Lim, Janghoo - Yale University - Biological & Biomedical Sciences

个人简介

Janghoo Lim received his undergraduate and master’s degrees in South Korea. He then completed his Ph.D. and postdoctoral trainings at Baylor College of Medicine, Houston, Texas. He joined Yale in 2010 and is currently an Associate Professor in the Departments of Genetics and of Neuroscience and in the Program in Cellular Neuroscience, Neurodegeneration and Repair (CNNR). PhD Baylor College of Medicine (2004) MS Korea Advanced Institute of Science and Technology, Daejeon, Korea (1999) BS Chonnam National University, Gwangju, Korea (1997) Postdoctoral Fellow Baylor College of Medicine

研究领域

Mental Disorders; Developmental Disabilities; Neuromuscular Diseases; Motor Neuron Disease; Neurodegenerative Diseases; Spinocerebellar Ataxias

近期论文

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Nemo-like kinase is a novel regulator of spinal and bulbar muscular atrophy. Todd TW, Kokubu H, Miranda HC, Cortes CJ, La Spada AR, and Lim J. (2015). Nemo-like kinase is a novel regulator of spinal and bulbar muscular atrophy. eLife 2015;4:e08493. Polyglutamine disease toxicity is regulated by Nemo-like kinase in spinocerebellar ataxia type 1. Ju H, Kokubu H, Todd TW, Kahle JJ, Kim S, Richman R, Chirala K, Orr HT, Zoghbi HY, and Lim J. (2013). Polyglutamine disease toxicity is regulated by Nemo-like kinase in spinocerebellar ataxia type 1. Journal of Neuroscience 33, 9328-9336. Opposing effects of polyglutamine expansion on native protein complexes contribute to SCA1. Lim J, Crespo-Barreto J, Jafar-Nejad P, Bowman AB, Richman R, Hill DE, Orr HT, and Zoghbi HY. (2008). Opposing effects of polyglutamine expansion on native protein complexes contribute to SCA1. Nature 452, 713-718. A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration. Lim J, Hao T, Shaw C, Patel AJ, Szabó G, Rual J-F, Fisk CJ, Li N, Smolyar A, Hill DE, Barabási A-L, Vidal M, and Zoghbi HY. (2006). A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration. Cell 125, 801-814. Todd TW, Kokubu H, Miranda HC, Cortes CJ, La Spada AR, Lim J: Nemo-like kinase is a novel regulator of spinal and bulbar muscular atrophy. Elife. 2015 Aug 26; 2015 Aug 26. PMID: 26308581 Ju H, Kokubu H, Lim J: Beyond the glutamine expansion: influence of posttranslational modifications of ataxin-1 in the pathogenesis of spinocerebellar ataxia type 1. Mol Neurobiol. 2014 Dec; 2014 Apr 22. PMID: 24752589 Kang J, Yeom E, Lim J, Choi KW: Bar represses dPax2 and decapentaplegic to regulate cell fate and morphogenetic cell death in Drosophila eye. PLoS One. 2014; 2014 Feb 5. PMID: 24505414 Kokubu H, Lim J: X-gal Staining on Adult Mouse Brain Sections. Bio Protoc. 2014; 2014 Mar 5. PMID: 27390760 Todd TW, Lim J: Aggregation formation in the polyglutamine diseases: protection at a cost? Mol Cells. 2013 Sep; 2013 Jun 19. PMID: 23794019 Kim S, Chahrour M, Ben-Shachar S, Lim J: Ube3a/E6AP is involved in a subset of MeCP2 functions. Biochem Biophys Res Commun. 2013 Jul 19; 2013 Jun 19. PMID: 23791832 Ju H, Kokubu H, Todd TW, Kahle JJ, Kim S, Richman R, Chirala K, Orr HT, Zoghbi HY, Lim J: Polyglutamine disease toxicity is regulated by Nemo-like kinase in spinocerebellar ataxia type 1. J Neurosci. 2013 May 29. PMID: 23719801