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成果及论文

2024

140. Guangyu Zhang,  Lei Wang, Yuan Qiao, Ziang Liu, Rensong Sun, Engin U. Akkaya, Overcoming Multidrug Resistance by a Singlet Oxygen Releasing Camptothecin-Endoperoxide, Chem. Commun., 2024

139. Lei Wang,* Hao Wu, Ziang Liu, Rensong Sun, Yanping Li, Yu Si, Yun Nie, Yuan Qiao, Xiao Qian, Shengli Zhang, Guangzhe Li, Wen Sun, Yue Pan,* and Engin U. Akkaya*, N-Phenyl-2-Pyridone-Derived Endoperoxide Suppressing both Lung Cancer and Idiopathic Pulmonary Fibrosis Progression by ThreePronged Action, Angew. Chem. Int. Ed. 2024, 63, e202408473.

138. Guangyu Zhang,  Lei Wang, Yuan Qiao, Ziang Liu, Rensong Sun, Engin U. Akkaya, Singlet Oxygen-Triggered Release of Nitric Oxide in an Endoperoxide-Arginine Conjugate, Chemistry - An Asian Journal, 2024

137. Zhenyan Zhou, Lei Wang,* Shoucai Yan, Ziang Liu, Rensong Sun, Yuan Qiao, Engin U. Akkaya*, Reversing Reprogramming of Cancer Cell Metabolism by Singlet Oxygen Triggered Release of Dichloroacetate Enhances Photodynamic Cytotoxicity, ChemPhotoChem 2024, e202400096.

136. Shengli Zhang, Xiangdong Tan, Yingxu Wu, Yu Si, Rensong Sun, Ziang Liu, Yun Nie, Zhigang Gao, Lei Wang*, Eur. J. Org. Chem. 2024, 27, e202400270.

135. Hao Wu, Lei Wang,* Xiao Qian, Wanwan Wang, Yu Si, Rensong Sun, Engin U. Akkaya*, Benzothiazole-endoperoxide conjugates protect PC12 cells against β-amyloid-induced cell death via singlet oxygen mediated oxidative detoxification of fibrils, Smart Mol. 2024, 2, e20230019.

134. Ziang Liu, Lei Wang,* Guangzhe Li, Rensong Sun, Kun Shao, Hao Wu, and Engin U. Akkaya*, Targeted Endoperoxides Delivering Singlet Oxygen to Cancer Cell Mitochondria: Exploration of the Therapeutic Potential, Chem. Eur. J. 2024, 30, e202401277.

133. Yiran Li, Lei Wang,* Shengli Zhang, Ziang Liu, Rensong Sun, Yuan Qiao and Engin U. Akkaya*, Self-reporting intracellular delivery agent for singlet oxygen, Chem. Commun., 2024, 60, 8111 – 8114.

2023

132. Shengli Zhang, Peng Liu, Li Li, Ziang Liu, Xiao Qian, Xueying Jiang, Wen Sun, Lei Wang,* and Engin U. Akkaya, Upconverting Nanoparticle-Based Photoactive Probes for Highly Efficient Labeling and Isolation of Target Proteins, ACS Appl. Mater. Interfaces 2023, 15, 40280 − 40291.

2022

131. Hao Wu, Lei Wang,* Yang Wang, Yujie Shao, Guangzhe Li, Kun Shao, and Engin U. Akkaya*, Targeted Singlet Oxygen Delivery: A Bioorthogonal Metabolic Shunt Linking Hypoxia to Fast Singlet Oxygen Release, Angew. Chem. Int. Ed. 2022, 61, e202210249  (VIP).

130. Jin Li, Lei Wang,* Jinrong Li, Yujie Shao, Ziang Liu, Guangzhe Li, and Engin U. Akkaya*, Taming of Singlet Oxygen: Towards Artificial Oxygen Carriers Based on 1,4-Dialkylnaphthalenes, Chem. Eur. J. 2022, 28, e202200506.

129. Hao Wu, Ziang Liu, Yujie Shao, Guangzhe Li, Yue Pan, Lei Wang* and Engin U. Akkaya*, Degradation of amyloid peptide aggregates by targeted singlet oxygen delivery from a benzothiazole functionalized naphthalene endoperoxide, Chem. Commun., 2022, 58, 3747 – 3750. (封面)

128. Lei Wang, Lei Tang, Yingjie Liu, Hao Wu, Ziang Liu, Jin Li, Yue Pan* and Engin U. Akkaya*, Prostate-specific membrane antigen (PSMA) targeted singlet oxygen delivery via endoperoxide tethered ligands, Chem. Commun., 2022, 58, 1902 – 1905. (背封面)

127. Deniz Yildiz, Serdal Kaya, Abdurrahman Turksoy*, Engin U. Akkaya*, Core–shell magnetic nanoparticles deliver singlet oxygen for mild oxidations: rechargeable, removable, reusable, Mol. Syst. Des. Eng., 2022, 7, 325-329.

