Acar, Murat - Yale University - Biological & Biomedical Sciences

个人简介

Biochemistry, Biophysics and Structural Biology: Cell Cycle and Signal Transduction; DNA Dynamics; Transcriptional Regulation Cell Biology; Epigenetics; Evolutionary Biology; Genetics and Genomics; Imaging (super-resolution); Quantitative/Systems Biology PhD MIT, Physics (2007) BS Bogazici University, Physics (2000) Postdoctoral Fellow CalTech

研究领域

Aging; Molecular Biology; Systems Biology; Gene Regulatory Networks; Synthetic Biology

近期论文

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Enhancement of cellular memory by reducing stochastic transitions "Enhancement of cellular memory by reducing stochastic transitions". Murat Acar, Attila Becskei, and Alexander van Oudenaarden. Nature 435, 228-232 (2005) Stochastic switching as a survival strategy in fluctuating environments "Stochastic switching as a survival strategy in fluctuating environments". Murat Acar, Jerome T. Mettetal, and Alexander van Oudenaarden. Nature Genetics 40, 471-475 (2008) A general mechanism for network-dosage compensation in gene circuits "A general mechanism for network-dosage compensation in gene circuits". Murat Acar, Bernardo F. Pando, Frances H. Arnold, Michael B. Elowitz, and Alexander van Oudenaarden. Science 329, 1656-1660 (2010) Elison GL, Song R, Acar M: A Precise Genome Editing Method Reveals Insights into the Activity of Eukaryotic Promoters. Cell Rep. 2017 Jan 3. PMID: 28052256 Peng W, Song R, Acar M: Noise reduction facilitated by dosage compensation in gene networks. Nat Commun. 2016 Oct 3; 2016 Oct 3. PMID: 27694830 Song R, Peng W, Liu P, Acar M: A cell size- and cell cycle-aware stochastic model for predicting time-dynamic gene network activity in individual cells. BMC Syst Biol. 2015 Dec 9; 2015 Dec 9. PMID: 26646617 Liu P, Young TZ, Acar M: Yeast Replicator: A High-Throughput Multiplexed Microfluidics Platform for Automated Measurements of Single-Cell Aging. Cell Rep. 2015 Oct 20; 2015 Oct 9. PMID: 26456818 Peng W, Liu P, Xue Y, Acar M: Evolution of gene network activity by tuning the strength of negative-feedback regulation. Nat Commun. 2015 Feb 11; 2015 Feb 11. PMID: 25670371 Song R, Liu P, Acar M: Network-dosage compensation topologies as recurrent network motifs in natural gene networks. BMC Syst Biol. 2014 Jun 14; 2014 Jun 14. PMID: 24929807