孙坚原 - 中国科学院生物物理研究所 -

个人简介

1993 博士，华东师范大学 1993-1997 讲师，副教授，华东师范大学生物系脑功能研究室 1997-1999 获马普奖学金，德国马普医学所博士后 1999-2002 美国华盛顿大学麻醉系研究助理 2002-2008 美国德州大学西南医学中心神经科学系研究助理教授 2008- 中国科学院生物物理研究所研究员

研究领域

1）怎样的分子生物学机制决定了神经突触钙通道与突触囊泡的耦合，这一耦合是如何调控突触囊泡释放率、释放动力学以及突触可塑性的；2）神经递质释放参与神经编码的信号机制

近期论文

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1.Sun J-Y*, Pang ZP, Qin D-Q, Fahim A, Adachi R, and Südhof TC*, A Dual-Ca2+-Sensor Model for Neurotransmitter Release in a central Synapse. NATURE , 450(7170):676-683, 2007 2.Khvotchev M, Dulubova I, Sun J-Y, Dai H, Rizo J, and Sudhof, Dual Modes of Munc18-1/SNARE Interactions Are Coupled by Functionally Critical Binding to Syntaxin-1 N Terminus, JOURNAL OF NEUROSCIENCE, 27(45):12147-55, 2007 3.Sun J-Y*, Bronk P, Liu X, Han W, Südhof TC*. Synapsins regulate use-dependent synaptic plasticity in the calyx of Held by a Ca2+/calmodulin-dependent pathway. Proc Natl Acad Sci USA, 103(8):2880-5, 2006 4.Pang ZP, Sun J-Y, Rizo J, Maximov A, Südhof TC. Genetic analysis of synaptotagmin 2 in spontaneous and Ca2+-triggered neurotransmitter release. EMBO JOURNAL, 25(10):2039-50, 2006(co-first author) 5.Wu, X-S, Sun J-Y, Evers AS, Crowder M, Wu L-G, Isoflurane inhibits transmitter release and the presynaptic action potential, ANESTHESIOLOGY, 100(3):663-670, 2004 6.Sun, J-Y, Wu W, Wu X-S, Jin S-X, Dondzillo A, Wu L-G, Capacitance Capacitance measurements at the calyx of Held in the medial nucleus of the trapezoid body, JOURNAL OF NEUROSCIENCE METHOD, 134(2):121-131, 2004 7.Sun J-Y, Wu X-S, Wu, L-G , Single and multiple vesicle fusion induce different rates of endocytosis at a central synapse, NATURE, 417(6888):555-559, 2002.(co-first author) 8.Sun J-Y, Wu L-G, Fast Kinetics of exocytosis revealed by simultaneous measurements of presynaptic capacitance and postsynaptic currents at a central synapse, NEURON, 30:171-182, 2001.