2021

126. Serdal Kaya, Yahya A. Ismaiel, Nahyun Kwon, Gyoungmi Kim, Jose L. Bila, Juyoung Yoon*, Ozlem Seven*, Engin U. Akkaya*, Imaging of intracellular singlet oxygen with bright BODIPY dyes, Dyes and Pigments, 2021, 188, 109158.

125. Lei Wang, Mary C. Casey, Sanjeev Kumar V. Vernekar, Rajkumar Lalji Sahani, Karen A. Kirby, Haijuan Du, Huanchun Zhang, Philip R. Tedbury, Jiashu Xie, Stefan G. Sarafianos, Zhengqiang Wang*, Novel PF74-like small molecules targeting the HIV-1 capsid protein: balance of potency and metabolic stability, Acta Pharmaceutica Sinica B, 2021, 11, 810 – 822. 

124. Meina Liu, Esma Ucar, Ziang Liu, Lei Wang,* Li Yang, Jiawei Xu and Engin U. Akkaya *, Anticoagulant activity of singlet oxygen released from a water soluble endoperoxide by thermal cycloreversion, RSC Adv., 2021, 11, 14513 – 14516. 

123. Min Qu, Nan Wu, Wanqing Jiang, Lei Wang,* Mahinur S. Akkaya* and Engin U. Akkaya*, Silyl-naphthalene endoperoxides as switchable sources of singlet oxygen for bactericidal activity, RSC Adv., 2021, 11, 19083 – 19087. 

122. Hande Gunduz, Safacan Kolemen, Engin U. Akkaya*, Singlet oxygen probes: Diversity in signal generation mechanisms yields a larger color palette, Coord. Chem. Rev., 2021, 429, 213641.

2020

121. Lei Wang#, Mary C. Casey#, Sanjeev Kumar V. Vernekar, Ha T. Do, Rajkumar Lalji Sahani, Karen A. Kirby, Haijuan Du, Atsuko Hachiya, Huanchun Zhang, Philip R. Tedbury, Jiashu Xie, Stefan G. Sarafianos, ZhengqiangWang*, Chemical profiling of HIV-1 capsid-targeting antiviral PF74, Eur. J. Med. Chem. 2020. 200. 112427.  

120. Lei Wang, Mary C. Casey, Sanjeev Kumar V. Vernekar, Rajkumar Lalji Sahani, Jayakanth Kankanala, Karen A. Kirby, Haijuan Du, Atsuko Hachiya, Huanchun Zhang, Philip R. Tedbury, Jiashu Xie, Stefan G. Sarafianos, Zhengqiang Wang, Novel HIV-1 capsid-targeting small molecules of the PF74 binding site, Eur. J. Med. Chem. 2020. 204. 112626.    

119. Seylan Ayan, Gurcan Gunaydin, Nisa Yesilgul-Mehmetcik, M. Emre Gedik, Ozlem Seven* and Engin U. Akkaya*, Proof-of-principle  for two-stage photodynamic therapy: hypoxia triggered release of singlet oxygen, Chem. Commun., 2020, 56, 14793-14796.

118. Abdurrahman Turksoy,‡ Deniz Yildiz,‡ Simay Aydonat,‡ Tutku Beduk, Merve Canyurt, Bilge Baytekin* and Engin U. Akkaya*, Mechanochemical generation of singlet oxygen, RSC Adv., 2020, 10, 9182–9186. 

117. Lei Wang, Stefan G. Sarafianos, Zhengqiang Wang*, Cutting into the Substrate Dominance: Pharmacophore and Structure-Based  Approaches toward Inhibiting HIV Reverse Transcriptase-Associated Ribonuclease H. Acc. Chem. Res. 2020, 53, 218-230.

2019

116. Ucar, E.; Xi, D.; Seven, O., Kaya, C.; Peng, X. J., Sun, W., Akkaya, E. U."Off-On" Switching of Intracellular Singlet Oxygen Release Under Biocompatible Conditions” Chem. Commun. 2019, 55, 13808-13811.

115. Turksoy, A.; Yildiz, D.; Akkaya, E. U. “Photosensitization and Controlled Photosensitization with Bodipy dyes” Coord. Chem. Rev. 2019, 379, 47-64.

114. Ucar, E.; Seven, O.; Lee, D.; Kim, G.; Yoon, J.; Akkaya, E. U. “Selectivity in Photodynamic Action: Higher Activity of Mitochondria Targeting Photosensitizers in Cancer Cells”,ChemPhotoChem, 2019, 3, 129-132.  

2018

113. Yesilgul, N., Seven, O., Guliyev, R., Akkaya, E. U. J. Org. Chem. 2018, 83, 13228-13232.

112. Kolemen, S., Akkaya, E. U. "Reaction-based Bodipy probes for bio-imaging" Coord. Chem. Rev. 2018, 354, 121-134.

111. Turan, I. S., Gunaydin, G., Ayan, S., Akkaya, E. U. “Molecular Demultiplexer as a Terminator Automaton" Nat. Commun. 2018, 9, 805.

