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个人简介

Dr Tai is a senior lecturer in Organic and Polymer Chemistry in the School of Chemistry at Bangor University. Dr Tai’s scientific background has covered a wide range and she has accumulated substantial research and industrial experience and expertise on the development of novel polymer materials, e.g. seeking their synthetic routes, characterising their structures, investigating their properties, evaluating their post processisiblity, and developing their applications. Dr Tai’s recent research focuses on the development of synthetic and natural polymeric biomaterials for wound healing and drug delivery. Dr Tai has published more than 30 articles in peer-reviewed journals and two book chapters. She has also presented her research findings at more than 30 national and international conferences. Dr Tai envisages that the rational designed multifunctional polymers have great potential as advanced macro-, micro- and nano- devices for wide applications, including in tissue engineering, targeted drug delivery, and sensing and imaging for diagnostics. Dr. Tai’s research interests focus on design, synthesis, engineering and formulation of functional synthetic biomacromolecules as polymeric macro/micro/nano- devices or polymeric/biopolymer hybrid systems for tissue engineering and drug delivery. She also works on the development of natural biopolymers from renewable sources for personal care and medical applications. Dr Tai teaches undergraduate and postgraduate modules on the subjects in Organic Chemistry and Polymer Chemistry, as well as General and Research skills for Chemists. Dr Tai is also the Director of Postgraduate Taught Programmes (MSc and MRes Courses Coordinator) in the School of Chemistry. Undergraduate (UG) Teaching: 1st Year: FXX0010: Essential Organic Chemistry FXX1005: Chemistry in Biology and Environment FXX1104: Chemistry of Us 2nd Year FXX2101: Core Organic Chemistry 1: Radical Reactions FXX2107: Core Organic Chemistry 2: Polymer Chemistry FXX2108: Tutorial (Polymer Chemistry) FXX2110: Polymer Chemistry lab FXX2104: Professional Skills for Chemists 3rd Year FXX3101: Pollution and Environment (Organic pollutants) FXX3502: Chemistry Biology (Biosynthesis and Chemical synthesis of Biopolymers) FXX3503: Research Skills: Public understanding of science FXX3116: Project module 4th Year (MChem) FXX4505: Web-based Literature Review FXX4507: Practical Project Postgraduate (PG) Teaching: Dr Tai is the MSc and MRes Taught Courses Coordinator and the Modules Organiser for the following modules. FXX4609: Diploma Laboratory Work (MSc) FXX4510: Diploma Report (PG) FXX4513: Project Thesis (MSc) FXX4618: Literature and Project Planning (MSc) FXX4520: Research Thesis (MRes) FXX4521: Advanced Research and Lab Skills (MRes)

研究领域

Dr Tai is a polymer scientist. Her research concerns both synthetic polymers and natural polymers, including the synthesis, isolation, functionalization and engineering of polymeric materials for a variety of applications, in particular, for biological and biomedical applications. Polymeric biomaterials with rational designed and engineered chemical composition, functionality and topologies are highly desirable for drug delivery, tissue engineering, sensing, imaging and diagnostics. We isolate, synthesize and functionalize polymeric biomaterials by chemical and/or enzymatic approaches, living/controlled radical polymerisations, click chemistry and bioconjugation techniques. In addition, self-assembly and colloidal behaviours of biomacromolecules as well as physical and processing properties of polymeric biomaterials are studies. More details for Dr Tai’s research work can be found on our departmental research pages for ‘Materials Chemistry’ and ‘Chemistry at Life Sciences Interface’. The current research projects in her group include: Development of Biodegradable and thermoresponsive synthetic polymers for injectable tissue engineering hydrogels Development of multifunctional pH responsive dendritic polymers for targeted drug delivery Synthesis and processing of biodegradable PLA and PLGA polymers Development of biobased hydrogels from polysaccharides and plant oils Extraction, characterisation and modification of biopolymers (e.g. alginate) from natural resources (e.g. brown seaweed) Development of alginate derivatives for hydrogel applications Development of crosslinkable polymers for 3D printing Current Main Collaborators: University College Dublin Vornia Biomaterials ConvaTec Ltd Revolymer Ltd Marine Biopolymer Ltd

