王江云 - 中国科学院生物物理研究所 -

个人简介

2007-current，中国科学院生物物理研究所，非编码核酸北京市重点实验室研究员 2003-2007，博士后, 美国Scripps 研究所 1998-2003，化学博士, 美国Univ. of Illinois at Urbana Champaign

研究领域

1. 发展蛋白质及RNA标记的新方法，研究蛋白质及RNA的定位，结构，折叠，以及相互作用 2. 研究含有金属卟啉和铜离子的蛋白质的结构功能，并在此基础上设计新的金属酶

近期论文

查看导师新发文章（温馨提示：请注意重名现象，建议点开原文通过作者单位确认）

Hu C, Liu X, Wang J*. Electrostatics affect the glow. Science. 2020, 367(6473):26. doi: 10.1126/science.aba0571. Huang SM, Yang F, Cai BY, He QT, Liu Q, Qu CX, Han MJ, Kong W, Jia YL, Li F, Yu X, Sun JP*, Wang J*. Genetically Encoded Fluorescent Amino Acid for Monitoring Protein Interactions through FRET. Anal Chem. 2019, 91(23):14936-14942. doi: 10.1021/acs.analchem.9b03305. Zheng DD, Zhang Y, Liu XH, Wang J*. Coupling natural systems with synthetic chemistry for light-driven enzymatic biocatalysis. Photosynth Res. 2019, doi.org/10.1007/s11120-019-00660-7 Xia L, Han MJ, Zhou L, Huang A, Yang Z, Wang T, Li F, Yu L, Tian C, Zang Z, Yang QZ, Liu C, Hong W, Lu Y, Alfonta L, Wang J*. S-Click Reaction for Isotropic Orientation of Oxidases on Electrodes to Promote Electron Transfer at Low Potentials. Angew Chem Int Ed Engl. 2019, 58(46):16480-16484. doi: 10.1002/anie.201909203. Yu Y#, Liu X#, Wang J*. Expansion of Redox Chemistry in Designer Metalloenzymes. Acc Chem Res. 2019, 52(3):557-565. doi: 10.1021/acs.accounts.8b00627. Liu X#, Kang F#, Hu C#, Wang L, Xu Z, Zheng D, Gong W, Lu Y, Ma Y, Wang J*. A genetically encoded photosensitizer protein facilitates the rational design of a miniature photocatalytic CO2-reducing enzyme. Nat Chem. 2018, 10 (12):1201-1206. doi: 10.1038/s41557-018-0150-4. Mu Z, Zou Z, Yang Y, Wang W, Xu Y, Huang J, Cai R, Liu Y, Mo Y, Wang B, Dang Y, Li Y, Liu Y, Jiang Y, Tan Q, Liu X, Hu C, Li H, Wei S, Lou C, Yu Y, Wang J*. A genetically engineered Escherichia coli that senses and degrades tetracycline antibiotic residue. Synth Syst Biotechnol. 2018, 3(3):196-203. doi: 10.1016/j.synbio.2018.05.001. Dong J, Li F, Gao F, Wei J, Lin Y, Zhang Y, Lou J, Liu G, Dong Y, Liu L, Liu H, Wang J, Gong W*. Structure of tRNA-Modifying Enzyme TiaS and Motions of Its Substrate Binding Zinc Ribbon. J Mol Biol. 2018, 430(21):4183-4194. doi: 10.1016/j.jmb.2018.08.015. Yang F#, Xiao P#, Qu CX#, Liu Q#, Wang LY, Liu ZX, He QT, Liu C, Xu JY, Li RR, Li MJ, Li Q, Guo XZ, Yang ZY, He DF, Yi F, Ruan K, Shen YM, Yu X, Sun JP*, Wang J*. Allosteric mechanisms underlie GPCR signaling to SH3-domain proteins through arrestin. Nat Chem Biol. 2018, 14(9):876-886. doi: 10.1038/s41589-018-0115-3. Wang L#, Chen X#, Guo X#, Li J, Liu Q, Kang F, Wang X, Hu C, Liu H, Gong W, Zhuang W, Liu X*, Wang J*. Significant expansion and red-shifting of fluorescent protein chromophore determined through computational design and genetic code expansion. Biophys Rep. 2018, 4(5):273-285. doi: 10.1007/s41048-018-0073-z. Zhang J#, Wang L#, Zhang J, Zhu J, Pan X, Cui Z, Wang J*, Fang W*, Li Y*. Identifying and Modulating Accidental Fermi Resonance: 2D IR and DFT Study of 4-Azido-l-phenylalanine. J Phys Chem B. 2018, 122(34):8122-8133. doi: 10.1021/acs.jpcb.8b03887. Li J, Griffith WP, Davis I, Shin I, Wang J, Li F, Wang Y, Wherritt DJ, Liu A*. Cleavage of a carbon-fluorine bond by an engineered cysteine dioxygenase. Nat Chem Biol. 2018, 14(9):853-860. doi: 10.1038/s41589-018-0085-5. Zhang F#, Zhou Q#, Yang G, An L, Li F*, Wang J*. A genetically encoded 19F NMR probe for lysine acetylation. Chem Commun (Camb). 2018, 54(31):3879-3882. doi: 10.1039/c7cc09825a. Chen L, Naowarojna N, Song H, Wang S, Wang J, Deng Z, Zhao C, Liu P*. Use of a Tyrosine Analogue To Modulate the Two Activities of a Nonheme Iron Enzyme OvoA in Ovothiol Biosynthesis, Cysteine Oxidation versus Oxidative C-S Bond Formation. J Am Chem Soc. 2018, 140(13):4604-4612. doi: 10.1021/jacs.7b13628. Yu Y, Hu C, Xia L, and Wang J*. Artificial Metalloenzyme Design with Unnatural Amino Acids and Non-Native Cofactors. ACS Catal. 2018, 8 (3):1851–1863 doi: 10.1021/acscatal.7b03754. Pan Y, Zhang H, Zheng Y, Zhou J, Yuan J, Yu Y, Wang J*. Resveratrol Exerts Antioxidant Effects by Activating SIRT2 To Deacetylate Prx1. Biochemistry. 2017, 56(48):6325-6328. doi: 10.1021/acs.biochem.7b00859. Lu J#, Zhang H#, Chen X#, Zou Y, Li J, Wang L, Wu M, Zang J, Yu Y, Zhuang W*, Xia Q*, Wang J*. A small molecule activator of SIRT3 promotes deacetylation and activation of manganese superoxide dismutase. Free Radic Biol Med. 2017, 112:287-297. doi: 10.1016/j.freeradbiomed.2017.07.012. Hu C#, Yu Y#, Wang J*. Improving artificial metalloenzymes' activity by optimizing electron transfer. Chem Commun (Camb). 2017, 53(30):4173-4186. doi: 10.1039/c6cc09921a. Yang F, Yu X, Liu C, Qu CX, Gong Z, Liu HD, Li FH, Wang HM, He DF, Yi F, Song C, Tian CL, Xiao KH, Wang JY*, Sun JP*. Phospho-selective mechanisms of arrestin conformations and functions revealed by unnatural amino acid incorporation and 19F-NMR. Nat Commun. 2015, 6:8202. doi: 10.1038/ncomms9202. Yang Y#, Zhou Q#, Wang L#, Liu X, Zhang W, Hu M, Dong J, Li J, Xiaoxuan L, Ouyang H, Li H, Gao F, Gong W, Lu Y*, Wang J*. Significant Improvement of Oxidase Activity through the Genetic Incorporation of a Redox-active Unnatural Amino Acid. Chem Sci. 2015, 6(7):3881-3885. doi: 10.1039/C5SC01126D