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个人简介

教育与工作经历 2003年09月-2007年06月,华南农业大学,动物科学专业攻读本科;2007年09月-2010年06月,华南农业大学,动物营养与饲料科学专业攻读硕士; 2010年09月-2013年06月,中山大学,生物学(生物技术)专业攻读博士; 2017年12月-2018年12月,美国贝勒医学院,儿童营养研究中心访学; 2013年09月至今,在南京农业大学动物科技学院任教 奖励及荣誉 2018-2019学年“可莱威”奖教金;中国畜牧兽医学会动物营养学分会第四届青年学者讲坛优秀奖 承担科研项目 1. 国家自然科学基金面上项目,31972528,琥珀酸/GPR91信号介导胆汁酸-FXR代谢轴调节猪肠道上皮屏障的作用及机制研究,在研,主持; 2. 国家重点研发计划项目,2021YFD1300205-4,白酒糟在生长猪上的营养价值评定,在研,主持; 3. 国家自然科学基金区域创新发展联合基金(重点支持项目),U21A20245-2,“微生物-肠-脑轴”调控猪食欲和采食量的作用机制研究,在研,任务负责人; 4. 江苏省农业科技自主创新资金,CX(19)3012,基于肠道微生物代谢靶点调控仔猪肠上皮屏障的抗腹泻饲料关键技术研发,结题,主持; 5. 南京农业大学联合项目,结题,主持; 6. 国家自然科学基金青年项目,31501962,肠道微生物通过丙酸调节猪采食的肠-脑神经内分泌机制,结题,主持; 7. 中央高校基本科研业务费项目(KYZ201535、KJQN201609),结题,主持; 8. 国家自然科学基金重点项目,31430082,生长猪肠道内微生物与营养代谢互作及其对机体整体代谢作用机制的研究,结题,参加; 9. 国家自然科学基金面上项目,31572414,粪菌接种物早期干预影响新生仔猪肠道菌群和肠黏膜免疫发育的机制研究,结题,参加。 教学活动 本科生课程:《饲料学》,《动物营养学》,《食物与胃肠道的相识与相知》

研究领域

单胃动物营养与肠道微生物;替抗饲粮、低蛋白饲粮等功能性饲料的研发与应用;猪生长发育与肉品质的营养调控、肠道微生物及其代谢产物对仔猪肠道健康的影响及机制;替抗饲粮、低蛋白饲粮等功能性饲料的研发与应用

