陈志翔研究员长期从事靶向蛋白降解的新药研发和药物合成方法学的研究。一方面，通过对分子的理性设计、精准调控和修饰，解决了PROTAC药物的口服吸收难题和分子胶药物的脱靶问题，成功开发了靶向CBP/p300、ERα、IKZF2等不同靶标的多款可口服且安全有效的临床候选药物，并揭示了CBP/p300降解剂的独特作用机制。另一方面，针对一些常见类型药物的合成问题，发展了一系列廉价铜/新型配体催化的高效C-O和C-N偶联方法，得到了广泛关注和应用。部分相关工作以唯一或共一第一作者发表于J Am Chem Soc（ESI高被引）、J Med Chem（3篇，1篇亮点文章）、Org Lett等著名期刊，并以第一或导师外第一（7项）、第二或导师外第二（4项）等发明人身份申请国际/美国专利16项，大部分专利已许可/转让给美国Proteovant公司进行后续临床开发。
论文列表：
1. Zhixiang Chen, Yongwen Jiang, Li Zhang, Yinlong Guo, Dawei Ma. Oxalic diamides and tert-butoxides: Two types of ligands enabling practical access to alkyl aryl ethers via Cu-catalyzed coupling reaction. Journal of the American Chemical Society, 2019, 141, 3541. (ESI高被引论文)
2. Zhixiang Chen,# Mi Wang,# Dimin Wu,# Longchuan Bai, Tianfeng Xu, Hoda Metwally, Yu Wang, Donna McEachern, Lijie Zhao, Ruiting Li, John Takyi-Williams, Meilin Wang, Lu Wang, Qiuxia Li, Bo Wen, Duxin Sun, Shaomeng Wang. Discovery of CBPD-268 as an exceptionally potent and orally efficacious CBP/p300 PROTAC degrader capable of achieving tumor regression. Journal of Medicinal Chemistry, 2024, 67, 5275. (被评为“Featured Article”)
3. Zhixiang Chen,# Mi Wang,# Dimin Wu, Lijie Zhao, Hoda Metwally, Wei Jiang, Yu Wang, Longchuan Bai, Donna McEachern, Jie Luo, Meilin Wang, Qiuxia Li, Aleksas Matvekas, Bo Wen, Duxin Sun, Arul M Chinnaiyan, Shaomeng Wang. Discovery of CBPD-409 as a highly potent, selective, and orally efficacious CBP/p300 PROTAC degrader for the treatment of advanced prostate cancer. Journal of Medicinal Chemistry, 2024, 67, 5351.
4. Zhixiang Chen,# Biao Hu,# Rohan Kalyan Rej,# Dimin Wu,# Ranjan Kumar Acharyya,# Mingliang Wang,# Tianfeng Xu,# Jianfeng Lu, Hoda Metwally, Yu Wang, Donna McEachern, Longchuan Bai, Christina L Gersch, Meilin Wang, Wenjing Zhang, Qiuxia Li, Bo Wen, Duxin Sun, James M Rae, Shaomeng Wang. Discovery of ERD-3111 as a potent and orally Efficacious estrogen receptor PROTAC degrader with strong antitumor activity. Journal of Medicinal Chemistry, 2023, 66, 12559.
5. Jie Luo,# Zhixiang Chen,# Yuanyuan Qiao,# Jean Ching-Yi Tien, Eleanor Young, Rahul Mannan, Somnath Mahapatra, Tongchen He, Sanjana Eyunni, Yuping Zhang, Yang Zheng, Fengyun Su, Xuhong Cao, Rui Wang, Yunhui Cheng, Rithvik Seri, James George, Miriam Shahine, Stephanie J. Miner, Ulka Vaishampayan, Mi Wang, Shaomeng Wang, Abhijit Parolia, Arul M. Chinnaiyan. p300/CBP degradation is required to disable the active AR enhanceosome in prostate cancer. (bioRxiv, doi: https://doi.org/10.1101/2024.03.29.587346)
6. Zhixiang Chen and Dawei Ma. Cu/N,N’-dibenzyloxalamide catalyzed N-arylation of heteroanilines. Organic Letters, 2019, 21, 6874.
7. Zhixiang Chen,# Harshil Dhruv,# Xuqing Zhang,# Longchuan Bai,# Rohan Kalyan Rej, Donna McEachern, Paul Kirchhoff, Rakesh Nagilla, Larry J. Jolivette, Cory T. Rice, Peter Orth, Corey O. Strickland, E. Scott Priestley, Helai P. Mohammad, Meilin Wang, Wenjing Zhang, Alejandra Duran, Bo Wen, Duxin Sun, Zhihua Sui, Shaomeng Wang. Discovery of PVTX-405 as a Potent, Highly Selective, and Orally Efficacious Molecular Glue Degrader of IKZF2 for the Treatment of Human Cancers. Journal of Medicinal Chemistry, 2024. (Submitted)
8. Rohan Kalyan Rej,# Biao Hu,# Zhixiang Chen,# Ranjan Kumar Acharyya,# Dimin Wu,# Hoda Metwally, Yu Wang, Wei Jiang, Longchuan Bai, Lorraine-Gersch Clark, Guozhang Xu, Weihong Zhang, Winston Wu, Scott Priestley, Zhihua Sui, Meilin Wang, Bo Wen, Duxin Sun, James M. Rae, Shaomeng Wang. Discovery of ERD-12310A as a Highly Potent and Orally Efficacious PROTAC Degrader of Estrogen Receptor α (ERα) for the Treatment of ER+ Human Breast Cancer. Journal of Medicinal Chemistry, 2024. (To be accepted after minor revision)
9. Ranjan Kumar Acharyya,# Rohan Kalyan Rej,# Biao Hu,# Zhixiang Chen,# Dimin Wu,# Jianfeng Lu, Hoda Metwally, Donna McEachern, Yu Wang, Wei Jiang, Longchuan Bai, Jelena Tosovic, Lorraine-Gersch Clark, Guozhang Xu, Weihong Zhang, WenXue Wu, E. Scott Priestley, Zhihua Sui, Farzad Sarkari, Bo Wen, Duxin Sun, James M. Rae, Shaomeng Wang. Discovery of ERD-1233 as a Potent and Orally Efficacious Estrogen Receptor PROTAC Degrader for the Treatment of ER+ Human Breast Cancer. Journal of Medicinal Chemistry, 2024. (To be accepted after minor revision)
10. Zhixiang Chen, Mengmeng Ning, Qingan Zou, Hua Cao, Yangliang Ye, Ying Leng, Jianhua Shen. Discovery and structure–activity relationship study of 4-phenoxythiazol-5-carboxamides as highly potent TGR5 agonists. Chemical and Pharmaceutical Bulletin, 2016, 64, 326.
11. Hua Cao, Zhi-Xiang Chen, Kai Wang, Meng-Meng Ning, Qing-An Zou, Ying Feng, Yang-Liang Ye, Ying Leng, Jian-Hua Shen. Intestinally-targeted TGR5 agonists equipped with quaternary ammonium have an improved hypoglycemic effect and reduced gallbladder filling effect. Scientific Reports, 2016, 6, 28676.
