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成果及论文
  1. Ando T, Arang N, Wang Z, Costea DE, Feng X, Goto Y, Izumi H, Gilardi M, Ando K, Gutkind JS. EGFR regulates the Hippo pathway by promoting the tyrosine phosphorylation of MOB1. Communications Biology. 2021 Nov 1;4(1):1237.   
  2. 冯晓东. 直接或间接靶向YAP/TAZ治疗头颈部肿瘤的策略选择[J]. 华西口腔医学杂志(专家论坛）, 2021, 39(5): 493-500.   

  3. Norgard RJ, Pitarresi JR, Maddipati R, Aiello-Couzo NM, Balli D, Li J, Yamazoe T, Wengyn MD, Millstein ID, Folkert IW, Rosario-Berrios DN, Kim IK, Bassett JB, Payne R, Berry CT, Feng X, Sun K, Cioffi M, Chakraborty P, Jolly MK, Gutkind JS, Lyden D, Freedman BD, Foskett JK, Rustgi AK, Stanger BZ. Calcium signaling induces a partial EMT. EMBO Reports. 2021 Jul 29:e51872.   

  4. Jiang Y, Li T, Wu Y, Xu H, Xie C, Dong Y, Zhong L, Wang Z, Zhao H, Zhou Y, Li J, Ji N, Zeng X, Feng X, Chen Q. GPR39 Overexpression in OSCC Promotes YAP-Sustained Malignant Progression. Journal of Dental Research. 2020 Jul;99(8):949-958.

  5. Goto Y, Ando T, Izumi H, Feng X, Arang N, Gilardi M, Wang Z, Ando K, Gutkind JS. Muscarinic receptors promote castration-resistant growth of prostate cancer through a FAK–YAP signaling axis. Oncogene. 2020 Mar 23.

  6. Wang Z, Feng X, Molinolo AA, Martin D, Vitale-Cross L, Nohata N, Ando M, Wahba A, Amornphimoltham P, Wu X, Gilardi M, Allevato M, Wu V, Steffen DJ, Tofilon P, Sonenberg N, Califano J, Chen Q, Lippman SM, Gutkind JS. 4E-BP1 Is a Tumor Suppressor Protein Reactivated by mTOR Inhibition in Head and Neck Cancer. Cancer Research. 2019 Mar 20.

  7. Annala S, Feng X, Shridhar N, Eryilmaz F, Patt J, Yang J, Pfeil EM, Cervantes-Villagrana RD, Inoue A, Häberlein F, Slodczyk T, Reher R, Kehraus S, Monteleone S, Schrage R, Heycke N, Rick U, Engel S, Pfeifer A, Kolb P, König G, Bünemann M, Tüting T, Vázquez-Prado J, Gutkind JS, Gaffal E, Kostenis E. Direct targeting of Gαq and Gα11 oncoproteins in cancer cells. Science Signaling. 2019 Mar 19;12(573).

  8. Feng X, Arang N, Rigiracciolo D, Lee J, Yeerna H, Wang Z, Lubrano S, Kishore A, Pachter JA, König GM, Maggiolini, M, Kostenis E, Schlaepfer DD, Tamayo P, Chen Q, Ruppin E, Gutkind JS. A Platform of Synthetic Lethal Gene Interaction Networks Reveals that the GNAQ Uveal Melanoma Oncogene Controls the Hippo Pathway through FAK. Cancer Cell. 2019 Mar 18;35(3):457-472.

  9. Martin D, Degese MS, Vitale-Cross L, Iglesias-Bartolome R, Valera JLC, Wang Z, Feng X, Yeerna H, Vadmal V, Moroishi T, Thorne RF, Zaida M, Siegele B, Cheong SC, Molinolo AA, Samuels Y, Tamayo P, Guan KL, Lippman SM, Lyons JG, Gutkind JS. Assembly and activation of the Hippo signalome by FAT1 tumor suppressor. Nat Commun. 2018 Jul 9;9(1):2372.

  10. O'Hayre M, Eichel K, Avino S, Zhao X, Steffen DJ, Feng X, Kawakami K, Aoki J, Messer K, Sunahara R, Inoue A, von Zastrow M, Gutkind JS. Genetic evidence that β-arrestins are dispensable for the initiation of β2-adrenergic receptor signaling to ERK. Science Signaling. 2017 Jun 20; 10(484).

  11. Feng X, Jiang Y, Xie L, Jiang L, Li J, Sun C, Xu H, Wang R, Zhou M, Zhou Y, Dan H, Wang Z, Ji N, Deng P, Liao G, Geng N, Wang Y, Zhang D, Lin Y, Ye L, Liang X, Li L, Luo G, Feng M, Fang J, Zeng X, Wang Z, Chen Q. Overexpression of proteasomal activator PA28α serves as a prognostic factor in oral squamous cell carcinoma. J Exp Clin Cancer Res. 2016 Feb 19;35:35.

