Kibbey, Richard Glenn - Yale University - Biological & Biomedical Sciences

个人简介

Dr. Kibbey obtained his undergraduate degrees in music (B.A.) and an honors degree in biochemistry (B.S.) at Trinity University in San Antonio in 1991. He then obtained his combined M.D. and Ph.D. at the University of Texas Southwestern Medical School in 2000. His Ph.D. was in Cellular and Molecular Biophysics and involved determining the NMR structure of peptides from the LDL receptor under his mentors Drs. R.G.W. Anderson and L. Gierasch. Subsequently, he went to Yale University in where he was selected for the ABIM short-track in Categorical Internal Medicine. In 2002 he stayed on for his Endocrinology fellowship at Yale and is now board certified in Internal Medicine and Endocrinology. While in his fellowship he worked in the laboratory of Dr. Gerald Shulman on metabolism in the pathophysiology of Type-2 Diabetes Mellitus. Here he identified mitochondrial GTP as a metabolic signal in the mitochondria sensing flux in the pancreatic beta-cell as a crucial component of the signal to secrete insulin. His laboratory also has developed a novel platform using stable isotopes and mass spectrometry named Mass Isotopomer MultiOrdinate Spectral Analysis (MIMOSA) that measures the flow of metabolism inside and between tissues. He is now an Associate Professor in the Departments of Internal Medicine/Endocrinology and Cellular & Molecular Physiology. He continues to see patients at Yale Health and has an independent NIH-supported laboratory doing research on islet and whole body physiology in order to understand/prevent/treat Type-2 diabetes. MD/PhD University of Texas Southwestern Medical School (2000) BS Trinity University (1991) BA Trinity University (1991) Resident Yale University School of Medicine Intern Yale University School of Medicine Fellow Yale University School of Medicine

研究领域

Diabetes Mellitus, Type 2; Endocrinology; Glucose; Insulin; Metabolism; Mitochondria; Physiology; Mass Spectrometry