110. Erbas-Cakmak, S., Kolemen, S., Sedgwick, A. C., Gunnlaugsson, T., James, T. D., Yoon, J., Akkaya, E. U. “Molecular Logic gates: the past, present and future” Chem. Soc. Rev. 2017, 47, 2228-2248.

2017

109. Wu, D., Sedgwick, A. C., Gunnlaugsson, T., Akkaya, E. U., Yoon, J., James, T. D., “Fluorescent Chemosensors: the past, present and future” Chem. Soc. Rev. 2017, 46, 7105-7123.

108. Akkaya, E. U., Katz, E.; Pischel, U. ChemPhysChem, 2017, 18, 1665-1666. 

107. Ozdemir, T.; Lu, Y.-C.; Kolemen, S.; Tanrıverdi-Ecik, E.; Akkaya, E. U. “Generation of Singlet Oxygen by Persistent Luminescent Nanoparticle-Photosensitizer Conjugates:  A proof of Principle for Photodynamic Therapy without Light" ChemPhotoChem 2017, 1, 183-187.  

106. Li, X., Kolemen, S., Yoon, J. and Akkaya, E. U. “Activatable Photosensitizers: Agents for Selective Photodynamic Therapy", Adv. Funct. Mater., 2017, 27, 1604053.

105. Yesilgul, N.; Uyar, T. B.; Seven, O.; Akkaya, E. U. “Singlet Oxygen Generation with Chemical Excitation of an Erythrosine-Luminol Conjugate" ACS Omega, 2017, 2, 1367–1371.

104. Turan, I. S.; Seven, O.; Ayan, S.; Akkaya, E. U. “Amplified Chemiluminescence Signal for Sensing Fluoride Ions" ACS Omega, 2017, 2, 3291–3295.


Before 2016

103. Cebula, M.; Turan, I. S.; Sjödin, B.; Thulasingam, M.; Brock, J.; Chmyrov, V.; Widengren, J.; Abe, H.; Mannervik, B.; Haeggström, J. Z.; Rinaldo-Matthis, A.; Akkaya, E. U.; Morgenstern, R. “Catalytic Conversion of Lipophilic Substrates by Phase constrained Enzymes in the Aqueous or in the Membrane Phase” Sci. Rep., 2016, 6, 38316.

102. Ozdemir, T.; Bila, J. L.; Sozmen, F.; Yildirim, L. T.; Akkaya, E.U. “Orthogonal Bodipy Trimers as Efficient Photosensitizers for Photodynamic Action" Org. Lett. 2016, 18, 4821–4823.

101. Kolemen, S.; Ozdemir, T.; Lee, D. Kim, G. M.; Karatas, T.; Yoon, J.; Akkaya, E. U. “Remote Controlled Release of Singlet Oxygen by the Plasmonic Heating of Gold Nanorods: Towards a Paradigm Change in Photodynamic Therapy"Angew. Chem. Int. Ed. 2016, 55, 3606–3610.

100. Turan, I. S.; Yildiz, D.; Turksoy, A.; Gunaydin, G.; Akkaya, E. U. “A Bifunctional Photosensitizer for Enhanced Fractional Photodynamic Therapy: Singlet Oxygen Generation in the Presence and Absence of Light” Angew. Chem. Int. Ed. 2016, 55, 2875-2878.

99. Kilic, B.; Yesilgul, N.; Polat, V.; Gercek, Z.; Akkaya, E. U. Bodipy-based photosensitizers with long alkyl tails at the meso position: efficient singlet oxygen generation in Cremophor-EL micelles, Tetrahedron Lett., 2016, 57, 1317-1320.

98. Turan, I, S.; Yilmaz, O.; Karatas, B.; Akkaya, E. U. “A sensitive and selective chemiluminogenic probe for palladium” RSC Adv. 2015, 5, 34535-34540.

97. Erbas-Cakmak, S.; Cakmak, F. P.; Topel, S. D.; Uyar, T. B.; Akkaya, E. U.“Selective photosensitization through an and logic response: optimization of the pH and glutathione response of activatable photosensitizers” Chem. Commun. 2015, 12258-12261.

96. Kölemen, S.; Işık, M.; Kim, G. M.; Kim, D.; Geng, H.; Buyuktemiz, M; Karatas,T.; Zhang, X.-F.; Dede, Y.; Yoon, J.; Akkaya, E. U. "Intracellular  Modulation of Excited State Dynamics in a Chromophore Dyad: Differential Enhancement of Photocytotoxicity Targeting Cancer Cells" Angew. Chem. Int. Ed., 2015, 54, 5340- 5344. FRONT COVER.

