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成果及论文


#第一作者,*通讯作者)

  

  - 2023年 

36. Li Z#, Zhang H#, Li Q, Feng W, Jia X, Zhou R, Huang Y, Li Y, Hu Z, Hu X, Zhu X*, Huang S*. GepLiver: an integrative liver expression atlas spanning developmental stages and liver disease phases. Sci Data2023;10(1):376.

35. Liao J#, Lai H#, Liu C, Zhang X, Ou Q, Li Q, Li Y, Wang Z, Liu C, Wu X, Wang H, Yu H, Sun S, Zhao X, Hu Z, Zhang Y, Lin Y, Yu B, Huang S*, Wang J*. Plasma extracellular vesicle transcriptomics identifies CD160 for predicting immunochemotherapy efficacy in lung cancer. Cancer Sci2023;114(7):2774-2786.

34. Zhao J#, Jia X#, Li Q, Zhang H, Wang J, Huang S, Hu Z*, Li C*Genomic and transcriptional characterization of early esophageal squamous cell carcinoma. BMC Med Genomics. 2023;16(1):153.

33. Chen B#, Li Q#, Li Y, Li Q, Lai H, Huang S, Li C*, Li Y*circTMEM181 upregulates ARHGAP29 to inhibit hepatocellular carcinoma migration and invasion by sponging miR-519a-5p. Hepatol Res. 2023;53(4):334-343.


  - 2022年 

32. Yang YS#, Jin X#, Li Q, Chen YY, Chen F, Zhang H, Su Y, Xiao Y, Di GH, Jiang YZ*, Huang S*, Shao ZM*. Superenhancer drives a tumor-specific splicing variant of MARCO to promote triple-negative breast cancer progression. Proc Natl Acad Sci U S A. 2022 Nov 16;119(46):e2207201119.

31. Liu C#, Chen J#, Liao J, Li Y, Yu H, Zhao X, Sun S, Hu Z, Zhang Y, Zhu Z, Fan M, Huang S*, Wang J*. Plasma Extracellular Vesicle Long RNA in Diagnosis and Prediction in Small Cell Lung Cancer. Cancers. 2022 Nov 9;14(22):5493.

30. Guo TA#, Lai HY#, Li C, Li Y, Li YC, Jin YT, Zhang ZZ, Huang HB, Huang SL*, Xu Y*. Plasma Extracellular Vesicle Long RNAs Have Potential as Biomarkers in Early Detection of Colorectal Cancer. Front Oncol. 2022 Apr 8;12:829230.

29. Yin Y#, Liu B#, Cao Y, Yao S, Liu Y, Jin G, Qin Y, Chen Y, Cui K, Zhou L, Bian Z, Fei B, Huang S*, Huang Z*. Colorectal Cancer-Derived Small Extracellular Vesicles Promote Tumor Immune Evasion by Upregulating PD-L1 Expression in Tumor-Associated Macrophages. Advanced Science. 2022 Jan 17;9(9):2102620.

28. Ye S#, Li Q#, Wu Y, Jiang W, Zhou S, Zhou X, Yang W, Tu X, Shan B, Huang S*, Yang H*. Integrative genomic and transcriptomic analysis reveals immune subtypes and prognostic markers in ovarian clear cell carcinoma. Br J Cancer. 2022 May;126(8):1215-1223.

27. Huang B#, Li Q#, Geng Q, Lao J, Guo J, Huang S*, Xu D*. ASTE1 frameshift mutation triggers the immune response in Epstein-Barr virus-associated gastric cancer. Signal Transduct Target Ther. 2022 Jan 5;7(1):4.

26. Lai H#, Li Y#, Zhang H, Hu J, Liao J, Su Y, Li Q, Chen B, Li C, Wang Z, Li Y, Wang J, Meng Z*, Huang Z*Huang S*. exoRBase 2.0: an atlas of mRNA, lncRNA and circRNA in extracellular vesicles from human biofluids. Nucleic Acids Res. 2022 Jan 7;50(D1):D118-D128

  2021年 

25. Su Y#, Li Y#, Guo R#, Zhao J, Chi W, Lai H, Wang J, Wang Z, Li L, Sang Y, Hou J, Xue J, Shao Z, Chi Y, Huang S*, Wu J*. Plasma extracellular vesicle long RNA profiles in the diagnosis and prediction of treatment response for breast cancer. NPJ Breast Cancer. 2021 Dec 10;7(1):154

24. Chen S#, Lai H#, Zhao J, Chen B, Li Y, Li Y, Li Q, Zheng Q, Huang S*, Zhu X*. The viral expression and immune status in human cancers and insights into novel biomarkers of immunotherapy. BMC Cancer. 2021 Nov 5;21(1):1183.

