■个人简历：
2001.09-2005.07 郑州大学，化学系基地班，化学，理学学士
2005.09-2010.12 武汉大学，化学与分子科学学院，有机化学，理学博士（硕博连读），导师：周翔 院士
2011.04-2013.04 美国斯坦福大学，医学院，分子医学，博士后，合作导师：Dr. Samuel So 亚裔肝脏中心主任
2013.12-2015.12 中山大学附属第六医院，分子医学，科研助理
2015.12-2022.12 中山大学附属第六医院，分子医学，助理研究员、硕士生导师
2022.12-至今 中山大学附属第六医院，分子医学，副研究员、硕士生导师
■科研方向及代表性成果：
一直致力于核酸的二级结构G-四链体在炎症性疾病和肿瘤中的机制研究及肿瘤标志物的临床化学检测。在既往研究中，首次发现偶氮苯类化合物可以在不同光照条件下可逆性光调控G-四链体（Angew Chem Int Ed Engl，2010，化学1区, Hot Paper；Org BiomolChem，2011），近年来，围绕G-四链体在结直肠癌发生发展中的作用及机制、炎-癌研究模型、炎症性疾病等科学问题，先后主持和参与多个国家级和省部级自然科学基金项目，相继在领域内国际著名期刊发表SCI论文30余篇。
代表性成果一、G4在炎症性疾病中的作用和机制研究：揭示了抵抗素及褪黑素等炎症因子在椎间盘退变中的作用及机制，并把G4融入炎症性疾病研究，首次在炎性微环境中发现G4-炎症正反馈环路的存在（Osteoarthritis Cartilage, 2017，Osteoarthritis Cartilage, 2020，专科1区；iScience, 2022, Cell子刊）。
代表性成果二、表观遗传学炎症免疫检测新技术的开发与应用：开发了一项可定量评估组织免疫反应的表观遗传学技术CD8+MeTIL，为定量评估肿瘤微环境中CD8+T细胞的浸润提供了技术支持（J ImmunoTher Cancer, 2021，医学1区）。新近发现了肿瘤的新型标志性特征——神经功能相关基因表观调控异常（BMC Cancer，2023，医学2区Top）。
代表性成果三、“钙-炎-癌”模型的构建及应用：拓展了经典“炎-癌”模型，构建了“钙-炎-癌”模型，拓展了其应用（J Exp Clin Cancer Res, 2017，医学1区；J Gastrointest Oncol, 2021，医学3区）。
■主持或参加科研项目（课题）情况：
(1) 国家自然科学基金委员会，面上项目，82372715，肿瘤细胞来源染色体外DNA诱导结直肠癌免疫逃逸的机制研究，2024-01至2027-12，49万元，在研，参加（第二）
(2) 国家自然科学基金委员会，面上项目，82272965，基于DNA甲基化绘制的肿瘤微环境图谱在评估结直肠癌免疫特征中的研究，2023-01至2026-12，52万元，在研，参加（第二）
(3) 国家自然科学基金委员会，面上项目，82173067，KDM2B-PRC2介导的衰老依赖型DNA甲基化促进结直肠癌发生发展的机制研究，2022-01至2025-12，54.7万元，在研，参加（第四）
(4) 国家自然科学基金委员会，面上项目，82173224，RNA结合蛋白RDM1通过激酶MK2依赖途径促进肝癌转移和复发的机制研究，2022-01至2025-12，54.7万元，在研，参加（第二）
(5) 国家自然科学基金委员会，面上项目，81972245，ANKRD13B基因DNA甲基化在结直肠癌发生发展中的作用及机制研究，2020-01至2023-12，55万元，在研，参加（第四）
(6) 国家自然科学基金委员会，面上项目，31970674，YAP及其关联的超级增强子对小鼠胚胎干细胞倾向性分化的作用和机制研究，2020-01至2023-12，58万元，在研，参加（第三）
(7) 国家自然科学基金委员会，面上项目，81773156，阻断小鼠TLX-LSD1复合体形成的多肽抑制恶性胶质瘤干细胞增殖的研究，2018-01至2021-12，51万元，已结题，参加（第二）
(8) 广东省自然科学基金管理委员会，自由申请项目，2018A0303130303，SNAI2介导HECW1基因启动子区甲基化修饰促进结直肠癌侵袭转移的机制研究，2018-05至2021-04，10万元，已结题，参加（第二）
(9) 广东省自然科学基金管理委员会，自由申请项目，2018A030313567，c-Myc调控INA基因启动子甲基化促进结直肠癌基因组不稳定机制研究，2018-05至2021-04，10万元，已结题，参加（第二）
(10) 国家自然科学基金委员会，面上项目，81672413，PEAK1在KRAS突变相关结直肠癌恶性化进展中的作用及机制研究，2017-01至2020-12，53万元，已结题，参加
(11) 国家自然科学基金委员会，青年科学基金项目，81600419，上调Wnt5a促肠隐窝重构在干预沙门氏菌致肠纤维化中的机制研究，2017-01至2019-12，17万元，已结题，参加
(12) 国家自然科学基金委员会，青年科学基金项目，81502022，C-Myc启动子区域G-四链体结构调控在结直肠癌治疗中的作用及机制研究，2016-01至2018-12，21.6万元，已结题，主持
