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成果及论文

49.  Feng, L.-M.; Liu, S.; Tu, Y.-H.; Rui, P.-X.; Hu, X.-G. Radical Deoxygenative Three-Component Reaction of Alcohols, Aryl Alkenes, and Cyanopyridines. Org. Lett. 2024, 26 (29), 6225-6229. DOI: 10.1021/acs.orglett.4c02150.



48.  Nai-Li Fan, Lu Zhang, Chun-Yan Peng, Wei-Lin Liao* and Xiang-Guo Hua*,  Synthesis and Biological Activities of Scleropentaside D. 2024, J. Org. Chem. 10.1021/acs.joc.4c00755


47.  Da-Peng Liu, Xiao-Sen Zhang, Shuai Liu, Xiang-Guo Hu*, Dehydroxylative Radical N-Glycosylation of Heterocycles with 1-Hydroxycarbohydrates Enabled by Copper Metallaphotoredox Catalysis. Nature Communications. 2024, https://doi.org/10.1038/s41467-024-47711-9.                       

                         

46. Rui-Hong Li#, Li-Tian Zhang#, Kai-Cheng Yu, Shuai Liu*, Xiang-Guo Hu *, Mu-Hua Huang*, Chemo- and site-selective aerobic oxidation of methylbenzenes to aromatic aldehydes enabled by an Fe(III) photocatalyst. Green Synthesis and Catalysis, 2024https://doi.org/10.1016/j.gresc.2024.02.002.


45. Yu, K. C.; Li, H.; Tu, Y. H.; Zhao, H.; Hu, X. G., Metallaphotoredox-Enabled Construction of the P(O)-N Bond from Aromatic Amines and P(O)-H Compounds. Org. Lett. 2022, 9130−9134.


44. Li, H.; Yu, K.-C.; Su, J.-K.; Ouyang, W.; Fan, N.-L.; Hu, X.-G., Photo-Medicated Synthesis of 1,2-Dideoxy-2-phosphinylated Carbohydrates from Glycals: The Reduction of Glycosyl Radicals to Glycosyl Anions. Green Chem. 2022. 10.1039/D2GC01513G.


43. Pan, Q.; Zhou, Q.-M.; Rui, P.-X.; Hu, X.-G., Preparation of glycosyl carboxylic acids via stereoselective synthesis and oxidative cleavage of C-vinyl glycosides. Org. Biomol. Chem. 2022. 10.1039/D2OB00896C.

Graphical abstract: Preparation of glycosyl carboxylic acids via stereoselective synthesis and oxidative cleavage of C-vinyl glycosides

42.   Zhang, Ming. , Hu, X.-G.* et al. De Novo Synthesis of Orthogonally-Protected C2-Fluoro Digitoxoses and Cymaroses: Development and Application for the Synthesis of Fluorinated Digoxin. J. Org. Chem. 2022, 87 (2), 1272-1284.

41.   Li, Cai-Yi., Hu, X.-G.* et al, Glycosyl-Radical-Based Synthesis of C-Alkyl Glycosides via Photomediated Defluorinative gem-Difluoroallylation. Org. Lett. 2021, 23, 8899-8904.

40.   Zhang, Ze-Ting, Hu, X.-G.* et al. Synthesis of (Non-classical) C-acyl-glycosides via Liebeskind–Srogl Coupling: Scope, Limitation, Improved Synthesis and Antioxidant Activity of Scleropentaside A. Manuscript submitted.

39.   Shi, W.-Z.; Li, H.; Mu, G.-C.; Lu, J.-L.; Tu, Y.-H.; Hu, X.-G.*, 1,2-trans-Stereoselective Synthesis of C-Glycosides of 2-Deoxy-2-amino-sugars Involving Glycosyl Radicals. Org. Lett. 2021. 10.1021/acs.orglett.1c00551. https://pubs.acs.org/doi/abs/10.1021/acs.orglett.1c00551

38.   Wan, C.; Pang, J.-Y.; Jiang, W.; Zhang, X.-W.; Hu, X.-G.*, Copper-Catalyzed Reductive Ring-Cleavage of Isoxazoles: Synthesis of Fluoroalkylated Enaminones and Application for the Preparation of Celecoxib, Deracoxib, and Mavacoxib. J. Org. Chem. 2021. 10.1021/acs.joc.0c02980. 


