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成果及论文

31. Yuan Ma, Cuirong Qin, Yanlin Lei, Xiaodong Yang, Zuhai Lei*, Tissue-seeking dyes for in vivo applicationsSmart Mol. 2024, e20240029. 

30. Xuan Zhao, Yongmin Ma, Zuhai Lei*Advanced optical imaging technology in the near infrared window for cell tracking in vivo. Coord Chem Rev., 2024, 521, 216178.

 

29. Xuan Zhao, Junfeng Cheng, Lu Zhang, Baofeng Yun, Kui Yan, Bin Wu, Xiao Liu, Fan Zhang, Zuhai Lei*, Near-Infrared II Emissive Diphenylaminoacridine Based on the Planarized Intramolecular Charge Transfer Mechanism, Cell Rep. Phys. Sci. 2023, 101691

28. Chong Cao, Hang Yin, Biao Yang, Qi Yue, Guoqing Wu, Meng Gu, Yuwen Zhang, Yang Fan, Xiaoyan Dong, Ting Wang, Cong Wang, Xiao Zhu*, Ying Mao*, Xiao-Yong Zhang*, Zuhai Lei*, Cong Li*, Intra-operative Definition of Glioma Infiltrative Margins by Visualizing Immunosuppressive Tumor-Associated MacrophagesAdv. Sci.2023, 23040.

27. Yunyi Liu, Lu Zhang, Ying Chen, Haitao Sun, Jiajian Chen, Ahmed Mohamed Ei-Toni,Aslam Khan, Zuhai Lei,* and Fan Zhang*, A Reversible NIR-II Ratiometric Fluorescent Probe forReal-Time In Vivo ATP DetectionAdv. Optical Mater.2023, 230114. 

26. Junfeng Cheng , Zuhai Lei*New High-Performance Fluorescent Dye Scaffolds: Applications for Bioimaging and BiosensingSynlett, 2023, DOI: 10.1055/a-2033-8557

25. Yiqi Gao, Zuhai Lei*The pursuit of xanthenoid fluorophores with near-infrared-II emission for in vivo applicationsAnal Bioanal Chem2023, 415, 3789–3797.

24. Qingchun Lan, Peng Yu, Kui Yan, Xiaomin Li, Fan Zhang, Zuhai Lei*Polymethine Molecular Platform for Ratiometric Fluorescent Probes in the Second near-Infrared Window, J. Am. Chem. Soc.2022, 144 21010-21015.

23. Xuan Zhao, Fan Zhang, Zuhai Lei*The pursuit of polymethine fluorophores with NIR-II emission and high brightness for in vivo applicationsChem. Sci., 2022, 13, 1280-11293.

22. Xin Zhang,Ying Chen,Haisheng He,Shangfeng Wang, Zuhai Lei*, Fan Zhang*, ROS/RNS and Base Dual Activatable Merocyanine-Based NIR-II Fluorescent Molecular Probe for in vivo BiosensingAngew. Chem. Int. Ed. , 2021, 60, 26337-26341

21. Yue He+, Shangfeng Wang+*, Peng Yu+, Kui Yan, Jiang Ming, Chenzhi Yao, Zuyang He, Ahmed Mohamed El-Toni, Aslam Khan, Xinyan Zhu, Caixia Sun, Zuhai Lei, and Fan Zhang*, NIR-II Cell Endocytosis-Activated Fluorescent Probes For In Vivo High-Contrast Bioimaging Diagnostics,  Chem. Sci., 2021, 12, 10474-10482.

20. Yicheng Wang,‡   Zuhai Lei,‡   Cong Wang,  Chong Cao,   Jiayi Hu,   Ling Du,*   Limei Han*, Cong Li*, Unsymmetrical pentamethine cyanines for visualizing physiological acidities from the whole-animal to the cellular scale with pH-responsive deep-red fluorescenceRSC Adv., 2021,11, 17871-17879.

19. Ying Chen, Peng Pei, Zuhai Lei, Xin Zhang, Dongrui Yin, Fan Zhang*, A Promising NIR‐II Fluorescent Sensor for Peptide‐Mediated Long‐term Monitoring of Kidney Dysfunction

Angew. Chem. Int. Ed.2021, 60, 15809–15815


18. Ying Chen, Hongxin Zhang, Zuhai Lei, Fan Zhang* , Recent Advances for Intraoperative Nerve Bioimaging: Fluorescence‐Guided Surgery for Nerve PreservationSmall Structures20201, 202000036.


17 Mengyao Zhao+, Jianbo Wang+*, Zuhai Lei, Lingfei Lu, Shangfeng Wang, Hongxin Zhang, Benhao Li, and Fan Zhang*.  NIR-II pH Sensor with FRET Adjustable Transition Point for In Situ Dynamic Tumor Microenvironment Visualization. Angew. Chem. Int. Ed.2021,  60, 5091-5095


16 Kai Xin†, Xinxing Li†, Yinghua Guo†, Youhuan Zhong†, Jungang Wang, Haotian Yang, Jie Zhao,Chunlei Guo, Yunxia Huang, Zuhai Lei, Yi-Lun Ying, Xiao Luo*, Haolu Wang, Xuhong Qian, Wen Yang*,Xiaowen Liang* & Youjun Yang,A Monochromophoric Approach to Succinct Ratiometric Fluorescent Probes without Probe-Product CrosstalkCCS Chem. 2020, 2, 2307–2315.

