近年主持主要科研项目
国家自然科学基金-国际合作项目，新型PI3K抑制剂的纳米递送增强免疫治疗对PIK3CA突变头颈癌疗效的研究，200万元，2020年10月至2023年9月 。
国家自然科学基金-面上项目，基于STELB抑制同源重组修复的联合用药抗胶质母细胞瘤研究，55万元，2021年1月至2024年12月。
国家自然科学基金-面上项目，STELB抑制胶质母细胞瘤的作用、分子机制及靶点研究，54万元，2017年1月至2020年12月。
国家自然科学基金-国际交流项目，精准医疗背景下创新药物的发现与研发，6万元，2018年9月至2018年12月。
国家自然科学基金-面上项目，以小分子探针研究靶向PI3K亚型抑制前列腺癌转移的作用和多重分子机理，60万元，2014年1月至2017年12月。
天津市科技重大专项-重大新药创制项目，抗肿瘤药物靶点发现平台KTC21的建设，100万元，2017年10月至2020年9月。
近年来著书
“Protein kinase inhibitors as sensitizing agents for cancer therapy”, Elsevier出版社，2019
《药理学》，华东理工大学出版社，副主编，2020。
近3年发表主要期刊论文
Zhang Z, Wang Y, Ma Q, Zhang S, Liu H, Zhao B, Liu R, Wang W, Du B, Zhong Y, Kong D*. Biomimetic carrier-free nanoparticle delivers digoxin and doxorubicin to exhibit synergetic antitumor activity in vitro and in vivo. Chem Eng J. 2020; doi.org/10.1016/j.cej.2020.126801.
Wang Y, Ma Q, Zhang S, Liu H, Zhao B, Du B, Wang W, Lin P, Zhang Z, Zhong Y, Kong D*. Digoxin Enhances the Anticancer Effect on Non-Small Cell Lung Cancer While Reducing the Cardiotoxicity of Adriamycin. Front Pharmacol. 2020, 11:186.
Shunli Pan, Xiaoxia Zhao, Chen Shao, Bingjie Fu, Yingying Huang, Ning Zhang, Xiaojing Dou, Zhe Zhang, Yuling Qiu, Ran Wang, Meihua Jin, Kong D*. STIM1 promotes angiogenesis by reducing exosomal miR-145 in breast cancer MDA-MB-231 cells. Cell Death Dis. 2021, 12: 38.
Yong-Qiang Hou, Ying-Ying Wang, Xing-Can Wang, Yao Liu, Chun-Ze Zhang, Zhe-Sheng Chen, Zhe Zhang, Wei Wang, De-Xin Kong. Multifaceted anti-colorectal tumor effect of digoxin on HCT8 and SW620 cells in vitro. Gastroenterol Rep. 2020, 8: 465-475.
Zhang L, Chen T, Dou Y, Zhang S, Liu H, Khishignyam T, Li X, Zuo D, Zhang Z, Jin M, Wang R, Qiu Y, Zhong Y, Kong D*. Atorvastatin Exerts Antileukemia Activity via Inhibiting Mevalonate-YAP Axis in K562 and HL60 Cells. Front. Oncol. 2019;9:1032.
Peng X, Liu Y, Zhu S, Peng X, Li H, Jiao W, Lin P, Zhang Z, Qiu Y, Jin M, Wang R, Kong D*. Co-targeting PI3K/Akt and MAPK/ERK pathways leads to an enhanced antitumor effect on human hypopharyngeal squamous cell carcinoma. J Cancer Res Clin Oncol. 2019;145: 2921-2936.
Ji N, Yang Y, Cai CY, Wang JQ, Lei ZN, Wu ZX, Cui Q, Yang DH, Chen ZS, Kong D*. Midostaurin Reverses ABCB1-Mediated Multidrug Resistance, an in vitro Study. Front Oncol. 2019, 9:514.
Pan S, Zhao X, Ji N, Shao C, Fu B, Zhang Z, Wang R, Qiu Y, Jin M, Kong D*. Inhibitory effect of taxifolin on mast cell activation and mast cell-mediated allergic inflammatory response. Int Immunopharmacol. 2019, 71:205-214.
Zhang Z, Liu J, Wang Y, Tan X, Zhao W, Xing X, Qiu Y, Wang R, Jin M, Fan G, Zhang P, Zhong Y, Kong D*. Phosphatidylinositol 3-kinase β and δ isoforms play key roles in metastasis of prostate cancer DU145 cells. FASEB J. 2018, 32: 5967-5975.
Ji N, Yang Y, Cai CY, Lei ZN, Wang JQ, Gupta P, Shukla S, Ambudkar SV, Kong D*, Chen ZS. Selonsertib (GS-4997), an ASK1 inhibitor, antagonizes multidrug resistance in ABCB1- and ABCG2-overexpressing cancer cells. Cancer Lett. 2019, 440-441:82-93.
