学术成果：
高洁老师自2009年以来一直在“多肽自组装生物材料”这一研究领域开展工作，在研究工作中充分利用多学科（材料学、化学、生物学等）交叉的优势，发挥自组装手段和多肽分子的特色与优势，围绕多肽自组装生物材料的研发及其在缺血性疾病和癌症诊疗方面的应用开展研究，为多肽自组装生物材料从研发向实际医疗应用转化积累了前期基础。取得的创新科研成果主要有：（一）现有缺血性疾病治疗手段难以解决梗死区域的血管修复问题，针对此医疗难点，研制了多个能够调控血管新生的多肽自组装材料，有效促进缺血部位血管新生，修复损伤组织或器官。（二）研发了一系列酶响应的自组装多肽纳米药物，有效解决疏水抗癌药物生物利用度低和靶向性差的问题，并且研发出靶向递送多种药物入细胞核的纳米体系，为新型抗癌药物的设计提供新策略。
共发表SCI收录论文40余篇，以通讯/第一作者发表论文34篇，包括J. Am. Chem. Soc. 3篇，Adv. Mater. 3篇，Angew. Chem. Int. Ed. 1篇，Chem. Soc. Rev. 1篇，Adv. Funct. Mater. 1篇，Adv. Sci. 1篇，Nano. Lett. 1篇， Chem. Eng. J. 1篇等。申请美国发明专利1项，中国发明专利4项，授权中国发明3项。在国际和国内学术会议做报告数十次。研究成果受到国内外同行专家的关注和广泛认可。
主要论文：
1. Zhang, X.; Zhang, B.; Zhang, Y.; Ding, Y.; Zhang, Z.; Liu, Q.; Yang, Z.; Wang, L.* and Gao, J.*, Copper-induced Supramolecular Peptide Assemblies for Multi-pathway Cell Death and Tumor Inhibition. Angew. Chem. Int. Ed. 2024, 2024, e202406602.（IF=16.6）
2. Zheng, D#; Guo J.#, Liu J.; Jin, Y.; Qi, C.; Li, X.; Shi, K.; Ding, Y.; Xie, L.; Wang, L.; Hu, Z.; Yang, Z.; Liu, Q.; Ning, W.* and Gao, J.*, Supramolecular Nanofibers Ameliorate Bleomycin-Induced Pulmonary Fibrosis by Restoring Autophagy. Adv. Sci. 2024, 2401327.（IF=15.1）
3. Cai, X.#; Cao, J.#; Wang, L.; Zou, J.; Li, R.; Sun, P.; Ding, X.; Zhang, B.; Liu, Z.; Pei, X.; Yang, J.; Zhan, Y.; Liu, N.; Liu, T.; Liang, R.*; Gao J.*; Wang S.*, Liraglutide Protects Pancreatic Islet From Ischemic Injury by Reducing Oxidative Stress and Activating Akt Signaling During Cold Preservation to Improve Islet Transplantation Outcomes. Transplantation 2024. DOI: 10.1097/tp.0000000000004949.（IF=6.2）
4. Zhang, X.; Wang, J.; Zhang, Y.; Yang, Z.; Gao, J.*; Gu, Z.*, Synthesizing biomaterials in living organisms. Chem. Soc. Rev. 2023, 52 (23), 8126-8164.（IF=46.2）
5. Chen, Y.; Li, W.; Wang, Z.; Yu, Y.; Li, J.; Ding, Y.; Hu, Z.; Liu, Q.; Yang, Z.*; Gao, J.*, A Transformable Supramolecular Bispecific Cell Engager for Augmenting Natural Killer and T Cell-Based Cancer Immunotherapy. Adv. Mater. 2023, 36 (3), 2306736.（IF=29.4）
6. Li, X.#; Zhang, Y.#; Wang, Y.; Chen, Y.; Xu, T.; Wang, L.*; Gao, J.*; Yang, Z.*, A blood-brain barrier crossing peptide. Sci. China. Mater. 2023, 66 (8), 3327-3336.（IF=8.1）
7. Yang, C.; Mu, G.; Zhang, Y.; Gao, Y.; Zhang, W.; Liu, J.; Zhang, W.; Li, P.; Yang, L.; Yang, Z.; Gao, J.*; Liu, J.*, Supramolecular Nitric Oxide Depot for Hypoxic Tumor Vessel Normalization and Radiosensitization. Adv. Mater. 2022, 34 (37), 2202625.（IF=29.4）