23. Li Y#, Li Y#, Yu S#, Qian L, Chen K, Lai H, Zhang H, Li Y, Zhang Y, Gu S, Meng Z, Huang S*, Wang P*. Circulating EVs long RNA-based subtyping and deconvolution enable prediction of immunogenic signatures and clinical outcome for PDAC. Mol Ther Nucleic Acids. 2021 Sep 24;26:488-501.

22. Li Y#, Chen B#, Zhao J, Li Q, Chen S, Guo T, Li Y, Lai H, Chen Z, Meng Z, Guo W*, He X*Huang S*. Advanced Science. HNRNPL Circularizes ARHGAP35 to Produce an Oncogenic Protein. 2021 May 1;8(13):2001701.

21. Qin Li#, Hongyan Lai#, Yuchen Li, Bing Chen, Siyuan Chen, Yan Li, Zhaohui Huang, Zhiqiang Meng, Peng Wang, Zhixiang Hu*Shenglin Huang*. RJunBase: a database of RNA splice junctions in human normal and cancerous tissues. Nucleic Acids Research. 2021;49(D1):D201-D211.

2020年 

20. Qiupeng Zheng#, Jingjing Zhao#, Hui Yu, Huajie Zong, Xigan He, Yiming Zhao, Yan Li, Yu Wang, Yichao Bao, Yuchen Li, Bing Chen, Weijie Guo, Yilin Wang, Zhiao Chen, Yingjun Zhao, Lu Wang*, Xianghuo He*, Shenglin Huang*. Tumor-specific Transcripts are Frequently Expressed in Hepatocellular Carcinoma with Clinical Implication and Potential Function. Hepatology. 2020;71(1):259-274. Epub 2019 Aug 12.

19. Yu S#, Li Y#, Liao Z#, Wang Z#, Wang Z, Li Y, Qian L, Zhao J, Zong H, Kang B, Zou WB, Chen K, He X, Meng Z, Chen Z*, Huang S*, Wang P*. Plasma extracellular vesicle long RNA profiling identifies a diagnostic signature for the detection of pancreatic ductal adenocarcinoma. Gut. 2020;69(3):540-550.

18. Ziteng Li#, Siyuan Chen#, Wanjing Feng, Yixiao Luo, Hongyan Lai, Qin Li, Bingqiu Xiu, Yuchen Li, Yan Li, Shenglin Huang*, Xiaodong Zhu*. A pan-cancer analysis of HER2 index revealed transcriptional pattern for precise selection of HER2-targeted therapy. EBioMedicine. 2020 Dec;62:103074.

17. Ziteng Li, Xiaodong Zhu, Shenglin Huang*. Extracellular vesicle long non-coding RNAs and circular RNAs: Biology, functions and applications in cancer. Cancer Lett. 2020 Oct 1;489:111-120. (Invited Review)

16. Wu Y#, Zhao Y#, Huan L, Zhao J, Zhou Y, Xu L, Hu Z, Liu Y, Chen Z, Wang L, Huang S*, He X*, Liang L*. An LTR Retrotransposon-Derived Long Noncoding RNA lncMER52A Promotes Hepatocellular Carcinoma Progression by Binding p120-Catenin. Cancer Res. 2020;80(5):976-987.

15. Chen S, Zhu X, Huang S*. Clinical applications of extracellular vesicle long RNAs. Crit Rev Clin Lab Sci. 2020 Dec;57(8):508-521. (Invited Review)

14. Yang LF, Yang F, Zhang FL, Xie YF, Hu ZX, Huang SL*, Shao ZM*, Li DQ*. Discrete functional and mechanistic roles of chromodomain Y-like 2 (CDYL2) transcript variants in breast cancer growth and metastasis. Theranostics. 2020;10(12):5242-5258.

- 2019年 -

13. Xiu B#, Chi Y#, Liu L#, Chi W, Zhang Q, Chen J, Guo R, Si J, Li L, Xue J, Shao ZM, Wu ZH*, Huang S*, Wu J*. LINC02273 drives breast cancer metastasis by epigenetically increasing AGR2 transcription. Mol Cancer. 2019;18(1):187.

