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成果及论文

发表文章:

2022-2024

[1] Wei Cong, Huaxing Shen, Xiufei Liao, Mengjun Zheng, Xianglong Kong, Zhe Wang, Si Chen, Yulei Li*, Honggang Hu*, Xiang Li*. Discovery of an orally effective double-stapled peptide for reducing ovariectomy-induced bone loss in mice. Acta Pharm Sin B 2023. https://doi.org/10.1016/j.apsb.2023.05.004.

[2] Jingwen; Yinxue Fu; XueHuang Li; Ting Zhang; Wei Cong; Honggang Hu; Zhiyuan Lu; Fang Yan*Yulei Li* All-hydrocarbon stapling enables improvement of antimicrobial activity and proteolytic stability of peptide Figainin 2Journal of Peptide Science2024.

[3] Yulei Li*, Minghao Wu, Yinxue Fu, Jingwen Xue, Fei Yuan, Tianci Qu, Anastassia N. Rissanou, Yilin Wang, Xiang Li*, Honggang Hu*. Therapeutic stapled peptides: Efficacy and molecular targets,Pharmacological Research,2024,DOI: 10.1016/j.phrs.2024.107137.

[4] H. Liu, X. Dai, N. Li, L. Zhang, Z. Wang, K. Ren, Yulei Li* X. Sun,* J. Wan*. Injectable Magnetic Hydrogel Incorporated with Anti-inflammatory Peptide for Efficient Magnetothermal Treatment of Endometriosis. Advanced Science, 2024, DOI: 10.1002/advs.202409778.


2022-2016

[1] YuLei, Li , Heng Jie , Sun Demeng *, Zhang Baochang, Zhang Xin,  Zheng Yu-Peng, Shi Wei-Wei, Wang Tong-Yue, Li Jiu-Yi,  Sun Xiaoou,  Liu Xiangyu,  Zheng Ji-Shen*,  Kobilka Brian K., Liu Lei *. Chemical Synthesis of a Full-Length G-Protein-Coupled Receptor β2-Adrenergic Receptor with Defined Modification Patterns at the C-Terminus. J. Am. Chem. Soc. 2021, 143, 42, 17566–17576. 

[2] Yulei Li, Yihan Zhang, Minghao Wu, Qi Chang, Xia Zhao*. Improving selectivity, proteolytic stability, and antitumor activity of host defense peptide hymenochirin-1B: A novel glycosylated staple strategy, ACS Chemical Biology, 2019, 14, 516-525.

[3] Yulei Li, Minghao Wu, Qi Chang, and Xia Zhao*. Stapling strategy enables to improve antitumor activity and proteolytic stability of host-defense peptide hymenochirin-1B, Rsc Advances, 2018, 8, 22268-22275.

[4] Yulei Li, Qi Chang, Minghao Wu, and Xia Zhao*. Total synthesis of five proline-enriched cyclic heptapeptides from the marine sponge Stylissa carteri. Tetrahedron Letters, 2018, 59, 1828–1831.

[5] Ye Wu, Yulei Li, Wei Cong, Yan Zou, Xiang Li, Honggang Hu. Total synthesis of TRADD death domain with arginine N-GlcNAcylation by hydrazide-based native chemical ligation, Chinese Chemical Letters, 2020, 31, 107-110. (co-auther)

[6] Xiang Li, Yulei Li, Yan Chen, Yan Zou, Xiaobin Zhuo, Qiuye Wu, Qingjie Zhao* and Honggang Hu* A silver-promoted solid-phase guanidylation process enables the first total synthesis of stictamide A, Rsc Advances, 2015, 5, 94654-94657. (co-auther)

[7] Yulei Li, Xuecui Bao, Yuanyuan Gao, Chao Liu, Yan Zou*, and Fang Yan*. Total synthesis of cyclic heptapeptide Stylissatin A, Chemistry of Natural Compounds, 2016, 52, 1069-1072.

