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成果及论文
  1. Jun Liu,Yixin Wang, William John Heelan, Yu Chen, Zhaoting Li, Quanyin Hu*.Mucoadhesive probiotic backpacks with ROS nano-scavengers enhance the bacteriotherapy for inflammatory bowel diseases. Science Advances 2022, 8, eabp8798.

  2. Jun Liu, Wen Li, Yixin Wang, Yingyue Ding, Angela Lee, Quanyin Hu*. Biomaterials coating for on-demand bacteria delivery: selective release, adhesion, and detachment. Nano Today 2021, 41, 101291.

  3. Wenqiang Chang#, Jun Liu#, Ming Zhang, Hongzhuo Shi, Sha Zheng, XueyangJinYanhui Gao, Shuqi Wang, Aiguo Ji, Hongxiang Lou*. Efflux pump-mediated resistance to antifungal compounds can be prevented by conjugation with triphenylphosphonium cation. Nature Communications 2018, 9, 1-12.

  4. Jun Liu#, Bin Sun#, Xiaoyu Zhao, Jie Xing, Yanhui Gao, Wenqiang Chang, Jianbo Ji, Hongbo Zheng, Changyi Cui, Aiguo Ji*, Hongxiang Lou*. Discovery of potent orally active protease-activated receptor 1 (PAR1) antagonists based on andrographolide. Journal of Medicinal Chemistry 2017, 60, 7166-7185.

  5. Jun Liu#, Lin Li#, Xiaobin Li, Xin Wang, Xiaoyu Zhao, YananQiaoYuliang Xu, Yong Sun, Lilin Qian, Zhaopeng Liu, Aiguo Ji, Hongxiang Lou*. Discovery of lysosome-targeted covalent anticancer agents based on isosteviol skeleton. European Journal of Medicinal Chemistry 2021, 209, 112896.

  6. Bin Sun#, Jun Liu#, Yun Gao, Hongbo Zheng, Lin Li, Qingwen Hu, Huiqing Yuan, Hongxiang Lou*. Design, synthesis and biological evaluation of nitrogen-containing macrocyclic bisbibenzyl derivatives as potent anticancer agents by targeting the lysosome. European Journal of Medicinal Chemistry 2017, 136, 603- 618.

  7. Xin Wang#, Jun Liu#Jinyao Chen#, Ming Zhang, Chuan Tian, Xiaoping Peng, Gang Li, Wenqiang Chang*, Hongxiang Lou*. Azole-triphenylphosphonium conjugates combat antifungal resistance and alleviate the development of drug-resistance. Bioorganic Chemistry 2021, 110, 104771.

  8. Jun LiuIndrajit Bandyopadhyay, Lei Zheng, Omar M. Khdour*, Sidney M. Hecht*. Antiferroptotic activity of lipophilic phenothiazine analogues: a novel therapeutic strategy for the treatment of oxidative stress related disease. ACS Medicinal Chemistry Letter 2020, 11, 2165-2173.

  9. Jun LiuYanling Mu, Jing JinShuxiang Cui*. Effect of Sulindac on miRNA-17 and miRNA-21 Expressions in Human Colon Cancer Cells. Chin. J. Cancer Prev. Treat, 2014, 21, 485-489.

  10. JunLiu,JingJin,ShuxiangCui*.AnimalModelsofLungCancer.J.Int.Oncol.,2013, 40, 758-761.

  11. JunLiu,ShuxiangCui*.AnimalModelsofCancerMetastasis.J.Int.Oncol.,2013,40, 412-415.

  12. Zhaoting Li, Yingyue Ding, Jun LiuJianxin Wang, Fanyi Mo, Yixin Wang, Ting-Jing Chen-Mayfield, Paul M. SondelSeungpyo Hong, Quanyin Hu*. Depletion of tumor associated macrophages enhances local and systemic platelet-mediated anti-PD-1 delivery for post-surgery tumor recurrence treatment. Nature Communications 2022, 13, 1-15.

  13. Zhaoting Li, Yixin Wang, Jun Liu, Piper RawdingJiyoon Bu, Seungpyo Hong, and Quanyin Hu*. Chemically and Biologically Engineered Bacteria Based Delivery Systems for Emerging Diagnosis and Advanced Therapy. Advanced Materials 2021, 33, 2102580.

  14. Zhaoting Li, Fanyi Mo, Yixin Wang, Wen Li, Yu Chen, Jun Liu, Ting-Jing Chen-Mayfield, Quanyin Hu. Enhancing Gasdermin-induced tumor pyroptosis through preventing ESCRT-dependent cell membrane repair augments antitumor immune responseNature Communications, 2022, 13, 6321.

  15. Changyi Cui, Jun LiuHongBo Zheng, Xue-Yang Jin, Xiao-Yu Zhao, Wen-Qiang Chang, Bin Sun, Hongxiang Lou*. Diversity-oriented Synthesis of Pyrazoles Derivatives from Flavones and Isoflavones Leads to the Discovery of Promising Reversal Agents of Fluconazole Resistance in Candida Albicans. Bioorg. Med. Chem. Lett., 2018, 28, 1545- 1549.

  16. XiaoyuZhao,BinSun,HongboZheng,JunLiu,LilinQian,XiaoningWang,Hongxiang Lou*. Synthesis and Biological Evaluation of 6-Hydroxyl C-aryl Glucoside Derivatives as Novel Sodium Glucose Co-transporter 2 (SGLT2) Inhibitors. Bioorg. Med. Chem. Lett., 2018, 28, 2201-2205.

  17. JinchuanZhou,JiaozhenZhang,RuijuanLi,JunLiu,PeihongFan,YiLi,MeiJi,Yiwen Dong, Huiqing Yuan, Hongxiang Lou*. Hapmnioides A-C, Rearranged Labdane-Type Diterpenoids from the Chinese Liverwort HaplomitriummnioidesOrg. Lett., 2016, 18, 4274-4276.

专利

 

 

 

 

  1.      娄红祥, 刘军,孙斌,异舔菊醇衍生物的制备方法及应用2020.5ZL201810106694.5,中国

  2.      娄红祥,刘军,孙斌,甜菊醇衍生物的制备方法及应用2019.12ZL201810107228.9,中国

  3.      Quanyin Hu, Jun Liu. Mucoadhesive probiotic backpacks with ROS nano-scavengers enhance the bacteriotherapy for inflammatory bowel diseasesP220262US01,美国

  4.      Quanyin Hu, Jun Liu.Biomaterials coating for on-demand bacteria delivery and method to treat colitis and irritable bowel syndromeP210279US01,美国

  5.      Hongxiang Lou, Bin Sun, Jun Liu, PAR1 inhibitor based on terpene derivative and preparation method and use in treatment of thrombotic diseases thereof2017.6PCT/CN2016/070851WIPO

  6.      OmarKhdour, Sidney Hecht,Jun Liu,Indrajit Bandyopadhyay, Mitochondrial therapeutic agents, 2021-9-14PCT/US21/50306WIPO

  7.      娄红祥,王鑫刘军一种三氮唑类化合物、制备方法及其在抗真菌药物中的应用2023.2ZL202010707336.7,中国

  8.      娄红祥孙斌刘军基于萜类衍生物的PAR-1抑制剂及其制备方法和在治疗血栓性疾病中的用途2018.8ZL201510975205.6,中国