12. Yuchen Li#, Jingjing Zhao#, Shulin Yu, Zhen Wang, Xigan He, Yonghui Su, Tianan Guo, Haoyue Sheng, Jie Chen, Qiupeng Zheng, Yan Li, Weijie Guo, Xiaohong Cai, Guohai Shi, Jiong Wu, Lu Wang, Peng Wang*, Xianghuo He*, Shenglin Huang*. Extracellular vesicles long RNA sequencing reveals abundant mRNA, circRNA and lncRNA in human blood as biomarkers for cancer diagnosis. Clinical Chemistry. 2019;65(6):798-808.

11. Jingjing Zhao#, Qin Li#, Yuchen Li, Xianghuo He, Qiupeng Zheng*, Shenglin Huang*. ASJA: Assembling Splice Junctions Analysis. Computational and Structural Biotechnology Journal, 2019;17:1143-1150.

- 2018年 -

10. Guo W#, Hu Z#, Bao Y, Li Y, Li S, Zheng Q, Lyu D, Chen D, Yu T, Li Y, Zhu X, Ding J, Zhao Y, He X*, Huang S*. A LIN28B Tumor-Specific Transcript in Cancer. Cell Reports. 2018; 22(8):2016-2025.

9. Shengli Li, Yuchen Li, Bing Chen, Jingjing Zhao, Shulin Yu, Yan Tang, Qiupeng Zheng, Yan Li, Peng Wang, Xianghuo He, Shenglin Huang*. exoRBase: a database of circRNA, lncRNA and mRNA in human blood exosomes. Nucleic Acids Research. 2018;46:D106–D112. 

8. Shengli Li, Jiwei Zhang, Shenglin Huang*, Xianghuo He*. Genome-wide analysis reveals that exon methylation facilitates its selective usage in the human transcriptome. Briefings in Bioinformatics. 2018;19(5):754-764. 

- 2017年前 -

7. Chen B, Huang S*. Circular RNA: An emerging non-coding RNA as a regulator and biomarker in cancer. Cancer Letters. 2018;418:41-50. (Invited Review)

6. Jie Chen#, Yan Li#, Qiupeng Zheng, Chunyang Bao, Jian He, Bing Chen, Dongbin Lyu, Biqiang Zheng, Yu Xu, Ziwen Long, Ye Zhou, Huiyan Zhu, Yanong Wang, Xianghuo He, Yingqiang Shi*, Shenglin Huang*. Circular RNA profile identifies circPVT1 as a proliferative factor and prognostic marker in gastric cancer. Cancer Letters. 2017; 388: 208-19. 

5. Dongbin Lyu, Shenglin Huang*. The emerging role and implication of human exonic circular RNA. RNA Biology. 2017;14(8):1000-1006. (Invited Review)

4. Qiupeng Zheng#, Chunyang Bao#, Weijie Guo, Shuyi Li, Jie Chen, Bin Chen, Yanting Luo, Dongbin Lyu, Yan Li, Guohai Shi, Linhui Liang, Jianren Gu, Xianghuo He*, Shenglin Huang*. Circular RNA profiling reveals an abundant circHIPK3 that regulates cell growth by sponging multiple miRNAs. Nature Communications. 2016; 7:11215.

3. Chunyang Bao#, Yan Li#, Lin Huan, Yuannv Zhang, Fangyu Zhao, Qifeng Wang, Linhui Liang, Jie Ding, Li Liu, Taoyang Chen, Jinjun Li, Ming Yao, Shenglin Huang*, Xianghuo He*. NF-kB signaling relieves negative regulation by miR-194 in hepatocellular carcinoma by suppressing the transcription factor HNF-1a. Science Signaling. 2015;8(387):ra75. 

2. Yan Li#, Qiupeng Zheng#, Chunyang Bao, Shuyi Li, Weijie Guo, Jiang Zhao, Di Chen, Jianren Gu, Xianghuo He*, Shenglin Huang*. Circular RNA is enriched and stable in exosomes: a promising biomarker for cancer diagnosis. Cell Research. 2015;25(8):981-4. 

1. Zheng Q#, Cai X#, Tan MH, Schaffert S, Arnold CP, Gong X, Chen CZ*, Huang S*. Precise gene deletion and replacement using the CRISPR/Cas9 system in human cells. Biotechniques. 2014;57(3):115-24.