动物营养与饲料科学

近期论文

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1. 期刊论文 Zhang Y, Li X, Huang G, Wang H, Chen H, Su Y, Yu K*, Zhu W. Propionate stimulates the secretion of satiety hormones and reduces acute appetite in a cecal fistula pig model. Animal Nutrition. 2022, doi.org/10.1016/j.aninu.2022.06.003 Zhang R, Huang G, Ren Y, Wang H, Ye Y, Guo J, Wang M, Zhu W, Yu K*. Effects of dietary indole-3-carboxaldehyde supplementation on growth performance, intestinal epithelial function, and intestinal microbial composition in weaned piglets[J]. Frontiers in Nutrition. 2022, 9:896815 Yu K#, He Y#, Hyseni I, Pei Z, Yang Y, Xu P, Cai X, Liu H, Qu N, Liu H, He Y, Yu M, Liang C, Yang T, Wang J, Gourdy P, Arnal JF, Lenfant F, Xu Y*, Wang C*. 17β-estradiol promotes acute refeeding in hungry mice via membrane-initiated ERɑ signaling. Molecular Metabolism. 2020, 42:101053 Yu K, Zhang Y, Chen H, Zhu W*. Hepatic metabolomic and transcriptomic responses induced by cecal infusion of sodium propionate in a fistula pig model. Journal of Agricultural and Food Chemistry. 2019, 67(47):13073-13081 Li X, Mao M, Zhang Y, Yu K*, Zhu W. Succinate modulates intestinal barrier function and inflammation response in pigs. Biomolecules. 2019, 9(9):E486 Zhang Y, Chen H, Zhu W, Yu K*. Cecal infusion of sodium propionate promotes intestinal development and jejunal barrier function in growing pigs. Animals. 2019, 9(6):E284 Zhang Y#, Yu K#*, Chen H, Su Y, Zhu W. Cecal infusion of the short chain fatty acid propionate affects the microbiota and expression of inflammatory cytokines in the colon in a fistula pig model. Microbial Biotechnology. 2018, 11(5):859–868 Yu K, Mu C, Yang Y, Su Y, Zhu W*. Segment-specific responses of intestinal epithelium transcriptome to in-feed antibiotics in pigs. Physiological Genomics. 2017, 49:582-591 Mo D#, Yu K#, Chen H, Chen L, Liu X, He Z, Cong P, Chen Y*. Transcriptome landscape of porcine intramuscular adipocytes during differentiation. Journal of Agricultural and Food Chemistry. 2017, 65:6317-6328 Yu K#, Mo D#, Wu M, Chen H, Chen L, Li M, Chen Y*. Activating transcription factor 4 regulates adipocyte differentiation via altering the coordinate expression of CCATT/enhancer binding protein β and peroxisome proliferator-activated receptor γ. FEBS Journal. 2014, 281(10):2399-2409 Yu K#, Shu G#, Yuan F, Zhu X, Gao P, Wang S, Wang L, Xi Q, Zhang S, Zhang Y, Li Y, Wu T, Yuan L*, Jiang Q*. Fatty acid and transcriptome profiling of longissimus dorsi muscles between pig breeds differing in meat quality. International Journal of Biological Sciences. 2013, 9(1):108-118 Ye H, Feng B, Wang C, Saito K, Yang Y, Ibrahimi L, Schaul S, Patel N, Saenz L, Luo P, Lai P, Torres V, Kota M, Dixit D, Cai X, Qu N, Hyseni I, Yu K, Jiang Y, Tong Q, Sun Z, Arenkiel BR, He Y*, Xu P*, Xu Y*. An estrogen-sensitive hypothalamus-midbrain neural circuit controls thermogenesis and physical activity. Science Advances. 2022, 8(3): eabk0185 Yang Y*, He Y, Liu H, Zhou W, Wang C, Xu P, Cai X, Liu H, Yu K, Pei Z, Hyseni I, Fukuda M, Tong Q, Xu J, Sun Z, O'Malley BW, Xu Y*. Hypothalamic steroid receptor coactivator-2 regulates adaptations to fasting and overnutrition. Cell Reports. 2021, 37(10): 110075 Shen J, Mu C, Wang H, Huang Z, Yu K, Zoetendal EG, Zhu W. Stimulation of Gastric Transit Function Driven by Hydrolyzed Casein Increases Small Intestinal Carbohydrate Availability and Its Microbial Metabolism. Molecular Nutrition & Food Research. 2020, 64(21):e2000250 He Y#, Xu P#, Wang C#, Xia Y#, Yu M, Yang Y, Yu K, Cai X, Qu N, Saito K, Wang J, Hyseni I, Robertson M, Piyarathna B, Gao M, Khan SA, Liu F, Chen R, Coarfa C, Zhao Z, Tong Q, Sun Z, Xu Y*. Estrogen receptor-α expressing neurons in the ventrolateral VMH regulate glucose balance. Nature Communications. 2020, 11(1):2165 Peng Y, Yu K, Mu C, Hang S, Che L, Zhu W*. Progressive response of large intestinal bacterial community and fermentation to the stepwise decrease of dietary crude protein level in growing pigs. Applied Microbiology and Biotechnology. 2017, 101(13):5415-5426 Mu C, Yang Y, Yu K, Yu M, Zhang C, Su Y, Zhu W*. Alteration of metabolomic markers of amino-acid metabolism in piglets with in-feed antibiotics. Amino Acids. 2017, 49(4):771-781 Yu M, Mu C, Yang Y, Zhang C, Su Y, Huang Z, Yu K, Zhu W*. Increases in circulating amino acids with in-feed antibiotics correlated with gene expression of intestinal amino acid transporters in piglets. Amino Acids. 2017, 49(9):1587-1599. Yu M, Zhang C, Yang Y, Mu C, Su Y, Yu K, Zhu W*. Long-term effects of early antibiotic intervention on blood parameters, apparent nutrient digestibility, and fecal microbial fermentation profile in pigs with different dietary protein levels. Journal of animal science and biotechnology. 2017, 1(8):60 Sun Y, Yu K, Zhou L, Fang L, Su Y*, Zhu W. Metabolomic and transcriptomic responses induced in the livers of pigs by the long-term intake of resistant starch. Journal of Animal Science. 2016, 94 (3):1083-1094 黄国文, 张若凡, 叶艳新, 李轩, 朱伟云, 余凯凡*. 琥珀酸对产肠毒素大肠杆菌K88感染小鼠肠道炎症的影响及其机制研究. 动物营养学报. 2022 毛明雨, 张若凡, 黄国文, 李轩, 成艳芬, 余凯凡*, 朱伟云. 猪源乳杆菌Lactobacillus reuteri strain DSM和Lactobacillus taiwanensis strain BCRC对肠道炎症的影响. 微生物学报. 2021, 61(11):3715-3725 张亚南, 李轩, 陈慧子, 余凯凡*, 朱伟云. 丙酸钠对IPEC-J2细胞紧密连接及炎症细胞因子的影响. 南京农业大学学报. 2019, 42(1):137-144 余凯凡, 张福哲, 朱伟云*. 猪不同肠段微生物体外培养对蛋氨酸的代谢特性. 微生物学报. 2018, 58(5):784-792 陈慧子, 张亚南, 余凯凡*, 朱伟云. 盲肠灌注丙酸对生长猪结肠黏膜基因表达的影响. 动物营养学报. 2018, 30(8):3134-3141 张亚南, 余凯凡*, 朱伟云. 肠道微生物调控宿主食欲的研究进展. 微生物学报. 2017, 57(7): 951-960 余凯凡, 李思奇, 朱伟云*. 不同规模猪场饲料粗蛋白水平及赖氨酸添加量的研究. 畜牧与兽医. 2017, 49(10):24-27 朱伟云*, 余凯凡, 慕春龙, 杨宇翔. 猪的肠道微生物与宿主营养代谢. 动物营养学报. 2014, 26(10):3053-3058 2. 会议论文 Yu K, Mu C, Yang Y, Zhu W. Transcriptomic responses in porcine intestinal epithelium induced by antibiotics. The 5th International Symposium on Gastrointestinal Microbial Ecology and Functionality, Hangzhou, China, 2016.05.23-05.25 Yu K, Mu C, Yang Y, Yu M, Su Y, Zhu W. Changes in gut microbiota induced by early antibiotic intervention modifies intestinal luminal amino acid metabolism in piglets. Amino Acids. 2015, 47(8): 1677. The 14th International Congress on Amino Acids, Peptides and Proteins, Vienna, Austria, 2015.08.03-08.07 朱伟云, 余凯凡. 猪利用氮营养素的机制及营养调控研究进展. 中国畜牧兽医学会动物营养学分会第十届全国代表大会暨十二届学术研讨会, 中国武汉, 2016.10.21-10.23

学术兼职

中国畜牧兽医学会会员,中国畜牧兽医学会动物营养学分会会员

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