PAPERS

2024

Development and characterisation of [¹⁸F] TTDP, a novel T cell immunoglobulin and ITIM domain tracer, in humanised mice and non-human primates

Jing Wang^#, Xinxin Hu^#, Yueqi Wang^#, Xiaoqian Li, Ying Sun, Zhengqi Guan, Xiaona Li, Yongyi Wu, Jiannan Wang, Fangyu Zhao, Yang Liu, Hongbin Wang, Hong Yu, Tianyi Wang, Mengyuan Zhu, Xinyu Li, Duoyi Zhang, Wei Chen, Zhaoguo Han^*, Xilin Sun^*

European Journal of Nuclear Medicine and Molecular Imaging, 1-11. https://link.springer.com/article/10.1007/s00259-024-06911-7

 Discovery of orally bioavailable ALK PROTACs based Ceritinib against ALK positive cancers

Haoxuan Zhou^#, Mingxing Hu^#, Hui Jie^#, Yujue Li, Kexin Tang, LiLi Pan, Chengyali Liu, Wei Chen, Yuanwei Chen, Yi Luo^*, Youling Gong^*, Yongmei Xie^*

European Journal of Medicinal Chemistry, 116827. https://www.sciencedirect.com/science/article/abs/pii/S0223523424007086

 Universal sulfatase-based chemiluminescence biosensing platform: Validation via AFP detection in clinical blood samples

Cheng Zheng^#, Mengyuan Cui^#, Yingyu Zhang, Li Liu, Wenqing Li, Jiaqi Zhang, Min Ji, Wei Chen, Wen Jiang^*, Peng Wang^*, Wancun Zhang^*

Biosensors and Bioelectronics, 116771. https://www.sciencedirect.com/science/article/abs/pii/S0956566324007772#preview-section-abstract

 Rapid Construction of 18F-Triazolyl-tetrazines through the Click Reaction

C Yang^#, K Lu^#, J Li, H Wu^*, W Chen^*

The Journal of Organic Chemistry. ASAP. https://pubs.acs.org/doi/abs/10.1021/acs.joc.4c00574

 Manufacturing 6-[¹⁸F]Fluoro-L-DOPA via Flow Chemistry-Enhanced Photoredox Radiofluorination

X Wu^*, W Chen^*, H Deng, L Wang, DA Nicewicz, Z Li, Z Wu^*

Organic Letters, 2024, 26, 20, 4308–4313. https://pubs.acs.org/doi/abs/10.1021/acs.orglett.4c01114

 Enabling Universal Access to Rapid and Stable Tetrazine Bioorthogonal Probes through Triazolyl-Tetrazine Formation

Haojie Yang^#, Hongbao Sun^#, Yinghan Chen^#, Yayue Wang, Cheng Yang, Fang Yuan, Xiaoai Wu, Wei Chen, Ping Yin, Yong Liang^*, Haoxing Wu^*

JACS Au 2024, 4, 8, 2853–2861. https://pubs.acs.org/doi/full/10.1021/jacsau.3c00843

 Noninvasive Monitoring of Immunotherapy in Lung Cancer by Lymphocyte Activation Gene 3 PET Imaging of Tumor-Infiltrating Lymphocytes

 Zhen Quan^#, Zhaoguo Han^#, Yang Yang, Jiannan Wang^#, Hui Wang, Lili Yang, A Rong, Xinxin Hu, Jing Wang, Xiaona Li, Xiaoqian Li, Hong Yu, Wei Chen, Kai Wang, Xilin Sun^*

Journal of Nuclear Medicine 65 (1), 25-32. https://jnm.snmjournals.org/content/65/1/25.abstract

Radiopharmaceuticals Targeting Gastrin-Releasing Peptide Receptor for Diagnosis and Therapy of Prostate Cancer

Y Zou^#, M Huang^#, M Hu, H Wang, W Chen, R Tian^*

Molecular Pharmaceutics 21 (9), 4199-4216. https://pubs.acs.org/doi/abs/10.1021/acs.molpharmaceut.4c00066

 

2023

Visualization of the ferroptosis in atherosclerotic plaques with nanoprobe engineered by macrophage cell membranes

Yinhui Gu, Mengyuan Cui, Weizhi Wang, Jiaqi Zhang, Huizhe Wang, Cheng Zheng, Lijuan Lei, Min Ji, Wei Chen^*, Yanni Xu^*, Peng Wang^*

Analytical Chemistry 96 (1), 281-291. https://pubs.acs.org/doi/abs/10.1021/acs.analchem.3c03999

Difluorocarbene-derived rapid late-stage trifluoromethylation of 5-iodotriazoles for the synthesis of ¹⁸F-labeled radiotracers

