【个人简历】
2011年9月-2016年6月 哈尔滨医科大学大学 公共卫生学院 医学学士
2016年9月-2020年6月 复旦大学 生物医学研究院 医学系统生物学博士
2020年7月至今 复旦大学 附属肿瘤医院 博士后
【研究方向】
血浆外泌体长链RNA的鉴定及潜在应用
【个人邮箱】
yuchen_li@foxmail.com
【发表论文】
1: Li Z#, Chen S#, Feng W, Luo Y, Lai H, Li Q, Xiu B, Li Y, Li Y, Huang S*, Zhu X*.A pan-cancer analysis of HER2 index revealed transcriptional pattern for precise selection of HER2-targeted therapy. EBioMedicine. 2020 Dec;62:103074.
2: Li Q#, Lai H#, Li Y, Chen B, Chen S, Li Y, Huang Z, Meng Z, Wang P, Hu Z*, Huang S*. RJunBase: a database of RNA splice junctions in human normal and cancerous tissues. Nucleic Acids Res. 2020 Nov 12:gkaa1056.
3: Li Y, He X, Li Q, Lai H, Zhang H, Hu Z, Li Y*, Huang S*. EV-origin: Enumerating the tissue-cellular origin of circulating extracellular vesicles using exLR profile. Comput Struct Biotechnol J. 2020 Oct 14;18:2851-2859.
4: Zheng Q#, Zhao J#, Yu H, Zong H, He X, Zhao Y, Li Y, Wang Y, Bao Y, Li Y, Chen B, Guo W, Wang Y, Chen Z, Zhao Y, Wang L*, He X*, Huang S*. Tumor-Specific Transcripts Are Frequently Expressed in Hepatocellular Carcinoma With Clinical Implication and Potential Function. Hepatology. 2020 Jan;71(1):259-274.
5: Shang Y, Li Y, Zhang Y, Wang J. ZNF436 promotes tumor cell proliferation through transcriptional activation of BCL10 in glioma. Biochem Biophys Res Commun. 2019 Aug 6;515(4):572-578.
6: Zhao J#, Li Q#, Li Y, He X, Zheng Q*, Huang S*. ASJA: A Program for Assembling Splice Junctions Analysis. Comput Struct Biotechnol J. 2019 Aug 7;17:1143-1150.
7: Hu Z, Dong L, Li S, Li Z, Qiao Y, Li Y, Ding J, Chen Z, Wu Y, Wang Z, Huang S, Gao Q, Zhao Y, He X. Splicing Regulator p54<sup>nrb</sup> /Non-POU Domain-Containing Octamer-Binding Protein Enhances Carcinogenesis Through Oncogenic Isoform Switch of MYC Box-Dependent Interacting Protein 1 in Hepatocellular Carcinoma. Hepatology. 2020 Aug;72(2):548-568.
8: Guo W#, Hu Z#, Bao Y, Li Y, Li S, Zheng Q, Lyu D, Chen D, Yu T, Li Y, Zhu X, Ding J, Zhao Y, He X*, Huang S*. A LIN28B Tumor-Specific Transcript in Cancer. Cell Rep. 2018 Feb 20;22(8):2016-2025.
9: Li Y#, Zhao J#, Yu S, Wang Z, He X, Su Y, Guo T, Sheng H, Chen J, Zheng Q, Li Y, Guo W, Cai X, Shi G, Wu J, Wang L, Wang P, He X*, Huang S*. Extracellular Vesicles Long RNA Sequencing Reveals Abundant mRNA, circRNA, and lncRNA in Human Blood as Potential Biomarkers for Cancer Diagnosis. Clin Chem. 2019 Jun;65(6):798-808.
10: Yu S#, Li Y#, Liao Z, Wang Z, Wang Z, Li Y, Qian L, Zhao J, Zong H, Kang B, Zou WB, Chen K, He X, Meng Z, Chen Z*, Huang S*, Wang P*. Plasma extracellular vesicle long RNA profiling identifies a diagnostic signature for the detection of pancreatic ductal adenocarcinoma. Gut. 2020 Mar;69(3):540-550.
11: Li S, Li Y, Chen B, Zhao J, Yu S, Tang Y, Zheng Q, Li Y, Wang P, He X, Huang S. exoRBase: a database of circRNA, lncRNA and mRNA in human blood exosomes. Nucleic Acids Res. 2018 Jan 4;46(D1):D106-D112.