教育经历

       2014.08-2019.07: 中山大学中山医学院 临床医学 本科

       2019.07至今：中山大学附属第六医院 外科学 直博

研究方向

       表观遗传学

       肿瘤免疫微环境

       免疫治疗抵抗

       计算基因组学

研究成果

       Xie Y, Lin J, Zhang N, et al. Prevalent Pseudoprogression and Pseudoresidue in Patients with Rectal Cancer Treated With Neoadjuvant Immune Checkpoint Inhibitors. J Natl Compr Canc Netw. 2023;21(2):133-142.e3.

       Xie Y, Lin J, Wang X, et al. The Addition of Preoperative Radiation Is Insufficient for Lateral Pelvic Control in a Subgroup of Patients With Low Locally Advanced Rectal Cancer: A Post Hoc Study of a Randomized Controlled Trial. Dis Colon Rectum. 2021;64(11): 1321-1330.

       Xie Y, Shi L, He X, Luo Y. Gastrointestinal cancers in China, the USA, and Europe. Gastroenterol Rep (Oxf). 2021;9(2):91-104.

       Li J, Xie Y, Huang Z, et al. Current treatment and surveillance modalities are not sufficient for advanced stage III colon cancer: Result from a multicenter cohort analysis. Cancer Med. 2021;10(24):8924-8933.

       会议论文：

Activated pyroptosis prior to treatment marks a potential response to immunotherapy in cancers. AACR Annual Meeting, 2023

Spatial deconvolution from bulk DNA methylation profiles determines intratumoral epigenetic heterogeneity. AACR Annual Meeting, 2022

Activated PI3K/Akt Signaling is Universally Involved in the Resistance to Immune Checkpoint Inhibitors across Multiple Cancers. CCO,2022

Pan-cancer Analyses Reveal a Universal Gene Signature Associated with the Response to Immune Checkpoint Inhibitors. CCTB, 2021

专利：

一种植入式人工肛门，发明专利，ZL202011508988.4

获得奖项

       博士生国家奖学金，2022

       中山大学校长奖学金，2022-2023

目前研究方向

Deciphering cell population and state in tumor microenvironment to uncover novel markers and targets for tumor immunotherapy