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个人简介

2008年/北京大学化学与分子工程学院/学士 2014年/斯坦福大学生物工程系/博士 2014-2015年/斯坦福大学生物工程系/博士后 2015-2015年/Agenovir公司/顾问研究员 2015-2021年/清华大学生命科学学院/助理教授 2022年-至今/清华大学生命科学学院/副教授

研究领域

重点关注分析化学和分子生物学技术的开发,并通过高通量精准定量分析,解决基础科研和临床诊疗中的分子和细胞测量问题。具体研究方向包括新型核酸和蛋白分析方法、疾病相关的分子病理分析、病原微生物遗传分析等。

近期论文

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X Liu#, J Yao#, Y Zhao, J Wang*, Hai Qi*. (2022). Heterogeneous plasma cells and long-lived subsets in response to immunization, autoantigen and microbiota. Nature Immunology 23, 1564. Xiannian Zhang#, Linna Peng#, Yingying Luo#, Shaosen Zhang#, Yang Pu#, Yamei Chen#, Wenjia Guo, Jiacheng Yao, Mingming Shao, Wenyi Fan, Qionghua Cui, Yiyi Xi, Yanxia Sun, Xiangjie Niu, Xuan Zhao, Liping Chen, Yuqian Wang, Yachen Liu, Xinyu Yang, Chengcheng Wang, Ce Zhong, Wen Tan, Jianbin Wang*, Chen Wu*, Dongxin Lin. (2021). Dissecting esophageal squamous-cell carcinoma ecosystem by single-cell transcriptomic analysis. Nature Communications. 12, 5291. Ruoyan Li#, Lin Di#, Jie Li#, Wenyi Fan#, Yachen Liu, Wenjia Guo, Weiling Liu, Lu Liu, Qiong Li, Liping Chen, Yamei Chen, Chuanwang Miao, Hongjin Liu, Yuqian Wang, Yuling Ma, Deshu Xu, Dongxin Lin*, Yanyi Huang*, Jianbin Wang*, Fan Bai*, Chen Wu*. (2021). A body map of somatic mutagenesis in morphologically normal human tissues. Nature. 597, 398–403. Xiaotian Li#, Lu Liu#, Jianyun Zhang, Ming Ma, Lisha Sun, Xuefen Li, Heyu Zhang*, Jianbin Wang*, Yanyi Huang*, Tiejun Li*. (2021). Improvement in the risk assessment of oral leukoplakia through morphology-related copy number analysis. Science China Life Sciences. 64, 1379–1391. Ming Ma#, Lu Liu#, Ruirui Shi#, Jianyun Zhang, Xiaotian Li, Xuefen Li, Jiaying Bai, Jianbin Wang*, Yanyi Huang*, Tiejun Li*. (2021). Copy number alteration profiling facilitates differential diagnosis between ossifying fibroma and fibrous dysplasia of the jaws. International Journal of Rral Science. 13, 21. Polakit Teekakirikul, Wenjuan Zhu, George C Gabriel, Cullen B Young, Kylia Williams, Lisa J Martin, Jennifer C Hill, Tara Richards, Marie Billaud, Julie A Phillippi, Jianbin Wang, Yijen Wu, Tuantuan Tan, William Devine, Jiuann-huey Lin, Abha S Bais, Jonathan Klonowski, Anne Moreau de Bellaing, Ankur Saini, Michael X Wang, Leonid Emerel, Nathan Salamacha, Samuel K Wyman, Carrie Lee, Hung Sing Li, Anastasia Miron, Jingyu Zhang, Jianhua Xing, Dennis M McNamara, Erik Fung, Paul Kirshbom, William Mahle, Lazaros K Kochilas, Yihua He, Vidu Garg, Peter White, Kim L McBride, D Woodrow Benson, Thomas G Gleason, Seema Mital, and Cecilia W Lo*. (2021). Common deletion variants causing protocadherin-a deficiency contribute to the complex genetics of BAV and left-sided congenital heart disease. Human Genetics and Genomics Advances. 2, 100037. Yong Li#, Yi He$, Junya Peng$, Zhendong Su, Zeyao Li, Bingjie Zhang, Jing Ma, Meilian Zhuo, Di Zou, Xinde Liu, Xinhong Liu, Wenze Wang, Dan Huang, Mengyue Xu, Jianbin Wang, Haiteng Deng, Jing Xue, Wei Xie, Xun Lan, Mo Chen, Yupei Zhao*, Wenming Wu*, Charles J David*. (2021). Mutant Kras co-opts a proto-oncogenic enhancer network in inflammation-induced metaplastic progenitor cells to initiate pancreatic cancer. Nature Cancer. 