个人简介

B.S., 1988, Tunghai University, Taiwan Ph.D., 1997, Washington University, Missouri Postdoctoral, 1997-99, University of Minnesota

研究领域

Organic Chemistry

My laboratory is interested in the development of novel carbohydrate-containing molecules with biological activities and the practical applications of these molecules. Several synthetic methodologies in carbohydrate chemistry as well as other areas have developed. New classes of antibiotics with activity against drug-resistant bacterial pathogens, including Klebsiella pneumoniae, methicillin-resistant Staphylococcus aureus (MRSA) and Pseudomonas aeruginosa and vancomycin-resistant Enterococcus (VRE), have been developed. Novel compounds with prominent activity against various pathogenic fungi have been discovered. My laboratory has also constructed two classes of anticancer agents: cyclopamine-carbohydrate conjugates and heterocyclic glycosides. In addition to basic research, the practical applications of results from my research program have been pursued. Several lead compounds from various projects have been propelled into animal model studies, patent applications, and license negotiations.

近期论文

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Mattis, V. B.; Ebert, A. D.; Fosso, M. Y.; Chang, C.-W. T.; Lorson, C. L. “Delivery of a read-through inducing compound, TC007, lessens the severity of a SMA animal model.” Human Molecular Genetics 2009, 18, 3906-3913. Zhang, J.; Litke, A.; Keller, K.; Rai, R.; Chang, C.-W. T. “Synthesis of Novel Aminoglycosides via Allylic Azide Rearrangement for Investigating the Significance of 2'-Amino Group.” Bioorg. Med. Chem. 2010, 18, 1396-1405. Tanifum, C. T.; Zhang, J.; Chang, C.-W. T. “Combination of Solid Phase and Solution Phase Synthesis of Oligosaccharides Using Sonication.” Tetrahedron Lett. 2010, 51, 4323-4327. Chang, C.-W. T.; Fosso, M.; Kawasaki , Y.; Shrestha, S.; Bensaci, M. F.; Wang, J.; Evans, C. K.; Takemoto, J. Y. “Converting an Antibacterial Aminoglycoside into a Fungicide via Simple Chemical Modification. New Strategy for Reviving Old Drugs.” J. Antibiot. 2010, 63, 667-672. Zhang, J.; Redman, N.; Litke, P.; Zeng, J.; Zhan, J.; Chan, K. Y.; Chang, C.-W. T. “Synthesis and Antibacterial Activity Study of a Novel Class of Cationic Anthraquinone Analogs.” Bioorg. Med. Chem. 2011, 19, 498-503. Chan, K. Y.; Zhang, J.; Chang, C.-W. T. “Mode of Action Investigation for the Antibacterial Cationic Anthraquinone Analogs.” Bioorg. Med. Chem. Lett. 2011, 21, 6353-6356. Fosso, M. Y.; Chan, K. Y.; Gregory, R.; Chang, C.-W. T. "Library Synthesis and Antibacterial Investigation of Cationic Anthraquinone Analogs." ACS Comb. Sci. 2012, 14, 231−235. Lee, S. T.; Panter, K. E.; Gardner, D. R.; Green, B. T.; Welch, K. D.; Zhang, J.; Chang, C.-W. T. "Development of a monoclonal antibody-based ELISA for the hedgehog inhibitors cyclopamine and cyclopamine-KAAD." J. Pharmaceut. Biomed. 2012, 66, 282-286. .Mattisa, V. B.; Chang, C.-W. T.; Lorson, C. L. "Analysis of a read-through promoting compound in a severe mouse model of Spinal Muscular Atrophy." Neurosci. Lett. 2012, 525, 72-75. Fosso, M. Y.; Nziko, V. P. N.; Chang, C.-W. T. "Chemical Synthesis of N-Aryl Glycosides." J. Carbohydr. Chem. 2012, 31, 603-619. Udumula, V.; Ham, Y. W.; Fosso, M. Y.; Chen, K. Y.; Rai, R.; Zhang, J.; Li, J.; Chang, C.-W. T. "Investigation of Antibacterial Mode of Action for Traditional and Amphiphilic Aminoglycosides." Bioorg. Med. Chem. Lett. 2013, 23, 1671–1675. Ito,T.; Chen, D; Chang, C.-W. T.; Kenmochi, T.; Saito, T.; Suzuki, S.; Takemoto, J. Y. "Mesobiliverdin-IXa Enhances Rat Pancreatic Islet Yield and Function." Frontiers in Drug Metabolism and Transport, 2013, 4, 1-8. Lee, S. T.; Green, B. T.; Welch, K. D.; Jordan, G. T.; Zhang, Q.; Panter, K. E.; Hughes, D.; Chang, C.-W. T.; Pfister, J. A.; Gardner, D. R. "Stereoselective Potencies and Relative Toxicities of g-Coniceine and N-Methylconiine Enantiomers." Chem. Res. Toxicol. 2013, 26, 616−621. Shrestha, S.; Grilley, M.; Fosso, M.-Y.; Chang, C.-W. T.; Takemoto, J. Y. "Membrane lipid-modulated mechanism of action and non-cytotoxicity of novel fungicide aminoglycoside FG08." PLOS ONE, 2013, 8, e73843. Shrestha, J. P.; Chang, C.-W. T. "Safe and Easy Route for the Synthesis of 1,3-Dimethyl-1,2,3-triazolium Salt and Investigation of Its Anticancer Activities" Bioorg. Med. Chem. Lett. 2013, 23, 5909-5911. Zhang, Q.; Shrestha, J. P.; Chang, C.-W. T. "Synthesis of bioactive 1-alkyl-1H-naphtho[2,3-d][1,2,3]triazole-4,9-diones and N-aryl-2-aminomethylene-1,3-indanediones using water as the solvent." Tetrahedron Lett. 2014, 55, 1839-1842. Shrestha, J. P.; Fosso, M. Y.; Bearss, J.; Chang, C.-W. T. "Synthesis and anticancer structure activity relationship investigation of cationic anthraquinone analogs." Eur. J. Med. Chem. 2014, 77, 96-102. Lee, S.; Welch, K. D.; Panter, K. E.; Gardner, D. R.; Garrossian, M.; Chang, C.-W. T. "Cyclopamine: From Cyclops Lambs to Cancer Treatment." J. Agric. Food Chem. 2014, 62, 7355−7362. Chang, C.-W. T.; Takemoto, J, Y. "Antifungal Amphiphilic Aminoglycosides." MedChemComm, 2014, 5, 1048-1057. Nziko, V. P. N.; Fosso, M. Y.; Chang, C.-W. T. "Quantitative structure activity relationship analysis of antibacterial cationic anthraquinone analogs using Hansch and Fujita models." Med. Chem. Res., 2014, (DOI: 10.1007/s00044-014-1069-y)..