(13) 高校基本科研业务费中山大学，青年教师培育计划项目，16ykpy35，改变G-四链体结构调控癌基因启动子活性在结直肠癌发生发展的作用研究，2016-01至2018-12，15万元，已结题，主持
(14) 高校基本科研业务费中山大学，青年教师重点培育计划项目，2015ykzd10，“癌化”相关DNA甲基化在结直肠癌发生发展中的作用机制研究，2015-09至2017-09，15万元，已结题，参加（第二）
(15) 中华人民共和国科学技术部，国家重点基础研究发展计划（973计划）课题，2015CB554001，腺瘤性息肉向CRC进化的早期分子事件研究，2015-01至2019-08，505万元，已结题，参加
■学术论文：
（共）第⼀/（共）通讯作者:
1. Shen D, Lin J, Xie Y, Zhuang Z, Xu G, Peng S, Tang G, Bai L, Zhu M, Zhang Y, Huang Z, Wang P, Liu X, Huang M, Luo Y, Wang X, Yu H. RNA demethylase ALKBH5 promotes colorectal cancer progression by posttranscriptional activation of RAB5A in an m6A-YTHDF2-dependent manner. Clin Transl Med. 2023 May;13(5):e1279. (Co-corresponding author; IF=10.6)
2. Li X, Cai D, Huang Y, Xie Y, Shen D, Yuan Z, Liu X, Huang M, Luo Y, Yu H, Wang X. Aberrant methylation in neurofunctional gene serves as a hallmark of tumorigenesis and progression in colorectal cancer. BMC Cancer. 2023 Apr 6;23(1):315. (Co-corresponding author; IF=3.8)
3. Wang X, Chen S, Zhao Z, Chen F, Huang Y, Guo X, Lei L, Wang W, Luo Y, Yu H, Wang J. Genomic G-quadruplex folding triggers a cytokine-mediated inflammatory feedback loop to aggravate inflammatory diseases. iScience. 2022 Oct 9;25(11):105312. (Co-first author; IF=5.8)
4. Zou Q, Wang X, Ren D, Hu B, Tang G, Zhang Y, Huang M, Pai RK, Buchanan DD, Win AK, Newcomb PA, Grady WM, Yu H, Luo Y. DNA methylation-based signature of CD8+ tumor-infiltrating lymphocytes enables evaluation of immune response and prognosis in colorectal cancer. J Immunother Cancer. 2021; 9(9):e002671. (Co-first author; IF=10.9)
5. Zhuang Z, Wang X, Huang M, Luo Y, Yu H. Serum calcium improved systemic inflammation marker for predicting survival outcome in rectal cancer. J Gastrointest Oncol. 2021;12(2):568-579. (Co-first author; IF=2.1)
6. Chen F, Liu H, Wang X, Li Z, Zhang J, Pei Y, Zheng Z, Wang J. Melatonin activates autophagy via the NF-κB signaling pathway to prevent extracellular matrix degeneration in intervertebral disc. Osteoarthritis Cartilage. 2020 Aug;28(8):1121-1132. (Co-first author; IF=7.0)
7. Jiang C, Long J, Liu B, Xu M, Wang W, Xie X, Wang X, Kuang M. miR-500a-3p promotes cancer stem cells properties via STAT3 pathway in human hepatocellular carcinoma. J Exp Clin Cancer Res. 2017;36(1):99. (Co-corresponding author; IF=11.3)