2, 49–65. Mengcheng Jiang, Peiyu Liao, Yue Sun, Xinyang Shao, Zitian Chen, Peng Fei, Jianbin Wang, Yanyi Huang*. (2021). Rotational scan digital LAMP for accurate quantitation of nucleic acids. Lab on a Chip. 21, 2265–2271. Jiaxin Gao, Eve W L Chow, Haitao Wang, Xiaoli Xu, Chunling Cai, Yabing Song, Jianbin Wang*, Yue Wang*. (2021). LncRNA DINOR is a virulence factor and global regulator of stress responses in Candida auris. Nature Microbiology. 6, 842–851. Yongxi Zhao#, Xiaolei Zuo#, Qian Li#, Feng Chen, Yan Ru Chen, Jinqi Deng, Da Han, Changlong Hao, Fujian Huang, Yanyi Huang, Guoliang Ke, Hua Kuang, Fan Li, Jiang Li, Min Li, Na Li, Zhenyu Lin, Dingbin Liu, Juewen Liu, Libing Liu, Xiaoguo Liu, Chunhua Lu, Fang Luo, Xiuhai Mao, Jiashu Sun, Bo Tang, Fei Wang, Jianbin Wang, Lihua Wang, Shu Wang, Lingling Wu, Zai Sheng Wu, Fan Xia, Chuanlai Xu, Yang Yang, Bi Feng Yuan, Quan Yuan, Chao Zhang, Zhi Zhu, Chaoyong Yang*, Xiao Bing Zhang*, Huanghao Yang*, Weihong Tan*, Chunhai Fan*. (2021). Nucleic Acids Analysis (Review). Science China Chemistry. 64, 171–203. Bo Liu, Yihan Lin, Jiacong Yan, Jiacheng Yao, Dan Liu, Weiwei Ma, Jianbin Wang, Wanli Liu, Chengshuo Wang, Luo Zhang, and Hai Qi*. (2021). Affinity-coupled CCL22 promotes positive selection in germinal centres. Nature. 592, 133–137. Shijun Xu, Lei Li, Yuwei Fu, Xin Wang, Hairui Sun, Jianbin Wang, Lu Han, Zining Wu, Yongmin Liu, Junming Zhu, Lizhong Sun, Feng Lan, Yihua He*, Hongjia Zhang*. (2020). Increased frequency of FBN1 frameshift and nonsense mutations in Marfan syndrome patients with aortic dissection. Molecular Genetics & Genomic Medicine. 8, e1041. Yuduo Wu, Hairui Sun, Jianbin Wang, Xin Wang, Ming Gong, Lu Han, Yihua He*, Hongjia Zhang*. (2020). Marfan syndrome: whole-exome sequencing reveals de novo mutations, second gene and genotype-phenotype correlations in the Chinese population. Bioscience reports. 40, 12. Chen Chen#, Jizhou Li#, Lin Di#, Qiuyu Jing#, Pengcheng Du#, Chuan Song, Jiarui Li, Qiong Li, Yunlong Cao, X Sunney Xie, Angela R Wu*, Hui Zeng*, Yanyi Huang*, and Jianbin Wang*. (2020). MINERVA: A Facile Strategy for SARS-CoV-2 Whole-Genome Deep Sequencing of Clinical Samples. Molecular Cell. 80, 1123. Pengcheng Du#, Chuan Song#, Rui Li#, Yangzi Song#, Jiarui Li, Nan Ding, Ju Zhang, Rui Song, Junyan Han, Guiju Gao, Jinglin Yue, Ang Duan, Yanyi Huang, Jing An, Jianbin Wang*, Fujie Zhang*, Chen Chen*, and Hui Zeng*. (2020). Specific re-distribution of SARS-CoV-2 variants in the respiratory system and intestinal tract. Clinical Infectious Diseases, Accepted. Xinghuo Pang#, Lili Ren#, Shuangsheng Wu#, Wentai Ma#, JianYang, Lin Di, Jie Li, Yan Xiao, Lu Kang, Shichang Du, Jing Du, Jing Wang, Gang Li, Shuguang Zhai, Lijuan Chen, Wenxiong Zhou, Shengjie Lai, Lei Gao, Yang Pan*, Quanyi Wang*, Mingkun Li*, Jianbin Wang*, Yanyi Huang*, Jianwei Wang*, COVID-19 Field Response Group, and COVID-19 Laboratory Testing Group. (2020). Cold-chain food contamination as the possible origin of Covid-19 resurgence in Beijing. National Science Review, 7, 1861. Pengcheng Du#, Nan Ding#, Jiarui Li#, Fujie Zhang#, Qi Wang#, Zhihai Chen, Chuan Song, Kai Han, Wen Xie, Jingyuan Liu, Linghang Wang, Lirong Wei, Shanfang Ma, Mingxi Hua, Fengting Yu, Lin Wang, Wei Wang, Kang An, Jianjun Chen, Haizhou