Staples, Chris - Bangor University - School of Medical Sciences

个人简介

Current Post: Research Lecturer in Genome Stability Sep 2016-Present Previous Post: PostDoctoral Research Associate, University of Sheffield Education: PhD in Cell Signalling and DNA damage. University of Dundee 2010 BSc (Hons) in Biochemistry, Queen’s University Belfast 2002 Current Grants NWCR DTP Studentship 2016-2020 Teaching BSX-2019 Molecular Biology and Biochemistry MSE-1017 Key Skills in Medical Science MSE-3008 Dissertation Keywords DNA repair, Genome stability, Uncharacterised proteins, cilia, centrosome, Homologous Recombination, Replication stress

研究领域

Genome stability is essential for life and a vital tumour suppressive mechanism. Genomic instability can underlie both inherited cancer predisposition and sporadic tumorigenesis, and contributes to tumour heterogeneity and drug resistance. Research in Dr Staples’ laboratory focuses on the study of the cellular roles of a series of completely uncharacterised proteins that have been identified as novel genome stability factors, alongside their relevance to cancer. Furthermore, he hopes to exploit novel aspects of the DNA damage response to sensitise cancer cells to existing chemotherapies. This includes novel DNA repair factors, and components of other processes that impact indirectly on repair processes and genomic integrity.

近期论文

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9. Staples CJ, Barone G, Myers KN, Patil AA, Beveridge RD, Maslen S, Skehel JM, Beniston R and Collis SJ. RadIP promotes DNA repair via interactions with the MRN complex. 2016, under revision 8. Beveridge RD, Staples CJ, Patil AA, Myers KN, Maslen S, Skehel JM, Boulton SJ, Collis SJ. The leukemia-associated Rho guanine nucleotide exchange factor LARG is required for efficient replication stress signaling. Cell Cycle. 2014; 13(21):3450-9. 7. Staples CJ, Myers KN, Beveridge RD, Patil AA, Howard AE, Barone G, Lee A, Swanton C, Howell M, Maslen S, Skehel MJ, Boulton SJ and Collis SJ. Ccdc13 is a novel human centriolar satellite protein required for ciliogenesis and genome stability. J Cell Sci. 2014 Jul 1; 127(Pt 13):2910-9. 6. Staples CJ, Myers KN, Beveridge RD, Patil AA, Lee AJ, Swanton C, Howell M, Boulton SJ, Collis SJ. The centriolar satellite protein Cep131 is important for genome stability. J Cell Sci. 2012 Oct 15; 125(Pt 20):4770-9. 5. Dickinson RJ, Delavaine L, Cejudo-Marín R, Stewart G, Staples CJ, Didmon MP, Trinidad AG, Alonso A, Pulido R, Keyse SM. Phosphorylation of the kinase interaction motif in mitogen-activated protein (MAP) kinase phosphatase-4 mediates cross-talk between protein kinase A and MAP kinase signaling pathways. J Biol Chem. 2011 Nov 4; 286(44):38018-26. 4. Staples CJ, Owens DM, Maier JV, Cato AC, Keyse SM. Cross-talk between the p38alpha and JNK MAPK pathways mediated by MAP kinase phosphatase-1 determines cellular sensitivity to UV radiation. J Biol Chem. 2010 Aug 20; 285(34):25928-40. 3. Kucharska A, Rushworth LK, Staples C, Morrice NA, Keyse SM. Regulation of the inducible nuclear dual-specificity phosphatase DUSP5 by ERK MAPK. Cell Signal. 2009 Dec;21(12):1794-805. 2. Ekerot M, Stavridis MP, Delavaine L, Mitchell MP, Staples C, Owens DM, Keenan ID, Dickinson RJ, Storey KG, Keyse SM. Negative-feedback regulation of FGF signalling by DUSP6/MKP-3 is driven by ERK1/2 and mediated by Ets factor binding to a conserved site within the DUSP6/MKP-3 gene promoter. Biochem J. 2008 Jun 1; 412(2):287-98. 1. Graham DA, Staples C, Wilson CJ, Jewhurst H, Cherry K, Gordon A, Rowley HM. Biophysical properties of salmonid alphaviruses: influence of temperature and pH on virus survival. J Fish Dis. 2007 Sep; 30(9):533-43.