Zhao W, Qiu Y, Kong D*. Class I phosphatidylinositol 3-kinase inhibitors for cancer therapy. Acta Pharmaceutica Sinica B, 2017, 7:27-37.
Wang Z, Wang Y, Zhu S, Liu Y, Peng X, Zhang S, Zhang Z, Qiu Y, Jin M, Wang R, Zhong Y, Kong D*. DT-13 Inhibits Proliferation and Metastasis of Human Prostate Cancer Cells Through Blocking PI3K/Akt Pathway. Front Pharmacol. 2018, 9:1450.
Liu J, Tan X, Zhao W, Liu J, Xing X, Fan G, Zhang P, Zhang Z, Zhong Y, Kong D*. In Vitro and In Vivo Antimetastatic Effects of ZSTK474 on Prostate Cancer DU145 Cells. Curr Cancer Drug Targets. 2018, 18:1-9. （IF:2018:2.72;5年:3.238; JCR: Q3; 被引频次：0）
Ji N, Yang Y, Lei ZN, Cai CY, Wang JQ, Gupta P, Xian X, Yang DH, Kong D*, Chen ZS*. Ulixertinib (BVD-523) antagonizes ABCB1- and ABCG2-mediated chemotherapeutic drug resistance. Biochem Pharmacol. 2018, 158:274-285.
Ji N, Yang Y, Cai CY, Lei ZN, Wang JQ, Gupta P, Teng QX, Chen ZS, Kong D*, Yang DH*. VS-4718 Antagonizes Multidrug Resistance in ABCB1- and ABCG2-Overexpressing Cancer Cells by Inhibiting the Efflux Function of ABC Transporters. Front Pharmacol. 2018, 30,9:1236.
Ji N, Pan S, Shao C, Chen Y, Zhang Z, Wang R, Qiu Y, Jin M, Kong D*. Spinacetin Suppresses the Mast Cell Activation and Passive Cutaneous Anaphylaxis in Mouse Model. Front Pharmacol.2018, 9:824.
Peng X, Liu Y, Peng X, Wang Z, Zhang Z, Qiu Y, Jin M, Wang R, Kong D*. Clinical features and the molecular biomarkers of olfactory neuroblastoma. Pathol Res Pract. 2018, 214:1123-1129.
Peng X, Wang Z, Liu Y, Peng X, Liu Y, Zhu S, Zhang Z, Qiu Y, Jin M, Wang R, Zhang Q, Kong D*. Oxyfadichalcone C inhibits melanoma A375 cell proliferation and metastasis via suppressing PI3K/Akt and MAPK/ERK pathways. Life Sci. 2018, 206:35-44.
Zhang L, Wang Z, Khishignyam T, Chen T, Zhou C, Zhang Z, Jin M, Wang R, Qiu Y, Kong D*. In vitro anti-leukemia activity of dual PI3K/mTOR inhibitor Voxtalisib on HL60 and K562 cells, as well as their multidrug resistance counterparts HL60/ADR and K562/A02 cells. Biomed Pharmacother. 2018, 103:1069-1078.
Peng X, Zhou C, Hou X, Liu Y, Wang Z, Peng X, Zhang, Wang R, Kong D*. Molecular characterization and bioactivity evaluation of two novel bombinin peptides from the skin secretion of Oriental fire-bellied toad, Bombina orientalis. Amino Acids. 2018, 50:241-253.
Zhou C, Wang Z, Peng X, Liu Y, Lin Y, Zhang Z, Qiu Y, Jin M, Wang R, Kong D*. Discovery of two Bombinin peptides with antimicrobial and anticancer activities from the skin secretion of Oriental Fire‐bellied toad, Bombina orientalis. Chem Biol Drug Des. 2018, 91:50-61.
Zhou Q, Chen Y, Zhang L, Zhong Y, Zhang Z, Wang R, Jin M, Gong M, Qiu Y, Kong D*. Antiproliferative effect of ZSTK474 alone or in combination with chemotherapeutic drugs on HL60 and HL60/ADR cells. Oncotarget, 2017, 8:39064-39076.
Chen Y, Zhou Q, Zhang L, Zhong Y, Fan G, Zhang Z, Wang R, Jin M, Qiu Y, Kong D*. Stellettin B induces apoptosis in human chronic myeloid leukemia cells via targeting PI3K and Stat5. Oncotarget, 2017, 8: 28906-28921.
Chen Y, Ji N, Pan S, Zhang Z, Wang R, Qiu Y, Jin M, Kong D*. Roburic Acid Suppresses NO and IL-6 Production via Targeting NF-κB and MAPK Pathway in RAW264.7 Cells. Inflammation, 2017, 40:1959-1966.