37.   Qiu, X.-F.; Liu, D.-Y.; Zhang, W.-F.; Hu, X.-G.*, Late-Stage Transformation of Carboxylic Acids to N-Trifluoroethylimides with Trifluoromethyl Diazomethane. Synthesis-Stuttgart 2021, 53, 961-970.

36.   Zou, L. J.; Pan, Q.; Li, C. Y.; Zhang, Z. T.; Zhang, X. W.; Hu, X. G. *, Cyanide-Free Synthesis of Glycosyl Carboxylic Acids and Application for the Synthesis of Scleropentaside A. Org. Lett. 2020, 22, 8302-8306.

35.   Zhu, Y.; Lu, J.; Zhao, Y.; Liao, W.; Xing, E.; Hu, X.; Ouyang, Y.; Luo, Y.; Shu, X., The research of palmitoyl hyperbranched polyglycerol synergized catalytic cracking reaction of hydrocarbons. Fuel 2020, 280.

34.   Zhang, X. W.; He, X. L.; Yan, N.; Zheng, H. X.; Hu, X. G. *, Oxidize Amines to Nitrile Oxides: One Type of Amine Oxidation and Its Application to Directly Construct Isoxazoles and Isoxazolines. J. Org. Chem. 2020, 85, 15726-15735.

33.  Xu, L.-Y.; Fan, N.-L.; Hu, X.-G. *, Recent development in the synthesis of C-glycosides involving glycosyl radicals. Org. Biomol. Chem. 2020, 18, 5095-5109.

Graphical abstract: Recent development in the synthesis of C-glycosides involving glycosyl radicals

32.  Chen, S.; Ruan, Y.; Lu, J. L.; Hunter, L.; Hu, X. G. *, Diastereoselective synthesis and conformational analysis of 4,5-difluoropipecolic acids. Org Biomol Chem 2020, 18, 8192-8198.

Graphical abstract: Diastereoselective synthesis and conformational analysis of 4,5-difluoropipecolic acids

31.  Zou, L.; Ruan, Y.; Jiang, W.; Yan, N.; Liu, D. Y.; Yu, C. Y.; Hu, X. G. *, Switchable Regioselectivity in the Opening of Aziridine by Fluoride: DFT Calculation and Synthesis of Fluorinated Piperidines. ChemistrySelect 2019, 4, 12683-12688.

30.  Gao, Y.; Peng, S.-Q.; Liu, D.-Y.; Rui, P.-X.; Hu, X.-G. *, Copper-Catalyzed Four-Component Reaction for the Synthesis of N-Difluoroethyl Imides. Eur. J. Org. Chem. 2019, 2019, 1715-1721.

29.  Chen, S.; Wang, H.; Jiang, W.; Rui, P.-X.; Hu, X.-G.*, Synthesis of tri(di)fluoroethylanilines via copper-catalyzed coupling reaction of tri(di)fluoroethylamine with (hetero)aromatic bromides. Org. Biomol. Chem. 2019, 17, 9799-9807.

28.  Zeng, Y.-J.; Duan, Y.; Zhao, H.; Hu, X.-G.*, Selectflour mediated, Efficient and Chemoselective Deprotection of N-t-Butoxycarbonyl (Boc) Group. Chin. J. Org. Chem. 2018, Doi: 10.6023/cjoc201801036. (SCI)

27.  Zhang, X.-W.; Hu, W.-L.; Chen, S.; Hu, X.-G.*, Cu-Catalyzed Synthesis of Fluoroalkylated Isoxazoles from Commercially Available Amines and Alkynes. Org. Lett. 2018, 20, 860-863. (SCI I)

Abstract Image

26.  Liu, Q.-Q.; Hu, X.-G.*, Application of Benzylic C-H Fluorination for the Formal Synthesis of syn-α, β-Difluoro-γ-Amino Acid. Chin. J. Org. Chem. 2018, DOI: 10.6023/cjoc201712020. (SCI)

25.  Chen, S.; Zhang, X.-W.; Zhao, H.; Guo, X.-H.; Hu, X.-G*., Switchable Synthesis of Iodoalkynes and Diiodoalkenes from Terminal Alkynes. Chin. J. Org. Chem. 2018, DOI: 10.6023/cjoc201711050. (SCI)

24.  Liu, T.; Yan, N.; Zhao, H.; Wang, Z.-X.; Hu, X.-G.*, Synthesis and antibacterial activity of 6(R)- and 6(S)-fluoropenibruguieramine As: Fluorine as a probe for testing the powerfulness of memory of chirality (MOC). J. Fluorine Chem. 2018, 207, 18-23. (SCI)