近期论文

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McMahon, S., Kennedy, R., Duffy, P., Vasquez, J., Wall, J. G., Tai, H., Wang, W. Poly(ethylene glycol) based hyperbranched polymer from RAFT and its application as a silver sulfadiazine loaded anti-bacterial hydrogel in wound care. ACS APPLIED MATERIALS & INTERFACES, 2016, 8(40), 26648–26656. Tai, H.; Tochwin, A.; El-Betany, A.; Wang, W. Degradable and thermal responsive hyperbranched polymers synthesized via one-pot RAFT polymerisation for injectable scaffold applications, TISSUE ENGINEERING PART A, 2015, Volume 21, Supplement 1, S54 Zhao, T.; Zhang, H.; Zhou, D.; Gao, Y.; Dong, Y.; Greiser, U.; Tai, H.; Wang, W.. ‘Water Soluble Hyperbranched Polymers from Controlled Radical Homopolymerization of PEG Diacrylate’, RSC ADVANCES, 2015, 5, 33823–33830. Omer, R. A.; Hughes, A.; Hama J. R. ; Wang, W. and Tai, H. Hydrogels from Dextran and Soybean Oil by UV Photopolymerisation, JOURNAL OF APPLIED POLYMER SCIENCE, 2014, 132, 41446. Kennedy, R., Hassan, W., Tochwin, A., Zhao, T., Dong, Y., Wang, Q., Tai, H., Wang, W. ;’In-situ Formed Hybrid Hydrogels from PEG-based Multifunctional Hyperbranched Copolymers: A RAFT Approach.’ POLYMER CHEMISTRY, 2014,5, 1838–1842 Tai, H., Tochwin, A., Wang, W. Thermoresponsive Hyperbranched Polymers via in-situ RAFT Copolymerisation of PEG based Monomethacrylate and Dimethacrylate Monomers, JOUNRAL OF POLYMER SCIENCE, PART A, POLYMER CHEMISTRY, 2013, 51, 3751–3761, Ref: JPOL-A-13–0205 Tai, H.; Duvall,C.L.; Hoffman, A.S.; Stayton, P.S.; Wang, W. pH-Responsive Hyperbranched Copolymers from One-pot Reversible Addition-Fragmentation Chain Transfer Copolymerization , MACROMOLECULAR MATERIALS &; ENGINEERING, 2012, 297, 1175–1183 Zheng, Y.; Newland,B.; Tai, H. ; Pandit, A.; and Wang, W. Single Cyclized Molecule Structure From RAFT Homopolymerization of Multi-vinyl Monomers, CHEMICAL COMMUNICATIONS, 2012, 48 (25), 3085–3087 Aied, A.; Glynn, B.; Cao, H.; Zheng, Y.; Tai, H.; Pandit, A.; Wang, W.; A Fluorescently Labeled, Hyperbranched Polymer Synthesized from DE-ATRP for the Detection of DNA Hybridization, POLYMER CHEMISTRY, 2012, 3,332–334 Dong, Y.; Hassan, W.; Zheng, Y.; Saeed, A.O.; Cao, H.; Tai, H.; Pandit, A.; and Wang, W. Thermoresponsive Hyperbranched Copolymer with Multi Acrylate Functionality for In Situ Cross-linkable Hyaluronic Acid Composite Semi-IPN Hydrogel, JOURNAL OF MATERIALS SCIENCE: MATERIALS IN MEDICINE, 2012, 23, 25–35 Dong,Y.; Saeed, A.O.; Hassan, W.; Tai, H.; Pandit, A.; and Wang, W. One-step Preparation of Thiol-Ene Clickable PEG Based Thermoresponsive Hyperbranched Copolymer for In Situ Crosslinking Hybrid Hydrogel, MACRPMOL. RAPID COMMUN, 2012, 22(2),120–126 White,L.J.; Hutter, V.; Tai, H.; Howdle, S.M.; Shakesheff, K.M. ‘The effect of processing variables on morphological and mechanical properties of supercritical CO2 foamed scaffolds for tissue engineering, ACTA BIOMATERIALS, 2012,8, 61–71 Dong, Y.; Cao, H.; Mathew, A.; Newland, B. E.; Saeed, A.O.; Gunning, P.; Magnusson, J.P.; Alexander, C.; Tai, H.; Pandit, A.; Wang, W. Dual stimuli responsive PEG based dendritic polymers, POLYMER CHEMISTRY, 2010, 1, 827–830 Newland, B. E.; Tai, H.; Zheng, Y.; Velascoa, D. B.; Howdle, S. M.; Alexander, C.; Wang, W.; Pandit, A.; A highly effective gene delivery vector – dendritic poly(2-(dimethylamino) ethyl