Fang Yuan^#, Hongbao Sun^#, Cheng Yang, Haojie Yang, Lili Pan, Xiaoyang Zhang, Rong Tian, Lingjun Li, Wei Chen, Xiaoai Wu^*, Haoxing Wu^*

Chinese Chemical Letters 34 (6), 107960. https://www.sciencedirect.com/science/article/abs/pii/S1001841722009718

Diversification of pharmaceutical molecules via late-stage C (sp2)–H functionalization

W Shang^#, H Sun^#, W Chen^*, J Liu^*

Green Synthesis and Catalysis 4 (2), 104-123. https://www.sciencedirect.com/science/article/pii/S2666554922001363

Development of [¹⁸F]F-5-OMe-Tryptophans through Photoredox Radiofluorination: A New Method to Access Tryptophan-Based PET Agents

Xuedan Wu, Xinrui Ma, Yaofeng Zhong, Wei Chen, Muyun Xu, He Zhang, Li Wang, Xianshuang Tu, Zhaoguo Han, Weiling Zhao, Zhanhong Wu, Stergios J Moschos^*, Zibo Li^*

Journal of medicinal chemistry 66 (5), 3262-3272. https://pubs.acs.org/doi/abs/10.1021/acs.jmedchem.2c01544

¹¹C-, ¹²C-, and ¹³C-cyanation of electron-rich arenes via organic photoredox catalysis

Xuedan Wu, Wei Chen, Natalie Holmberg-Douglas, Gerald Thomas Bida, Xianshuang Tu, Xinrui Ma, Zhanhong Wu, David A Nicewicz^*, Zibo Li^*

Chem 9 (2), 343-362. https://www.cell.com/chem/fulltext/S2451-9294(22)00650-7

 

2022

Direct C–H Radiocyanation of Arenes via Organic Photoredox Catalysis

Wei Chen, Xuedan Wu, Joshua B McManus, Gerald T Bida, Kang-Po Li, Zhanhong Wu, David A Nicewicz^*, Zibo Li^*

Organic Letters 24 (50), 9316-9321. https://pubs.acs.org/doi/abs/10.1021/acs.orglett.2c03940

 Arene radiofluorination enabled by photoredox-mediated halide interconversion

Wei Chen, Hui Wang, Nicholas ES Tay, Vincent A Pistritto, Kang-Po Li, Tao Zhang, Zhanhong Wu, David A. Nicewicz^*, Zibo Li^*

Nature chemistry 14 (2), 216-223. https://www.nature.com/articles/s41557-021-00835-7

2020

Direct Radiofluorination of Arene C–H Bonds via Photoredox Catalysis Using a Peroxide as the Terminal Oxidant

L Wang, AR White, W Chen, Z Wu, DA Nicewicz^*, Z Li^*

Organic letters 22 (20), 7971-7975. https://pubs.acs.org/doi/abs/10.1021/acs.orglett.0c02815

 ¹⁹F- and ¹⁸F-arene deoxyfluorination via organic photoredox-catalysed polarity-reversed nucleophilic aromatic substitution

Nicholas ES Tay^#, Wei Chen^#, Alison Levens^#, Vincent A Pistritto, Zeng Huang, Zhanhong Wu, Zibo Li^*, David A Nicewicz^*

Nature catalysis 3 (9), 734-742. https://www.nature.com/articles/s41929-020-0495-0

 

2019

Direct arene C–H fluorination with ¹⁸F− via organic photoredox catalysis

Wei Chen^#, Zeng Huang^#, Nicholas ES Tay^#, Benjamin Giglio, Mengzhe Wang, Hui Wang, Zhanhong Wu, David A Nicewicz^*, Zibo Li^*

Science 364 (6446), 1170-1174. https://www.science.org/doi/full/10.1126/science.aav7019

2017

Highly selective fluorescent recognition of glutathione by using a water soluble binaphthyl aldehyde

W Chen, X Wu, L Pu^*

Tetrahedron Letters 58 (18), 1781-1783

2015

Addition of terminal alkynes to α-ketone esters to synthesize α-tertiary-hydroxy esters promoted by zinc and an alkyl halide

W Zhang, Y Cao, W Chen, G Zhao^*, L Pu^*

Tetrahedron letters 56 (46), 6430-6432

2013

Catalytic Asymmetric Enyne Addition to Aldehydes and Rh (I)-Catalyzed Stereoselective Domino Pauson–Khand/[4+ 2] Cycloaddition

W Chen, JH Tay, J Ying, XQ Yu^*, L Pu^*

The Journal of Organic Chemistry 78 (6), 2256-2265

A quick access to the spirotricyclic core analogue of mangicol A by a Rh (i)-catalyzed tandem Pauson–Khand/[4+ 2] cycloaddition