[8] Yulei Li, Qi Chang, Wenwei Han, Xia Zhao*. Total synthesis of cyclic octapeptide reniochalistatins E, Chemistry of natural compounds, 2018, 54, 1131-1134.

[9] Yulei Li, Minghao Wu, Qi Chang, Xia Zhao* Solid-phase synthesis of cyclic octapeptide Phakellistatin 15, Chemistry of Natural Compounds 2019, 55, 520-524.

[10] YuLei, Li , Qian Qu, Yun-Kun Qi, Lei Liu, Ke Wei Wang, Yani Liu*, Ge-Min Fang*. Comparison of different strategies towards the [11] chemical synthesis of long-chain scorpion toxin AaH-II. J Pep Sci. 2022;28:e3365.

[12] Shi, Wei-Wei; Shi, Chaowei; Wang, Tong-Yue; Li, Yulei; Zhou, Yong-Kang; Zhang, Xu-Han; Berer, Donald; Zheng, Ji-Shen; Liu, Lei ; Total Chemical Synthesis of Correctly Folded Disulfide-Rich Proteins Using a Removable O-Linked β-N-Acetylglucosamine Strategy., Journal of the America Chemical Society, 2022, 144(1): 349-357.

授权专利:

(1) 李玉磊; 杨路平; 卢志远; 丁艳娇; 薛晶文; 程瑞雪; 窦春慧; 付银雪 ; 一种订书肽及其制备方法应用, 2023-12-12, 中国, ZL 2023 1 0438710.1。
(2) 胡宏岗; 李翔; 邹燕; 李玉磊; 吴秋业 ; 一种高效识别蛋白精氨酸鼠李糖基化的多克隆抗体及其制方法, 2015-12-7, 中国, ZL201510891290.8。

(3) 李玉磊; 付银雪; 薛晶文; 杨路平; 卢志远; 丁艳娇; 程瑞雪; 窦春慧; 订书肽及其制备方法和应用, 2024-03-26, 中国,ZL 2023 1 1448578.9。

(4) 卢志远; 薛晶文; 李玉磊; 付银雪; 杨路平; 窦春慧; 丁艳娇;程瑞雪;一种抗菌订书肽及其制备方法和应用,2024-03-12,中国,ZL 2023 1 1452121.5。

(5) 李玉磊; 付银雪; 薛晶文; 窦春慧; 卢志远; 杨路平; 丁艳娇;程瑞雪;一种具有抗菌活性的订书肽及其制备方法和应用,2024-03-26,中国,ZL 2023 1 1547187.2。

(6) 李玉磊; 薛晶文; 付银雪; 窦春慧; 杨路平; 卢志远; 程瑞雪; 丁艳娇; 一种提高抗耐药菌活性的订书肽及其制备方法和应用, 2024-04-12,中国,ZL 2023 1 1547292.6。

(7) 丁艳娇; 卢志远; 李玉磊; 薛晶文; 付银雪; 杨路平; 窦春慧; 程瑞雪; 订书肽、其制备方法和应用, 2024年04月16日, 中国,ZL 2023 1 1453511.4

(8)胡宏岗;杜笑茹;阎芳;李玉磊;刘炜佳;卢志远;丁艳娇;孙志朋;付银雪;薛晶文;汪磊;窦春慧;曲天慈;一种订书肽及其应用,2024年05月24日,中国,ZL 2023 1 1781975.8。

(9) 于涛;袁菲;綦慧敏;李玉磊;刘炜佳;卢志远;丁艳娇;付银雪; 薛晶文;曲天慈;窦春慧;杜笑茹;杨浩; 一种订书肽及其制药用途; 2024年08月09日, 中国, ZL 2023 1 1782032.7


科研项目:

[1] 均一结构糖基化干扰素ε的化学合成及功能研究;项目批准号:22207065, 经费:30万;国家自然科学基金青年项目;

[2] 泰山学者青年项目,No. tsqn202306268; 75万,山东省科技厅;

[3] 司美格鲁多肽固相合成前期工艺开发,江苏申琅生物科技有限公司(山东省医学科学院药物研究所); 15万,横向课题;
























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