95. T. Özdemir, Z. Köstereli, R. Guliyev, S. Yalçın, Y. Dede, E.U. Akkaya, "Ion Responsive Near-IR Bodipy Dyes: Two Isomers, Two Different Signals," RSC Advances, vol. 4, 14915-14918 (2014)

94. T. Özdemir, F. Sözmen, S. Mamur, T. Tekinay, E.U. Akkaya, "Fast Responding and Selective Near-IR Bodipy Dye for Hydrogen Sulfide Sensing," Chem. Commun., vol. 50, 5455-5457 (2014)

93. A. Atılgan, E. T. Eçik, R. Guliyev, T. B. Uyar, S. Erbaş-Çakmak, E.U. Akkaya, "Near-IR Triggered, Remote-Controlled Release of Metal Ions: A Novel Strategy for Caged Ions," Angew. Chem.-Int. Ed., 53, 10678-10681 (2014)

92. E. Ertem, A. Bekdemir, A. Atılgan, E.U. Akkaya, "Near IR Absorbing Bodipy-functionalized SPIONs: A Potential Magnetic Nanoplatform for Diagnosis and Therapy," Pure and Applied Chemistry, vol. 86, 899-903 (2014)

91. S. Erbaş-Çakmak, E.U. Akkaya, "Toward Singlet Oxygen Delivery at a Measured Rate: A Self-reporting Photosensitizer," Org. Lett., vol. 16, 2946-2949 (2014)

90. S. D. Topel, G. T. Cin, E.U. Akkaya, "Near IR Excitation of Heavy-atom Free Photosensitizers Through the Intermediacy of Upconverting Nanoparticles," Chem. Commun., 50, pp. 8896-8899 (2014)

89. S. Kölemen, Y. Çakmak, T. Özdemir, S. Erten-Ela, M. Büyüktemiz, Y. Dede, E.U. Akkaya, "Design and Synthesis of Bodipy Derivatives for Bulk Heterojunction Solar Cells," Tetrahedron, vol. 70, 6229-6234 (2014)

88. Y. Çakmak, T. Nalbantoğlu, T. Durgut, E.U. Akkaya, "PEGylated Calix[4]arene as a Carrier for a Bodipy-based Photosensitizer," Tetrahedron Lett., vol. 45, 538-540 (2014)

87. F. Sözmen, S. Kölemen, H.-O. Kumada, M. Ono, H. Saji, E.U. Akkaya, "Designing Bodipy-based Probes for Fluorescence Imaging of beta-amyloid Plaques," RSC Adv., vol. 4, 51032-51037 (2014)

86. I.S. Turan, E.U. Akkaya, "Chemiluminescence Sensing of Fluoride Ions Using a Self-Immolative Amplifier," Org. Lett., 16, 1680-1683 (2014)

85. E. Tanriverdi-Ecik, A. Atilgan, R. Guliyev, T.B. Uyar, A. Gumus, E.U. Akkaya, "Modular logic gates: cascading independent logic gates via metal ion signals," Dalton Transactions, vol. 43, 67-70 (2014) . JOURNAL COVER

84. S. Kolemen, Y. Cakmak, Z. Kostereli, E.U. Akkaya, “Atropisomeric Dyes: Axial Chirality in Orthogonal BODIPY Oligomers," Org. Lett., vol. 16, 660-663 (2014)

83. M. Isik, R. Guliyev, S. Kolemen, Y. Altay, B. Senturk, T. Tekinay, E.U. Akkaya, "Designing an Intracellular Fluorescent Probe for Glutathione: Two Modulation Sites for Selective Signal Transduction," Org. Lett., vol. 16, 3260-3263 (2014)

82. I. S. Turan,  F. P. Çakmak, D. C. Yıldırım, R. Çetin-Atalay, E.U. Akkaya, "Near-IR Absorbing BODIPY Derivatives as Glutathione-Activated Photosensitizers for Selective Photodynamic Action,"  Chem. Eur. J., 20, 16088-16092 (2014)

81. Erbas-Cakmak, S.; Akkaya, E.U. “Cascading of Molecular Logic Gates for Advanced Functions: A Self-Reporting, Activatable Photosensitizer” Angew. Chem. Int. Ed. 2013, 52, 11364-11368. 

80. Buyukcakir, O.; Yasar, F.T.; Bozdemir, O.A.; Icli, B.; Akkaya, E.U. “Autonomous Shuttling Driven by an Oscillating Reaction: Proof of Principle in a Cucurbit[7]uril-Bodipy Pseudorotaxane” Org. Lett. 2013, 15, 1012-1015.

79. Isik, M; Ozdemir, T.; Turan, I.S.; Kolemen, S.; Akkaya, E.U. “Chromogenic and Fluorogenic Sensing of Biological Thiols in Aqueous Solutions Using BODIPY-Based Reagents” Org. Lett. 2013, 15, 216-219. 

78. Erbas-Cakmak, S.; Bozdemir, O.A.;  Cakmak, Y.; Akkaya, E.U. “Proof of principle for a molecular 1:2 demultiplexer to function as an autonomously switching theranostic device” Chem. Sci. 2013, 4, 858-862. 

77. Sozmen, F.; Oksal, B.S.; Bozdemir, O.A.; Buyukcakir, O.; Akkaya, E.U. “Heteroleptic Metallosupramolecular Complexes of Bodipy Dyes as Energy Transfer Cassettes” Org. Lett. 2012, 14, 5286-5289.

