Rehder, Vincent - Georgia State University

个人简介

Ph.D. Zoology Free University, Berlin 1987 Neurobiology & Behavior Group Cellular, Molecular Biology and Physiology Group Developmental Neurobiology

研究领域

My laboratory is concerned with the development of the nervous system and understanding the mechanisms by which neurons establish neurons establish their specific connections. After birth, neurons initiate axons and dendrites that are tipped by growth cones. The latter are important structures not only for neurite elongation, pathfinding, target identification and, likely, synapse formation, but also in the regenerating nervous system, where growth cones are formed from the proximal axonal stumps of injured neurons. It is the regulation of neuronal growth cone form, especially the regulation of filopodia, that is in the center of our research. We employ identified neurons from the pond snail Helisoma trivolvis and dorsal root ganglion (DRG) neurons from chicks to investigate the signaling pathways by which growth cone filopodia are being regulated in length and number. With this knowledge we start to understand how extracellular signals such as trophic factors, molecules of the extracellular matrix, neurotransmitter, etc., can, by activating specific second messenger systems, stereotypically affect neuronal filopodia with likely far-reaching consequences for growth cone navigation. In our studies we employ light microscopy, electron microscopy, immunocytochemistry, video-enhanced imaging, quantitative calcium imaging and molecular biological techniques.

近期论文

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Evolutionary insights into T-type Ca2+ channel structure, function, and ion selectivity from the Trichoplax adhaerens homologue. Smith CL, Abdallah S, Wong YY, Le P, Harracksingh AN, Artinian L, Tamvacakis AN, Rehder V, Reese TS, Senatore A. J Gen Physiol. 2017 Apr 3;149(4):483-510. doi: 10.1085/jgp.201611683. Epub 2017 Mar 22. Match of Solubility Parameters Between Oil and Surfactants as a Rational Approach for the Formulation of Microemulsion with a High Dispersed Volume of Copaiba Oil and Low Surfactant Content. Xavier-Junior FH, Huang N, Vachon JJ, Rehder VL, do Egito ES, Vauthier C. Pharm Res. 2016 Dec;33(12):3031-3043. Epub 2016 Sep 6. In vitro Activities of Pfaffia glomerata Root Extract, Its Hydrolyzed Fractions and Pfaffic Acid Against Trypanosoma cruzi Trypomastigotes. Silva ML, Pereira AC, Ferreira DS, Esperandim VR, Símaro GV, Lima TC, Januário AH, Pauletti PM, Rehder VL, Crevelin EJ, Cunha WR, Crotti AE, Bastos JK. Chem Biodivers. 2017 Jan;14(1). doi: 10.1002/cbdv.201600175. Epub 2017 Jan 3. Modulation of growth cone filopodial length by carbon monoxide. Estes S, Artinian L, Rehder V. Dev Neurobiol. 2017 Jun;77(6):677-690. doi: 10.1002/dneu.22430. Epub 2016 Aug 22. Regulation of electrical activity and neuronal excitability in Helisoma trivolvis by carbon monoxide. Estes S, Zhong LR, Artinian L, Rehder V. Neuroscience. 2015 Dec 17;311:453-63. doi: 10.1016/j.neuroscience.2015.10.056. Epub 2015 Nov 3. Chemical Characterization and Antimicrobial Activity Evaluation of Natural Oil Nanostructured Emulsions. Alencar EN, Xavier-Júnior FH, Morais AR, Dantas TR, Dantas-Santos N, Verissimo LM, Rehder VL, Chaves GM, Oliveira AG, Egitol ES. J Nanosci Nanotechnol. 2015 Jan;15(1):880-8. The Histone Demethylase UTX Promotes Brown Adipocyte Thermogenic Program Via Coordinated Regulation of H3K27 Demethylation and Acetylation. Zha L, Li F, Wu R, Artinian L, Rehder V, Yu L, Liang H, Xue B, Shi H. J Biol Chem. 2015 Oct 9;290(41):25151-63. doi: 10.1074/jbc.M115.662650. Epub 2015 Aug 25. Cell-specific regulation of neuronal activity by endogenous production of nitric oxide. Zhong LR, Estes S, Artinian L, Rehder V. Eur J Neurosci. 2015 Apr;41(8):1013-24. doi: 10.1111/ejn.12875. Epub 2015 Mar 25.