201906538

• [2] M Zou, R Jin*, Y Hu, Y Zhang, H Wang, G Liu, Y Nie*, Y Wang*. A thermo-sensitive, injectable and biodegradable in situ hydrogel as a potential formulation for uveitis treatment. J. Mater. Chem. B, 2019, 7, 4402.

DOI: 10.1039/c9tb00939f

• [3] H Liang, A Hu, X Chen, R Jin, K Wang*, B Ke, Y Nie*. Structure optimization of dendritic lipopeptide based gene vectors with the assistance from molecular dynamic simulation. J. Mater. Chem. B, 2019,7, 915-926.

DOI: 10.1039/c8tb02650e

• [4] T Luo, H Liang, R Jin*, Y Nie*. Virus-inspired and mimetic designs in non-viral gene delivery. Journal of Gene Medicine, 2019, 21(7): e3090.

DOI: 10.1002/jgm.3090

• [5] Q Jiang, X Chen, H Liang, Y Nie*, R Jin, M Barz, D Yue, Z Gu*. Multistage rocket: integrational design of a prodrug-based siRNA delivery system with sequential release for enhanced antitumor efficacy. Nanoscale Adv., 2019,1, 498-507.

DOI: 10.1039/c8na00191j

• [6] Q Jiang, Y Nie*, X Chen, Y He, D Yue, Z Gu*. pH-triggered pinpointed cascading Acta Pharmaceutica Sinica B charge-conversion and redox-controlled gene release design: modularized fabrication for nonviral gene transfection. Advanced Functional Materials, 2017, 27(26):1701571.

DOI: 10.1002/adfm.201701571

• [7] X Chen, J Yang, H Liang, Q Jiang, B Ke*, Y Nie*. Disulfide modified self-assembly of lipopeptides with arginine-rich periphery achieve excellent gene transfection efficiency at relatively low nitrogen to phosphorus ratios. Journal of Materials Chemistry B, 2017, 5(7), 1482-97.

DOI: 10.1039/c6tb02945k

• [8] Gongyan Liu, Xiaobing Chen, Weihua Zhuang, Yu Nie∗, Kai Zhang, Li Yang, Yunbing Wang*. Comparison of Biomimetic Block Copolymer Micelles as Drug Carriers for Cancer Therapy. Journal of Biomedical Nanotechnology, 2017, 13, 1500-1511.

DOI: 10.1166/jbn.2017.2447

• [9] Q Jiang, D Yue, Y Nie*, X Xu, Y He, S Zhang, E Wagner, Z Gu*. Specially-Made Lipid-based Assemblies for Improving Transmembrane Gene Delivery: Comparison of Basic Amino Acid Residues-Rich Periphery. Molecular Pharmaceutics, 2016, 13 (6):1809-1821.

DOI: 10.1021/acs.molpharmaceut.5b00967

• [10] Q Yin, B Ke, X Chen, Y Guan, P Feng, G Chen, Y Kang, W Zhang*, Y Nie*. Effects of Liposomes Charge on Extending Sciatic Nerve Blockade of N-ethyl Bromide of Lidocaine in Rats. Sci Rep., 2016; 6: 38582.

DOI: 10.1038/srep38582

• [11] G Liu, W Zhuang, X Chen, A Yin, Y Nie*, Y Wang*. Drug carrier system self-assembled from biomimetic polyphosphorycholine and biodegradable polypeptide based diblock copolymers. Polymer, 2016, 100, 45-55.

DOI: 10.1016/j.polymer.2016.08.012

• [12] X Xu, Q Jiang, X Zhang, Y Nie*, Z Zhang, Y Li, G Cheng, Z Gu*. Virus-inspired mimics: self-assembly of dendritic lipopeptides into arginine-rich nanovectors for improving gene delivery. J. Mater. Chem. B, 2015, 3, 7006-7010.

DOI: 10.1039/c5tb01070e

• [13] L Xie, Q Jiang, Y He, Y Nie*, Dong Yue and Zhongwei Gu. Insight into the efficient transfection activity of a designed low aggregated magnetic polyethyleneimine/DNA complex in serumcontaining medium and the application in vivo. Biomaterials Science, 2015, 3, 446-56.

DOI: 10.1039/c4bm00317a

• [14] Y Yang, N Li, Y Nie*, M Sheng, D Yue, G Wang, J. Tang, Z Gu*. Folate-modified poly (malic acid) graft polymeric nanoparticles for targeted delivery of doxorubicin: synthesis, characterization and folate receptor expressed cell specificity. J. Biomed. Nanotechnol., 2015, 11, 1628-1639.

DOI: 10.1166/jbn.2015.2132

• [15] Y He, Y Nie*, L Xie, H Song, Z Gu*. p53 mediated apoptosis by reduction sensitive shielding ternary complexes based on disulfide linked PEI ternary complexes. Biomaterials, 2014, 35, 1657-1666.

DOI: 10.1016/j.biomaterials.2013.10.073

• [16] L Xie, W Jiang, Y Nie*, Y He, Q Jiang, F Lan, Y Wu, Z Gu*. Low aggregation magnetic polyethyleneimine complexes with different saturation magnetization for efficient gene transfection in vitro and in vivo. RSC Advances, 2013, 3, 23571-23581.

DOI: 10.1039/c3ra43588a

• [17] Y He, G Cheng, L Xie, Y Nie*, B He, Z Gu*. Polyethyleneimine/DNA polyplexes with reduction-sensitive hyaluronic acid derivatives shielding for targeted gene delivery. Biomaterials, 2013, 34 (4): 1235-45.

DOI: 10.1016/j.biomaterials.2012.09.049

• [18] G Cheng, Y He, L Xie, Y Nie*, B He, Z Zhang, Z Gu*. Development of a reduction-sensitive diselenide-conjugated oligoethylenimine nanoparticulate system as a gene carrier. Int. J. Nanomed., 2012, 7, 3991-4006.

DOI: 10.2147/ijn.s32961

• [19] Y Nie, Z Zhang, B He, Z Gu*. Investigation of PEG-PLGA-PEG nanoparticles-based multipolyplexes for IL-18 gene delivery. J. Biomater. Appl., 2012, 893-9162.

DOI: 10.1177/0885328210384889

• [20] Y Nie, L Ji, H Ding, L Xie, L Li, B He, Y Wu, ZW Gu*. Cholesterol derivatives based charged liposomes for doxorubicin delivery: preparation, in vitro and in vivo characterization. Theranostics, 2012, 2(11):1092-1103.

DOI: 10.7150/thno.4949

• [21] Y Nie, M Günther, ZW Gu, E Wagner. Pyridylhydrazone-based PEGylation for pH-reversible lipopolyplex shielding. Biomaterials, 2011, 32, 858-869.

DOI: 10.1016/j.biomaterials.2010.09.032

• [22] Y Nie, D Schaffert, W Rödl, M Ogris, E Wagner, M Günther. Dual-targeted polyplexes: One step towards a synthetic virus for cancer gene therapy. Journal of Controlled Release, 2011, 152, 127-34.

DOI: 10.1016/j.jconrel.2011.02.028

• [23] Y Nie, M Günther, Z Gu, E Wa. Investigation of PEG-PLGA-PEG nanoparticles-based multipolyplexes for IL-18 gene delivery gner*. Pyridylhydrazone-based PEG for pH reversible lipopolyplex shielding. Drug Discov. Today, 2010, 15, 23-24.

DOI: 10.1016/j.drudis.2010.09.382