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51. Y. Deng, Z. Lu, S. K.-M. Lai, X. Mo, S. He, D. L. Phillips, E. C. M. Tse, H. Y. Au-Yeung, "Modulating the Coordination Properties of 4-Coordinate Copper(I) Using Catenane Ligands Composed of Differently Sized Macrocycles" ChemRxiv2024, DOI: 10.26434/chemrxiv-2024-tdjrk [link


50. Y. Shi, L. Zhu, Y. Deng, X. Mo, Y. Wang, E. C. M. Tse, H. Y. Au-Yeung, "A 2D array of copper(I) catenane catalyst grafted on a metal-organic layer for high fidelity cross-coupling" ChemRxiv2024, DOI: 10.26434/chemrxiv-2024-hk44r [link


49. S. He, M. Quan, L.-P. Yang, H. Y. Au-Yeung, W. Jiang "Correlating kinetics and thermodynamics of conformational changes in ammonium complexes of a flexible naphthocage" ChemRxiv2023, DOI: 10.26434/chemrxiv-2023-9c2v5 [link


48. M. P. Tang, L. Zhu, Y. Deng, Y. Shi, S. K.-M. Lai, X.-Y. Pang, C. Liu, W. Jiang, H. Y. Au-Yeung, "Water and air stable copper(I) complexes of tetracationic catenane ligands for oxidative C-C cross-coupling", Angew. Chem. Int. Ed. 2024, accepted article (DOI: 10.1002/anie.202405971)

preprint: ChemRxiv2023, DOI: 10.26434/chemrxiv-2023-jbd2z [link

highlighted in 化学深耕堂 (in Chinese) [link]; X-Mol (in Chinese) [link] [link]

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47. Y. Yao, Y. C. Tse, S. K.-M. Lai, Y. Shi, K.-H. Low, H. Y. Au-Yeung, "Dynamic mechanostereochemical switching of a co-conformationally flexible [2]catenane controlled by specific ionic guests", Nat. Commun. 202415, 1952 [link]
preprint: ChemRxiv2023, DOI: 10.26434/chemrxiv-2023-jm9nw [link

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46. Y. C. Tse, H. Y. Au-Yeung, "Catenane and Rotaxane Synthesis from Cucurbit[6]uril-Mediated Azide-Alkyne Cycloaddition", Chem. Asian J.202318e202300290 [link]

Special issue celebrating the 60th anniversary of The Chinese University of Hong Kong

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45. W. Y. Yau, S. K.-M. Lai, P. Blasco, X. C. Li, K. M. Ng, C. N. Lok, H. Y. Au-Yeung, "Activity-based Fluorescent Imaging of Alcohol Dehydrogenase Activity in Living Cells", Anal. Sens. 2023, e202300012 [link]

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44. X. Mo, Y. Deng, S. K.-M. Lai, X. Gao, H.-L. Yu, K.-H. Low, H.-L. Wu, H. Y. Au-Yeung, E. C. M. Tse, "Mechanical Interlocking Enhances the Electrocatalytic Oxygen Reduction Activity and Selectivity of Molecular Copper Complexes", J. Am. Chem. Soc. 2023145, 6087-6099 [link

preprint: ChemRxiv 2022DOI: 10.26434/chemrxiv-2022-5sqh3 [link]

highlighted in Nat. Rev. Chem. [link]X-Mol (in Chinese) [link] [link]

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43. M. H. Y. Lau, C.-H. Wong, H. Y. E. Chan, H. Y. Au-Yeung, "Development of Fluorescent Probe for CAG-RNA Repeats" Biosensors202212, 1080 [link


42. Y. Yao, Y. Deng, L. Kong, H. Y. Au-Yeung, "Efficient Copper(I) Extraction by Ethylenediamine from Stable Catenane Complexes", Eur. J. Inorg. Chem. 202222e202200271 [link]

Institute Feature: Hong Kong Universities [link]

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41. Y. Deng, X. Ren, M. P. Tang, S. K.-M. Lai, A. W. H. Ng, C.-N. Li, H. Y. Au-Yeung, "Differences in dynamics and responsive behavior of homologous hetero[4]rotaxanes derived from cucurbit[6]uril and β-/γ-cyclodextrin", Mater. Today Chem. 202224, 100952 [link]

