个人简介

B.Sc. (CUHK), Ph.D. 1989(Alberta)

研究领域

Analytical Chemistry)

Analytical spectroscopy, Fundamental studies of ICP excitation mechanisms, Single-cell analysis, Laboratory automation, Sample introduction methods for the ICP, e.g., laser sampling, direct sample insertion, and capillary electrophoresis-ICP interface. Dr. Chan's research programmes: Research interests are in the areas of analytical spectroscopy, with emphasis on the development and application of atomic spectrochemical measurement systems. Current research projects include time-resolved inductively coupled plasma- mass spectrometry (ICP-MS) and atomic emission spectrometry (ICP-AES) for single-cell and single-particle analysis, tandem technique of coupling microfluidic devices to the ICP, bottom-view ICP-AES, and direct sample insertion (DSI) for the ICP. Current Projects: 1. Time-resolved ICP-MS and ICP-AES for single-cell and single-particle analysis The project involves development of methodology of single particle introduction into the ICP, calibration with polydisperse standard particles, and characterization of the signal-production processes of nano-particles in ICP. The time-resolved ICP-MS method provides information on the distribution of metals in biological cells and the number density of the cells (on-line cytometry). Determination of the distribution of trace metals adsorbed / absorbed in biological cells is applied in the study of metal-cell interactions. 2. Ultrasonic dispersion of oils for the determination of trace metals and wear metal particles in oils We have developed a surfactant-free ultrasonic method for the preparation of oil-in-water dispersion for direct introduction of oils into the ICP for ICP-MS measurements. The method also allows single-particle analysis of nanoparticles in oils. Conventional microwave digestion for oil sample preparation will give only the average metal concentrations. 3. Bottom-view ICP-AES We have developed a method to measure ICP emission via the bottom of the ICP torch. A conventional radial-viewing ICP can be readily adapted to bottom-viewing. Similar enhancement in sensitivity as the axial-viewing ICP was observed: signal-to-background ratio (SBR) was increased by 5 times or more for atomic lines and 2-4 times for ionic lines. 4. Direct sample insertion (DSI) The project involves development of novel DSI probes for one-step analyte preconcentration/ matrix separation and fundamental studies of the effects of probe insertion on the excitation conditions of the ICP using conventional solid sample probe and hollow sample probe.

近期论文

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G.C.Y. Chan, W.T. Chan. J. Chem. Educ. 2001, 78, 1285-1288. G.C.Y. Chan, W.T. Chan. Spectrochim. Acta Part B 2002, 57, 1771-1787. G.C.Y. Chan, W.T. Chan. Spectrochim. Acta Part B 2003, 58, 1301-1317. G.C.Y. Chan, W.T. Chan. Spectrochim. Acta Part B 2004, 59, 41-58. A.W.K. Cheung, W.T. Chan. J. Anal. At. Spectrom. 2004, 19, 1111-1118. A.Y.N. Hui, G. Wang, B. Lin, W.T. Chan. Lab. Chip. 2005, 5, 1173-1177. M.H.P. Yau, W.T. Chan. J. Anal. At. Spectrom. 2005, 20, 1197-1202. A.Y.N. Hui, G. Wang, B. Lin, W.T. Chan. J. Anal. At. Spectrom. 2006, 21, 134-140. T.B.L. Tse, W.T. Chan. Spectrochim. Acta Part B 2008, 63, 861-867. K.S. Ho, W.T. Chan. J. Anal. At. Spectrom. 2010, 25, 1114-1122.