Liu, Guiju Gao, Sa Wang, Yanyi Huang, Angela R. Wu, Jianbin Wang*, Di Liu*, Hui Zeng*, Chen Chen*. (2020). Genomic surveillance of COVID-19 cases in Beijing. Nature Communications, 11, 5503. Peiyu Liao#, Mengcheng Jiang#, Zitian Chen, Fangli Zhang, Yue Sun, Jun Nie, Meijie Du, Jianbin Wang*, Peng Fei*, and Yanyi Huang*. (2020). Lossless and Contamination-Free Digital PCR. Proc. Natl. Acad. Sci. USA. 117, 25628. Meijie Du, Yihua He, Jian Chen, Hairui Sun, Yuwei Fu, and Jianbin Wang*. (2020). Unique dual indexing PCR reduces chimeric contamination and improves mutation detection in cell-free DNA of pregnant women. Talanta 217, 121035. Hairui Sun, T Yi, Xiaoyan Hao, H Yan, Jianbin Wang, Q Li, Xiaoyan Gu, X Zhou, S Wang, X Wang, P Wan, Ling Han, Jian Chen, H Zhu, Hongjia Zhang*, and Yihua He*. (2020). Contribution of single‐gene defects to congenital cardiac left‐sided lesions in the prenatal setting. Ultrasound in Obstetrics and Gynecology 56, 225–232. Zeyao Li#, Haitao Wang#, Chunling Cai, Ada Hang-Heng Wong, Jianbin Wang*, Jiaxin Gao*, and Yue Wang*. (2020). Genome-wide piggyBac transposon-based mutagenesis and quantitative insertion-site analysis in haploid Candida species. Nature Protocols 15, 2075-27. Jiacheng Yao#, Qionghua Cui#, Wenyi Fan#, Yuling Ma#, Yamei Chen#, Tianyuan Liu#, Xiannian Zhang, Yiyi Xi, Chengcheng Wang, Linna Peng, Yingying Luo, Ai Lin, Wenjia Guo, Lin Lin, Yuan Lin, Wen Tan, Dongxin Lin*, Chen Wu*, and Jianbin Wang*. (2020). Single-cell transcriptomic analysis in a mouse model deciphers cell transition states in the multistep development of esophageal cancer. Nature Communications 11, 3715. Lin Di#, Yusi Fu#, Yue Sun, Jie Li, Lu Liu, Jiacheng Yao, Guanbo Wang, Yalei Wu, Kaiqin Lao, Raymond W Lee, Genhua Zheng, Jun Xu, Juntaek Oh, Dong Wang, X Sunney Xie*, Yanyi Huang*, and Jianbin Wang*. (2020). RNA sequencing by direct tagmentation of RNA/DNA hybrids. Proc. Natl. Acad. Sci. USA., 117, 2886–2893. Ruozhu Zhao, Xin Chen, Weiwei Ma, Jinyu Zhang, Jie Guo, Xiu Zhong, Jiacheng Yao, Jiahui Sun, Julian Rubinfien, Xuyu Zhou, Jianbin Wang, and Hai Qi*. (2020). A GPR174–CCL21 module imparts sexual dimorphism to humoral immunity. Nature. 577, 416-420. Pengchong Wang#, Wei Tang#, Zeyao Li#, Zhongyu Zou, Ying Zhou, Ran Li, Tianyu Xiong, Jianbin Wang*, Peng Zou*. (2019). Mapping spatial transcriptome with light-activated proximity-dependent RNA labeling. Nature Chemical Biology. 15, 1110-9 . Shuang Geng, Jing Wang, Xiannian Zhang, Jia jia Zhang, Fan Wu, Yuhong Pang, Yuping Zhong, Jianbin Wang, Wenming Wang, Xiaoqing Lyu, Yanyi Huang*, and Hongmei Jing*. (2019). Single‐cell RNA sequencing reveals chemokine self‐feeding of myeloma cells promotes extramedullary metastasis. FEBS Letters. 594, 452–465. Ying Zhou#, Gang Wang#, Pengchong Wang, Zeyao Li, Tieqiang Yue, Jianbin Wang, and Peng Zou*. (2019). Expanding APEX2 Substrates for Proximity-Dependent Labeling of Nucleic Acids and Proteins in Living Cells. Angewandte Chemie International Edition. 