Small, Dana - Yale University - Biological & Biomedical Sciences

个人简介

PhD McGill University (2001) MSc McGill University (1998)

研究领域

Dopamine; Motivation; Neurophysiology; Obesity; Psychophysics; Stress, Psychological; Neuroimaging; Psychiatry and Psychology

近期论文

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Neuroimaging techniques such as functional magnetic resonance imaging (fMRI) and positron emission tomography have made it possible to study brain representation of sensation, motivation and cognition in humans. The primary interest of my lab is to use these techniques in conjunction with psychophysics and behavioral testing to uncover brain substrates of taste, smell, flavor, and food reward. We are particularly interested in multisensory integration of taste and smell as well as in understanding how sensory processing interacts with behavioral choices such as decisions to eat or stop eating in healthy individuals and in people with eating disorders. A new research aim is to examine similarities and differences in the neural representation of food and drug reward to answer questions such as how nicotine addiction may influence the ability of food odors to induce eating. We currently have a fully automated and fMRI compatible olfactometer and gustometer and are using these devices to study taste, smell and food reward in the 3 Tesla Magnet at the Yale MR Imaging Research Center. Sun X, Luquet S, Small DM: DRD2: Bridging the Genome and Ingestive Behavior. Trends Cogn Sci. 2017 May; 2017 Mar 31. PMID: 28372879 Small DM: Dopamine Adaptations as a Common Pathway for Neurocognitive Impairment in Diabetes and Obesity: A Neuropsychological Perspective. Front Neurosci. 2017; 2017 Mar 28. PMID: 28400713 Geha P, Cecchi G, Todd Constable R, Abdallah C, Small DM: Reorganization of brain connectivity in obesity. Hum Brain Mapp. 2017 Mar; 2016 Nov 16. PMID: 27859973 Heni M, Kullmann S, Ahlqvist E, Wagner R, Machicao F, Staiger H, Häring HU, Almgren P, Groop LC, Small DM, Fritsche A, Preissl H: Interaction between the obesity-risk gene FTO and the dopamine D2 receptor gene ANKK1/TaqIA on insulin sensitivity. Diabetologia. 2016 Dec; 2016 Sep 6. PMID: 27600277 Kroemer NB, Small DM: Fuel not fun: Reinterpreting attenuated brain responses to reward in obesity. Physiol Behav. 2016 Aug 1; 2016 Apr 13. PMID: 27085908 Stoeckel LE, Arvanitakis Z, Gandy S, Small D, Kahn CR, Pascual-Leone A, Pawlyk A, Sherwin R, Smith P: Complex mechanisms linking neurocognitive dysfunction to insulin resistance and other metabolic dysfunction. F1000Res. 2016; 2016 Mar 15. PMID: 27303627 Sun X, Veldhuizen MG, Babbs AE, Sinha R, Small DM: Perceptual and Brain Response to Odors Is Associated with Body Mass Index and Postprandial Total Ghrelin Reactivity to a Meal. Chem Senses. 2016 Mar; 2016 Jan 28. PMID: 26826114 Kroemer NB, Sun X, Veldhuizen MG, Babbs AE, de Araujo IE, Small DM: Weighing the evidence: Variance in brain responses to milkshake receipt is predictive of eating behavior. Neuroimage. 2016 Mar; 2015 Dec 24. PMID: 26724781 van Kooten MJ, Veldhuizen MG, de Araujo IE, O'Malley SS, Small DM: Fatty acid amide supplementation decreases impulsivity in young adult heavy drinkers. Physiol Behav. 2016 Mar 1; 2015 Nov 30. PMID: 26656766 Burke MV, Small DM: Physiological mechanisms by which non-nutritive sweeteners may impact body weight and metabolism. Physiol Behav. 2015 Dec 1; 2015 Jun 3. PMID: 26048305 Small DM, Pelphrey KA: Autism spectrum disorder: sniffing out a new biomarker. Curr Biol. 2015 Aug 3. PMID: 26241147 Patel BP, Aschenbrenner K, Shamah D, Small DM: Greater perceived ability to form vivid mental images in individuals with high compared to low BMI. Appetite. 2015 Aug; 2015 Apr 9. PMID: 25865661 Sun X, Kroemer NB, Veldhuizen MG, Babbs AE, de Araujo IE, Gitelman DR, Sherwin RS, Sinha R, Small DM: Basolateral amygdala response to food cues in the absence of hunger is associated with weight gain susceptibility. J Neurosci. 2015 May 20. PMID: 25995480 Cosgrove KP, Veldhuizen MG, Sandiego CM, Morris ED, Small DM: Opposing relationships of BMI with BOLD and dopamine D2/3 receptor binding potential in the dorsal striatum. Synapse. 2015 Apr; 2015 Mar 11. PMID: 25664726 Frost R, Quiñones I, Veldhuizen M, Alava JI, Small D, Carreiras M: What can the brain teach us about winemaking? An fMRI study of alcohol level preferences. PLoS One. 2015; 2015 Mar 18. PMID: 25785844 Coppin G, Nolan-Poupart S, Jones-Gotman M, Small DM: Working memory and reward association learning impairments in obesity. Neuropsychologia. 2014 Dec; 2014 Oct 14. PMID: 25447070 Small DM, Geary N: Introduction to the 2013 SSIB Special Issue. Physiol Behav. 2014 Sep; 2014 Nov 15. PMID: 25455126 Sun X, Veldhuizen MG, Wray AE, de Araujo IE, Sherwin RS, Sinha R, Small DM: The neural signature of satiation is associated with ghrelin response and triglyceride metabolism. Physiol Behav. 2014 Sep; 2014 Apr 13. PMID: 24732416 Geha P, Dearaujo I, Green B, Small DM: Decreased food pleasure and disrupted satiety signals in chronic low back pain. Pain. 2014 Apr; 2013 Dec 31. PMID: 24384160 Babbs RK, Sun X, Felsted J, Chouinard-Decorte F, Veldhuizen MG, Small DM: Decreased caudate response to milkshake is associated with higher body mass index and greater impulsivity. Physiol Behav. 2013 Sep 10; 2013 Apr 3. PMID: 23562867 Rudenga KJ, Small DM: Ventromedial prefrontal cortex response to concentrated sucrose reflects liking rather than sweet quality coding. Chem Senses. 2013 Sep; 2013 Jul 4. PMID: 23828907 Veldhuizen MG, Nachtigal DJ, Flammer LJ, de Araujo IE, Small DM: Verbal descriptors influence hypothalamic response to low-calorie drinks. Mol Metab. 2013; 2013 Jun 26. PMID: 24049739 Jastreboff AM, Sinha R, Lacadie C, Small DM, Sherwin RS, Potenza MN: Neural correlates of stress- and food cue-induced food craving in obesity: association with insulin levels. Diabetes Care. 2013 Feb; 2012 Oct 15. PMID: 23069840 de Araujo IE, Geha P, Small DM: Orosensory and Homeostatic Functions of the Insular Taste Cortex. Chemosens Percept. 2012 Mar 1. PMID: 25485032