Steitz, Joan A - Yale University - Biological & Biomedical Sciences

个人简介

As a college student in the 1960s, Joan Steitz never imagined herself as a top-flight scientist. Certainly, she was fascinated by science. She even assisted senior scientists in laboratories at the Massachusetts Institute of Technology, where she was befriended by James D. Watson, co-discoverer of the DNA double helix, and at the Max Planck Institute in Germany. But when it came time to choose a career path, she had never seen a female professor or head of lab. So, she never aspired to such goals. Today, Prof. Joan Steitz is one of leading scientists in her field. Steitz is best known for her pioneering work in RNA. She and her student Michael Lerner discovered and defined the function of small ribonucleoproteins (snRNPs) in pre-messenger RNA—the earliest product of DNA transcription—and was the first to learn that these cellular complexes (snRNPs) play a key role in processing messenger RNA by excising noncoding regions and splicing together the resulting segments. Her breakthroughs into the previously mysterious splicing process have clarified the science behind the formation of proteins and other biological processes, including the intricate changes that occur as the immune system and brain develop. Steitz earned her Ph.D. from Harvard in 1967. After completing postdoctoral work in Cambridge, England, she joined the Department of Molecular Biophysics and Biochemistry at Yale as an assistant professor and later became an associate and full professor, as well as chair of the department. PhD Harvard University (1967) BS Antioch College (1963) Postdoctoral Fellow Medical Research Council Laboratory of Molecular Biology, Cambridge, England

研究领域

Autoantibodies; Biochemistry; Biophysics; Cell Transformation, Viral; RNA Processing, Post-Transcriptional; Gene Expression; Ribonucleoproteins, Small Nuclear

近期论文

查看导师新发文章（温馨提示：请注意重名现象，建议点开原文通过作者单位确认）

Herpesvirus saimiri microRNAs Preferentially Target Host Cell-Cycle Regulators. Guo YE, Oei T, Steitz JA. Herpesvirus saimiri microRNAs Preferentially Target Host Cell-Cycle Regulators. J Virol. 2015 Aug 19. pii: JVI.01884-15. 2015 [Epub ahead of print] The host Integrator complex acts in transcription-independent maturation of herpesvirus microRNA 3' ends. Xie M, Zhang W, Shu MD, Xu A, Lenis DA, DiMaio D, Steitz JA. The host Integrator complex acts in transcription-independent maturation of herpesvirus microRNA 3' ends. Genes Dev. 2015 Jul 15;29(14):1552-64. doi: 10.1101/gad.266973.115. Noncoding RNA-guided recruitment of transcription factors: A prevalent but undocumented mechanism? Lee N, Steitz JA. Bioessays. 2015 Sep;37(9):936-41. doi: 10.1002/bies.201500060. Epub 2015 Jul 22. Widespread Inducible Transcription Downstream of Human Genes. Vilborg A, Passarelli MC, Yario TA, Tycowski KT, Steitz JA. Mol Cell. 2015 Aug 6;59(3):449-61. doi: 10.1016/j.molcel.2015.06.016. Epub 2015 Jul 16. Proteomics and Transcriptomics of BJAB Cells Expressing the Epstein-Barr Virus Noncoding RNAs EBER1 and EBER2. Pimienta G, Fok V, Haslip M, Nagy M, Takyar S, Steitz JA. PLoS One. 2015 Jun 29;10(6):e0124638. doi: 10.1371/journal.pone.0124638. eCollection 2015. In silico discovery and modeling of non-coding RNA structure in viruses. Moss WN, Steitz JA. Methods. 2015 Jun 23. pii: S1046-2023(15)30003-7. doi: 10.1016/j.ymeth.2015.06.015. [Epub ahead of print] Review. Viral noncoding RNAs: more surprises. Tycowski KT, Guo YE, Lee N, Moss WN, Vallery TK, Xie M, Steitz JA. Genes Dev. 2015 Mar 15;29(6):567-84. doi: 10.1101/gad.259077.115. Review. Virus meets host microRNA: the destroyer, the booster, the hijacker. Guo, Y.E., and Steitz, J.A. (2014). Virus meets host microRNA: the destroyer, the booster, the hijacker. Molec. Cell Biol. 34, 3780-3787. Structural insights into the stabilization of MALAT1 noncoding RNA by formation of a bipartite triple helix. Brown, J.A., Bulkley, D., Wang, J., Valenstein, M.L., Yario, T.A., Steitz, T.A., and Steitz, J.A. (2014). Structural insights into the stabilization of MALAT1 noncoding RNA by formation of a bipartite triple helix. Nat. Struct. Mol. Biol 21, 633-640. PMCID: PMC4096706 Alternative capture of noncoding RNAs or protein-coding genes by Herpesviruses to alter host T-cell function. Guo, Y.E., Riley, K.J., Iwasaki, A., Steitz, J.A. (2014) Alternative capture of noncoding RNAs or protein-coding genes by Herpesviruses to alter host T-cell function. Molec. Cell 54, 67-79. PMCID: PMC4039351 Genome-wide analyses of Epstein-Barr virus reveal conserved RNA structures and a novel stable intronic sequence RNA. Moss, W.N., and Steitz, J.A. (2013). Genome-wide analyses of Epstein-Barr virus reveal conserved RNA structures and a novel stable intronic sequence RNA. BMC Genomics 14, 543. PMCID: PMC3751371 Human spliceosomal protein CWC22 plays a role in coupling splicing to exon junction complex deposition and nonsense-mediated decay. Alexandrov, A., Colognori, D., Shu, M-D., and Steitz, J.A. (2012). Human spliceosomal protein CWC22 plays a role in coupling splicing to exon junction complex deposition and nonsense-mediated decay. Proc. Natl. Acad. Sci., USA. 109, 21313-21318. PMCID: PMC3535618 Formation of triple-helical structures by the 3'-end sequences of MALAT1 and MENß noncoding RNAs