W Chen, JH Tay, J Ying, M Sabat, XQ Yu^*, L Pu^*

Chemical Communications 49 (2), 170-172

2012

Diastereoselective [4 + 1] Cycloaddition of Alkenyl Propargyl Acetates with CO Catalyzed by [RhCl(CO)2]2

W Chen, JH Tay, XQ Yu^*, L Pu^*

The Journal of organic chemistry 77 (14), 6215-6222

2010

Synthesis of a C1 symmetric BINOL–terpyridine ligand and highly enantioselective methyl propiolate addition to aromatic aldehydes

X Chen, W Chen, L Wang, XQ Yu^*, DS Huang, L Pu^*

Tetrahedron 66 (11), 1990-1993

PATENTS

1. Direct aromatic carbon-oxygen and carbon-hydrogen bond functionalization via organic photoredox catalyst

Z Li, D Nicewicz, W Chen

US Patent App. 17/434,677. https://patents.google.com/patent/US20220169581A1/en

2.Process for preparation of furo[2, 3-d]pyrimidin-4-ylamine derivatives and their application

Wang, K.-M.; Zhao, G. ; Liu, J.-F; Pu, L. Chen, W., Faming Zhuanli Shenqing (2017), CN 106946896 B 20190521

3.Preparation of indole derivatives as antitumor agents

 Wang, K.-M.; Chen, W.; Zhao, G.; Liu, J.-F; Pu, L.

Faming Zhuanli Shenqing (2016), CN 105669521 B 20160615

4. Process for synthesis of propargyl alcohols

Chen, W.; Zhang, W.; Zhao, G.; Pu, L.; Liu, J.-F.,

 Faming Zhuanli Shenqing (2015), CN 105017016 B 20160817

5.Simple method for synthesizing insulin-degrading enzyme inhibitor ML345

Chen, W.; Zhao, G.; Pu, L.; Liu, J.-F.,

 Faming Zhuanli Shenqing (2015), CN 104961706 B 20170301.

6.Process for the preparation of bone morphogenetic protein acceptor inhibitor

Chen, W.; Zhao, G.; Pu, L.; Liu, J.-F.,

Faming Zhuanli Shenqing (2015), CN CN 105130991 B 2017091

MEETING ABSTRACTS

2024

First in human study of ¹⁸F-FDOPA generated by photoredox radiofluorination

L Wang, Z Lv, X Wu, L Yang, W Chen, Y Zhu, Z Wu, Y Chen, Z Li

Journal of Nuclear Medicine 65 (supplement 2), 241997-241997. https://jnm.snmjournals.org/content/65/supplement_2/241997.abstract

 Novel SV2A PET Tracers Generated from Photoredox-Catalyzed ¹⁸F-Labeling

L Wang, X Wu, X Ma, M Hu, W Chen, H Yuan, Z Wu, Z Li

Journal of Nuclear Medicine 65 (supplement 2), 242439-242439. https://jnm.snmjournals.org/content/65/supplement_2/242439.abstract

 Preliminary evaluation of a ¹⁸F-labeled guanidine derivative in pheochromocytoma model

Yueqi Wang, W Chen

Journal of Nuclear Medicine 65 (supplement 2), 242511-242511. https://jnm.snmjournals.org/content/65/supplement_2/242511.abstract

 PET imaging of PARP-1 expression using a novel ¹⁸F-labeled Olaparib

Y Zou, H Wang, M Hu, W Chen, R Tian

Journal of Nuclear Medicine 65 (supplement 2), 242088-242088. https://jnm.snmjournals.org/content/65/supplement_2/242088.abstract

2023

Efficient ¹¹C-Cyanation of Electron-Rich Arenes via Organic Photoredox Catalysis

Xuedan Wu, Wei Chen, Natalie Douglas, Gerald Bida, Xianshuang Tu, Xinrui Ma, Zhanhong Wu, David Nicewicz, Zibo Li

Journal of Nuclear Medicine 64 (supplement 1), P1074-P1074. https://jnm.snmjournals.org/content/64/supplement_1/P1074.abstract

Photoredox Radiofluorination assisted by Flow Chemistry: A Practical Manufacture Example for Cartridge based L-[¹⁸F] FDOPA production

X Wu, W Chen, H Deng, Z Wu, D Nicewicz, Z Li

Journal of Nuclear Medicine 64 (supplement 1), P1118-P1118. https://jnm.snmjournals.org/content/64/supplement_1/P1118.abstract

2021

Radiofluorination of Electron-Rich Arenes via LED-Promoted Photoredox Reactions

L Wang, W Chen, Z Wu, D Nicewicz, Z Li

Journal of Nuclear Medicine 62 (supplement 1), 1458-1458. https://jnm.snmjournals.org/content/62/supplement_1/1458.abstract