Special Issue on the occasion of 80th birthday of Sir Fraser Stoddart

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40. W. Liu, L. Kong, M. Quan, H. Yao, L. Yang, H. Y. Au-Yeung, W. Jiang, "Selective recognition of methyl viologen by an endo-functionalized naphthobox" Chin. Chem. Lett. 202233, 4896-4899 [link]


39. H. Y. Au-Yeung, Y. Deng, "Distinctive Features and Challenges in Catenane Chemistry", Chem. Sci. 202213, 3315-3334 [link]

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38. A. W. H. Ng, S. K.-M. Lai, C.-C. Yee, H. Y. Au-Yeung, "Macrocycle Dynamics in a Branched [8]Catenane Controlled by Three Different Stimuli in Three Different Regions", Angew. Chem. Int. Ed. 202261, e202110200 [link]

highlighted in 化学与材料科学 (in Chinese) [link]; X-MOL (in Chinese) [link] [link]; WileyChem (in Chinese) [link]



37. S. Peng, P. Guo, X. Lin, Y. An, K. H. Sze, M. H. Y. Lau, Z. S. Chen, Q. Wang, W. Li, J. K.-L. Sun, S. Y. Ma, T.-F. Chan, K.-F. Lau, J. C. K. Ngo, K. M. Kwan, C.-H. Wong, S. L. Lam, S. C. Zimmerman, T. Tuccinardi, Z. Zuo, H. Y. Au-Yeung, H.-M. Chow, H. Y. E. Chan, "CAG RNAs induce DNA damage and apoptosis by silencing NUDT16 expression in polyglutamine degeneration" Proc. Natl. Acad. Sci. USA 2021118, e2022940118 [link]


36. A. W. H. Ng, Y. H. Leung, H. Y. Au-Yeung, "Dynamics of Mechanically Bonded Macrocycles in Radial Hetero[4]Catenane Isomers", Org. Chem. Front. 20218, 2182-2189 [link]

Macrocycle-based Supramolecular Elements themed collection


35. Y. Deng, S. K.-M. Lai, L. Kong, H. Y. Au-Yeung, "Fine-Tuning of the Optical Output in a Dual Responsive Catenane Switch", Chem. Commun. 202157, 2931-2934 [link]

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34. L. Zhu, J. Li, J. Yang, H. Y. Au-Yeung, "Cross Dehydrogenative C–O Coupling Catalysed by a Catenane-Coordinated Copper(I)", Chem. Sci. 202011, 13008-13014 [link]

featured as the journal back cover

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33. W.-E. Liu, M. Quan, H. Zhou, L.-P. Yang, H. Y. Au-Yeung, W. Jiang, "Stabilization of the Closed-Ring Isomer of Spiropyran by Amide Naphthotube in Water and Its Application in Naked-Eye Detection of Toxic Paraoxon" ChemPhyChem 202021, 2249-2253 [link]


32. T. S.-C. Tam, Y.-H. Cheng, C.-N. Lok, H. Y. Au-Yeung, W.-X. Ni, X.-L. Wei, K.-M. Ng, "Surface Optimization of Gold Nanoparticle Mass Tags for the Sensitive Detection of Protein Biomarkers via Immuno-Capture LI-MS" Analyst 2020145, 6237-6242 [link]


31. Z. H. Yu, C. J. Reinhardt, T. H.‐F. Wong, K. Y. Tong, J. Chan, H. Y. Au‐Yeung, "Activity‐Based Sensing of Ascorbate by Using Copper‐Mediated Oxidative Bond Cleavage", Chem. Eur. J.202026, 8794-8800 [link]

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30. F. K. Tang, Z. H. Yu, T. H.-F. Wong, C. Y.-S. Chung, H. Hirao, H. Y. Au-Yeung, "Fluorescein-Containing Superoxide Probes with a Modular Copper-Based Trigger", ChemPlusChem202085, 653-658 [link]

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29. H. Y. Au-Yeung, A. W. H. Ng, "Mechanical Interlocking of Macrocycles in Different Sequences", Synlett202031, 309-314 [link]


