Chung, Jean-Ju - Yale University - Biological & Biomedical Sciences

个人简介

Jean-Ju L. Chung received her bachelors and masters degree from Seoul National University, Korea and her Ph.D. from Johns Hopkins University in 2007. She was a postdoctoral fellow with David E. Clapham in the Department of Neurobiology at Harvard Medical School. She joined Yale's Department of Cellular and Molecular Physiology as a faculty member in 2015. Her research is devoted to investigating cellular signaling via the membrane receptors and ion channels, with a current emphasis on mature spermatozoan motility and fertilization capacity. She has focused her efforts on the primary calcium channel of spermatozoa, CatSper, and has defined its subunits, its distribution in spermatozoa, its function in capacitation, and its effects on fertility. The Chung laboratory applies novel technologies to sperm biology and reproductive research including super-resolution imaging methods, and is continuing to study physiologically relevant molecular changes during mammalian fertilization. PhD Johns Hopkins University School of Medicine, Neuroscience and Biochemistry (2007) MS Seoul National University, Neuroendocrinology (1999) BS Seoul National University, Molecular Biology (1997) Instructor Harvard Medical School, Children's Hospital Boston Postdoctoral fellow Harvard Medical School, Children's Hospital Boston

研究领域

Fertility; Ion Channels; Reproduction; Sperm Capacitation; Sperm Motility; Signal Transduction; Membrane Microdomains

近期论文

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CatSperz Regulates the Structural Continuity of Sperm Ca2+ Signaling Domains and is Required for Normal Fertility. Chung, J.J.*, Miki, K., Kim, D., Shim, S.H., Shi, H.F., Hwang, J.Y., Cai, X., Iseri, Y., Zhuang, X., and Clapham, D.E.* (2017) eLife 10.7554/eLife.23082 Sugarcoated sperm Chung, J.J. (2016) Sugarcoated sperm. Mol Reprod Dev. dos:10.1002/mrd.22732 Sperm flagellar Ca2+ signaling domains Chung, J.J. (2016) Sperm flagellar Ca2+ signaling domains. Mol Reprod Dev. doi: 10.1002/mrd.22628. The Concise Guide to PHARMACOLOGY 2015/16: Overview Alexander, S.P., Kelly, E., Marrion, N., Peters, J.A., Benson, H.E., Faccenda, E., Dawson, A.J., Sharman, J.L., Southan, C., Buneman, O.P., Cattrall, W.A., Cidlowski, J.A., Davenport, A.P., Fabbro, D., Fan, G., McGrath, J.C., Spedding, M., Davies, J.A.; CGTP Collaborators. The Concise Guide to PHARMACOLOGY 2015/16: Overview. Br J Pharmacol. 2015 Dec;172(24):5729-43. doi: 10.1111/bph.13347. Structurally distinct Ca2+ signaling domains of sperm flagella orchestrate tyrosine phosphorylation and motility Chung, J.J.*, Shim, S.H.*, Everley, R.A. Gygi, S.P. Zhuang, X., and Clapham, D.E. (2014) Structurally distinct Ca2+ signaling domains of sperm flagella orchestrate tyrosine phosphorylation and motility. Cell 157 (4): 808-822. (*Equal contribution) (Selected for PaperFlicks; Cell video abstract online, Recommended by Faculty of 1000) The control of male fertility by spermatozoan ion channels Lishko, P., Kirichok, Y., Ren, D., Navarro, B., Chung, J.J., and Clapham, D.E. (2012) The control of male fertility by spermatozoan ion channels. Ann. Rev. of Physiol. 74: 453-470. A novel gene required for male fertility and functional CATSPER channel formation in spermatozoa Chung, J.J., Navarro, B., Krapivinsky, G., Krapivinsky, L., and Clapham, D.E. (2011) A novel gene required for male fertility and functional CATSPER channel formation in spermatozoa. Nat Commun 2: 153 doi:10.1038/ncomms1153. PI3K/Akt signaling-mediated surface expression sensed by 14-3-3 interacting motif Chung, J.J., Okamoto, Y., Coblitz, B., Li, M., Qiu, Y., and Shikano, S. (2009) PI3K/Akt signaling-mediated surface expression sensed by 14-3-3 interacting motif. FEBS Let. 276 (19): 5547-58. Ion channels that control fertility in mammalian spermatozoa Navarro, B., Kirichok, Y., Chung, J.J., and Clapham, D.E. (2008) Ion channels that control fertility in mammalian spermatozoa Int. J. Dev. Biol. 52: 607-613. Biochemical characterization of the native Kv2.1 potassium channel. Chung, J.J. and Li, M. (2005) Biochemical characterization of the native Kv2.1 potassium channel. FEBS J. 272 (14): 3743-55. Genome-wide Analyses of Carboxyl-terminal Sequences Chung, J.J., Yang, H., and Li M. (2003) Genome-wide Analyses of Carboxyl-terminal Sequences. Mol Cell Proteomics 2(3): 173-81. Functional diversity of protein C-termini: more than zipcoding? Chung, J.J., Shikano, S., Hanyu, Y., and Li, M. (2002) Functional diversity of protein C-termini: more than zipcoding? Trends Cell Biol. 12(3):146-50. A functional retinoic acid response element (RARE) is present within the distal promoter of the rat gonadotropin-releasing hormone (GnRH) gene