近期论文

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Hyperglucagonemia precedes beta-cell dysfunction and causes hyperglycemia in chronically glucose-infused rats. Jamison RA, Stark R, Dong J, Yonemitsu S, Zhang D, Shulman GI, *Kibbey RG. (2011) Hyperglucagonemia precedes beta-cell dysfunction and causes hyperglycemia in chronically glucose-infused rats. Epub ahead of print: Am J Physiology-Endocrinology SGLT2 Deletion Improves Glucose Homeostasis and Preserves Pancreatic ß-cell Function. Jurczak MJ, Lee HY, Birkenfeld AL, Jornayvaz FR, Frederick DW, Pongratz RL, Zhao X, Moeckel GW, Samuel VT, Whaley JM, Shulman GI, *Kibbey RG. (2011) SGLT2 Deletion Improves Glucose Homeostasis and Preserves Pancreatic ß-cell Function. Diabetes. 2011 Mar;60(3):890-8. PMID: 21357472 Mitochondiral PEPCK links anaplerosis and mitochondrial GTP with insulin secretion. Stark R, Pasquel F, Turcu A, Pongratz RL, Roden M, Cline GW, Shulman GI, *Kibbey RG (2009) Mitochondiral PEPCK links anaplerosis and mitochondrial GTP with insulin secretion. J. Biol. Chem. 284(39): 26578-90 PMID: 19635791 Mitochondrial GTP regulates glucose-stimulated insulin secretion. Kibbey, R.G., Pongratz, R.L., Romanelli, A.J., Wollheim, C.B., Cline, G.W., and Shulman, G.I. (2007). Mitochondrial GTP regulates glucose-stimulated insulin secretion. Cell Metab 5, 253-264. Cytosolic and mitochondrial malic enzyme isoforms differentially control insulin secretion. Pongratz, R.L., Kibbey, R.G., Shulman, G.I., and Cline, G.W. (2007). Cytosolic and mitochondrial malic enzyme isoforms differentially control insulin secretion. J Biol Chem 282, 200-207. 13C NMR isotopomer analysis of anaplerotic pathways in INS-1 cells. Cline, G.W., Lepine, R.L., Papas, K.K., Kibbey, R.G., and Shulman, G.I. (2004). 13C NMR isotopomer analysis of anaplerotic pathways in INS-1 cells. J Biol Chem 279, 44370-44375. Yu P, Wilhelm K, Dubrac A, Tung JK, Alves TC, Fang JS, Xie Y, Zhu J, Chen Z, De Smet F, Zhang J, Jin SW, Sun L, Sun H, Kibbey RG, Hirschi KK, Hay N, Carmeliet P, Chittenden TW, Eichmann A, Potente M, Simons M: FGF-dependent metabolic control of vascular development. Nature. 2017 May 11; 2017 May 3. PMID: 28467822 Perry RJ, Cardone RL, Petersen MC, Zhang D, Fouqueray P, Hallakou-Bozec S, Bolze S, Shulman GI, Petersen KF, Kibbey RG: Imeglimin lowers glucose primarily by amplifying glucose-stimulated insulin secretion in high-fat-fed rodents. Am J Physiol Endocrinol Metab. 2016 Aug 1; 2016 Jul 12. PMID: 27406738 Madiraju AK, Alves T, Zhao X, Cline GW, Zhang D, Bhanot S, Samuel VT, Kibbey RG, Shulman GI: Argininosuccinate synthetase regulates hepatic AMPK linking protein catabolism and ureagenesis to hepatic lipid metabolism. Proc Natl Acad Sci U S A. 2016 Jun 14; 2016 May 31. PMID: 27247419 Perry RJ, Peng L, Barry NA, Cline GW, Zhang D, Cardone RL, Petersen KF, Kibbey RG, Goodman AL, Shulman GI: Acetate mediates a microbiome-brain-β-cell axis to promote metabolic syndrome. Nature. 2016 Jun 9. PMID: 27279214 Perry RJ, Borders CB, Cline GW, Zhang XM, Alves TC, Petersen KF, Rothman DL, Kibbey RG, Shulman GI: Propionate Increases Hepatic Pyruvate Cycling and Anaplerosis and Alters Mitochondrial Metabolism. J Biol Chem. 2016 Jun 3; 2016 Mar 21. PMID: 27002151 Alves TC, Pongratz RL, Zhao X, Yarborough O, Sereda S, Shirihai O, Cline GW, Mason G, Kibbey RG: Integrated, Step-Wise, Mass-Isotopomeric Flux Analysis of the TCA Cycle. Cell Metab. 2015 Nov 3; 2015 Sep 24. PMID: 26411341 Petersen KF, Morino K, Alves TC, Kibbey RG, Dufour S, Sono S, Yoo PS, Cline GW, Shulman GI: Effect of aging on muscle mitochondrial substrate utilization in humans. Proc Natl Acad Sci U S A. 2015 Sep 8; 2015 Aug 24. PMID: 26305973 Buescher JM, Antoniewicz MR, Boros LG, Burgess SC, Brunengraber H, Clish CB, DeBerardinis RJ, Feron O, Frezza C, Ghesquiere B, Gottlieb E, Hiller K, Jones RG, Kamphorst JJ, Kibbey RG, Kimmelman AC, Locasale JW, Lunt SY, Maddocks OD, Malloy C, Metallo CM, Meuillet EJ, Munger J, Nöh K, Rabinowitz JD, Ralser M, Sauer U, Stephanopoulos G, St-Pierre J, Tennant DA, Wittmann C, Vander Heiden MG, Vazquez A, Vousden K, Young JD, Zamboni N, Fendt SM: A roadmap for interpreting (13)C metabolite labeling patterns from cells. Curr Opin Biotechnol. 2015 Aug; 2015 Feb 28. PMID: 25731751 Kibbey RG: SGLT-2 inhibition and glucagon: Cause for alarm? Trends Endocrinol Metab. 2015 Jul; 2015 Jun 6. PMID: 26059706 Befroy DE, Kibbey RG, Perry RJ, Petersen KF, Rothman DL, Shulman GI: Response to burgess. Nat Med. 2015 Feb. PMID: 25654597 Kibbey RG, Choi CS, Lee HY, Cabrera O, Pongratz RL, Zhao X, Birkenfeld AL, Li C, Berggren PO, Stanley C, Shulman GI: Mitochondrial GTP insensitivity contributes to hypoglycemia in hyperinsulinemia hyperammonemia by inhibiting glucagon release. Diabetes. 2014 Dec; 2014 Jul 14. PMID: 25024374 Kim JD, Toda C, D'Agostino G, Zeiss CJ, DiLeone RJ, Elsworth JD, Kibbey RG, Chan O, Harvey BK, Richie CT, Savolainen M, Myöhänen T, Jeong JK, Diano S: Hypothalamic prolyl endopeptidase (PREP) regulates pancreatic insulin and glucagon secretion in mice. Proc Natl Acad Sci U S A. 2014 Aug 12; 2014 Jul 28. PMID: 25071172 Madiraju AK, Erion DM, Rahimi Y, Zhang XM, Braddock DT, Albright RA, Prigaro BJ, Wood JL, Bhanot S, MacDonald MJ, Jurczak MJ, Camporez JP, Lee HY, Cline GW, Samuel VT, Kibbey RG, Shulman GI: Metformin suppresses gluconeogenesis by inhibiting mitochondrial glycerophosphate dehydrogenase. Nature. 2014 Jun 26; 2014 May 21. PMID: 24847880