23.  Zhao, H.*Hu, X.-G.*; Xu, M.-J.; Cai, Q.-X.; Liu, Y.-J.; Su, D.-M.; Chen, S.-J.; Wang, K.; Gong, Z.-N., Six-step synthesis of Leonurine and toxicity study on zebrafish. Chin. Chem. Lett. 2017, 28, 1172-1175. (SCI)

22.  Fang, Z.; Hu, W. L.; Liu, D. Y.; Yu, C. Y.; Hu, X. G.*, Synthesis of tetrazines from gem-difluoroalkenes under aerobic conditions at room temperature. Green Chem. 2017, 19, 1299-1302. (SCI I)

Graphical abstract: Synthesis of tetrazines from gem-difluoroalkenes under aerobic conditions at room temperature

21.  Yan, N.; Lei, Z. W.; Su, J. K.; Liao, W. L.; Hu, X. G.*, Ring opening of sugar-derived epoxides by TBAF/KHF2: An attractive alternative for the introduction of fluorine into the carbohydrate scaffold. Chin. Chem. Lett. 2017, 28, 467-470.

20.  Peng, S. Q.; Zhang, X. W.; Zhang, L. *Hu, X. G. *, Esterification of Carboxylic Acids with Difluoromethyl Diazomethane and Interrupted Esterification with Trifluoromethyl Diazomethane: A Fluorine Effect. Org. Lett. 2017, 19, 5689-5692. (SCI I)

Abstract Image


19.  Cheerlavancha, R.; Ahmed, A.; Leung, Y. C.; Lawer, A.; Liu, Q.-Q.; Cagnes, M.; Jang, H.-C.; Hu, X.-G.*; Hunter, L., Homologated amino acids with three vicinal fluorines positioned along the backbone: development of a stereoselective synthesis. Beilstein J. Org. Chem. 2017, 13, 2316-2325. (SCI)

18.  Hu, W.-L.; Hu, X.-G.*; Hunter, L.*, Recent Developments in the Deoxyfluorination of Alcohols and Phenols: New Reagents, Mechanistic Insights, and Applications. Synthesis 2017, 49, 4917-4930. (SCI)

17.  Yan, N.; Fang, Z.; Liu, Q.-Q.; Guo, X.-H.; Hu, X.-G.*, Conformation-induced regioselective and divergent opening of epoxides by fluoride: facile access to hydroxylated fluoro-piperidines. Org. Biomol. Chem. 2016, 14, 3469-3475. (SCI II)

16.  Patel, A. R.; Hu, X. G.; Lawer, A.; Ahmed, M. I.; Au, C.; Jwad, R.; Trinh, J.; Gonzalez, C.; Hannah, E.; Bhadbhade, M. M.; Hunter, L., Scalable, stereoselective syntheses of alpha,beta-difluoro-gamma-amino acids. Tetrahedron 2016, 72, 3305-3317. (SCI)

15.  Hu, X. G.; Lawer, A.; Peterson, M. B.; Iranmanesh, H.; Ball, G. E.; Hunter, L., Diastereoselective Synthesis and Conformational Analysis of (2R)- and (2S)-Fluorostatines: An Approach Based on Organocatalytic Fluorination of a Chiral Aldehyde. Org. Lett. 2016, 18, 662-665. (SCI I区)

14.  Hu, X. G.; Thomas, D. S.; Griffith, R.; Hunter, L.*, Stereoselective Fluorination Alters the Geometry of a Cyclic Peptide: Exploration of Backbone-Fluorinated Analogues of Unguisin A. Angew. Chem. Int. Ed. 2014, 53, 6176-6179. (SCI I区 top)

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13.  Hu, X. G.*; Ariawan, A. D.; Hunter, L.*, A D-ribose-derived alpha-amino nitrile as a versatile intermediate for the collective synthesis of piperidine-type iminosugar C-glycosides. Tetrahedron Lett. 2014, 55, 7222-7225. (SCI )

12.  Zhu, J. S.; Nakagawa, S.; Chen, W.; Adachi, I.; Jia, Y. M.; Hu, X. G.; Fleet, G. W. J.; Wilson, F. X.; Nitoda, T.; Horne, G.; van Well, R.; Kato, A.; Yu, C. Y. *, Synthesis of Eight Stereoisomers of Pochonicine: Nanomolar Inhibition of beta-N-Acetylhexosaminidases. J. Org. Chem. 2013, 78, 10298-10309. (SCI II)