8. Li Z, Wang X, Pan H, Yang H, Li X, Zhang K, Wang H, Zheng Z, Liu H, Wang J. Resistin promotes CCL4 expression through toll-like receptor-4 and activation of the p38-MAPK and NF-κB signaling pathways: implications for intervertebral disc degeneration. Osteoarthritis Cartilage. 2017;25(2):341-350. (Co-first author; IF=7.0)
9. Xing X, Wang X, Xu L, Tai Y, Dai L, Zheng X, Mao W, Xu X, Zhou X. Light-driven conformational regulation of human telomeric G-quadruplex DNA in physiological conditions. Org Biomol Chem. 2011;9(19):6639-45. (Co-first author; IF=3.2)
10. Wang X, Huang J, Zhou Y, Yan S, Weng X, Wu X, Deng M, Zhou X. Conformational switching of G-quadruplex DNA by photoregulation. Angew Chem Int Ed Engl. 2010;49(31):5305-9. (IF=16.6)
共同作者:
11. Liu X, Peng S, Tang G, Xu G, Xie Y, Shen D, Zhu M, Huang Y, Wang X, Yu H, Huang M, Luo Y. Fasting-mimicking diet synergizes with ferroptosis against quiescent, chemotherapy-resistant cells. EBioMedicine. 2023, 90:104496.
12. Xie Y, Lin J, Zhang N, Wang X, Wang P, Peng S, Li J, Wu Y, Wu Y, Zhuang Z, Shen D, Zhu M, Liu X, Liu G, Meng X, Huang M, Yu H, Luo Y. Prevalent Pseudoprogression and Pseudoresidue in Rectal Cancer Patients Treated with Neoadjuvant Immune Checkpoint Inhibitors. J Natl Compr Canc Netw. 2023, 21(2):133-142.
13. Zhu M, Bai L, Liu X, Peng S, Xie Y, Bai H, Yu H, Wang X, Yuan P, Ma R, Lin J, Wu L, Huang M, Li Y, Luo Y, Silence of a dependence receptor CSF1R in colorectal cancer cells activates tumor-associated macrophages. J Immunother Cancer. 2022, 10(12):e005610.
14. Yu H, Wang X, Bai L, Tang G, Carter KT, Cui J, Huang P, Liang L, Ding Y, Cai M, Huang M, Liu H, Cao G, Gallinger S, Pai RK, Buchanan DD, Win AK, Newcomb PA, Wang J, Grady WM, Luo Y. DNA methylation profile in CpG-depleted regions uncovers a high-risk subtype of early-stage colorectal cancer. J Natl Cancer Inst. 2023, 115(1):52-61.
15. Shen D, Wang P, Xie Y, Zhuang Z, Zhu M, Wang X, Huang M, Luo Y, Yu H. Clinical spectrum of rectal cancer identifies hallmarks of early-onset patients and next-generation treatment strategies. Cancer Med. 2023, 12(3):3433-3441.