76. Kostereli, Z.; Ozdemir, T.; Buyukcakir, O.; Akkaya, E.U. “Tetrastyryl-BODIPY-Based Dendritic Light Harvester and Estimation of Energy Transfer Efficiency” Org. Lett. 2012, 14, 3636-3639.

75. Duman, S.; Cakmak, Y.; Kolemen, S.; Akkaya, E.U., Dede, Y. “Heavy Atom Free Singlet Oxygen Generation: Doubly Substituted Configurations Dominate S-1 States of Bis-BODIPYs” J. Org. Chem. 2012, 77, 4516-4527.

74. Expanded Bodipy Dyes: Anion Sensing Using a Bodipy Analog with an Additional Difluoroboron Bridge, Guliyev, R.; Ozturk, S.; Sahin, E.; Akkaya, E.U. Org. Lett. 2012, 14, 1528.

73. Designing Excited States: Theory-Guided Access to Efficient Photosensitizers for Photodynamic Action, Cakmak, Y.; Kolemen, S.; Duman, S.; Dede, Y.; Dolen, Y.; Kilic, B.; Kostereli, Z.; Yildirim, L. T.; Dogan, A. L.; Guc, D.;  Akkaya, E. U. Angew. Chem. Int. Ed. 2011, 50, 11937-11941.

72. Towards Unimolecular Luminescent Solar Concentrators: Bodipy-based Dendritic Energy-Transfer Cascade with Panchromatic Absorption and Monochromatized Emission, Bozdemir, O. A.; Erbas-Cakmak, S.; Ekiz, O. O.; Dana, A.; Akkaya, E. U. Angew. Chem. Int. Ed. 2011, 50, 10907-10912.

71. From Virtual to Physical: Integration of Chemical Logic Gates, Guliyev, R.; Ozturk, S. Kostereli, Z.; Akkaya, E. U. Angew. Chem. Int. Ed. 2011, 50, 9826-9831. Selected as the frontispiece for the “communications” section.

70. Optimization of distyryl-Bodipy chromophores for efficient panchromatic sensitization in dye sensitized solar cells, Kolemen, S.; Bozdemir, O. A.; Cakmak, Y.; Barin, G.; Erten-Ela, S.; Marszalek, M.; Yum, J. H.; Zakeeruddin, S. M.; Nazeeruddin, M. K.; Gratzel, M.; Akkaya, E. U. Chem. Sci.  2011, 2, 949.

69. Selective Hg(II) sensing with Improved Stokes Shift by Coupling ICT Process to Excitation Energy Transfer, Atilgan, S.; Ozdemir, T.; Akkaya, E. U. Org. Lett. 2010, 12, 4792.

68. Solid-State Dye-Sensitized Solar Cells Using Red and Near IR absorbing Bodipy Sensitizers, Kolemen, S.; Cakmak, Y.; Erten-Ela, S.; Altay, Y.; Brendel, J.; Thelakkat, M.; Akkaya, E. U. Org. Lett. 2010, 12, 3892.

67. Reaction-based Sensing of Fluoride Ions Using Built-In Triggers for ICT and PET, Bozdemir, O. A.; Sozmen, F.; Buyukcakir, O.; Guliyev, R.; Cakmak, Y.;  Akkaya, E. U. Org. Lett. 2010, 12, 1400-1403.

66. Selective Manipulation of ICT and PET Processes in Styryl-Bodipy Derivatives: Applications in Molecular Logic and Simultaneous Sensing of Multiple Metal Ions. Bozdemir, O. A.; Guliyev, R.; Buyukcakir, O.; Selcuk, S.; Kolemen, S.; Gulseren, G.; Nalbantoglu, T.; Boyaci, H.; Akkaya, E. U. J. Am. Chem. Soc. 2010, 132, 8029-8036.  JOURNAL COVER Featured on the cover of issue June 16, 2010.

65. Synthesis of Symmetrical Multichromophoric BODIPY Dyes and Their Facile Transformation into Energy Transfer Cassettes, Bozdemir, O. A.; Cakmak, Y.; Sozmen, F.; Ozdemir, T.; Siemiarczuk, A.; Akkaya, E. U. Chem. Eur. J. 2010, 16, 6346-6351.

64. Convergent synthesis and light harvesting properties of dendritic boradiazaindacene (BODIPY) appended perylenediimide dyes, Bozdemir, O. A.; Yilmaz, M. D.; Buyukcakir, O.; Siemiarczuk, A.; Tutas, M.; Akkaya, E. U. New J. Chem. 2010, 34, 151-155.

63. Tetrastyryl-Bodipy Dyes: Convenient Synthesis and Characterization of Elusive Near IR Fluorophores, Buyukcakir, O.; Bozdemir, O. A.; Kolemen, S.; Erbas, S.;  Akkaya, E. U. Org. Lett. 2009, 11, 4644-4667.