11.  Zhao, W. B.; Nakagawa, S.; Kato, A.; Adachi, I.; Jia, Y. M.; Hu, X. G.; Fleet, G. W. J.; Wilson, F. X.; Horne, G.; Yoshihara, A.; Izumori, K.; Yu, C. Y.*, General Synthesis of Sugar-Derived Azepane Nitrones: Precursors of Azepane Iminosugars. J. Org. Chem. 2013, 78, 3208-3221. (SCI II)

10.  Zhao, H.; Wang, W. B.; Nakagawa, S.; Jia, Y. M.; Hu, X. G.; Fleet, G. W. J.; Wilson, F. X.; Nash, R. J.; Kato, A.; Yu, C. Y. *, Novel 2-aryl-3,4,5-trihydroxypiperidines: Synthesis and glycosidase inhibition. Chin. Chem. Lett. 2013, 24, 1059-1063. (SCI)

9.  Zhang, N.; Li, Y. F.; Zhou, Y. M.; Hou, J.; He, Q.; Hu, X. G.; Jia, Y. M.; Yu, C. Y. ; Nie, Z. X. *, Rapid detection of polyhydroxylated alkaloids in mulberry using leaf spray mass spectrometry. Analytical Methods 2013, 5, 2455-2460. (SCI)

8.  Hu, X. G.; Hunter, L.*, Stereoselectively fluorinated N-heterocycles: a brief survey. Beilstein J. Org. Chem. 2013, 9, 2696-2708. (SCI)

7.  Zhang, Z. L.; Nakagawa, S.; Kato, A.; Jia, Y. M.; Hu, X. G.; Yu, C. Y.*, A concise stereoselective synthesis of (-)-erycibelline. Org. Biomol. Chem. 2011, 9, 7713-7719. (SCI II)

6.  Zhang, W.; Sato, K.; Kato, A.; Jia, Y. M.; Hu, X. G.; Wilson, F. X.; van Well, R.; Horne, G.; Fleet, G. W. J.; Nash, R. J.; Yu, C. Y.*, Synthesis of Fully Substituted Polyhydroxylated Pyrrolizidines via Cope-House Cyclization. Org. Lett. 2011, 13, 4414-4417. (SCI I)

5.  Wang, W. B.; Huang, M. H.; Li, Y. X.; Rui, P. X.; Hu, X. G.; Zhang, W.; Su, J. K.; Zhang, Z. L.; Zhu, J. S.; Xu, W. H.; Xie, X. Q.; Jia, Y. M.; Yu, C. Y.*, A Practical Synthesis of Sugar-Derived Cyclic Nitrones: Powerful Synthons for the Synthesis of Iminosugars. Synlett 2010, 488-492. (SCI )

4..  Michalik, A.; Hollinshead, J.; Jones, L.; Fleet, G. W. J.; Yu, C. Y.; Hu, X. G.; van Well, R.; Horne, G.; Wilson, F. X.; Kato, A.; Jenkinson, S. F.; Nash, R. J.*, Steviamine, a new indolizidine alkaloid from Stevia rebaudiana. Phytochemistry Letters 2010, 3, 136-138. (SCI )

3.  Hu, X. G.; Jia, Y. M.; Xiang, J. F.; Yu, C. Y., Exploratory Studies en Route to 5-Alkyl-Hyacinthacines: Synthesis of 5-epi-(-)-Hyacinthacine A(3) and (-)-Hyacinthacine A(3). Synlett 2010, 982-986. (SCI )

2.  Hu, X. G.; Bartholomew, B.; Nash, R. J. *; Wilson, F. X.; Fleet, G. W. J.; Nakagawa, S.; Kato, A.; Jia, Y. M.; van Well, R.; Yu, C. Y., Synthesis and Glycosidase Inhibition of the Enantiomer of (-)-Steviamine, the First Example of a New Class of Indolizidine Alkaloid. Org. Lett. 2010, 12, 2562-2565. (SCI )

1.  Thompson, A. L.; Michalik, A.; Nash, R. J*.; Wilson, F. X.; van Well, R.; Johnson, P.; Fleet, G. W. J.; Yu, C. Y.; Hu, X. G.; Cooper, R. I.; Watkin, D. J., Steviamine, a new class of indolizidine alkaloid [(1R,2S,3R,5R,8aR)-3-hydroxymethyl-5-methyloctahydroindolizine-1,2-diol hydrobromide]. Acta Crystallographica Section E-Structure Reports Online 2009, 65, O2904-U2232. (SCI )