58, 11763-7. Xi Chen, Lin Wang, Rujin Huang, Hui Qiu, Peizhe Wang, Daren Wu, Yonglin Zhu, Jia Ming, Yangming Wang, Jianbin Wang, and Jie Na*. (2019). Dgcr8 deletion in the primitive heart uncovered novel microRNA regulating the balance of cardiac-vascular gene program. Protein & Cell. 10, 327–346. Jian Chen, Jianbin Wang, Hairui Sun, Xiaoyan Gu, Xiaoyan Hao, Yuwei Fu, Ye Zhang, Xiaowei Liu, Hongjia Zhang, Ling Han, and Yihua He*. (2019). Fetal cardiac tumors: fetal echocardiography, clinical outcome and genetic analysis in 53 cases. Ultrasound in Obstetrics and Gynecology. 2, 6159. Yusi Fu#, Fangli Zhang#, Xiannian Zhang, Junlong Yin, Meijie Du, Mengcheng Jiang, Lu Liu, Jie Li, Yanyi Huang*, and Jianbin Wang*. (2019). High-throughput single-cell whole-genome amplification through centrifugal emulsification and eMDA. Communications Biology. 2, 147. Dongqing Jiang, Xiannian Zhang, Yuhong Pang, Jianyun Zhang, Jianbin Wang*, Yanyi Huang*. (2018). Terminal transfer amplification and sequencing for high- efficiency and low-bias copy number profiling of fragmented DNA samples. Protein Cell. 10, 229. Xiannian Zhang#, Tianqi Li#, Feng Liu#, Yaqi Chen#, Jiacheng Yao, Zeyao Li, Yanyi Huang*, and Jianbin Wang*. (2019). Comparative analysis of droplet-based ultra-high-throughput single-cell RNA-seq systems. Molecular Cell. 73, 130. Jiaxin Gao, Haitao Wang, Zeyao Li, Ada Hang-Heng Wong, Yizheng Wang, Yahui Guo, Xin Lin, Guisheng Zeng, Yue Wang*, and Jianbin Wang*. (2018). Candida albicans gains azole resistance by altering sphingolipid composition. Nature Communications. 9, 4495. Yi Zhang#, Jiaxin Gao#, Yanyi Huang*, and Jianbin Wang*. (2018). Recent Developments in Single-Cell RNA-Seq of Microorganisms (Review). Biophysical Journal, 115, 173–180. Guanqun Wang#, Meijie Du#, Jianbin Wang*, Ting F Zhu*. (2018). Genetic variation may confound analysis of CRISPR-Cas9 off-target mutations. Cell Discovery. 4, 18. He Chen, Jiacheng Yao, Yusi Fu, Yuhong Pang, Jianbin Wang*, Yanyi Huang*. (2018). Tagmentation on microbeads: restore long-range DNA sequence information using next generation sequencing with library prepared by surface-immobilized transposomes. ACS Applied Materials & Interfaces, 10, 11539-11545. Jianbin Wang*, Angela R Wu*. (2018). A head-to-toe makeover for classical sequencing-by-synthesis helps users to squeeze more out of each base (Highlight). National Science Review. 35, 1170. Angela R Wu*, Jianbin Wang*, Aaron M Streets*, Yanyi Huang*. (2017). Single-Cell Transcriptional Analysis (Review). Annual Review of Analytical Chemistry, 10, 439–462. Stephanie Tzouanas Schmidt, Stephanie M Zimmerman, Jianbin Wang, Stuart K Kim, Stephen R Quake*. (2017). Quantitative Analysis of Synthetic Cell Lineage Tracing Using Nuclease Barcoding. ACS Synthetic Biology, 6, 936–942 . Peter A Underhill*, G David Poznik, Siiri Rootsi, Mari J?rve, Alice A Lin, Jianbin Wang, Ben Passarelli, Jad Kanbar, Natalie M Myres, Roy J King, Julie Di Cristofaro, Hovhannes Sahakyan, Doron M Behar, Alena Kushniarevich, Jelena ?arac, Tena ?aric, Pavao Rudan, Ajai Kumar Pathak, Gyaneshwer Chaubey, Viola Grugni, Ornella Semino, Levon Yepiskoposyan, Ardeshir Bahmanimehr, Shirin Farjadian, Oleg Balanovsky, Elza K Khusnutdinova, Rene J Herrera, Jacques Chiaroni, Carlos D Bustamante, Stephen R Quake, Toomas Kivisild, and Richard Villems. (2015). The phylogenetic and geographic structure of Y-chromosome haplogroup R1a. European Journal of Human Genetics, 23(1), 124-31. Jianbin Wang and Stephen R