methacrylate) from in-situ deactivation enhanced ATRP, CHEMICAL COMMUNICATIONS, 2010, 46, 4698–4700 Tai, H.; Upton, C.; White, L.; Pini, R.; Storti, G.; Mazzotti, M.; Shakesheff, K.M.; Howdle, S.M. Studies of interactions of CO2 with biodegradable poly (DL-lactic acid) and poly (lactic acid-co-glycolic acid) copolymers using high pressure ATR-IR and high pressure rheology, POLYMER, 2010, 51,1425–1431 Tai, H.; Howard, D.; Takae, S.; Wang, W.; Vermonden, T.; Hennink, W. E.; Stayton P.S.; Hoffman, A.S.; Endruweit, A.; Alexander, C.; Howdle, S.M.; Shakesheff, K.M. Photocrosslinked hydrogels from thermoresponsive PEGMEMA-PPGMA-EGDMA copolymers containing multiple methacrylate groups: mechanical property, swelling, protein release and cytotoxicity, BIOMACROMOLECULES, 2009, 10(10), 2895–2903. Tai, H.; Wang, W.; Vermonden, T., Heath, F.; Hennink, W E., Alexander, C.; Shakesheff, K. M. and Howdle, S. M., Thermoresponsive and photocrosslinkable PEGMEMA-PPGMA-EGDMA copolymers from one-step ATRP synthesis, BIOMACROMOLECULES, 2009, 10 (4), 822–828 Tai, H.; Wang, W.; Alexander, C.; Shakesheff, K. M.; Howdle, S. M., Thermal-responsive and photocrosslinkable hyperbranched polymers synthesised by deactivation enhanced ATRP and RAFT polymerisations, JOURNAL OF CONTROLLED RELEASE, 132, 3, e48-e50, 2008 (Proceedings of the Tenth European Symposium on Controlled Drug Delivery, Noordwijk aan Zee, The Netherlands, 02–04 April 2008) Tai, H.; Shakesheff, K. M.; Howdle, S. M., Interactions of CO2 with poly (DL-lactic acid) and poly (lactic acid-co-glycolic acid) copolymers, EUROPEAN CELLS AND MATERIALS, 2008, 16(3), 92 Mather, M.; Morgan, S. P.; White, L. J.; Tai, H.; Koceknberger, W.; Howdle, S. M.; Shakesheff, K. M.; Crowe, J. A. Image based characterization of foamed polymeric tissue scaffolds, BIOMEDICAL MATERIALS, 2008, 3, 015011 Davies, O. W.; Lewis, A. L.; Whitaker M. J.; Tai, H.; Shakesheff, K. M.; and Howdle, S. M., Applications of supercritical CO2 in the fabrication of polymer systems for drug delivery and tissue Engineering, ADVANCED DRUG DELIVERY REVIEWS, 2008, 60, 373–387. Pini, R.; Storti, G.; Mazzotti, M.; Tai, H.; Shakesheff, K. M.; Howdle, S. M. Measurement of sorption and swelling of amorphous PLA and PLGAs in the presence of supercritical carbon dioxide: experimental and modelling, JOURNAL OF POLYMER SCIENCE,PART B, POLYMER PHYSICS, 2008,46, 483–496 Tai, H.; Mather, M. L.; Howard, D.; Wang, W.; White, L. J.; Crowe, J. A.; Morgan, S. P.; Chandra, A.; Williams, D. J.; Howdle, S. M.; and Shakesheff, K. M , Control of pore size and structure of tissue engineering scaffolds produced by supercritical fluid processing: Discussion with Reviewers. EUROPEAN CELLS & MATERIALS, 2007,14, 76–77 Tai, H.; Mather, M. L.; Howard, D.; Wang, W.; White, L. J.; Crowe, J. A.; Morgan, S. P.; Chandra, A.; Williams, D. J.; Howdle, S. M.; and Shakesheff, K. M, Control of pore size and structure of tissue engineering scaffolds produced by supercritical fluid processing, EUROPEAN CELLS &; MATERIALS, 2007,14, 64–76 Tai, H.; Popov, V. K.; Shakesheff, K. M.; and Howdle, S. M., Putting the fizz into chemistry: Applications of supercritical carbon dioxide in tissue engineering, drug delivery and synthesis of novel block copolymers, BIOCHEMICAL SOCIETY TRANSACTIONS, 2007, 35, 516–521.

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