62. Design Strategies for Ratiometric Chemosensors: Modulation of Excitation Energy Transfer at the Energy Donor Site, Guliyev, R.; Coskun, A.; Akkaya, E. U. J. Am. Chem. Soc. 2009, 131, 9007-9013.

61. Non-covalent Functionalized SWNTs as Delivery Agents for Novel Bodipy-based Potential PDT Sensitizers, Erbas, S.; Gorgulu, A.; Kocakusakogullari, Akkaya, E. U. Chem. Comm. 2009, 4956-4958.

60. Solid-State Emissive BODIPY Dyes with Bulky Substituents As Spacers, Ozdemir, T.; Atilgan, S.; Kutuk, I.; Yildirim, L. T.; Tulek, A.; Bayindir, M.; Akkaya, E. U.  Org. Lett. 2009, 11, 2105-2107.

59. Novel Molecular Building Blocks Based on the Boradiazaindacene Chromophore: Applications in Fluorescent Metallosupramolecular Coordination Polymers, Bozdemir, O. A.; Buyukcakir, O.; Akkaya, E. U. Chem. Eur. J. 2009, 15, 3830-3838.

58. Boradiazaindacene (Bodipy)-based building blocks for the construction of energy transfer cassettes, Barin, G.; Yilmaz, M. D.; Akkaya, E. U. Tetrahedron Lett. 2009, 50, 1738-1740.

57. Phenylethynyl-BODIPY Oligomers: Bright Dyes and Fluorescent Building Blocks, Cakmak, Y.; Akkaya, E. U. Org. Lett. 2009, 11, 85-88.

56. Thinking Outside the Silicon Box: Molecular AND Logic As an Additional Layer of Selectivity in Singlet Oxygen Generation for Photodynamic Therapy, Ozlem, S.; Akkaya, E. U. J. Am. Chem. Soc. 2009, 131, 48-49. (featured in C & EN News, Science and Technology Concentrates, January 19, 2009) 

55. A sensitive and selective ratiometric near IR fluorescent probe for zinc ions based on the distyryl-bodipy fluorophore, Atilgan, S.; Ozdemir, T., Akkaya, E. U. Org. Lett. 2008, 10, 4065-4067.

54. Bidirectional Switching of Near IR Emitting Boradiazaindacene Fluorophores, Deniz, E.; Isbasar, G. C.; Bozdemir, O. A.; Yildirim, L. T.; Siemiarczuk, A.; Akkaya, E. U. Org. Lett. 2008, 10, 3401-3403.

53. A panchromatic boradiazaindacene (BODIPY) sensitizer for dye-sensitized solar cells, Ela-Erten, S.; Yilmaz, M. D.; Icli, B.; Dede, Y.; Icli, S.; Akkaya, E. U. Org. Lett. 2008, 10, 3299-3301.

52. A Monostyryl-boradiazaindacene (BODIPY) Derivative as Colorimetric and Fluorescent Probe for Cyanide Ions, Ekmekci, Z.; Yilmaz, M. D.; Akkaya, E.U. Org. Lett. 2008, 10, 461-464. 

51. Sensitive fluorescent chemosensor for anions based on a styryl-boradiazaindacene framework, Coskun A.; Deniz, E.; Akkaya, E.U. Tetrahedron Lett. 2007, 48, 5359-5361.

50. Dipyridyl-substituted boratriaazaindacene as a NIR emitting chemosensor for Hg(II).  Coskun, A; Yilmaz, M. D.; Akkaya, E.U. Org. Lett. 2007, 9, 607-609. 

49. Signal Ratio Amplification via Modulation of Resonance Energy Transfer: Proof of Principle in an Emission Ratiometric Hg(II) Sensor, Coskun, A; Akkaya, E.U. J. Am. Chem. Soc. 2006, 128, 14474-14475.

48. Dye sensitized artificial photosynthesis in the gas phase over thin and thick TiO2 films under UV and visible light irradiation. Ozcan, O.; Yukruk, F.; Akkaya, E. U.; Uner, D. Appl. Cat. B. Environmental 2007, 71, 291-297.

47. Water soluble distyryl-boradiazaindacenes as efficient photosensitizers for photodynamic therapy, Atilgan, S.; Ekmekci, Z.; Dogan, A. L.; Guc, D.; Akkaya, E. U. Chem. Commun. 2006, 4398-4399.  (presented as  HOT ARTICLE in ChemCommun web site) 

46. Dye sensitized CO2 reduction over pure and platinized TiO2, Ozcan, O.; Yukruk, F.; Akkaya, E. U.; Uner, D. Topics Catal. 2007, 44, 523-528.

45. Light Harvesting and Efficient Energy Transfer in a Boron-dipyrrin (BODIPY) Functionalized Perylenediimide Derivative, Yilmaz, M. D.; Bozdemir, O. A.; Akkaya, E. U. Org. Lett. 2006, 8, 2871-2873.

44. Distyryl-boradiazaindacenes: facile synthesis of novel near IR emitting fluorophores, Dost, Z.; Atilgan, S.; Akkaya, E. U.  Tetrahedron 2006, 62, 8484-8488.

