1）国家自然科学基金委员会青年科学基金项目，重塑肿瘤微环境的铋氧化物纳米片的构建及其胰腺癌声动力/放射增敏协同治疗研究，主持，2021.01-2023.12
2）浙江省自然科学基金，基于胰腺癌微环境重塑的紫杉醇/NLG919/氧化铋纳米体系构建及放化疗联合免疫治疗的协同机制研究，主持，2021.01-2023.12
3）浙江省医药卫生科技计划项目面上项目，pH响应型IDO-1抑制剂/铂纳米酶协同递送体系的构建及声动力/免疫联合治疗肿瘤的协同机制研究，主持，2021.01-2023.12
4）浙江省药学会医院药学科研专项，基于多功能纳米复合药物抗微环境治疗联合同步放化疗的胰腺癌靶向治疗研究，主持，2020.01-2020.12
近5年发表论文：
1）Wei Bian#, Xi Hu*#, Ruixue Xiao#, Rui Yao#, Bo Zhang, Mingjian Zhu, Tianqi Liu, Yamin Liu, Jing Li, Peihua Lin, An Xie, Fangyuan Li*, and Daishun Ling*, Catalytic dual-mode immunotherapy: anisotropic AuPt heterostructure decorated with starry Pt nanoclusters for robust cancer photometalloimmunotherapy, Advanced Science, 2024, e2403116.
2）Zongfu Pan#, Xixuan Lu#, Xi Hu#, Ruixi Yu, Yulu Che, Jie Wang, Lin Xiao, Jianqiang Chen, Xiaofen Yi, Zhuo Tan, Fangyuan Li, Daishun Ling*, Ping Huang*, Minghua Ge*, Disrupting glycolysis and DNA repair in anaplastic thyroid cancer with nucleus-targeting platinum nanoclusters, Journal of Controlled Release, 2024,369, 517-530.
3）Xi Hu#, Pengzhan Wang#, Canyu Huang, Chunyan Fang, Fangyuan Li*, Daishun Ling*, The role of ligands on synthesis, functional control, and biomedical applications of near-infrared light-responsive metal-based nanoparticles, Coordination Chemistry Reviews, 2023, 502, 215632.
4）Pin Li#, Zheng Chen#, Fan Xia#, Nan Wang, Jing Zhao, Xi Hu, Mingjian Zhu, Shiyi Yu, Daishun Ling*, Fangyuan Li*, Leveraging coupling effect‐enhanced surface plasmon resonance of ruthenium nanocrystal‐decorated mesoporous silica nanoparticles for boosted photothermal immunotherapy, Advanced Healthcare Materials, 2023, 12, 2302111.
5）Lilan Xu#, Jiafu Mu#, Zhiyuan Ma#, Peihua Lin#, Fan Xia, Xi Hu, Jiahe Wu, Jian Cao, Shanbiao Liu, Tianchen Huang, Daishun Ling*, Jianqing Gao*, and Fangyuan Li*, Nanozyme-integrated thermoresponsive in situ forming hydrogel enhances mesenchymal stem cell viability and paracrine effect for efficient spinal cord repair, ACS Applied Materials & Interfaces, 2023, 15 (31), 37193-37204.
5) Dao Shi#, Nan Wang#, Jie Zhang#, Xi Hu, Qiyue Wang, Ruixue Xiao, Baoyue Ding*, Fangyuan Li*, Daishun Ling*, Tumor-responsive dynamic nanoassemblies for boosted photoimmunotherapy, Nano research, 2023, 1-14.
6) Min Wei#, Jiahe Wu#, Heng Sun#, Bo Zhang#, Xi Hu, Qiyue Wang, Bowen Li, Lilan Xu, Teng Ma, Jianqing Gao*, Fangyuan Li*, Daishun Ling*, An enzymatic antibiotic adjuvant modulates the infectious microenvironment to overcome antimicrobial resistance of pathogens, Small, 2023, 2205471. Back Cover.
7) Fangyuan Li#, Heng Sun#, Jiafeng Ren#, Bo Zhang#, Xi Hu, Chunyan Fang, Jiyoung Lee, Hongzhou Gu, Daishun Ling*, A nuclease-mimetic platinum nanozyme induces concurrent DNA platination and oxidative cleavage to overcome cancer drug resistance, Nature Communications, 2022,13 (1), 1-16.
8) Xi Hu#, Yu Sun#, Xiaoqi Zhou, Bo Zhang, Hanxi Guan, Fan Xia, Shuangying Gui, Xueqian Kong, Fangyuan Li*, and Daishun Ling*, Insight into drug loading regulated micellar rigidity by nuclear magnetic resonance, ACS Nano, 2022, 16 (12), 21407-21416.
9) Lingxiao Zhang#, Jing Zhao#, Xi Hu#, Chenhan Wang#, Yingbo Jia, Chaojie Zhu, Shangzhi Xie, Jiyoung Lee, Fangyuan Li*, and Daishun Ling*. A peritumorally injected immunomodulating adjuvant elicits robust and safe metalloimmunotherapy against solid tumors, Advanced Materials, 2022, 2206915.
10) Fan Xia#, Xi Hu#, Bo Zhang#, Xun Wang#, Yunan Guan, Peihua Lin, Zhiyuan Ma, Jianpeng Sheng, Daishun Ling*, and Fangyuan Li*. Ultrasmall ruthenium nanoparticles with boosted antioxidant activity upregulate regulatory T cells for highly efficient liver injury therapy, Small, 2022, 18 (29), 2201558.
11) Xi Hu#, Nan Wang#, Xia Guo#, Zeyu Liang#, Heng Sun, Hongwei Liao, Fan Xia, Yunan Guan, Jiyoung Lee, Daishun Ling*, Fangyuan Li*. A sub-nanostructural transformable nanozyme for tumor photocatalytic therapy, Nano-Micro Letters, 2022,14 (1),101.
12）Xi Hu#, Yu Sun#, Xiaoqi Zhou, Bo Zhang, Hanxi Guan, Fan Xia, Shuangying Gui, Xueqian Kong, Fangyuan Li*, Daishun Ling*, Insight into Drug Loading Regulated Micellar Rigidity by Nuclear Magnetic Resonance, ACS Nano, 2022,16, 21407-21416.
13）Yixuan Guo#, Yu Liu#, Wei Wu#, Daishun Ling, Qiao Zhang, Peng Zhao*, Xi Hu*, Indoleamine 2,3-dioxygenase (IDO) Inhibitors and Their Nanomedicines for Cancer Immunotherapy, Biomaterials,2021,276,121018.
14）Xi Hu#, Fangyuan Li#, Fan Xia, Qiyue Wang, Peihua Lin, Min Wei, Linji Gong, Liang Ee Low, Ji Young Lee, Daishun Ling*, Dynamic Nanoassembly-Based Drug Delivery System (DNDDS): Learning from Nature, Advanced Drug Delivery Reviews, 2021,175,113830.
15）Xi Hu#, Fangyuan Li#, Fan Xia#, Xia Guo, Nan Wang, Lili Liang, Bo Yang, Kelong Fan, Xiyun Yan, Daishun Ling*, Biodegradation-Mediated Enzymatic Activity-Tunable Molybdenum Oxide Nanourchins for Tumor-Specific Cascade Catalytic Therapy, Journal of the American Chemical Society,2020,142(3),1636-1644.