8. Li, X.; Yu, Z.; Jiang, S.; Dai, X.; Wang, G.; Wang, Y.; Yang, Z.; Gao, J.*; Zou, H.*, An amelogenin-based peptide hydrogel promoted the odontogenic differentiation of human dental pulp cells. Regen. Biomater. 2022, 9, rbac039.（IF=6.7）
9. Zhang, Y.; Yu, Y.; Gao, J.*, Supramolecular Nanomedicines of In-Situ Self-Assembling Peptides. Front. Chem. 2022, 10, 815551.（IF=5.5）
10. Li, X.; Wang, Y.; Zhang, Y.; Yang, Z.; Gao, J.*; Shi, Y.*, Enzyme Instructed Self-assembly (EISA) Assists the Self-assembly and Hydrogelation of Hydrophobic Peptides. J. Mater. Chem. B. 2022, 10 (17), 3242-3247.（IF=7）
11. Ai, S.; Li, H.; Zheng, H.; Liu, J.; Gao, J.*; Liu, J.*; Chen, Q.*; Yang, Z.*, A SupraGel for efficient production of cell spheroids. Sci. China Mater. 2022, 65 (6), 1655-1661.（IF=8.1）
12. Zheng, D.; Liu, J.; Ding, Y.; Xie, L.; Zhang, Y.; Chen, Y.; Peng, R.; Cai, M.; Wang, L.; Wang, H.*; Gao, J.*; Yang, Z.*, Tandem molecular self-assembly for selective lung cancer therapy with an increase in efficiency by two orders of magnitude. Nanoscale 2021, 13 (24), 10891-10897.（IF=6.7）
13. Zhang, Y.; Ding, Y.; Li, X.; Zheng, D.; Gao, J.*; Yang, Z.*, Supramolecular hydrogels of self-assembled zwitterionic-peptides. Chin. Chem. Lett. 2021. 32 (11), 3636-3640.（IF=9.1）
14. Shang, Y.; Liu, H.; Peng, R.; Ren, C.; Luo, X.; Ma, C.; Gao, Y.; Wang, Z.; Gao, J.*; Liu, J.*; Yang, Z.*, PDGF-mimicking supramolecular nanofibers for ionizing radiation-induced injury repair. Chem. Eng. J. 2021, 410, 128309.（IF=15.1）
15. Feng, K.; Ma, C.; Liu, Y.; Yang, X.; Yang, Z.; Chen, Y.; Xu, T.; Yang, C.; Zhang, S.; Li, Q.; Wei, Z.; Zhao, D.; Zeng, P.; Han, J.; Gao, J.*; Chen, Y.*; Duan, Y.*, Encapsulation of LXR ligand by D-Nap-GFFY hydrogel enhances anti-tumorigenic actions of LXR and removes LXR-induced lipogenesis. Theranostics 2021, 11 (6), 2634-2654.（IF=12.4）
16. Liang, C.; Wang, Z.; Xu, T.; Chen, Y.; Zheng, D.; Zhang, L.; Zhang, W.; Yang, Z.; Shi, Y.*; Gao, J.*, Preorganization Increases the Self-Assembling Ability and Antitumor Efficacy of Peptide Nanomedicine. ACS Appl. Mater. Interfaces 2020, 12 (20), 22492-22498.（IF=9.5）
17. Gao, J.; Gu, Z.*, Toward nanoscopic cellular imaging by X-ray. Natl. Sci. Rev. 2020, nwaa206.（IF=20.7）
18. Shang, Y.; Liao, Y.; Ye, Z. J.; Wang, Z. Y.; Xiao, L.; Gao, J.*; Wang, Q.*; Yang, Z.*, Supramolecular protein glue to boost enzyme activity. Sci. China Mater. 2019, 62 (9), 1341-1349.（IF=8.1）
