Koleske, Anthony J - Yale University - Biological & Biomedical Sciences

个人简介

Anthony J. Koleske is an expert in understanding the biochemical mechanisms that control changes in cell shape and movement. After receiving a B.S. in Biochemistry and Molecular Biology at the University of Wisconsin-Madison, Dr. Koleske performed his Ph.D. studies with Dr. Richard Young at the Whitehead Institute/Massachusetts Institute of Technology. For his Ph.D. thesis, Dr. Koleske discovered the RNA polymerase II holoenzyme, an important advancement in understanding how gene transcription is turned on. Dr. Koleske went on to do a postdoctoral fellowship with Nobel Laureate Dr. David Baltimore at M.I.T., where he began his work studying cellular functions of Abl family kinases, which his laboratory has shown are essential regulators of the cytoskeleton in diverse cell types. Dr. Koleske joined the Department of Molecular Biophysics and Biochemistry at Yale University in 1998, where he currently is Professor and holds a joint appointment in the Department of Neurobiology. Dr. Koleske is the recipient of numerous awards including a Jane Coffin Childs Postdoctoral Fellowship, Special Fellowship and Scholar Awards from the Leukemia and Lymphoma Society, a NARSAD Young Investigator Award, and an Established Investigator Award from the American Heart Association.He has served widely on review panels, including terms as Chair of the Basic Science Study Section for the American Heart Association and the Neurodifferentiation, Plasticity, Repair, and Rhythmicity Study Section of the NIH. He currently directs the combined Ph.D. programs in the Biological and Biomedical Sciences at Yale, the China Scholarship Council-Yale World Scholars Program, and co-directs (with Mike Nitabach) the Medical Research Scholars Program at Yale. He is married to Ruth Koleske and is father to twins Ben and Emily. PhD Massachusetts Institute of Technology (1993) BS University of Wisconsin (1988)

研究领域

Biochemistry; Biophysics; Molecular Biology; Morphogenesis; Schizophrenia; Stress, Physiological