43. An acenaphthopyrrolone-dipicolylamine derivative as a selective and sensitive chemosensor for group IIB cations, Coşkun, A.; Yılmaz, M. D.; Akkaya, E.U. Tetrahedron Lett.  2006, 47, 3689-3691.

42. Excimer emission and energy transfer in cofacial boradiazaindacene (BODIPY) dimers built on a xanthene scaffold, Saki, N.; Dinc, T.; Akkaya, E.U. Tetrahedron 2006, 62, 2721-2725.

41. Unexpected Cyclization of Dipyridyl-glycoluril in the Presence of Formaldehyde and Strong Acid: A New Scaffold with a Potential as a Receptor, Saki, N.; Icli, B.; Cevheroglu, O. J. Inc. Phen. Macrocycl. Chem. 2006, 55,  219-222.

40. Effective PET and ICT Switching of Boradiazaindacene Emission: A Unimolecular, Emission Mode Molecular Half-Subtractor with Reconfigurable Logic Gates, Coskun, A.; Deniz, E.; Akkaya, E.U. Org. Lett. 2005, 7, 5187-5189. 

39. Ion Sensing Coupled to Resonance Energy Transfer:  A Highly Selective and Sensitive Ratiometric Fluorescent Chemosensor for Ag(I) by a Modular Approach, Coskun, A.; Akkaya, E. U. J. Am. Chem. Soc. 2005, 127, 10464-10465.

38. Modulation of internal charge transfer (ICT) in a bay region hydroxylated perylenediimide (PDI) chromophore: A chromogenic chemosensor for pH. Yukruk, F.; Akkaya, E. U. Tetrahedron Lett. 2005, 46, 5931-5933.

37. Cation modulation of dipyrrinone fluorescence: emission ratiometric calcium sensing, Coskun, A.; Deniz, E.; Akkaya, E.U.  J. Mater. Chem. 2005, 15, 2908-2912.

36. Water soluble green Perylenediimide (PDI) dyes as novel sensitizers for photodynamic therapy, Yukruk, F.; Dogan, A.L.; Canpinar, H.; Guc, D.; Akkaya, E.U. Org. Lett. 2005, 7, 2885-2887.

35. Synthesis, p-nitrophenolate complexation and competitive anion signaling of a novel calixpyrrole dimer, Saki, N.; Akkaya, E.U. J. Inc. Phen. Macrocycl. Chem. 2005 53, 269-273.

34. A calixpyridinium-pyranine complex as a selective anion sensing assembly via the indicator displacement strategy, Atilgan, S.; Akkaya, E. U. Tetrahedron Lett. 2004 45, 9269-9271.

33. Three-point recognition and selective fluorescence sensing of L-DOPA., Coskun, A.; Akkaya, E.U. Org. Lett. 2004, 6, 3107-3109.

32. Bifunctional catalysis of ester hydrolysis: novel hydrolytic enzyme models based on xanthene framework, Saki, N.; Akkaya, E.U. J. Mol. Catal. A. Chemical 2004, 219, 227-232.

31. Difluoroboradiaza-s-indacene dyes as highly selective dosimetric reagents for fluoride anions, Coskun, A.; Akkaya, E.U. Tetrahedron Lett. 2004, 45, 4947-4949.

30. Differential and substrate selective catalysis by calixarene derivatives with cyclenyl-Zinc(II) modifications at the upper rim, Gulsum Ozturk, Engin U. Akkaya Org. Lett. 2004, 6, 241-243.

29. Novel fluorescent chemosensor for anions via modulation of oxidative PET: A remarkable 25-fold enhancement of emission, Ali Coşkun, Bilge T. Baytekin, Engin U. Akkaya Tetrahedron Lett. 2003, 44, 5649-5651.

28. Fiber optic sodium and potassium sensing by using a newly synthesized squaraine dye in PVC matrix. Ertekin, K.; Tepe, M.; Yenigül, B.; Akkaya, E.U.; Henden, E. Talanta, 2002, 58, 719-727.

27. Modulation of Boradiazaindacene Emission by Cation Mediated Oxidative PET, Turfan, B.; Akkaya, E.U., Org. Lett. 2002, 4, 2857-2859.

26. Selective chromogenic response via regioselective binding of cations: A novel approach in chemosensor design, Ataman, D.; Akkaya, E.U. Tetrahedron Lett. 2002, 43, 3981-3983.

25. Potassium sensing by using a newly synthesized squaraine dye in sol-gel matrix, Ertekin, K.; Yenigül, B.; Akkaya, E.U. J. Fluorescence 2002, 12, 263. 

24. Boradiazaindacene appended calix[4]arene: Fluorescence sensing of pH near neutrality, Baki, C. N.; Akkaya, E.U. J. Org. Chem. 2001, 66, 1512.

23. Remarkable cooperative action of two zinc centers in the hydrolysis of plasmid DNA, Aka, F. N.; Akkaya, M. S.; Akkaya, E.U. J. Mol. Catal. A. Chemical 2001, 165, 291-294. 

