【个人简历】

2003.9 - 2008.7, 济宁医学院, 临床医学专业, 学士

2008.9 - 2011.7, 上海交通大学, 肿瘤学专业, 硕士

2011.9 - 2014.7, 上海交通大学, 生物化学与分子生物学专业, 博士

2014.7 - 2019.12, 复旦大学附属肿瘤医院, 肿瘤研究所, 助理研究员

2019.12 - 至今， 复旦大学附属肿瘤医院, 肿瘤研究所, 副研究员 

【研究方向】

1、非编码RNA在消化道肿瘤中的鉴定、功能及分子机制研究。

2、肿瘤细胞外泌体中核酸、蛋白的鉴定、功能及其临床意义。 

【个人邮箱】

yan_li@fudan.edu.cn 

【发表论文】

1. Yuchen Li, Xigan He, Qin Li, Hongyan Lai,  Hena Zhang, Zhixiang Hu, Yan Li*, Shenglin Huang*.EV-origin: Enumerating the tissue-cellular origin of circulating extracellular vesicles using exLR profile. Comput Struct Biotechnol J. 2020; 18: 2851–2859.

2. Li Yan^#, Chen Bing, Huang Shenglin*, Identification of circRNAs for miRNA Targets by Argonaute2 RNA Immunoprecipitation and Luciferase Screening Assays. Methods Mol Biol. 2018;1724:209-218.

3. Shengli Li, Yuchen Li, Bing Chen, Jingjing Zhao, Shulin Yu, Yan Tang, Qiupeng Zheng, Yan Li, Peng Wang, Xianghuo He, Shenglin Huang*. exoRBase: a database of circRNA, lncRNA and mRNA in human blood exosomes. Nucleic Acids Research. 2018;46:D106–D112.

4. Zhou Zhenhua^#, Li Yan^#, Wang Xudong^#, Hu Jingjing, Kuang Muyu,Wang Zhiwei, Li Song, Xu Weidong, Xiao Jianru*. ALCAM(+) stromal cells:role in giant cell tumor of bone progression. Cell Death & Disease, 2018;9:299.

5. Jie Chen^#, Yan Li^#, Qiupeng Zheng, Chunyang Bao, Jian He, Bing Chen, Dongbin Lyu, Biqiang Zheng, Yu Xu, Ziwen Long, Ye Zhou, Huiyan Zhu, Yanong Wang, Xianghuo He, Yingqiang Shi*, Shenglin Huang*. Circular RNA profile identifies circPVT1 as a proliferative factor and prognostic marker in gastric cancer. Cancer Letters, 2017; 388: 208-19.

6. Qiupeng Zheng^#, Chunyang Bao^#, Weijie Guo, Shuyi Li, Jie Chen, Bin Chen,Yanting Luo, Dongbin Lyu, Yan Li, Guohai Shi, Linhui Liang, Jianren Gu, Xianghuo He*, Shenglin Huang*. Circular RNA profiling reveals an abundant circHIPK3 that regulates cell growth by sponging multiple miRNAs. Nature Communications. 2016; 7:11215.

7. Yan Li^#, Qiupeng Zheng^#, Chunyang Bao, Shuyi Li, Weijie Guo, Jiang Zhao, Di Chen, Jianren Gu, Xianghuo He*, Shenglin Huang*. Circular RNA is enriched and stable in exosomes: a promising biomarker for cancer diagnosis. Cell Research. 2015;25(8):981-4.

8. Chunyang Bao^#, Yan Li^#, Lin Huan, Yuannv Zhang, Fangyu Zhao, Qifeng Wang, Linhui Liang, Jie Ding, Li Liu, Taoyang Chen, Jinjun Li, Ming Yao, Shenglin Huang*, Xianghuo He*. NF-kB signaling relieves negative regulation by miR-194 in hepatocellular carcinoma by suppressing the transcription factor HNF-1a. Science Signaling. 2015;8(387):ra75.

9. Li Y^#, Xu D^#, Bao C^#, Zhang Y, Chen D, Zhao F, Ding J, Liang L, Wang Q, Liu L, Li J, Yao M, Huang S*, He X*. MicroRNA-135b, a HSF1 target, promotes tumor invasion and metastasis by regulating RECK and EVI5 in hepatocellular carcinoma. Oncotarget. 2015;6(4):2421-33.