28. Z. L. Xu, P. C. Wang, H. B. Wang, Z. H. Yu, H. Y. Au-Yeung, T. Hirayama, H. Z. Sun, A. X. Yan, "Zinc excess increases cellular demand for iron and decreases tolerance to copper in Escherichia coli", J. Biol. Chem.2019294, 16978-16991 [link]


27. A. W. H. Ng, C.-C. Yee, H. Y. Au-Yeung, "Radial hetero[5]catenanes: Peripheral isomer sequences of the interlocked macrocycles", Angew. Chem. Int. Ed.2019, 58, 17375-17382 [link]

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26. K. Y. Tong, J. Zhao, C.-W. Tse, P.-K. Wan, J. Rong,  H. Y. Au-Yeung, "Selective catecholamine detection in living cells by a copper-mediated oxidative bond cleavage", Chem. Sci., 201910, 8519-8526 [link]

2019 Chemical Science HOT Article Collection
highlighted as the journal front cover

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25. J. Y. H. Man, H. Y. Au-Yeung, "Synthesis of a [6]rotaxane with singly threaded γ-cyclodextrins as a single stereoisomer", Beilstein J. Org. Chem., 201915, 1829-1837 [link]

Novel Macrocycles – and Old Ones Doing New Tricks thematic issue

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24. W.-E. Liu, Z. Chen, L.-P. Yang, H. Y. Au-Yeung, W. Jiang, "Molecular recognition of organophosphorus compound in water and inhibition of their toxicity to acetylcholinesterase", Chem. Commun., 201955, 9797-9800 [link]

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23. C.-C. Yee, A. W. H. Ng, H. Y. Au-Yeung, "Control over the macrocyclisation pathway and product topology in a copper-templated catenane synthesis", Chem. Commun., 2019, 55, 6169-6172 [link]

highlighted as the journal inside front cover

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22. H. Hong, A. C. Koon, Z. S. Chen, Y. Wei, Y. An, W. Li, M. H. Y. Lau, K.-F. Lau, J. C. K. Ngo, C.-H. Wong, H. Y. Au-Yeung, S. C. Zimmerman, H. Y. E. Chan, "AQAMAN, a bisamidine-based inhibitor of toxic protein inclusions in neurons, ameliorates cytotoxicity in polyglutamine disease models", J. Biol. Chem., 20192942757-2770 [link]


21. A. W. H. Ng, H. Y. Au-Yeung, "Molecular links and knots from naphthalenediimide: a balance of weak interactions" Chem. Asian J., 2019, 14, 1602-1612 [link]

π‐Conjugated Compounds for Molecular Materials special issue

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20. V. Venkataramani, T. R. Doeppner, D. Willkommen, C. M. Cahill, Y. Xin, G. Ye, Y. Liu, A. Southon, A. Aron, H. Y. Au-Yeung, X. Huang, D. K. Lahiri, F. Wang, A. I. Bush, G. G. Wulf, P. Ströbel, B. Michalke, J. T. Rogers, "Manganese causes neurotoxiciron accumulation via translational repression of amyloid precursor protein (APP) and H‐ferritin", J. Neurochem.2018147, 831-848 [link]


19. A. W. H. Ng, C.-C. Yee, K. Wang, H. Y. Au-Yeung, "Efficient catenane synthesis by cucurbit[6]uril-mediated azide-alkyne cycloaddition" Beilstein J. Org. Chem., 201814, 1846-1853 [link]

Macrocyclic and Supramolecular Chemistry thematic issue

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18. H. Y. Au-Yeung, C.-C. Yee, A. W. H. Ng, K. Hu, "Strategies to assemble catenanes with multiple interlocked macrocycles", Inorg. Chem., 201857, 3475-3485 [link]

Self-Assembled Cages and Macrocycles special issue

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17. Z. H. Yu, C. Y.-S. Chung, F. K. Tang, T. F. Brewer, H. Y. Au-Yeung, "A modular trigger for the development of selective superoxide probes", Chem. Commun.201753, 10042- 10045 [link]

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16. H. Y. Au-Yeung, C. Y. Chan, K. Y. Tong, Z. H. Yu, "Copper-based reactions in analyte-responsive fluorescent probes for biological applications", J. Inorg. Biochem., 2017177, 300-312 [link]

