Hochstrasser, Mark W - Yale University - Biological & Biomedical Sciences

个人简介

Part of the Yale faculty since 2000, Prof. Mark Hochstrasser holds appointments in the Department of Molecular Biophysics and Biochemistry, the Department of Molecular, Cellular and Developmental Biology and the School of Medicine’s Biological and Biomedical Sciences Program. He earned his B.A. at Rutgers University and his Ph.D. at the University of California, San Francisco, and conducted postdoctoral research at the Massachusetts Institute of Technology. He has earned numerous honors for his scientific contributions, including a Young Investigator Award from the Cancer Research Foundation and designation as a Searle Scholar and a Fletcher Scholar. Prof. Hochstrasser holds two patents related to this work, which has been published in numerous scientific and medical journals, including Nature, the Journal of Cell Biology, Cell, the Proceedings of the National Academy of Sciences, Genetics and Nature Cell Biology. A member of the editorial board/virtual faculty of the Targeted Proteins Database and the journal Cell, Hochstrasser has served on several National Institutes of Health study sections. He is a member of the American Society for Biochemistry and Molecular Biology, the American Association for the Advancement of Science and the American Society for Microbiology. PhD University of Califoria-San Francisco (1987) Postdoctoral Fellow Massachusetts Institute of Technology

研究领域

Enzymes; Molecular Biology; Saccharomyces cerevisiae; Mass Spectrometry; Transcription Factors; Microscopy, Immunoelectron; Gene Deletion; Ubiquitin; Cell Growth Processes; Mutant Chimeric Proteins

近期论文

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A multimeric assembly factor controls formation of alternative 20S proteasomes. Kusmierczyk, A., Kunjappu, M. J., Funakoshi, M. and Hochstrasser, M. A multimeric assembly factor controls formation of alternative 20S proteasomes. Nature Struct. Mol. Biol. 15, 237-244 (2008) Autoregulation of an E2 enzyme by ubiquitin-chain assembly on its catalytic residue. Ravid, T. and Hochstrasser, M. (2007). Autoregulation of an E2 enzyme by ubiquitin-chain assembly on its catalytic residue. Nat. Cell Biol. 9:422-427. Spatially regulated ubiquitin ligation by an ER/nuclear membrane ligase. Deng, M. and Hochstrasser, M. (2006). Spatially regulated ubiquitin ligation by an ER/nuclear membrane ligase. Nature 443:827-831. A nuclear envelope protein linking nuclear pore basket assembly, SUMO protease regulation, and mRNA surveillance. Lewis, A., Felberbaum, R. and Hochstrasser, M. A nuclear envelope protein linking nuclear pore basket assembly, SUMO protease regulation, and mRNA surveillance. J. Cell Biol. 178, 813-827 (2007) b-Subunit appendages promote 20S proteasome assembly by overcoming an Ump1-dependent checkpoint. Li, X., Kusmierczyk, A., Wong, P., Emili, A. and Hochstrasser, M. b-Subunit appendages promote 20S proteasome assembly by overcoming an Ump1-dependent checkpoint. EMBO J. 26, 2339-2349 (2007) A multimeric assembly factor controls formation of alternative 20S proteasomes. Kusmierczyk, A., Kunjappu, M. J., Funakoshi, M. and Hochstrasser, M. A multimeric assembly factor controls formation of alternative 20S proteasomes. Nature Struct. Mol. Biol. 15, 237-244 (2008) Autoregulation of an E2 enzyme by ubiquitin-chain assembly on its catalytic residue. Ravid, T. and Hochstrasser, M. (2007). Autoregulation of an E2 enzyme by ubiquitin-chain assembly on its catalytic residue. Nat. Cell Biol. 9:422-427. Spatially regulated ubiquitin ligation by an ER/nuclear membrane ligase. Deng, M. and Hochstrasser, M. (2006). Spatially regulated ubiquitin ligation by an ER/nuclear membrane ligase. Nature 443:827-831. A nuclear envelope protein linking nuclear pore basket assembly, SUMO protease regulation, and mRNA surveillance. Lewis, A., Felberbaum, R. and Hochstrasser, M. A nuclear envelope protein linking nuclear pore basket assembly, SUMO protease regulation, and mRNA surveillance. J. Cell Biol. 178, 813-827 (2007) b-Subunit appendages promote 20S proteasome assembly by overcoming an Ump1-dependent checkpoint. Li, X., Kusmierczyk, A., Wong, P., Emili, A. and Hochstrasser, M. b-Subunit appendages promote 20S proteasome assembly by overcoming an Ump1-dependent checkpoint. EMBO J. 26, 2339-2349 (2007)