19. Shang, Y.; Zhi, D.; Feng, G.; Wang, Z.; Mao, D.; Guo, S.; Liu, R.; Liu, L.; Zhang, S.; Sun, S.; Wang, K.*; Kong, D.; Gao, J.*; Yang, Z.*, Supramolecular Nanofibers with Superior Bioactivity to Insulin-Like Growth Factor-I. Nano Lett. 2019, 19 (3), 1560-1569.（IF=10.8）
20. Gao, J.; Zhan, J.; Yang, Z.*, Enzyme-Instructed Self-Assembly (EISA) and Hydrogelation of Peptides. Adv. Mater. 2019, 0 (0), 1805798.（IF=29.4）
21. Zhang, Y.; Pan, Y.-C.; Wang, Y.; Guo, D.-S.*; Gao, J.*; Yang, Z., Fast naked-eye detection of zinc ions by molecular assembly-assisted polymerization of diacetylene. Nanoscale 2018, 10 (39), 18829-18834.（IF=6.7）
22. Li, H.#; Gao, J.#; Shang, Y.; Hua, Y.; Ye, M.; Yang, Z.*; Ou, C.*; Chen, M.*, Folic Acid Derived Hydrogel Enhances the Survival and Promotes Therapeutic Efficacy of iPS Cells for Acute Myocardial Infarction. ACS Appl. Mater. Interfaces 2018, 10 (29), 24459-24468. (#equal contribution)（IF=9.5）
23. Zhan, J.; Cai, Y.; Ji, S.; Shang, Y.; Gao, J.*; Yang, Z.*, Supramolecular silk from a peptide hydrogel. Mater. Chem. Front. 2017, 1 (5), 911-915.（IF=7）
24. Wang, Z.; Cai, Y.; Yi, L.; Gao, J.*; Yang, Z.*, Supramolecular Hydrogels of Indole-Capped Short Peptides as Vaccine Adjuvants. Chin. J. Chem. 2017, 35 (7), 1057-1062.（IF=5.4）
25. Chen, G.; Li, J.; Song, M.; Wu, Z.; Zhang, W.; Wang, Z.; Gao, J.*; Yang, Z.*; Ou, C.*, A Mixed Component Supramolecular Hydrogel to Improve Mice Cardiac Function and Alleviate Ventricular Remodeling after Acute Myocardial Infarction. Adv. Funct. Mater. 2017, 27 (34), 1701798.（IF=19）
26. Cai, Y.; Shen, H.; Zhan, J.; Lin, M.; Dai, L.; Ren, C.; Shi, Y.; Liu, J.*; Gao, J.*; Yang, Z.*, Supramolecular “Trojan Horse” for Nuclear Delivery of Dual Anticancer Drugs. J. Am. Chem. Soc. 2017, 139 (8), 4.（IF=15）
27. Wang, J.; Zheng, J.; Cai, Y.; Zheng, J.; Gao, J.*; Gong, Q.*; Yang, Z.*, Imaging cellular distribution of fluorescent supramolecular nanofibers. Sci. China Chem. 2016, 59 (6), 719-723.（IF=9.6）
28. Xu, C.; Cai, Y.; Ren, C.; Gao, J.*; Hao, J.*, Zinc-Triggered Hydrogelation of Self-assembled Small Molecules to Inhibit Bacterial Growth. Sci. Rep. 2015, 5.（IF=4.6）
29. Chen, G.; Chen, J.; Liu, Q.; Ou, C.*; Gao, J.*, Enzymatic formation of a meta-stable supramolecular hydrogel for 3D cell culture. RSC Adv. 2015, 5 (39), 30675-30678.（IF=3.9）
30. Gao, J.; Shi, Y.; Wang, Y.; Cai, Y.; Shen, J.; Kong, D.*; Yang, Z.*, Enzyme-controllable F-NMR turn on through disassembly of peptide-based nanospheres for enzyme detection. Org. Biomol. Chem. 2014, 12 (9), 1383-1386.（IF=3.2）