22. A Molecular NAND gate based on Watson-Crick base-pairing, Baytekin, H. T.; Akkaya, E.U. Organic Lett. 2000, 2, 1725-1727.

21. Infrared fluorescence sensing of submicromolar calcium: Pushing the limits of photoinduced electron transfer, Ozmen, B.; Akkaya, E.U. Tetrahedron Lett. 2000, 41, 9185-9188. 

20. Simultaneous determination of cadmium and zinc using a fiber optic device and fluorescence spectrometry, Ertas, N.; Akkaya, E. U.; Ataman, O. Y. Talanta, 2000, 51, 693-699.

19. Novel squaraine signalling Zn(II) ions: Three-state fluorescence response to a single input , Dilek, G.; Akkaya, E.U. Tetrahedron Lett. 2000, 41, 3721-3724.

18. A Novel cyclodextrin homodimer with dual-mode substrate binding and esterase activity, Tastan, P.; Akkaya, E.U. J. Mol. Catal. A. Chemical 2000, 157, 261-263.

17. Red to Near IR Fluorescent Signalling of Carbohydrates, Kukrer, B.; Akkaya, E.U. Tetrahedron Lett. 1999, 40, 9125-9128.

16. A Novel Lanthanide Complex with Remarkable Phosphodiester Transesterification Activity and DNA-conjugatable Functionality, Baykal, U. Akkaya, M.S., Akkaya, E.U. J. Inc. Phen. 1999, 35, 311.

15. Remarkable phosphodiester hydrolysis activity of a novel CeIV complex in neutral aqueous solutions, Baykal, U.; Akkaya, M.S.; Akkaya, E.U. J. Mol. Catal. A. Chemical 1999, 145, 309.

14. An Efficient Synthesis of a Novel Bifunctional Chelating Agent, Erdogan, B.; Akkaya, E.U. Tetrahedron Lett., 1998, 39, 9107.

13. One-Pot Synthesis of Squaraine Fluoroionophores, Oguz, U.; Akkaya, E.U. J. Org. Chem., 1998, 63, 6059.

12. Synthesis and Phosphodiester Transesterification Activity of the La(III)-complex of a Novel Functionalized Octadentate Ligand, Baykal, U.; Akkaya, E.U. Tetrahedron Lett., 1998, 39, 5861.

11. A Squaraine-based Sodium Selective Fluorescent Chemosensor, Oguz, U.; Akkaya, E.U. Tetrahedron Lett., 1998, 39, 5857.

10. Chemosensing in Deep Red: A Squaraine-based Fluorescent Chemosensor for pH, Isgor, Y.G.; Akkaya, E.U. Tetrahedron Lett., 1997, 38, 7417.

9. A Squaraine-based Near IR Fluorescent Chemosensor for Calcium, Akkaya, E.U.; Turkyilmaz, S. Tetrahedron Lett., 1997, 38, 4513.

8. One-Pot Synthesis of a Red-Fluorescent Chemosensor from an Azacrown, Phloroglucinol and Squaric Acid: A Simple In-solution Construction of a Functional Molecular Device, Oguz, U.; Akkaya, E.U. Tetrahedron Lett., 1997, 38, 4509.

7. Simultaneous Determination of Cd and Zn by Fluorescence Spectrometry Using a Novel Reagent and Surfactants, Ertas, N.; Akkaya, E.U.; Ataman, O.Y., Quimica Analytica, 1997, 16, S101.

6. Styryl-based Wavelength-Ratiometric Probes: A New Class of Fluorescent Calcium Probes with Long Wavelength Emission and a Large Stokes’ Shift, Akkaya, E.U.; Lakowicz, J.R. Analytical Biochem., 1993, 213, 285.

5. Synthesis and Transacylating Activity of Isomeric Co(III)-cyclodextrin Artificial Metalloenzymes, Akkaya, E.U.; Czarnik, A.W. J. Phys. Org. Chem., 1992, 5, 540.

4. Synthesis and Characterization of a Reactive Binuclear Co(III) Complex:  Cooperative Promotion of Phosphodiester Hydrolysis, Chung, Y. Akkaya, E.U.; Venkatachalam, T.K.; Czarnik, A.W. Tetrahedron Lett., 1990, 31, 5413.

3. Chelation Enhanced Fluorescence of Anthrylazamacrocycle Conjugate Probes in Aqueous Solutions, Akkaya, E.U., Huston, M.E.; Czarnik, A.W. J. Am. Chem. Soc., 1990, 112, 3590.

2. Chelation Enhanced Fluorescence Detection of Non-metal Ions, Huston, M.E.; Akkaya, E.U.; Czarnik, A.W. J. Am. Chem. Soc., 1989, 111, 8735.

1. Synthesis and Reactivity of Cobalt(III) Complexes Bearing Primary and Secondary Side Cyclodextrin Binding Sites: A Tale of Two CD’s, Akkaya, E.U.; Czarnik, A.W. J. Am. Chem. Soc., 1988, 110, 8553.