15 Meng Lv+, Yang Yu+, María E. Sandoval-Salinas+, Jianhua Xu, Zuhai Lei*, David Casanova*, Youjun Yang*, Jinquan Chen*. Engineering Charge Transfer State to Facilitate Spin-orbit Charge Transfer Intersystem Crossing in Spirobis[anthracene]diones. Angew. Chem. Int. Ed.2020, 59,22179-22184. 

14 Zuhai Lei , Fan Zhang* . Molecular Engineering of NIR-II Fluorophores for Improved  Biomedical Detection Angew. Chem. Int. Ed.2021, 60, 16294-16308.




博士及博后期间论文

13. Zuhai Lei, Caixia Sun, Peng Pei, Shangfeng Wang, Dandan Li, Xin Zhang, Fan Zhang*. Stable, Wavelength‐Tunable Fluorescent Dyes in the NIR‐II Region for In Vivo High‐Contrast Bioimaging and Multiplexed BiosensingAngew. Chem. Int. Ed.2019, 58, 8166 – 8171. 

12. Zuhai Lei, Xinran Li, Xiao Luo, Jing Zheng, Xuhong Qian, and Youjun Yang*. Bright, stable and biocompatible organic fluorophores absorbing/emitting in the deep near-infrared spectral region. Angew. Chem. Int. Ed.2017, 56, 2979 – 2983. 

11. Zuhai Lei, Youjun Yang*. A concise colorimetric and fluorimetric probe for Sarin related threats designed via the covalent-assembly approach. J. Am. Chem. Soc.2014, 136, 65946597. 

10. Zuhai Lei, Xinran Li, Youjun Yang*. Synthesis of Sterically Protected Xanthene Dyes with Bulky Groups at C-3’ and C-7’. J. Org. Chem.2015, 80, 11538-11543.

9. Zuhai Lei#, Ping Yue#, Xueli Wang, Xinran Li, Yi Li, Haihong He, Xiao Luo, Xiangming Meng*, Jinquan Chen*, Xuhong Qian, Youjun Yang*. TPZ, a bright centrosymmetric two-photon scaffold for bioimaging. Chem. Commun.2017, 53, 10938-1094. 

8. Zuhai Lei, Zhenhua Zeng, Xuhong Qian, Youjun Yang*. A novel chromogenic and fluorogenic scaffold for detection of oxidative radicals. Chin. Chem. Let. 2017, 28, 2001-2004. 

7. Zuhai Lei, Kai Xin, Shaobing Qiu, Liling Hou, Xiangming Meng*, Youjun Yang*. A Threshold-Limited Fluorescence Probes for Viscosity. Front. Chem. 2019, 7, 342-349. 

6. Linlin Song#, Zuhai Lei#, Baoyan Zhang, Zhiping Xu, Zhong Li and Youjun Yang*. A Zero-Background Fluorescent Probe for Hg2+ Designed via the Covalent-Assembly Principle. Anal. Methods2014, 6, 7597-7600. 

5. Benhao Li, Lingfei Lu, Mengyao Zhao, Zuhai Lei, Fan Zhang*. Efficient 1064-nm NIR-II Excitation Heptameth-ine Cyanine Dyes for High-resolution Deep-tissue Dynamic Bioimaging. Angew.Chem. 2018, 130, 7605 –7609. 

4. Shangfeng Wang, Yong Fan, Dandan Li, Caixia Sun, Zuhai Lei, Lingfei Lu, Ting Wang, Fan Zhang*. Anti-quenching NIR-II molecular fluorophores for in vivo high-contrast imaging and pH sensing. Nat. Commun. 2019, 10, 1058-1069. 

3. Xiao Luo, Liujia Qian, Yansheng Xiao, Yao Tang, Yang Zhao, Xia Wang, Luyan Gu, Zuhai Lei, Jianming Bao, Jiahui Wu, Tingting He, Fupin Hu, Jing Zheng, Honglin Li, Weiping Zhu, Lei Shao, Xiaojing Dong, Daijie Chen*, Xuhong Qian*, Youjun Yang*. A diversity-oriented rhodamine library for wide-spectrum bactericidal agents with low inducible resistance against resistant pathogensNat. Commun. 2019, 10, 258-270. 

2. Dandan Li, Shangfeng Wang, Zuhai Lei, Caixia Sun, Ahmed Mohamed El-Toni, Mansour Saleh Alhoshan, Yong Fan, Fan Zhang*. Peroxynitrite activatable NIR-II fluorescent molecular probe for drug-induced hepatotoxicity monitoring. Ana. Chem.2019, 91, 4771-4779. 

1. Caixia Sun, Benhao Li, Mengyao Zhao, Shangfeng Wang, Zuhai Lei, Lingfei Lu, Hongxin Zhang, Lishuai Feng, Chaoran Dou, Dongrui Yin, Huixiong Xu, Yingsheng Cheng, Fan Zhang*. J-Aggregates of Cyanine Dye for NIR-II in Vivo Dynamic Vascular Imaging beyond 1500 nm. J. Am. Chem. Soc. 2019, 141, 19221-19225.