Canessa, Cecilia - Yale University - Biological & Biomedical Sciences

个人简介

MD Cayetano Heredia University Lima, Peru (1982) Residency Henepin County Medical Center, University of Minnesota Fellowship Univerisity of Alabama

研究领域

Central Nervous System; Electrophysiology; Kidney; Nephrology; Physiology; Epithelial Sodium Channels

近期论文

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Multiple translational isoforms give functional specificity to serum- and glucocorticoid-induced kinase 1 Arteaga MF, Alvarez de la Rosa D, Alvarez JA, Canessa CM. Multiple translational isoforms give functional specificity to serum- and glucocorticoid-induced kinase 1. Mol Biol Cell, 18:2072-80, 2007. A short amphipathic helix targets Sgk1 to the ER-associated ubiquitin-conjugation machinery Arteaga MF, Wang L, Ravid T, Hochstrasser M, Canessa CM. A short amphipathic helix targets Sgk1 to the ER-associated ubiquitin-conjugation machinery. Proc Natl Acad Sci USA, 103:11178-83, 2006. Gating of acid-sensitive ion channel-1: Release of Ca²⁺ block vs. allosteric mechanism Zhang P, Sigworth FJ, Canessa CM. Gating of acid-sensitive ion channel-1: Release of Ca²⁺ block vs. allosteric mechanism. J Gen Physiol, 127:109-17, 2006. SGK1 activates Na⁺-K⁺-ATPase in amphibian renal epithelial cells Alvarez de la Rosa D, Gimenez I, Forbush B, Canessa CM. SGK1 activates Na⁺-K⁺-ATPase in amphibian renal epithelial cells. Am J Physiol Cell Physiol, 290:C492-8, 2006. Proton sensitivity of ASIC1 appeared with the rise of fishes by changes of residues in the region that follows TM1 in the ectodomain of the channel Coric T, Zheng D, Gerstein M, Canessa CM. Proton sensitivity of ASIC1 appeared with the rise of fishes by changes of residues in the region that follows TM1 in the ectodomain of the channel. J Physiol, 568:725-35, 2005. González-Fernández R, Ávila J, Arteaga MF, Canessa CM, Martín-Vasallo P: The neuronal-specific SGK1.1 (SGK1_v2) kinase as a transcriptional modulator of BAG4, Brox, and PPP1CB genes expression. Int J Mol Sci. 2015 Apr 2; 2015 Apr 2. PMID: 25849655 Li T, Yang Y, Canessa CM: A method for activation of endogenous acid-sensing ion channel 1a (ASIC1a) in the nervous system with high spatial and temporal precision. J Biol Chem. 2014 May 30; 2014 Apr 11. PMID: 24727474 Li T, Yang Y, Canessa CM: Impact of recovery from desensitization on acid-sensing ion channel-1a (ASIC1a) current and response to high frequency stimulation. J Biol Chem. 2012 Nov 23; 2012 Oct 9. PMID: 23048040 Li T, Yang Y, Canessa CM: Outlines of the pore in open and closed conformations describe the gating mechanism of ASIC1. Nat Commun. 2011 Jul 19; 2011 Jul 19. PMID: 21772270 Li T, Yang Y, Canessa CM: Asp433 in the closing gate of ASIC1 determines stability of the open state without changing properties of the selectivity filter or Ca2+ block. J Gen Physiol. 2011 Mar. PMID: 21357733 Li T, Yang Y, Canessa CM: Asn415 in the beta11-beta12 linker decreases proton-dependent desensitization of ASIC1. J Biol Chem. 2010 Oct 8; 2010 Jul 30. PMID: 20675379 Li T, Yang Y, Canessa CM: Leu85 in the beta1-beta2 linker of ASIC1 slows activation and decreases the apparent proton affinity by stabilizing a closed conformation. J Biol Chem. 2010 Jul 16; 2010 May 17. PMID: 20479002 Li T, Yang Y, Canessa CM: Two residues in the extracellular domain convert a nonfunctional ASIC1 into a proton-activated channel. Am J Physiol Cell Physiol. 2010 Jul; 2010 Apr 28. PMID: 20427715 Li T, Yang Y, Canessa CM: Interaction of the aromatics Tyr-72/Trp-288 in the interface of the extracellular and transmembrane domains is essential for proton gating of acid-sensing ion channels. J Biol Chem. 2009 Feb 13; 2008 Dec 11. PMID: 19074149 Coric T, Passamaneck YJ, Zhang P, Di Gregorio A, Canessa CM: Simple chordates exhibit a proton-independent function of acid-sensing ion channels. FASEB J. 2008 Jun; 2008 Jan 22. PMID: 18211956 Arteaga MF, Coric T, Straub C, Canessa CM: A brain-specific SGK1 splice isoform regulates expression of ASIC1 in neurons. Proc Natl Acad Sci U S A. 2008 Mar 18; 2008 Mar 11. PMID: 18334630 Arteaga MF, Alvarez de la Rosa D, Alvarez JA, Canessa CM: Multiple translational isoforms give functional specificity to serum- and glucocorticoid-induced kinase 1. Mol Biol Cell. 2007 Jun; 2007 Mar 21. PMID: 17377066 Arteaga MF, Wang L, Ravid T, Hochstrasser M, Canessa CM: An amphipathic helix targets serum and glucocorticoid-induced kinase 1 to the endoplasmic reticulum-associated ubiquitin-conjugation machinery. Proc Natl Acad Sci U S A. 2006 Jul 25; 2006 Jul 17. PMID: 16847254 Leng Q, Kahle KT, Rinehart J, MacGregor GG, Wilson FH, Canessa CM, Lifton RP, Hebert SC: WNK3, a kinase related to genes mutated in hereditary hypertension with hyperkalaemia, regulates the K+ channel ROMK1 (Kir1.1). J Physiol. 2006 Mar 1; 2005 Dec 15. PMID: 16357011 Zhang P, Sigworth FJ, Canessa CM: Gating of acid-sensitive ion channel-1: release of Ca2+ block vs. allosteric mechanism. J Gen Physiol. 2006 Feb; 2006 Jan 17. PMID: 16418400