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个人简介

1997-2001 南京大学基础教学强化部,获理学学士学位 2001-2006 清华大学医学院,获生物物理学博士学位 2006-今 中国科学院生物物理研究所,研究员;课题组组长;蛋白质科学研究平台生物成像中心首席科学家(兼主任)。 2018.01-今 中国科学院大学, 生命科学学院, 长江青年学者

研究领域

生物大分子复合体(如膜蛋白、超分子蛋白复合体)的结构与功能

近期论文

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1. Ren Z., Zhang Y., Zhang Y., He Y., Du P., Wang Z., Sun F.* and Ren H.* (2019) Cryo-EM structure of actin filaments from Zea mays pollen. Plant Cell. pii: tpc.00973.2018. doi: 10.1105/tpc.18.00973. 2. Zhu G., Zeng H., Zhang S., Juli J., Pang X., Hoffmann J., Zhang Y., Morgner N., Zhu Y., Peng G., Michel H., Sun F. (2019) A 3.3 ?-resolution Structure of Hyperthermophilic Respiratory Complex III Reveals the Mechanism of its Thermal Stability. Angewandte Chemie. (In press) doi: 10.1002/anie.201911554 3. Li X., Zhang S., Zhang J. and Sun F.* (2018), In situ protein micro-crystal fabrication by cryo-FIB for electron diffraction. Biophysics Reports, 4(6): 339-347. doi: 10.1007/s41048-018-0075-x. 4. Gong H., LI L., Xu A., Tang Y., Ji W., Gao R., Wang S., Yu L., Tian C., Li J., Yen H.Y., Lam S.M., Shui G., Yang X., Sun Y., Li X., Jia M., Yang C., Jiang B., Lou Z., Robinson C., Wong L.L., Guddat L.W., Sun F.*, Wang Q.* and Rao Z.* (2018), A electron transfer path connects subunits of a mycobacterial respiratory supercomplex. Science 362(6418), pii: eaat8923. doi: 10.1126/science.aat8923. 5. Sun F.* (2018) Orienting the future of bio-macromolecular electron microscopy. Chinese Physics B, 27 (6) : 060503. doi: 10.1088/1674-1056/27/6/06360. [Review-CPB-Orienting the future of bio-macromolecular electron microscopy.pdf] 6. Xin Y., Shi Y., Niu T., Wang Q., Niu W., Huang X., Ding W., Yang L., Blankenship R. E., Xu X.* and Sun F.* (2018) Cryo-EM structure of the RC-LH core complex from an early branching photosynthetic prokaryote. Nature communications, 9 : 1568. doi: 10.1038/s41467-018-03881-x. 7. Li S., Ji G.*, Shi Y., Klausen L.H., Niu T., Wang S., Huang X., Ding W., Zhang X., Dong M., Xu W., and Sun F.* (2018), High-vacuum optical platform for cryo-CLEM(HOPE): a new solution for non-integrated multiscale correlative light and electron microscopy. Journal of Structural Biology, 201(1): 63-75. 8. Lu G., Xu Y., Zhang K., Xiong Y., Li H., Cui L., Wang X., Lou J., Zhai Y.*, Sun F.* and Zhang X.C.* (2017), Crystal structure of E. coli apolipoprotein N-acyltransferase. Nature Communications, 8:15948. 9. Chen R., Gao B., Liu, X., Ruan F., Zhang Y., Lou J., Feng K., Wunsch C., Li S.M., Dai J.* and Sun F.* (2016), Molecular insights into the enzyme promiscuity of an aromatic prenyltransferase. Nature Chemical Biology (Advanced online at Dec. 19, 2016) 10. Wei R., Wang X., Zhang Y., Mukherjee S., Zhang L., Chen Q., Huang X., Jing S., Liu C., Li S., Wang G., Xu Y., Zhu S., Williams A., Sun F.* and Yin C.C.* (2016), Structural insights into Ca2+ -activated long-range allosteric channel gating of RyR1. Cell Research 26: 977-994 (Cover story). 11. Deng Y., Chen Y., Zhang Y., Wang S., Zhang F.* and Sun F.* (2016), ICON: 3D reconstruction with ‘missing-information’ restoration in biological electron tomography. Journal of Structural Biology 195(1) : 100-112. 12. Pang, X., Fan, J., Zhang, Y., Zhang, K., Gao, B., Ma, J., Li, J., Deng, Y., Zhou, Q., Egelman, E.H., Hsu, V.W.* and Sun, F.* (2014), A PH Domain in ACAP1 Possesses Key Features of the BAR Domain in Promoting Membrane Curvature. Developmental Cell, 31(1) : 73-86 13. Zhou, Q., Li, J., Yu, H., Zhai, Y., Gao Z., Liu, Y., Pang, X., Zhang, L., Schulten K., Sun, F.* and Chen, C.* (2014), Molecular insights into the membrane-associated phosphatidylinositol 4-kinase IIα. Nature Communications, 5:3552. 14. Wang, X., Xu, F., Liu, J., Gao, B., Liu, Y., Zhai, Y., Ma, J., Zhang, K., Baker, T. S., Schulten, K., Zheng, D.*, Pang, H.*, and Sun, F.* (2013) Atomic model of rabbit hemorrhagic disease virus by cryo-electron microscopy and crystallography. PLoS Pathog 9, e1003132

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