Quake*. (2014). RNA-guided endonuclease provides a therapeutic strategy to cure latent herpesviridae infection. Proc. Natl. Acad. Sci. USA., 111(36), 13157–62. Charles F A de Bourcy#, Iwijn De Vlaminck#, Jad N Kanbar#, Jianbin Wang, Charles Gawad, and Stephen R Quake*. (2014). A Quantitative Comparison of Single-Cell Whole Genome Amplification Methods. PLoS ONE, 9(8), e105585. Jianbin Wang#, H Christina Fan#, Barry Behr, and Stephen R Quake*. (2012). Genome-wide single-cell analysis of recombination activity and de novo mutation rates in human sperm. Cell, 150(2), 402–12. H Christina Fan#3, Wei Gu#, Jianbin Wang, Yair J Blumenfeld, Yasser Y El-Sayed, and Stephen R Quake*. (2012). Non-invasive prenatal measurement of the fetal genome. Nature, 487(7407), 320–4. Yongfan Men#, Qiang Yu#, Zitian Chen, Jianbin Wang, Yanyi Huang*, and Hongwei Guo*. (2012). A high-throughput imaging system to quantitatively analyze the growth dynamics of plant seedlings. Integrative Biology, 4(8), 945–52. Chunhong Zheng, Jingwen Wang, Yuhong Pang, Jianbin Wang, Wenbin Li, Zigang Ge*, and Yanyi Huang*. (2012). High-throughput immunoassay through in-channel microfluidic patterning. Lab Chip, 12(14), 2487-90. Piero Dalerba#, Tomer kalisky#, Debashis Sahoo#, Pradeep S Rajendran, Michael E Rothenberg, Anne A Leyrat, Sopheak Sim, Jennifer Okamoto, Darius M Johnston, Dalong Qian, Maider Zabala, Janet Bueno, Norma F Neff, Jianbin Wang, Andrew A Shelton, Brendan Visser, Shigeo Hisamori, Yohei Shimono, Marc van de Wetering, Hans Clevers, Michael F Clarke*, and Stephen R Quake*. (2011). Single-cell dissection of transcriptional heterogeneity in human colon tumors. Nat Biotechnol, 29(12), 1120-7. Xun Xu, Harish Nagarajan, Nathan E Lewis, Shengkai Pan, Zhiming Cai, Xin Liu, Wenbin Chen, Min Xie, Wenliang Wang, Stephanie Hammond, Mikael R Andersen, Norma Neff, Benedetto Passarelli, Winston Koh, H Christina Fan, Jianbin Wang, Yaoting Gui, Kelvin H Lee, Michael J Betenbaugh, Stephen R Quake, Iman Famili, Bernhard O Palsson, and Jun Wang. (2011). The Genomic Sequence of the Chinese Hamster Ovary (CHO)-K1 Cell Line. Nat Biotechnol, 29(8), 735-41. H Christina Fan, Jianbin Wang, Anastasia Potanina, and Stephen R Quake*. (2011). Whole Genome Molecular Haplotyping of Single Cells. Nat Biotechnol, 29(1), 51-7. Jianbin Wang#, Ying Zhou#, Haiwei Qiu, Huang Huang, Changhong Sun, Jianzhong Xi*, and Yanyi Huang*. (2009). A chip-to-chip nanoliter microfluidic dispenser. Lab Chip, 9(13), 1831-5. Lin Li, Jianbin Wang, Shuang Zhou, and Meiping Zhao*. (2008). Development and characterization of an immunoaffinity monolith for selective on-line extraction of bisphenol A from environmental water samples. Anal Chim Acta, 620(1-2), 1-7. Zhiyong Chen, Li Xu, Yuan Liang, Jianbin Wang, Meiping Zhao*, and Yuanzong Li*. (2008). Polyethylene glycol diacrylate-based supermacroporous monolithic cryogel as high-performance liquid chromatography stationary phase for protein and polymeric nanoparticle separation. J Chromatogr A, 1182(1), 128-31. Jianbin Wang, H X Wang, and T B Ng*. (2007). A peptide with HIV-1 reverse transcriptase inhibitory activity from the medicinal mushroom Russula paludosa. Peptides, 28(3), 560-5.

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