31. Zheng, W.#; Gao, J.#; Song, L.; Chen, C.; Guan, D.; Wang, Z.; Li, Z.*; Kong, D.*; Yang, Z.*, Surface-Induced Hydrogelation Inhibits Platelet Aggregation. J. Am. Chem. Soc. 2013, 135 (1), 266-271. (#equal contribution)（IF=15）
32. Gao, J.; Zheng, W.; Zhang, J.; Guan, D.; Yang, Z.*; Kong, D.; Zhao, Q.*, Enzyme-controllable delivery of nitric oxide from a molecular hydrogel. Chem. Commun. 2013, 49 (80), 9173-9175.（IF=4.9）
33. Gao, J.; Zheng, W.; Kong, D.*; Yang, Z.*, Dual enzymes regulate the molecular self-assembly of tetra-peptide derivatives. Soft Matter 2011, 7 (21), 10443-10448.（IF=3.4）
34. Gao, J.; Wang, H.; Wang, L.; Wang, J.; Kong, D.*; Yang, Z.*, Enzyme Promotes the Hydrogelation from a Hydrophobic Small Molecule. J. Am. Chem. Soc. 2009, 131 (32), 11286-11287.（IF=15）
其他论文：
35. Zhang, S.-Y.; Wang, Z.-Y.; Gao, J.; Wang, K.; Gianolio, E.; Aime, S.; Shi, W.*; Zhou, Z.; Cheng, P.*; Zaworotko, M. J.*, A Gadolinium(III) Zeolite-like Metal-Organic-Framework-Based Magnetic Resonance Thermometer. Chem 2019, 5 (6), 1609-1618.（IF=23.5）
36. Shang, Y.; Wang, Z.; Zhang, R.; Li, X.; Zhang, S.; Gao, J.; Li, X.*; Yang, Z.*, A novel thermogel system of self-assembling peptides manipulated by enzymatic dephosphorylation. Chem. Commun. 2019, 55 (35), 5123-5126.（IF=4.9）
37. Huang, A.; Liu, D.; Qi, X.; Yue, Z.; Cao, H.; Zhang, K.; Lei, X.; Wang, Y.; Kong, D.; Gao, J.; Li, Z.*; Liu, N.*; Wang, Y.*, Self-assembled GFFYK peptide hydrogel enhances the therapeutic efficacy of mesenchymal stem cells in a mouse hindlimb ischemia model. Acta Biomater. 2019, 85, 94-105.（IF=9.7）
38. Wang, Y. Z.; Gao, J.; Yang, Z. M.*, Short Peptide-based Hydrogels: Mild Preparation Methods and Their Application as Vaccine Adjuvant. Acta Polymerica Sinica 2018, (1), 9-20.（IF=1.9）
39. Cai, Y.; Zhang, J.; He, Y.; Li, Z.; Hua, Y.; Wu, Z.; Gao, J.; Ou, C.*; Chen, M.*, A Supramolecular Hydrogel of Puerarin. J. Biomed. Nanotechnol. 2018, 14 (2), 257-266.（IF=2.9）
40. Chen, G.; Li, J.; Cai, Y.; Zhan, J.; Gao, J.; Song, M.; Shi, Y.*; Yang, Z.*, A Glycyrrhetinic Acid-Modified Curcumin Supramolecular Hydrogel for liver tumor targeting therapy. Sci. Rep. 2017, 7.（IF=4.6）
41. Ren, X.; Yang, C.; Li, C.; Gao, J.; Shi, Y.*; Yang, Z.*, Controlling the width of nanosheets by peptide length in peptoid-peptide biohybrid hydrogels. RSC Adv. 2016, 6 (71), 67025-67028.（IF=3.9）