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15. M. C. Heffern, H. M. Park, H. Y. Au-Yeung, G. C. Van de Bittner, C. M. Ackerman, A. Stahl, C. J. Chang, "In vivo bioluminescence imaging reveals copper deficiency in a murine model of nonalcoholic fatty liver disease", Proc. Natl. Acad. Sci. USA, 2016113, 14219-14224 [link

highlighted in Chemical & Engineering News, 94(49), December 19, 2016


14. K. Wang, C.-C. Yee, H. Y. Au-Yeung, "Facile syntheses of [3]-, [4]- and [6]catenanes templated by orthogonal supramolecular interactions", Chem. Sci., 20167, 2787-2792 [link]

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13. K.-L. Tong, C.-C. Yee, Y. C. Tse, H. Y. Au-Yeung, "Discoveries from a phenanthroline-based dynamic combinatorial library: catenane from a copper(I) or copper(II) template?", Inorg. Chem. Front., 2016, 3, 348-353 [link]

Emerging investigators themed collection
highlighted as the 
journal front cover

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12. R. H. F. Wong, T. Kwong, K.-H. Yau, H. Y. Au-Yeung, "Real time detection of live microbes using a highly sensitive bioluminescent nitroreductase probe", Chem. Commun., 2015, 51, 4440-4442 [link]

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11. H. Y. Au-Yeung, J. Chan, T. Chantarojsiri, C. J. Chang, "Molecular imaging of labile iron(II) pools in living cells with a turn-on fluorescent probe", J. Am. Chem. Soc., 2013135, 15165-15173 [link]


10. H. Y. Au-Yeung, E. J. New, C. J. Chang, "A selective reaction-based fluorescent probe for detecting cobalt in living cells", Chem. Commun., 201248, 5268-5270 [link]


9. F. B. L. Cougnon, H. Y. Au-Yeung, G. D. Pantoș, J. K. M. Sanders, "Exploring the formation pathways of donor-acceptor catenanes in aqueous dynamic combinatorial libraries", J. Am. Chem. Soc.2011133, 3198-3207 [link]


8. H. Y. Au-Yeung, G. D. Pantoș, J. K. M. Sanders, "Donor-acceptor dynamic combinatorial catenanes in water: access to unconventional and unexpected structures", J. Org. Chem.201176, 1257-1268 [link]


7. F. M. Mansfeld, H. Y. Au-Yeung, J. K. M. Sanders, S. Otto, "Dynamic combinatorial chemistry at the phospholipid bilayer interface", J. Syst. Chem.2010, 1:12 [link]


6. H. Y. Au-Yeung, F. B. L. Cougnon, S. Otto, G. D. Pantoș, J. K. M. Sanders, "Exploiting donor-acceptor interactions in aqueous dynamic combinatorial libraries: exploratory studies of simple systems", Chem. Sci.20101, 567-574 [link

featured as inside front cover


5. H. Y. Au-Yeung, G. D. Pantoș, J. K. M. Sanders, "A water soluble donor-acceptor [2]catenane that can switch between a coplanar and Gemini-sign conformation", Angew. Chem., Int. Ed.201049, 5331-5334 [link]


4. H. Y. Au-Yeung, G. D. Pantoș, J. K. M. Sanders, "Amplifying different [2]catenanes in an aqueous donor-acceptor dynamic combinatorial library", J. Am. Chem. Soc.2009131, 16030-16032 [link]


3. H. Y. Au-Yeung, G. D. Pantoș, J. K. M. Sanders, "Dynamic combinatorial synthesis of a catenane based on donor-acceptor interactions in water", Proc. Natl. Acad. Sci. USA2009106, 10466-10470 [link]

highlighted in Nature Chemistry Feb 2009, DOI: 10.1038/nchem.127


2. H. Y. Au-Yeung, P. Pengo, G. D. Pantoș, S. Otto, J. K. M. Sanders, "Templated amplification of a naphthalenediimide-based receptor from a donor-acceptor dynamic combinatorial library in water", Chem. Commun., 2009, 419-421 [link]


1. H. Y. Au-Yeung, C. H. Lam, C.-K. Lam, W.-Y. Wong, H. K. Lee, "Unusual iron(II) and cobalt(II) complexes derived from monodentate arylamido ligands"Inorg. Chem.200746, 7695-7697 [link]