近期论文

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Integrin ß1 signals through Arg to regulate postnatal dendritic arborization, synapse density, and behavior. Warren, M.S., Gourley, S.L., Lin, Y.-C., Simpson, M.A., Taylor, J.R., Greer, C.A. and Koleske, A.J. (2012) Integrin ß1 signals through Arg to regulate postnatal dendritic arborization, synapse density, and behavior. J Neurosci. In press. Arg kinase regulates prefrontal dendritic spine refinement and cocaine-induced plasticity. Gourley, S.L., Olevska, A., Warren, M.S., Taylor, J., and Koleske, A.J. (2012) Arg kinase regulates prefrontal dendritic spine refinement and cocaine-induced plasticity. J Neurosci. In press. MacGrath, S.M. and Koleske, A.J. (2012) Cell Science at a glance: cortactin. J Cell Sci, In press. An EGFR-Src-Arg-cortactin pathway mediates functional maturation of invadopodia and breast cancer cell invasion. Mader, C.C., Oser, M., Magalhaes, M., *Condeelis, J., *Koleske, A.J., and Gil-Henn, H. (2011) EGF signaling through a Src-Arg-cortactin relay regulates breast cancer invasiveness by controlling invadopodia maturation and function. Cancer Research, 71(5):1730-41. *Corresponding Author Mechanisms that promote long-term synapse and dendrite stability: disruption in psychiatric and neurodegenerative disorders. Lin, Y.-C., and Koleske, A.J. (2010) Mechanisms that promote long-term synapse and dendrite stability: disruption in psychiatric and neurodegenerative disorders. Ann Rev Neurosci., 33:349-78. Loss of dendrite stabilization by the Abl-related gene (Arg) kinase regulates behavioral flexibility and sensitivity to cocaine. Gourley, S.L. Koleske, A.J., and Taylor, J.R. (2009) Loss of dendrite stabilization by the Abl-related gene (Arg) kinase regulates behavioral flexibility and sensitivity to cocaine. Proc. Natl. Acad. Sci. USA, 106(39):16859-64 Regulation of cell migration and morphogenesis by Abl family kinases: emerging mechanisms and physiological contexts. Bradley, W.D., and Koleske, A.J. Regulation of cell migration and morphogenesis by Abl family kinases: emerging mechanisms and physiological contexts. (2009) J. Cell Sci, in press. Arg interacts with cortactin to promote adhesion-dependent cell edge protrusion. Lapetina, S., Mader, C.C., Machida, K., Mayer, B.J., and Koleske, A.J. (2009) Arg interacts with cortactin to promote adhesion-dependent cell edge protrusion. J. Cell Biol., 185: 503-19 Rosenberg BJ, Gil-Henn H, Mader CC, Halo T, Yin T, Condeelis J, Machida K, Wu YI, Koleske AJ: Phosphorylated cortactin recruits Vav2 guanine nucleotide exchange factor to activate Rac3 and promote invadopodial function in invasive breast cancer cells. Mol Biol Cell. 2017 May 15; 2017 Mar 29. PMID: 28356423 Shapiro LP, Parsons RG, Koleske AJ, Gourley SL: Differential expression of cytoskeletal regulatory factors in the adolescent prefrontal cortex: Implications for cortical development. J Neurosci Res. 2017 May; 2016 Oct 13. PMID: 27735056 Wetzel DM, Rhodes EL, Li S, McMahon-Pratt D, Koleske AJ: The Src kinases Hck, Fgr and Lyn activate Arg to facilitate IgG-mediated phagocytosis and Leishmania infection. J Cell Sci. 2016 Aug 15; 2016 Jun 29. PMID: 27358479 Xiao X, Levy AD, Rosenberg BJ, Higley MJ, Koleske AJ: Disruption of Coordinated Presynaptic and Postsynaptic Maturation Underlies the Defects in Hippocampal Synapse Stability and Plasticity in Abl2/Arg-Deficient Mice. J Neurosci. 2016 Jun 22. PMID: 27335408 Katrancha SM, Koleske AJ: SNARE Complex Dysfunction: A Unifying Hypothesis for Schizophrenia. Biol Psychiatry. 2015 Sep 15. PMID: 26296424 Nygaard HB, Wagner AF, Bowen GS, Good SP, MacAvoy MG, Strittmatter KA, Kaufman AC, Rosenberg BJ, Sekine-Konno T, Varma P, Chen K, Koleske AJ, Reiman EM, Strittmatter SM, van Dyck CH: A phase Ib multiple ascending dose study of the safety, tolerability, and central nervous system availability of AZD0530 (saracatinib) in Alzheimer's disease. Alzheimers Res Ther. 2015; 2015 Apr 14. PMID: 25874001 Ha BH, Simpson MA, Koleske AJ, Boggon TJ: Structure of the ABL2/ARG kinase in complex with dasatinib. Acta Crystallogr F Struct Biol Commun. 2015 Apr; 2015 Mar 20. PMID: 25849507 Simpson MA, Bradley WD, Harburger D, Parsons M, Calderwood DA, Koleske AJ: Direct interactions with the integrin β1 cytoplasmic tail activate the Abl2/Arg kinase. J Biol Chem. 2015 Mar 27; 2015 Feb 18. PMID: 25694433 Courtemanche N, Gifford SM, Simpson MA, Pollard TD, Koleske AJ: Abl2/Abl-related gene stabilizes actin filaments, stimulates actin branching by actin-related protein 2/3 complex, and promotes actin filament severing by cofilin. J Biol Chem. 2015 Feb 13; 2014 Dec 24. PMID: 25540195 DePoy LM, Perszyk RE, Zimmermann KS, Koleske AJ, Gourley SL: Adolescent cocaine exposure simplifies orbitofrontal cortical dendritic arbors. Front Pharmacol. 2014; 2014 Oct 27. PMID: 25452728