42. Feng, G.; Zhang, J.; Li, Y.; Nie, Y.; Zhu, D.; Wang, R.; Liu, J.; Gao, J.; Liu, N.; He, N.; Du, W.; Tao, H.; Che, Y.; Xu, Y.; Kong, D.*; Zhao, Q.*; Li, Z.*, IGF-1 C Domain-Modified Hydrogel Enhances Cell Therapy for AKI. J. Am. Soc. Nephrol. 2016, 27 (8), 2357-2369.（IF=13.6）
43. Yao, X.; Liu, Y.; Gao, J.; Yang, L.; Mao, D.; Stefanitsch, C.; Li, Y.; Zhang, J.; Ou, L.; Kong, D.*; Zhao, Q.*; Li, Z.*, Nitric oxide releasing hydrogel enhances the therapeutic efficacy of mesenchymal stem cells for myocardial infarction. Biomaterials 2015, 60, 130-140.（IF=14）
44. Zhang, J.; Gao, J.; Chen, M.*; Yang, Z.*, Using Phosphatases to Generate Self-Assembled Nanostructures and Their Applications. Antioxidants & Redox Signaling 2014, 20 (14), 2179-2190.（IF=6.6）
45. Wang, W.; Li, G.; Zhang, W.; Gao, J.; Zhang, J.; Li, C.; Ding, D.*; Kong, D.*, Reduction-triggered formation of EFK8 molecular hydrogel for 3D cell culture. RSC Adv. 2014, 4 (57), 30168-30171.（IF=3.9）
46. Miao, X.; Cao, W.; Zheng, W.; Wang, J.; Zhang, X.; Gao, J.; Yang, C.; Kong, D.; Xu, H.*; Wang, L.*; Yang, Z.*, Switchable Catalytic Activity: Selenium-Containing Peptides with Redox-Controllable Self-Assembly Properties. Angew. Chem. Int. Ed. Engl. 2013, 52 (30), 7781-7785.（IF=16.6）
47. Wang, H.; Wang, Z.; Song, D.; Wang, J.; Gao, J.; Wang, L.; Kong, D.*; Yang, Z.*, Enzyme-assisted formation of nanosphere: a potential carrier for hydrophobic compounds. Nanotechnology 2010, 21 (15).（IF=3.5）
48. Wang, J.; Wang, Z.; Gao, J.; Wang, L.*; Yang, Z.; Kong, D.*; Yang, Z.*, Incorporation of supramolecular hydrogels into agarose hydrogels-a potential drug delivery carrier. J. Mater. Chem. 2009, 19 (42), 7892-7896.（IF=6.626）
专利：
1. 一种多肽分子FcGH及其纳米制剂FcGHcu、FcGHcu-HCPT的相应应用，中国发明专利，2024-04-28，申请号：2024105177853
2. 一种酶固定化多肽自组装水凝胶及其制备方法和应用，2023-11-22，中国发明专利，申请号：2023115616621
3. 一种促进细胞增殖的多肽及其应用，2023-11-21，中国发明专利，申请号：202311552543X
4. 一种碱性磷酸酶响应和可转化的超分子双特异性细胞接合剂多肽及其制备方法和应用，2023-8-17，中国发明专利，申请号：2023110384736
5. NITRIC OXIDE HYDROGEL FOR PROMOTING TUMOR VASCULAR NORMALIZATION ANDRADIOSENSITIZATION AND PREPARATION METHOD THEREOF，2022-12-19，美国发明专利，申请号：18/067,991
6. 一种穿越血脑屏障的多肽及其制备方法、纳米结构及其制备方法和应用，2022-09-20，中国发明专利，专利号：ZL202211142764.5
7. 促进肿瘤血管正常化和放疗增敏的一氧化氮水凝胶及其制备方法，2021-12-24，中国发明专利，专利号：ZL202111604730.9
8. 可模拟血小板衍生因子生物活性的多肽衍生物、纳米纤维及其应用，2019-11-21，中国发明专利，专利号：ZL201911146406.X
9. 一种促进细胞增殖的多肽衍生物及其制备方法及应用，2017-12-14,中国发明专利，专利号：ZL201711342486.7