1. Differentiation and transplantation of embryonic stem cells / induced pluripotent stem cells (iPS cells) / somatic stem cells 2. Direct reprogramming of melanocytes / liver cells / keratinocytes 3. Construction of skin / liver organoid by multicellular co-culture 4. To establish a disease model using iPS cells of patients 5. To explore the relationship between HPV virus genotypes and clinical outcome and cervical cancer in patients with condyloma acuminatum.