  12. Luo X, Xu H, He M, Han Q, Wang H, Sun C, Li J, Jiang L, Zhou Y, Dan H, Feng X, Zeng X, Chen Q. Accuracy of autofluorescence in diagnosing oral squamous cell carcinoma and oral potentially malignant disorders: a comparative study with aero-digestive lesions. Scientific Reports. 2016 Jul 15;6:29943.

  13. Iglesias-Bartolome R, Torres D, Marone R, Feng X, Martin D, Chen M, Weinstein SL, Taylor SS, Molinolo AA, and Gutkind JS. Inactivation of a Gαs-PKA tumor suppressor pathway in skin stem cells initiates basal-cell carcinogenesis. Nature Cell Biology. 2015 Jun;17(6):793-803.

  14. Li J, Feng X, Sun C, Zeng X, Xie L, Xu H, Li T, Wang R, Xu X, Zhou X, Zhou M, Zhou Y, Dan H, Wang Z, Ji N, Deng P, Liao G, Geng N, Wang Y, Zhang D, Lin Y, Ye L, Liang X, Li L, Luo G, Jiang L, Wang Z, Chen Q. Associations between proteasomal activator PA28γ and outcome of oral squamous cell carcinoma: Evidence from cohort studies and functional analyses. EBioMedicine. 2015 Jul 10;2(8):851-8.

  15. Feng X, Degese MS, Iglesias-Bartolome R, Vaque JP, Molinolo AA, Rodrigues M, Zaidi MR, Ksander BR, Merlino G, Sodhi A, Chen Q, Gutkind JS. Hippo-independent activation of YAP by the GNAQ uveal melanoma oncogene through a trio-regulated rho GTPase signaling circuitry. Cancer Cell. 2014 Jun 16;25(6):831-45. （封面论文）

  16. Feng X, Chen Q, Gutkind JS. Oncotargeting G proteins: The Hippo in the room. Oncotarget. 2014 Nov 30;5(22):10997-9.

  17. Vaqué JP, Dorsam RT, Feng X, Iglesias-Bartolome R, Forsthoefel DJ, Chen Q, Debant A, Seeger MA, Ksander BR, Teramoto H, Gutkind JS. A genome-wide RNAi screen reveals a Trio-regulated Rho GTPase circuitry transducing GPCR-initiated mitogenic signals. Molecular Cell. 2013 Jan 10;49(1):94-108.

  18. Zhou Y, Zhu X, Lu R, Dan H, Wang F, Wang J, Li J, Feng X, Wang H, Ji N, Zhou M, Zeng X, Jiang L, Chen Q. Vesicular stomatitis virus matrix protein (VSVMP) inhibits the cell growth and tumor angiogenesis in oral squamous cell carcinoma. Oral Oncology. 2012 Feb;48(2):110-6.

  19. Li J, Guo Y, Feng X, Wang Z, Wang Y, Deng P, Zhang D, Wang R, Xie L, Xu X, Zhou Y, Ji N, Hu J, Zhou M, Liao G, Geng N, Jiang L, Wang Z, Chen Q. Receptor for activated C kinase 1 (RACK1): a regulator for migration and invasion in oral squamous cell carcinoma cells. J Cancer Res Clin Oncol. 2012 Apr; 138(4):563-71.

  20. Li J, Gong C, Feng X, Zhou X, Xu X, Xie L, Wang R, Zhang D, Wang H, Deng P, Zhou M, Ji N, Zhou Y, Wang Y, Wang Z, Liao G, Geng N, Chu L, Qian Z, Wang Z, Chen Q. Biodegradable thermosensitive hydrogel for SAHA and DDP delivery: therapeutic effects on oral squamous cell carcinoma xenografts. PLoS One. 2012;7(4):e33860.

  21. Wang Z, Feng X, Li J, Ji N. Biomarker identification in oral cancer by using proteomics. Interface Oral Health Science 2009. 2010 pp: 167-168.

  22. Wang Z, Zhang B, Jiang L, Zeng X, Chen Y, Feng X, Guo Y, Chen Q. RACK1, an excellent predictor for poor clinical outcome in oral squamous carcinoma, similar to Ki67. Eur J Cancer. 2009 Feb; 45(3): 490-6.

  23. Wang Z, Feng X, Liu X, Jiang L, Zeng X, Ji N, Li J, Li L, Chen Q. Involvement of potential pathways in malignant transformation from Oral Leukoplakia to Oral Squamous Cell Carcinoma revealed by proteomic analysis. BMC Genomics. 2009 Aug 19;10(1): 383.

  24. Zhou C, Zhou Y, Li J, Zhang Y, Jiang L, Zeng X, Feng X, Wang Z. The Arg194Trp polymorphism in the X-ray repair cross-complementing group 1 gene as a potential risk factor of oral cancer: a meta-analysis. Tohoku J Exp Med. 2009 Sep; 219(1): 43-51.