16. Cao X, Li W, Wang T, Ran D, Davalos V, Planas-Serra L, Pujol A, Esteller M, Wang X, Yu H. Accelerated biological aging in COVID-19 patients. Nat Commun. 2022;13(1):2135.
17. Shen D, Wang X, Wang H, Xu G, Xie Y, Zhuang Z, Huang Z, Li J, Lin J, Wang P, Huang M, Luo Y, Yu H. Current Surveillance After Treatment is Not Sufficient for Patients With Rectal Cancer With Negative Baseline CEA. J Natl Compr Canc Netw. 2022. 20(6): 653-662.
18. Li J, Xie Y, Huang Z, Shen D, Zhuang Z, Zhu M, Huang Y, He R, Wang X, Huang M, Luo Y, Yu H. Current treatment and surveillance modalities are not sufficient for advanced stage III colon cancer: Result from a multicenter cohort analysis. Cancer Med. 2021.10(24):8924-8933.
19. Cao X, Wang X, Wang H, Xu G, Yu H. Systemic Inflammation Status Relates to Anti-inflammatory Drug Benefit and Survival in Rectal Cancer. J Surg Res. 2022; 269:249-259.
20. Zhuang Z, Liu Z, Li J, Wang X, Xie P, Xiong F, Hu J, Meng X, Huang M, Deng Y, Lan P, Yu H, Luo Y. Radiomic signature of the FOWARC trial predicts pathological response to neoadjuvant treatment in rectal cancer. J Transl Med. 2021;19(1):256.
21. Xie Y, Lin J, Wang X, Wang P, Zhuang Z, Zou Q, Cai D, Huang Z, Bai L, Tang G, Huang M, Wang J, Yu H, Luo Y. The Addition of Preoperative Radiation Is Insufficient for Lateral Pelvic Control in a Subgroup of Patients With Low Locally Advanced Rectal Cancer: A Post Hoc Study of a Randomized Controlled Trial. Dis Colon Rectum. 2021;64(11):1321-1330.
22. Fu B, Li Y, Peng S, Wang X, Hu J, Lv L, Xia C, Lu D, Qin C. Synthesis and pharmacological characterization of glucopyranosyl-conjugated benzyl derivatives as novel selective cytotoxic agents against colon cancer. R Soc Open Sci. 2021;8(2):201642.
23. Chen Z, Huang Z, Luo Y, Zou Q, Bai L, Tang G, Wang X, Cao G, Huang M, Xiang J, Yu H. Genome-wide analysis identifies critical DNA methylations within NTRKs genes in colorectal cancer. J Transl Med. 2021;19(1):73.
24. Zou Q, Ren D, Wang X, Bai L, Tang G, Huang M, Luo Y, Yu H. Improved Survival Outcome and Access to Cancer Screening from Hemorrhoid in Patients with Rectal Cancer. Gastroenterol Res Pract. 2020; 2020:5045142.
25. Li Y, Bai L, Yu H, Cai D, Wang X, Huang B, Peng S, Huang M, Cao G, Kaz AM, Grady WM, Wang J, Luo Y. Epigenetic Inactivation of α-Internexin Accelerates Microtubule Polymerization in Colorectal Cancer. Cancer Res. 2020;80(23):5203-5215.
26. Huang Z, Wang X, Zou Q, Zhuang Z, Xie Y, Cai D, Bai L, Tang G, Huang M, Luo Y, Yu H. High platelet-to-lymphocyte ratio predicts improved survival outcome for perioperative NSAID use in patients with rectal cancer. Int J Colorectal Dis. 2020;35(4):695-704.
27. Yu Z, Yu H, Zou Q, Huang Z, Wang X, Tang G, Bai L, Zhou C, Zhuang Z, Xie Y, Wang H, Xu G, Chen Z, Fu X, Huang M, Luo Y. Nomograms for Prediction of Molecular Phenotypes in Colorectal Cancer. Onco Targets Ther. 2020; 13:309-321.
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